Abstract: It is the patient compliance and stability in
combination with controlled drug delivery and biocompatibility that
forms the core feature in present research and development of
sustained biodegradable patch formulation intended for wound
healing. The aim was to impart sustained degradation, sterile
formulation, significant folding endurance, elasticity,
biodegradability, bio-acceptability and strength. The optimized
formulation comprised of polymers including Hydroxypropyl methyl
cellulose, Ethylcellulose, and Gelatin, and Citric Acid PEG Citric
acid (CPEGC) triblock dendrimers and active Curcumin. Polymeric
mixture dissolved in geometric order in suitable medium through
continuous stirring under ambient conditions. With continued stirring
Curcumin was added with aid of DCM and Methanol in optimized
ratio to get homogenous dispersion. The dispersion was sonicated
with optimum frequency and for given time and later casted to form a
patch form. All steps were carried out under strict aseptic conditions.
The formulations obtained in the acceptable working range were
decided based on thickness, uniformity of drug content, smooth
texture and flexibility and brittleness. The patch kept on stability
using butter paper in sterile pack displayed folding endurance in
range of 20 to 23 times without any evidence of crack in an
optimized formulation at room temperature (RT) (24 ± 2°C). The
patch displayed acceptable parameters after stability study conducted
in refrigerated conditions (8±0.2°C) and at RT (24 ± 2°C) up to 90
days. Further, no significant changes were observed in critical
parameters such as elasticity, biodegradability, drug release and drug
content during stability study conducted at RT 24±2°C for 45 and 90
days. The drug content was in range 95 to 102%, moisture content
didn’t exceeded 19.2% and patch passed the content uniformity test.
Percentage cumulative drug release was found to be 80% in 12h and
matched the biodegradation rate as drug release with correlation
factor R2>0.9. The biodegradable patch based formulation developed
shows promising results in terms of stability and release profiles.
Abstract: The possibility of application the dietary fibers in
production of crackers was observed in this work, as well as their
influence on rheological and textural properties on the dough for
crackers and influence on sensory properties of obtained crackers.
Three different dietary fibers, oat, potato and pea fibers, replaced
10% of wheat flour. Long fermentation process and baking test
method were used for crackers production. The changes of dough for
crackers were observed by rheological methods of determination the
viscoelastic dough properties and by textural measurements. Sensory
quality of obtained crackers was described using quantity descriptive
method (QDA) by trained members of descriptive panel. Additional
analysis of crackers surface was performed by videometer. Based on
rheological determination, viscoelastic properties of dough for
crackers were reduced by application of dietary fibers. Manipulation
of dough with 10% of potato fiber was disabled, thus the recipe
modification included increase in water content at 35%. Dough
compliance to constant stress for samples with dietary fibers
decreased, due to more rigid and stiffer dough consistency compared
to control sample. Also, hardness of dough for these samples
increased and dough extensibility decreased. Sensory properties of
final products, crackers, were reduced compared to control sample.
Application of dietary fibers affected mostly hardness, structure and
crispness of the crackers. Observed crackers were low marked for
flavor and taste, due to influence of fibers specific aroma. The sample
with 10% of potato fibers and increased water content was the most
adaptable to applied stresses and to production process. Also this
sample was close to control sample without dietary fibers by
evaluation of sensory properties and by results of videometer method.
Abstract: This paper applied factor conditions from Porter’s
Diamond Model (1990) to understand the various challenges facing
the AMISA. Factor conditions highlighted in Porter’s model are
grouped into two groups namely, basic and advance factors. Two
AMISA associations representing over 10 000 employees were
interviewed. The largest Clothing, Textiles and Leather (CTL)
apparel retail group was also interviewed with a government
department implementing the industrialization policy were
interviewed. The paper points out that AMISA have basic factor conditions
necessary for competitive advantage in the apparel industries.
However advance factor creation has proven to be a challenge for
AMISA, Higher Education Institutions (HEIs) and government. Poor
infrastructural maintenance has contributed to high manufacturing
costs and poor quick response technologies. The use of Porter’s
Factor Conditions as a tool to analyze the sector’s competitive
advantage challenges and opportunities has increased knowledge
regarding factors that limit the AMISA’s competitiveness. It is
therefore argued that other studies on Porter’s Diamond model
factors like Demand conditions, Firm strategy, structure and rivalry
and Related and supporting industries can be used to analyze the
situation of the AMISA for the purposes of improving competitive
advantage.
