A study of Cancer-related MicroRNAs through Expression Data and Literature Search

MicroRNAs (miRNAs) are a class of non-coding RNAs that hybridize to mRNAs and induce either translation repression or mRNA cleavage. Recently, it has been reported that miRNAs could possibly play an important role in human diseases. By integrating miRNA target genes, cancer genes, miRNA and mRNA expression profiles information, a database is developed to link miRNAs to cancer target genes. The database provides experimentally verified human miRNA target genes information, including oncogenes and tumor suppressor genes. In addition, fragile sites information for miRNAs, and the strength of the correlation of miRNA and its target mRNA expression level for nine tissue types are computed, which serve as an indicator for suggesting miRNAs could play a role in human cancer. The database is freely accessible at http://ppi.bioinfo.asia.edu.tw/mirna_target/index.html.

Evaluating Alternative Fuel Vehicles from Technical, Environmental and Economic Perspectives: Case of Light-Duty Vehicles in Iran

This paper presents an environmental and technoeconomic evaluation of light duty vehicles in Iran. A comprehensive well-to-wheel (WTW) analysis is applied to compare different automotive fuel chains, conventional internal combustion engines and innovative vehicle powertrains. The study examines the competitiveness of 15 various pathways in terms of energy efficiencies, GHG emissions, and levelized cost of different energy carriers. The results indicate that electric vehicles including battery electric vehicles (BEV), fuel cell vehicles (FCV) and plug-in hybrid electric vehicles (PHEV) increase the WTW energy efficiency by 54%, 51% and 46%, respectively, compared to common internal combustion engines powered by gasoline. On the other hand, greenhouse gas (GHG) emissions per kilometer of FCV and BEV would be 48% lower than that of gasoline engines. It is concluded that BEV has the lowest total cost of energy consumption and external cost of emission, followed by internal combustion engines (ICE) fueled by CNG. Conventional internal combustion engines fueled by gasoline, on the other hand, would have the highest costs.

A Hybrid Approach to Fault Detection and Diagnosis in a Diesel Fuel Hydrotreatment Process

It is estimated that the total cost of abnormal conditions to US process industries is around $20 billion dollars in annual losses. The hydrotreatment (HDT) of diesel fuel in petroleum refineries is a conversion process that leads to high profitable economical returns. However, this is a difficult process to control because it is operated continuously, with high hydrogen pressures and it is also subject to disturbances in feed properties and catalyst performance. So, the automatic detection of fault and diagnosis plays an important role in this context. In this work, a hybrid approach based on neural networks together with a pos-processing classification algorithm is used to detect faults in a simulated HDT unit. Nine classes (8 faults and the normal operation) were correctly classified using the proposed approach in a maximum time of 5 minutes, based on on-line data process measurements.

Query Optimization Techniques for XML Databases

Over the past few years, XML (eXtensible Mark-up Language) has emerged as the standard for information representation and data exchange over the Internet. This paper provides a kick-start for new researches venturing in XML databases field. We survey the storage representation for XML document, review the XML query processing and optimization techniques with respect to the particular storage instance. Various optimization technologies have been developed to solve the query retrieval and updating problems. Towards the later year, most researchers proposed hybrid optimization techniques. Hybrid system opens the possibility of covering each technology-s weakness by its strengths. This paper reviews the advantages and limitations of optimization techniques.

A Novel Hybrid Mobile Agent Based Distributed Intrusion Detection System

The first generation of Mobile Agents based Intrusion Detection System just had two components namely data collection and single centralized analyzer. The disadvantage of this type of intrusion detection is if connection to the analyzer fails, the entire system will become useless. In this work, we propose novel hybrid model for Mobile Agent based Distributed Intrusion Detection System to overcome the current problem. The proposed model has new features such as robustness, capability of detecting intrusion against the IDS itself and capability of updating itself to detect new pattern of intrusions. In addition, our proposed model is also capable of tackling some of the weaknesses of centralized Intrusion Detection System models.

