Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: Tool Tracker is a client-server based application. It is essentially a catalogue of various network monitoring and management tools that are available online. There is a database maintained on the server side that contains the information about various tools. Several clients can access this information simultaneously and utilize this information. The various categories of tools considered are packet sniffers, port mappers, port scanners, encryption tools, and vulnerability scanners etc for the development of this application. This application provides a front end through which the user can invoke any tool from a central repository for the purpose of packet sniffing, port scanning, network analysis etc. Apart from the tool, its description and the help files associated with it would also be stored in the central repository. This facility will enable the user to view the documentation pertaining to the tool without having to download and install the tool. The application would update the central repository with the latest versions of the tools. The application would inform the user about the availability of a newer version of the tool currently being used and give the choice of installing the newer version to the user. Thus ToolTracker provides any network administrator that much needed abstraction and ease-ofuse with respect to the tools that he can use to efficiently monitor a network.
Abstract: Fourier transform infrared (FT-IR) spectroscopic imaging
is an emerging technique that provides both chemically and
spatially resolved information. The rich chemical content of data
may be utilized for computer-aided determinations of structure and
pathologic state (cancer diagnosis) in histological tissue sections for
prostate cancer. FT-IR spectroscopic imaging of prostate tissue has
shown that tissue type (histological) classification can be performed to
a high degree of accuracy [1] and cancer diagnosis can be performed
with an accuracy of about 80% [2] on a microscopic (≈ 6μm)
length scale. In performing these analyses, it has been observed
that there is large variability (more than 60%) between spectra from
different points on tissue that is expected to consist of the same
essential chemical constituents. Spectra at the edges of tissues are
characteristically and consistently different from chemically similar
tissue in the middle of the same sample. Here, we explain these
differences using a rigorous electromagnetic model for light-sample
interaction. Spectra from FT-IR spectroscopic imaging of chemically
heterogeneous samples are different from bulk spectra of individual
chemical constituents of the sample. This is because spectra not
only depend on chemistry, but also on the shape of the sample.
Using coupled wave analysis, we characterize and quantify the nature
of spectral distortions at the edges of tissues. Furthermore, we
present a method of performing histological classification of tissue
samples. Since the mid-infrared spectrum is typically assumed to
be a quantitative measure of chemical composition, classification
results can vary widely due to spectral distortions. However, we
demonstrate that the selection of localized metrics based on chemical
information can make our data robust to the spectral distortions
caused by scattering at the tissue boundary.
Abstract: Documents clustering become an essential technology
with the popularity of the Internet. That also means that fast and
high-quality document clustering technique play core topics. Text
clustering or shortly clustering is about discovering semantically
related groups in an unstructured collection of documents. Clustering
has been very popular for a long time because it provides unique
ways of digesting and generalizing large amounts of information.
One of the issues of clustering is to extract proper feature (concept)
of a problem domain. The existing clustering technology mainly
focuses on term weight calculation. To achieve more accurate
document clustering, more informative features including concept
weight are important. Feature Selection is important for clustering
process because some of the irrelevant or redundant feature may
misguide the clustering results. To counteract this issue, the proposed
system presents the concept weight for text clustering system
developed based on a k-means algorithm in accordance with the
principles of ontology so that the important of words of a cluster can
be identified by the weight values. To a certain extent, it has resolved
the semantic problem in specific areas.
Abstract: Predicting short term wind speed is essential in order
to prevent systems in-action from the effects of strong winds. It also
helps in using wind energy as an alternative source of energy, mainly
for Electrical power generation. Wind speed prediction has
applications in Military and civilian fields for air traffic control,
rocket launch, ship navigation etc. The wind speed in near future
depends on the values of other meteorological variables, such as
atmospheric pressure, moisture content, humidity, rainfall etc. The
values of these parameters are obtained from a nearest weather
station and are used to train various forms of neural networks. The
trained model of neural networks is validated using a similar set of
data. The model is then used to predict the wind speed, using the
same meteorological information. This paper reports an Artificial
Neural Network model for short term wind speed prediction, which
uses back propagation algorithm.
Abstract: For numerical prediction of the NOX in the exhaust of
a compression ignition engine a model was developed by considering
the parameter equivalence ratio. This model was validated by
comparing the predicted results of NOX with experimental ones. The
ultimate aim of the work was to access the applicability, robustness
and performance of the improved NOX model against other NOX
models.
Abstract: The size, complexity and number of databases used
for protein information have caused bioinformatics to lag behind in
adapting to the need to handle this distributed information.
