Abstract: Early breast cancer detection is an emerging field of
research as it can save the women infected by malignant tumors.
Microwave breast imaging is based on the electrical property contrast
between healthy and malignant tumor. This contrast can be detected
by use of microwave energy with an array of antennas that illuminate
the breast through coupling medium and by measuring the scattered
fields. In this paper, author has been presented the design and
simulation results of the bowtie antenna. This bowtie antenna is
designed for the detection of breast cancer detection.
Abstract: This paper presents a novel approach to finding a
priori interesting regions in mammograms. In order to delineate those
regions of interest (ROI-s) in mammograms, which appear to be
prominent, a topographic representation called the iso-level contour
map consisting of iso-level contours at multiple intensity levels and
region segmentation based-thresholding have been proposed. The
simulation results indicate that the computed boundary gives the
detection rate of 99.5% accuracy.
Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: In this paper, a clustering algorithm named KHarmonic
means (KHM) was employed in the training of Radial
Basis Function Networks (RBFNs). KHM organized the data in
clusters and determined the centres of the basis function. The popular
clustering algorithms, namely K-means (KM) and Fuzzy c-means
(FCM), are highly dependent on the initial identification of elements
that represent the cluster well. In KHM, the problem can be avoided.
This leads to improvement in the classification performance when
compared to other clustering algorithms. A comparison of the
classification accuracy was performed between KM, FCM and KHM.
The classification performance is based on the benchmark data sets:
Iris Plant, Diabetes and Breast Cancer. RBFN training with the KHM
algorithm shows better accuracy in classification problem.
Abstract: This article addresses feature selection for breast
cancer diagnosis. The present process contains a wrapper approach
based on Genetic Algorithm (GA) and case-based reasoning (CBR).
GA is used for searching the problem space to find all of the possible
subsets of features and CBR is employed to estimate the evaluation
result of each subset. The results of experiment show that the
proposed model is comparable to the other models on Wisconsin
breast cancer (WDBC) dataset.
Abstract: UWB is a very attractive technology for many
applications. It provides many advantages such as fine resolution and high power efficiency. Our interest in the current study is the use of
UWB radar technique in microwave medical imaging systems, especially for early breast cancer detection. The Federal Communications Commission FCC allowed frequency bandwidth of
3.1 to 10.6 GHz for this purpose. In this paper we suggest an UWB Bowtie slot antenna with enhanced bandwidth. Effects of varying the geometry of the antenna
on its performance and bandwidth are studied. The proposed antenna
is simulated in CST Microwave Studio. Details of antenna design and
simulation results such as return loss and radiation patterns are discussed in this paper. The final antenna structure exhibits good
UWB characteristics and has surpassed the bandwidth requirements.
Abstract: Accurate assessment of the primary tumor response to
treatment is important in the management of breast cancer. This
paper introduces a new set of treatment evaluation indicators for
breast cancer cases based on the computational process of three
known metrics, the Euclidian, Hamming and Levenshtein distances.
The distance principals are applied to pairs of mammograms and/or
echograms, recorded before and after treatment, determining a
reference point in judging the evolution amount of the studied
carcinoma. The obtained numerical results are indeed very
transparent and indicate not only the evolution or the involution of
the tumor under treatment, but also a quantitative measurement of the
benefit in using the selected method of treatment.
Abstract: Purpose of this work is to develop an automatic classification system that could be useful for radiologists in the breast cancer investigation. The software has been designed in the framework of the MAGIC-5 collaboration. In an automatic classification system the suspicious regions with high probability to include a lesion are extracted from the image as regions of interest (ROIs). Each ROI is characterized by some features based generally on morphological lesion differences. A study in the space features representation is made and some classifiers are tested to distinguish the pathological regions from the healthy ones. The results provided in terms of sensitivity and specificity will be presented through the ROC (Receiver Operating Characteristic) curves. In particular the best performances are obtained with the Neural Networks in comparison with the K-Nearest Neighbours and the Support Vector Machine: The Radial Basis Function supply the best results with 0.89 ± 0.01 of area under ROC curve but similar results are obtained with the Probabilistic Neural Network and a Multi Layer Perceptron.
Abstract: The objective of the present research manuscript is to
perform parametric, nonparametric, and decision tree analysis to
evaluate two treatments that are being used for breast cancer patients.
Our study is based on utilizing real data which was initially used in
“Tamoxifen with or without breast irradiation in women of 50 years
of age or older with early breast cancer" [1], and the data is supplied
to us by N.A. Ibrahim “Decision tree for competing risks survival
probability in breast cancer study" [2]. We agree upon certain aspects
of our findings with the published results. However, in this
manuscript, we focus on relapse time of breast cancer patients instead
of survival time and parametric analysis instead of semi-parametric
decision tree analysis is applied to provide more precise
recommendations of effectiveness of the two treatments with respect
to reoccurrence of breast cancer.
Abstract: In this study, we present an advanced detection
technique for mass type breast cancer based on texture information
of organs. The proposed method detects the cancer areas in three
stages. In the first stage, the midpoints of mass area are determined
based on AHE (Adaptive Histogram Equalization). In the second
stage, we set the threshold coefficient of homogeneity by using
MLE (Maximum Likelihood Estimation) to compute the uniformity
of texture. Finally, mass type cancer tissues are extracted from the
original image. As a result, it was observed that the proposed
method shows an improved detection performance on dense breast
tissues of Korean women compared with the existing methods. It is
expected that the proposed method may provide additional
diagnostic information for detection of mass-type breast cancer.
Abstract: The ability to distinguish missense nucleotide
substitutions that contribute to harmful effect from those that do not
is a difficult problem usually accomplished through functional in
vivo analyses. In this study, instead current biochemical methods, the
effects of missense mutations upon protein structure and function
were assayed by means of computational methods and information
from the databases. For this order, the effects of new missense
mutations in exon 5 of PTEN gene upon protein structure and
function were examined. The gene coding for PTEN was identified
and localized on chromosome region 10q23.3 as the tumor
suppressor gene. The utilization of these methods were shown that
c.319G>A and c.341T>G missense mutations that were recognized in
patients with breast cancer and Cowden disease, could be pathogenic.
This method could be use for analysis of missense mutation in others
genes.