Abstract: This study was aimed to investigate the machining
stability of a spindle tool with different preloaded amount. To this end,
the vibration tests were conducted on the spindle unit with different
preload to assess the dynamic characteristics and machining stability
of the milling machine. Current results demonstrate that the tool tip
frequency response characteristics and the machining stabilities in X
and Y direction are affected to change due to the different preload of
spindle bearings. As found from the results, a high preloaded spindle
tool shows higher limited cutting depth at mid position, while a spindle
with low preload shows a higher limited depth. This indicates that the
machining stability of a milling machine is affected to vary by the
spindle unit when it was assembled with different bearing preload.
Abstract: The first part of the paper analyzes the dynamics of
the total fertility rate both at the national and regional level, pointing
out the regional disparities in the distribution of this indicator. At the
same time, we also focus on the collapse of the number of live births,
on the changes in the fertility rate by birth rank, as well as on the
failure of acquiring the desired number of children. The second part
of the study centres upon a survey applied to urban families with 3
and more than 3 offspring. The preliminary analysis highlights the
fact that an increased fertility (more than 3rd rank) is triggered by the
parents’ above the average material condition and superior education.
The current situation of Romania, which is still passing through a
period of relatively rapid demographic changes, marked by numerous
convulsions, requires a new approach, in compliance with the recent
interpretations appropriate to a new post-transitional demographic
regime.
Abstract: We proposed a Hyperbolic Gompertz Growth Model
(HGGM), which was developed by introducing a shape parameter
(allometric). This was achieved by convoluting hyperbolic sine
function on the intrinsic rate of growth in the classical gompertz
growth equation. The resulting integral solution obtained
deterministically was reprogrammed into a statistical model and used
in modeling the height and diameter of Pines (Pinus caribaea). Its
ability in model prediction was compared with the classical gompertz
growth model, an approach which mimicked the natural variability of
height/diameter increment with respect to age and therefore provides
a more realistic height/diameter predictions using goodness of fit
tests and model selection criteria. The Kolmogorov Smirnov test and
Shapiro-Wilk test was also used to test the compliance of the error
term to normality assumptions while the independence of the error
term was confirmed using the runs test. The mean function of top
height/Dbh over age using the two models under study predicted
closely the observed values of top height/Dbh in the hyperbolic
gompertz growth models better than the source model (classical
gompertz growth model) while the results of R2, Adj. R2, MSE and
AIC confirmed the predictive power of the Hyperbolic Gompertz
growth models over its source model.
Abstract: The intrinsic contradictions of entrepreneurship
development and self-development strategies complicate the task of
reaching compliance between the state economic policy and the
company entrepreneurship policy: on the one hand, there is a
contradiction between the social and the competitive order within
economic order policy and on the other hand, the contradiction exists
between entrepreneurship strategy and entrepreneurship culture
within entrepreneurship policy.
Abstract: Within the framework of this research, the regulatory
documents, which are in force in relation to this industry, were
analyzed. The main attention is turned to their modernization and
necessity of their compliance with European standards.
It is a current issue to direct the efforts of state policy on support
of business by implementing infrastructural projects, as well as by
development of human resources, which may be possible by
supporting the relevant higher and vocational studying-educational
programs.
Abstract: The key role in phenomenological modelling of cyclic
plasticity is good understanding of stress-strain behaviour of given
material. There are many models describing behaviour of materials
using numerous parameters and constants. Combination of individual
parameters in those material models significantly determines whether
observed and predicted results are in compliance. Parameter
identification techniques such as random gradient, genetic algorithm
and sensitivity analysis are used for identification of parameters using
numerical modelling and simulation. In this paper genetic algorithm
and sensitivity analysis are used to study effect of 4 parameters of
modified AbdelKarim-Ohno cyclic plasticity model. Results
predicted by Finite Element (FE) simulation are compared with
experimental data from biaxial ratcheting test with semi-elliptical
loading path.
Abstract: There is a trend in development discourse to
understand and explain the level of corruption in Nigeria, its anticorruption
crusade and why it is failing, as well as its level of
compliance with International standards of United Nations
Convention against Corruption (UNCAC) & African Union
Convention on Converting and Preventing Corruption) to which
Nigeria is a signatory. This paper discusses the legal and
Constitutional provisions relating to corrupt practices and safeguards
in Nigeria, as well as the obstacles to the implementation of these
Conventions.