Hybrid Method Using Wavelets and Predictive Method for Compression of Speech Signal

The development of the signal compression algorithms is having compressive progress. These algorithms are continuously improved by new tools and aim to reduce, an average, the number of bits necessary to the signal representation by means of minimizing the reconstruction error. The following article proposes the compression of Arabic speech signal by a hybrid method combining the wavelet transform and the linear prediction. The adopted approach rests, on one hand, on the original signal decomposition by ways of analysis filters, which is followed by the compression stage, and on the other hand, on the application of the order 5, as well as, the compression signal coefficients. The aim of this approach is the estimation of the predicted error, which will be coded and transmitted. The decoding operation is then used to reconstitute the original signal. Thus, the adequate choice of the bench of filters is useful to the transform in necessary to increase the compression rate and induce an impercevable distortion from an auditive point of view.

Soft-Sensor for Estimation of Gasoline Octane Number in Platforming Processes with Adaptive Neuro-Fuzzy Inference Systems (ANFIS)

Gasoline Octane Number is the standard measure of the anti-knock properties of a motor in platforming processes, that is one of the important unit operations for oil refineries and can be determined with online measurement or use CFR (Cooperative Fuel Research) engines. Online measurements of the Octane number can be done using direct octane number analyzers, that it is too expensive, so we have to find feasible analyzer, like ANFIS estimators. ANFIS is the systems that neural network incorporated in fuzzy systems, using data automatically by learning algorithms of NNs. ANFIS constructs an input-output mapping based both on human knowledge and on generated input-output data pairs. In this research, 31 industrial data sets are used (21 data for training and the rest of the data used for generalization). Results show that, according to this simulation, hybrid method training algorithm in ANFIS has good agreements between industrial data and simulated results.

Capacitor Placement in Distribution Systems Using Simulating Annealing (SA)

This paper undertakes the problem of optimal capacitor placement in a distribution system. The problem is how to optimally determine the locations to install capacitors, the types and sizes of capacitors to he installed and, during each load level,the control settings of these capacitors in order that a desired objective function is minimized while the load constraints,network constraints and operational constraints (e.g. voltage profile) at different load levels are satisfied. The problem is formulated as a combinatorial optimization problem with a nondifferentiable objective function. Four solution mythologies based on algorithms (GA),tabu search (TS), and hybrid GA-SA algorithms are presented.The solution methodologies are preceded by a sensitivity analysis to select the candidate capacitor installation locations.

Prediction of Post Underwater Shock Properties of Polymer - Clay/Silica Hybrid Nanocomposites through Regression Models

Exploding concentrated underwater charges to damage underwater structures such as ship hulls is a part of naval warfare strategies. Adding small amounts of foreign particles (like clay or silica) of nanosize significantly improves the engineering properties of the polymers. In the present work the clay in terms 1, 2 and 3 percent by weight was surface treated with a suitable silane agent. The hybrid nanocomposite was prepared by the hand lay-up technique. Mathematical regression models have been employed for theoretical prediction. This will result in considerable savings in terms of project time, effort and cost.

Evolutionary Computation Technique for Solving Riccati Differential Equation of Arbitrary Order

In this article an evolutionary technique has been used for the solution of nonlinear Riccati differential equations of fractional order. In this method, genetic algorithm is used as a tool for the competent global search method hybridized with active-set algorithm for efficient local search. The proposed method has been successfully applied to solve the different forms of Riccati differential equations. The strength of proposed method has in its equal applicability for the integer order case, as well as, fractional order case. Comparison of the method has been made with standard numerical techniques as well as the analytic solutions. It is found that the designed method can provide the solution to the equation with better accuracy than its counterpart deterministic approaches. Another advantage of the given approach is to provide results on entire finite continuous domain unlike other numerical methods which provide solutions only on discrete grid of points.