Integrating all the information from different databases into one
database is a challenging problem. Our main research is to develop a
tool which can be used to access and manipulate protein information
from difference databases. In our approach, we have integrated
difference databases such as Swiss-prot, PDB, Interpro, and EMBL
and transformed these databases in flat file format into relational
form using XML and Bioperl. As a result, we showed this tool can
search different sizes of protein information stored in relational
database and the result can be retrieved faster compared to flat file
database. A web based user interface is provided to allow user to
access or search for protein information in the local database.
Abstract: Rice husk is one of the alternative fuels for Thailand because of its high potential and environmental benefits. Nonetheless, the environmental profile of the electricity production from rice husk must be assessed to ensure reduced environmental damage. A 10 MW pilot plant using rice husk as feedstock is the study site. The environmental impacts from rice husk power plant are evaluated by using the Life Cycle Assessment (LCA) methodology. Energy, material and carbon balances have been determined for tracing the system flow. Carbon closure has been used for describing of the net amount of CO2 released from the system in relation to the amount being recycled between the power plant and the CO2 adsorbed by rice husk. The transportation of rice husk to the power plant has significant on global warming, but not on acidification and photo-oxidant formation. The results showed that the impact potentials from rice husk power plant are lesser than the conventional plants for most of the categories considered; except the photo-oxidant formation potential from CO. The high CO from rice husk power plant may be due to low boiler efficiency and high moisture content in rice husk. The performance of the study site can be enhanced by improving the combustion efficiency.
Abstract: We present a new method to reconstruct a temporally
coherent 3D animation from single or multi-view RGB-D video data
using unbiased feature point sampling. Given RGB-D video data, in
form of a 3D point cloud sequence, our method first extracts feature
points using both color and depth information. In the subsequent
steps, these feature points are used to match two 3D point clouds in
consecutive frames independent of their resolution. Our new motion
vectors based dynamic alignement method then fully reconstruct
a spatio-temporally coherent 3D animation. We perform extensive
quantitative validation using novel error functions to analyze the
results. We show that despite the limiting factors of temporal and
spatial noise associated to RGB-D data, it is possible to extract
temporal coherence to faithfully reconstruct a temporally coherent
3D animation from RGB-D video data.
Abstract: Control chart pattern recognition is one of the most important tools to identify the process state in statistical process control. The abnormal process state could be classified by the recognition of unnatural patterns that arise from assignable causes. In this study, a wavelet based neural network approach is proposed for the recognition of control chart patterns that have various characteristics. The procedure of proposed control chart pattern recognizer comprises three stages. First, multi-resolution wavelet analysis is used to generate time-shape and time-frequency coefficients that have detail information about the patterns. Second, distance based features are extracted by a bi-directional Kohonen network to make reduced and robust information. Third, a back-propagation network classifier is trained by these features. The accuracy of the proposed method is shown by the performance evaluation with numerical results.
Abstract: Business transformation initiatives are required by
any organization to jump from its normal mode of operation to the
one that is suitable for the change in the environment such as
competitive pressures, regulatory requirements, changes in labor
market, etc., or internal such as changes in strategy/vision, changes in
the capability, change in the management, etc. Recent advances in
information technology in automating the business processes have
the potential to transform an organization to provide it with a
sustained competitive advantage. Process constitutes the skeleton of
a business. Thus, for a business to exist and compete well, it is
essential for the skeleton to be robust and agile. This paper details
“transformation" from a business perspective, methodologies to bring
about an effective transformation, process-based transformation, and
the role of services computing in this. Further, it details the benefits
that could be achieved through services computing.
Abstract: Arc welding creates a weld pool to realize continuity between pieces of assembly. The thermal history of the weld is dependent on heat transfer and fluid flow in the weld pool. The metallurgical transformation during welding and cooling are modeled in the literature only at solid state neglecting the fluid flow. In the present paper we associate a heat transfer – fluid flow and metallurgical model for the 16MnD5 steel. The metallurgical transformation model is based on Leblond model for the diffusion kinetics and on the Koistinen-Marburger equation for Marteniste transformation. The predicted thermal history and metallurgical transformations are compared to a simulation without fluid phase. This comparison shows the great importance of the fluid flow modeling.
Abstract: In order to provide existing SOAP (Simple Object
Access Protocol)-based Web services with users who are familiar with
REST (REpresentational State Transfer)-style Web services, this
paper proposes Web service providing method using Web service
transformation. This enables SOAP-based service providers to define
rules for mapping from RESTful Web services to SOAP-based ones.
Using these mapping rules, HTTP request messages for RESTful
services are converted automatically into SOAP-based service
invocations. Web service providers need not develop duplicate
RESTful services and they can avoid programming mediation
modules per service. Furthermore, they need not equip mediation
middleware like ESB (Enterprise Service Bus) only for the purpose of
transformation of two different Web service styles.