The paper highlights the challenges posed to the Anti-Corruption
crusade by analysing the loopholes that exist both in administrative
structure and in scope of the relevant laws. The paper argues that
Nigerian Constitution did not make adequate provisions for the
implementation of the conventions, hence a proposal which will
ensure adequate provision for implementing the conventions to better
the lives of Nigerians. The paper concludes that there is the need to
build institutional parameters, adequate constitutional and structural
safeguards, as well as to synergise strategies, collaborations and
alliances to facilitate the timely domestication and implementation of
the conventions.
Abstract: In its efforts to utilize the information and
communication technology to enhance the quality of public service
delivery, national and local governments around the world are
competing to introduce more ICT applications as tools to automate
processes related to law enforcement or policy execution, increase
citizen orientation, trust, and satisfaction, and create one-stop-shops
for public services. In its implementation, e-Government ICTs need
to maintain transparency, participation, and collaboration. Due to this
diverse of mixed goals and requirements, e-Government systems
need to be designed based on special design considerations in order
to eliminate the risks of failure to compliance to government
regulations, citizen dissatisfaction, or market repulsion.
In this article we suggest a framework with guidelines for
designing government information systems that takes into
consideration the special requirements of the public sector. Then we
introduce two case studies and show how applying those guidelines
would result in a more solid system design.
Abstract: Advances in the use of health care technology have
resulted in increased adverse events (AEs) related to the use of
medical devices. The study focused on the existing reporting systems.
This study was conducted in a tertiary care public sector hospital.
Devices included Syringe infusion pumps, Cardiac monitors, Pulse
oximeters, Ventilators and Defibrillators. A total of 211 respondents
were recruited. Interviews were held with 30 key informants. Medical
records were scrutinized. Relevant statistical tests were used.
Resident doctors reported maximum frequency of AEs, followed
by nurses; and least by consultants. A significant association was
found between the cadre of health care personnel and awareness that
the patients and bystanders have a risk of sustaining AE. Awareness
regarding reporting of AEs was low, and it was generally done
verbally. Other critical findings are discussed in the light of the
barriers to reporting, reasons for non-compliance, recording system,
and so on.
Abstract: The paper presents a plastic analysis procedure based
on the energy balance concept for performance based seismic retrofit
of multi-story multi-bay masonry infilled reinforced concrete (R/C)
frames with a ‘soft’ ground story using passive energy dissipation
(PED) devices with the objective of achieving a target performance
level of the retrofitted R/C frame for a given seismic hazard level at
the building site. The proposed energy based plastic analysis
procedure was employed for developing performance based design
(PBD) formulations for PED devices for a simulated application in
seismic retrofit of existing frame structures designed in compliance
with the prevalent standard codes of practice. The PBD formulations
developed for PED devices were implemented for simulated seismic
retrofit of a representative code-compliant masonry infilled R/C
frame with a ‘soft’ ground story using friction dampers as the PED
device. Non-linear dynamic analyses of the retrofitted masonry
infilled R/C frames is performed to investigate the efficacy and
accuracy of the proposed energy based plastic analysis procedure in
achieving the target performance level under design level
earthquakes. Results of non-linear dynamic analyses demonstrate that
the maximum inter-story drifts in the masonry infilled R/C frames
with a ‘soft’ ground story that is retrofitted with the friction dampers
designed using the proposed PBD formulations are controlled within
the target drifts under near-field as well far-field earthquakes.
Abstract: A cleaner production project was implemented in a
bakery. The project is based on the substitution of the best available
technique for an obsolete leaven production technology. The new
technology enables production of durable, high-quality leavens.
Moreover, 25% of flour as the original raw material can be replaced
by pastry from the previous day production which has not been sold.
That pastry was previously disposed in a waste incineration plant.
Besides the environmental benefits resulting from less waste, lower
consumption of energy, reduction of sewage waters quantity and
floury dustiness there are also significant economic benefits. Payback
period of investment was calculated with help of static method of
financial analysis about 2.6 years, using dynamic method 3.5 years
and an internal rate of return more than 29%. The supposed annual
average profit after taxationin the second year of operation was
incompliance with the real profit.
Abstract: Maturity models, used descriptively to explain
changes in reality or normatively to guide managers to make
interventions to make organizations more effective and efficient, are
based on the principles of statistical quality control and PDCA
continuous improvement (Plan, Do, Check, Act). Some frameworks
developed over the concept of maturity models include COBIT,
CMM, and ITIL.