Increase in Solar Thermal Energy Storage by using a Hybrid Energy Storage System

The intermittent nature of solar energy and the energy requirements of buildings necessitate the storage of thermal energy. In this paper a hybrid system of storing solar energy has been analyzed. Adding a LHS medium to a commercial solar water heater, the required energy for heating a small room was obtained in addition to preparing hot water. In other words, the suggested hybrid storage system consists of two tanks: a water tank as a SHS medium; and a paraffin tank as a LHS medium. A computing program was used to find the optimized time schedule of charging the storage tanks during each day, according to the solar radiation conditions. The results show that the use of such system can improve the capability of energy gathering comparing to the individual water storage tank during the cold months of the year. Of course, because of the solar radiation angles and shorten daylight in December & January, the performance will be the same as the simple solar water heaters (in the northern hemisphere). But the extra energy stored in November, February, March & April, can be useful for heating a small room for 3 hours during the cold days.

Hybrid Feature and Adaptive Particle Filter for Robust Object Tracking

A hybrid feature based adaptive particle filter algorithm is presented for object tracking in real scenarios with static camera. The hybrid feature is combined by two effective features: the Grayscale Arranging Pairs (GAP) feature and the color histogram feature. The GAP feature has high discriminative ability even under conditions of severe illumination variation and dynamic background elements, while the color histogram feature has high reliability to identify the detected objects. The combination of two features covers the shortage of single feature. Furthermore, we adopt an updating target model so that some external problems such as visual angles can be overcame well. An automatic initialization algorithm is introduced which provides precise initial positions of objects. The experimental results show the good performance of the proposed method.

Mining Genes Relations in Microarray Data Combined with Ontology in Colon Cancer Automated Diagnosis System

MATCH project [1] entitle the development of an automatic diagnosis system that aims to support treatment of colon cancer diseases by discovering mutations that occurs to tumour suppressor genes (TSGs) and contributes to the development of cancerous tumours. The constitution of the system is based on a) colon cancer clinical data and b) biological information that will be derived by data mining techniques from genomic and proteomic sources The core mining module will consist of the popular, well tested hybrid feature extraction methods, and new combined algorithms, designed especially for the project. Elements of rough sets, evolutionary computing, cluster analysis, self-organization maps and association rules will be used to discover the annotations between genes, and their influence on tumours [2]-[11]. The methods used to process the data have to address their high complexity, potential inconsistency and problems of dealing with the missing values. They must integrate all the useful information necessary to solve the expert's question. For this purpose, the system has to learn from data, or be able to interactively specify by a domain specialist, the part of the knowledge structure it needs to answer a given query. The program should also take into account the importance/rank of the particular parts of data it analyses, and adjusts the used algorithms accordingly.

Network Based High Performance Computing

In the past few years there is a change in the view of high performance applications and parallel computing. Initially such applications were targeted towards dedicated parallel machines. Recently trend is changing towards building meta-applications composed of several modules that exploit heterogeneous platforms and employ hybrid forms of parallelism. The aim of this paper is to propose a model of virtual parallel computing. Virtual parallel computing system provides a flexible object oriented software framework that makes it easy for programmers to write various parallel applications.

Detecting Interactions between Behavioral Requirements with OWL and SWRL

High quality requirements analysis is one of the most crucial activities to ensure the success of a software project, so that requirements verification for software system becomes more and more important in Requirements Engineering (RE) and it is one of the most helpful strategies for improving the quality of software system. Related works show that requirement elicitation and analysis can be facilitated by ontological approaches and semantic web technologies. In this paper, we proposed a hybrid method which aims to verify requirements with structural and formal semantics to detect interactions. The proposed method is twofold: one is for modeling requirements with the semantic web language OWL, to construct a semantic context; the other is a set of interaction detection rules which are derived from scenario-based analysis and represented with semantic web rule language (SWRL). SWRL based rules are working with rule engines like Jess to reason in semantic context for requirements thus to detect interactions. The benefits of the proposed method lie in three aspects: the method (i) provides systematic steps for modeling requirements with an ontological approach, (ii) offers synergy of requirements elicitation and domain engineering for knowledge sharing, and (3)the proposed rules can systematically assist in requirements interaction detection.