Abstract: Cancer classification to their corresponding cohorts has been key area of research in bioinformatics aiming better prognosis of the disease. High dimensionality of gene data has been makes it a complex task and requires significance data identification technique in order to reducing the dimensionality and identification of significant information. In this paper, we have proposed a novel approach for classification of oral cancer into metastasis positive and negative patients. We have used significance analysis of microarrays (SAM) for identifying significant genes which constitutes gene signature. 3 different gene signatures were identified using SAM from 3 different combination of training datasets and their classification accuracy was calculated on corresponding testing datasets using k-Nearest Neighbour (kNN), Fuzzy C-Means Clustering (FCM), Support Vector Machine (SVM) and Backpropagation Neural Network (BPNN). A final gene signature of only 9 genes was obtained from above 3 individual gene signatures. 9 gene signature-s classification capability was compared using same classifiers on same testing datasets. Results obtained from experimentation shows that 9 gene signature classified all samples in testing dataset accurately while individual genes could not classify all accurately.
Abstract: An attractor neural network on the small-world topology
is studied. A learning pattern is presented to the network, then
a stimulus carrying local information is applied to the neurons and
the retrieval of block-like structure is investigated. A synaptic noise
decreases the memory capability. The change of stability from local
to global attractors is shown to depend on the long-range character
of the network connectivity.
Abstract: A novel path planning approach is presented to solve
optimal path in stochastic, time-varying networks under priori traffic
information. Most existing studies make use of dynamic programming
to find optimal path. However, those methods are proved to
be unable to obtain global optimal value, moreover, how to design
efficient algorithms is also another challenge.
This paper employs a decision theoretic framework for defining
optimal path: for a given source S and destination D in urban transit
network, we seek an S - D path of lowest expected travel time
where its link travel times are discrete random variables. To solve
deficiency caused by the methods of dynamic programming, such as
curse of dimensionality and violation of optimal principle, an integer
programming model is built to realize assignment of discrete travel
time variables to arcs. Simultaneously, pruning techniques are also
applied to reduce computation complexity in the algorithm. The final
experiments show the feasibility of the novel approach.
Abstract: In recent years, everything is trending toward digitalization
and with the rapid development of the Internet technologies,
digital media needs to be transmitted conveniently over the network.
Attacks, misuse or unauthorized access of information is of great
concern today which makes the protection of documents through
digital media a priority problem. This urges us to devise new data
hiding techniques to protect and secure the data of vital significance.
In this respect, steganography often comes to the fore as a tool for
hiding information. Steganography is a process that involves hiding
a message in an appropriate carrier like image or audio. It is of
Greek origin and means "covered or hidden writing". The goal of
steganography is covert communication. Here the carrier can be sent
to a receiver without any one except the authenticated receiver only
knows existence of the information. Considerable amount of work
has been carried out by different researchers on steganography. In this
work the authors propose a novel Steganographic method for hiding
information within the spatial domain of the gray scale image. The
proposed approach works by selecting the embedding pixels using
some mathematical function and then finds the 8 neighborhood of
the each selected pixel and map each bit of the secret message in
each of the neighbor pixel coordinate position in a specified manner.
Before embedding a checking has been done to find out whether the
selected pixel or its neighbor lies at the boundary of the image or not.
This solution is independent of the nature of the data to be hidden
and produces a stego image with minimum degradation.
Abstract: In projects like waterpower, transportation and
mining, etc., proving up the rock-mass structure and hidden tectonic
to estimate the geological body-s activity is very important.
Integrating the seismic results, drilling and trenching data,
CSAMT method was carried out at a planning dame site in southwest
China to evaluate the stability of a deformation. 2D and imitated 3D
inversion resistivity results of CSAMT method were analyzed. The
results indicated that CSAMT was an effective method for defining
an outline of deformation body to several hundred meters deep; the
Lung Pan Deformation was stable in natural conditions; but uncertain
after the future reservoir was impounded.
This research presents a good case study of the fine surveying and
research on complex geological structure and hidden tectonic in
engineering project.
Abstract: The rheological properties, structure and potential synergistic interactions of whey proteins (1-6%) and inulin (20%) in mixed gels in the presence of CaCl2 was the aim of this study. Whey proteins have a strong influence on inulin gel formation. At low concentrations (2%) whey proteins did not impair in inulin gel formation. At higher concentration (4%) whey proteins impaired inulin gelation and inulin impaired the formation of a Ca2+-induced whey protein network. The presence of whey proteins at a level allowing for protein gel network formation (6%) significantly increased the rheological parameters values of the gels. SEM micrographs showed that whey protein structure was coated by inulin moieties which could make the mixed gels firmer. The protein surface hydrophobicity measurements did not exclude synergistic interactions between inulin and whey proteins, however. The use of an electrophoretic technique did not show any stable inulin-whey protein complexes.