This paper presents some limitations of traditional maturity
models, most of them related to the mechanistic and reductionist
principles over which those models are built. As systems theory helps
the understanding of the dynamics of organizations and
organizational change, the development of a systemic maturity model
can help to overcome some of those limitations.
This document proposes a systemic maturity model, based on a
systemic conceptualization of organizations, focused on the study of
the functioning of the parties, the relationships among them, and their
behavior as a whole. The concept of maturity from the system theory
perspective is conceptually defined as an emergent property of the
organization, which arises as a result of the degree of alignment and
integration of their processes. This concept is operationalized through
a systemic function that measures the maturity of organizations, and
finally validated by the measuring of maturity in some organizations.
For its operationalization and validation, the model was applied to
measure the maturity of organizational Governance, Risk and
Compliance (GRC) processes.
Abstract: This paper presents the variation of the dynamic
characteristics of a spindle with the change of bearing preload. The
correlations between the variation of bearing preload and fundamental
modal parameters were first examined by conducting vibration tests on
physical spindle units. Experimental measurements show that the
dynamic compliance and damping ratio associated with the
dominating modes were affected to vary with variation of the bearing
preload. When the bearing preload was slightly deviated from a
standard value, the modal frequency and damping ability also vary to
different extent, which further enable the spindle to perform with
different compliance. For the spindle used in this study, a standard
preload value set on bearings would enable the spindle to behave a
higher stiffness as compared with others with a preload variation. This
characteristic can be served as a reference to examine the variation of
bearing preload of spindle in assemblage or operation.
Abstract: We present a dedicated video-based monitoring
system for quantification of patient’s attention to visual feedback
during robot assisted gait rehabilitation. Two different approaches for
eye gaze and head pose tracking are tested and compared. Several
metrics for assessment of patient’s attention are also presented.
Experimental results with healthy volunteers demonstrate that
unobtrusive video-based gaze tracking during the robot-assisted gait
rehabilitation is possible and is sufficiently robust for quantification
of patient’s attention and assessment of compliance with the
rehabilitation therapy.
Abstract: The Ballast Water Convention requires less than 5% of the world tonnage for ratification. Consequently, ships will have to comply with the requirements. Compliance evaluation and enforcement will become mandatory. Ship owners have to invest in treatment systems and shipboard personnel have to operate them and ensure compliance. The monitoring and enforcement will be the responsibilities of the Administrations. Herein, a review of the current status of the Ballast Water Management and the issues faced by these are projected. Issues range from efficacy and economics of the treatment systems to sampling and testing. Health issues of chemical systems, paucity of data for decision support etc., are other issues. It is emphasized that management of ballast water must be extended to ashore and sustainable solutions must be researched upon. An exemplar treatment system based on ship’s waste heat is also suggested.
Abstract: It is widely assumed that the case of Customs Supply Chain is classified as a complex system, due to not only the variety and large number of actors, but also their complex structural links, and the interactions between these actors, that’s why this system is subject to various types of Risks. The economic, political and social impacts of those risks are highly detrimental to countries, businesses and the public, for this reason, Risk management in the customs supply chain is becoming a crucial issue to ensure the sustainability, security and safety. The main characteristic of customs risk management approach is determining which goods and means of transport should be examined? To what extend? And where future compliance resources should be directed? The purposes of this article are, firstly to deal with the concept of customs supply chain, secondly present our risk management approach based on Cross Activity Based Costing (ABC) Method as an interactive tool to support decision making in customs risk management. Finally, analysis of case study of Moroccan customs to putting theory into practice and will thus draw together the various elements of a structured and efficient risk management approach.
Abstract: The prologue of new High Voltage (HV) transmission mains into the community necessitates earthing design to ensure safety compliance of the system. Concrete poles are widely used within HV transmission mains; many retired transmission mains with timber poles are being replaced with concrete ones, green transmission mains are deploying concrete poles. The earthing arrangement of the concrete poles could have an impact on the earth grid impedance also on the input impedance of the system from the fault point of view. This paper endeavors to provide information on the soil resistivity of the area and the deployments of concrete poles. It introduce the cut off soil resistivity value ρSC, this value aid in determine the impact of deploying the concrete poles on the earthing system. Multiple cases were discussed in this paper.