Design and Implementation of Cyber Video Consultation System Using Hybrid P2P

This paper describes the design and implementation of cyber video consultation systems(CVCS) using hybrid P2P for video consultation between remote sites. The proposed system is based on client-server and P2P(Peer to Peer) architecture, where client-server is used for communication with the MCU(Multipoint Control Unit) and P2P is used for the cyber video consultation. The developed video consultation system decreases server traffic, and cuts down network expenses, as the multimedia data decentralizes to the client by hybrid P2P architecture. Also the developed system is tested by the group-type video consultation system using communication protocol and application software through Ethernet networks.

Heuristic Search Algorithms for Tuning PUMA 560 Fuzzy PID Controller

This paper compares the heuristic Global Search Techniques; Genetic Algorithm, Particle Swarm Optimization, Simulated Annealing, Generalized Pattern Search, genetic algorithm hybridized with Nelder–Mead and Generalized pattern search technique for tuning of fuzzy PID controller for Puma 560. Since the actual control is in joint space ,inverse kinematics is used to generate various joint angles correspoding to desired cartesian space trajectory. Efficient dynamics and kinematics are modeled on Matlab which takes very less simulation time. Performances of all the tuning methods with and without disturbance are compared in terms of ITSE in joint space and ISE in cartesian space for spiral trajectory tracking. Genetic Algorithm hybridized with Generalized Pattern Search is showing best performance.

Accurate Time Domain Method for Simulation of Microstructured Electromagnetic and Photonic Structures

A time-domain numerical model within the framework of transmission line modeling (TLM) is developed to simulate electromagnetic pulse propagation inside multiple microcavities forming photonic crystal (PhC) structures. The model developed is quite general and is capable of simulating complex electromagnetic problems accurately. The field quantities can be mapped onto a passive electrical circuit equivalent what ensures that TLM is provably stable and conservative at a local level. Furthermore, the circuit representation allows a high level of hybridization of TLM with other techniques and lumped circuit models of components and devices. A photonic crystal structure formed by rods (or blocks) of high-permittivity dieletric material embedded in a low-dielectric background medium is simulated as an example. The model developed gives vital spatio-temporal information about the signal, and also gives spectral information over a wide frequency range in a single run. The model has wide applications in microwave communication systems, optical waveguides and electromagnetic materials simulations.

Selective Harmonic Elimination of PWM AC/AC Voltage Controller Using Hybrid RGA-PS Approach

Selective harmonic elimination-pulse width modulation techniques offer a tight control of the harmonic spectrum of a given voltage waveform generated by a power electronic converter along with a low number of switching transitions. Traditional optimization methods suffer from various drawbacks, such as prolonged and tedious computational steps and convergence to local optima; thus, the more the number of harmonics to be eliminated, the larger the computational complexity and time. This paper presents a novel method for output voltage harmonic elimination and voltage control of PWM AC/AC voltage converters using the principle of hybrid Real-Coded Genetic Algorithm-Pattern Search (RGA-PS) method. RGA is the primary optimizer exploiting its global search capabilities, PS is then employed to fine tune the best solution provided by RGA in each evolution. The proposed method enables linear control of the fundamental component of the output voltage and complete elimination of its harmonic contents up to a specified order. Theoretical studies have been carried out to show the effectiveness and robustness of the proposed method of selective harmonic elimination. Theoretical results are validated through simulation studies using PSIM software package.

A Hybrid Particle Swarm Optimization Solution to Ramping Rate Constrained Dynamic Economic Dispatch

This paper presents the application of an enhanced Particle Swarm Optimization (EPSO) combined with Gaussian Mutation (GM) for solving the Dynamic Economic Dispatch (DED) problem considering the operating constraints of generators. The EPSO consists of the standard PSO and a modified heuristic search approaches. Namely, the ability of the traditional PSO is enhanced by applying the modified heuristic search approach to prevent the solutions from violating the constraints. In addition, Gaussian Mutation is aimed at increasing the diversity of global search, whilst it also prevents being trapped in suboptimal points during search. To illustrate its efficiency and effectiveness, the developed EPSO-GM approach is tested on the 3-unit and 10-unit 24-hour systems considering valve-point effect. From the experimental results, it can be concluded that the proposed EPSO-GM provides, the accurate solution, the efficiency, and the feature of robust computation compared with other algorithms under consideration.