Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: In this paper, parallelism in the solution of Ordinary
Differential Equations (ODEs) to increase the computational speed is
studied. The focus is the development of parallel algorithm of the two
point Block Backward Differentiation Formulas (PBBDF) that can
take advantage of the parallel architecture in computer technology.
Parallelism is obtained by using Message Passing Interface (MPI).
Numerical results are given to validate the efficiency of the PBBDF
implementation as compared to the sequential implementation.
Abstract: The paradigm of mobile agent provides a promising technology for the development of distributed and open applications. However, one of the main obstacles to widespread adoption of the mobile agent paradigm seems to be security. This paper treats the security of the mobile agent against malicious host attacks. It describes generic mobile agent protection architecture. The proposed approach is based on the dynamic adaptability and adopts the reflexivity as a model of conception and implantation. In order to protect it against behaviour analysis attempts, the suggested approach supplies the mobile agent with a flexibility faculty allowing it to present an unexpected behaviour. Furthermore, some classical protective mechanisms are used to reinforce the level of security.
Abstract: Workload and resource management are two essential functions provided at the service level of the grid software infrastructure. To improve the global throughput of these software environments, workloads have to be evenly scheduled among the available resources. To realize this goal several load balancing strategies and algorithms have been proposed. Most strategies were developed in mind, assuming homogeneous set of sites linked with homogeneous and fast networks. However for computational grids we must address main new issues, namely: heterogeneity, scalability and adaptability. In this paper, we propose a layered algorithm which achieve dynamic load balancing in grid computing. Based on a tree model, our algorithm presents the following main features: (i) it is layered; (ii) it supports heterogeneity and scalability; and, (iii) it is totally independent from any physical architecture of a grid.
Abstract: This paper focuses on the 3D reconstruction of
the architectural design of Darul Ridzuan Museum. It has
concentrated on designing exterior part of the building according
to colored digital photo of the real museum. Besides viewing the
architecture, walkthroughs are generated for the user to control
it in an easier way. User can travel through the museum to get
the feel of the environment and to explore the design of the
museum as a whole; both exterior and interior. The result has
shown positive result in terms of realism, navigation, collision
detection, suitability, usability and user-s acceptance. In brief,
the 3D virtual museum has provided an alternative to present a
real museum.
Abstract: In this paper we propose a framework for
multisensor intrusion detection called Fuzzy Agent-Based Intrusion
Detection System. A unique feature of this model is that the agent
uses data from multiple sensors and the fuzzy logic to process log
files. Use of this feature reduces the overhead in a distributed
intrusion detection system. We have developed an agent
communication architecture that provides a prototype
implementation. This paper discusses also the issues of combining
intelligent agent technology with the intrusion detection domain.
Abstract: Tackling emergency situations is performed based on emergency scenarios. These scenarios do not have a uniform form in the Czech Republic. They are unstructured and developed primarily in the text form. This does not allow solving emergency situations efficiently. For this reason, the paper aims at defining a Process Oriented Architecture to support and thus to improve tackling emergency situations in the Czech Republic. The innovative Process Oriented Architecture is based on the Workflow Reference Model while taking into account the options of Business Process Management Suites for the implementation of process oriented emergency scenarios. To verify the proposed architecture the Proof of Concept has been used which covers the reception of an emergency event at the district emergency operations centre. Within the particular implementation of the proposed architecture the Bonita Open Solution has been used. The architecture created in this way is suitable not only for emergency management, but also for educational purposes.
Abstract: Rapid prototyping (RP) techniques are a group of
advanced manufacturing processes that can produce custom made
objects directly from computer data such as Computer Aided Design
(CAD), Computed Tomography (CT) and Magnetic Resonance
Imaging (MRI) data. Using RP fabrication techniques, constructs
with controllable and complex internal architecture with appropriate
mechanical properties can be achieved. One of the attractive and
promising utilization of RP techniques is related to tissue engineering
(TE) scaffold fabrication. Tissue engineering scaffold is a 3D
construction that acts as a template for tissue regeneration. Although
several conventional techniques such as solvent casting and gas
forming are utilized in scaffold fabrication; these processes show
poor interconnectivity and uncontrollable porosity of the produced
scaffolds. So, RP techniques become the best alternative fabrication
methods of TE scaffolds. This paper reviews the current state of the
art in the area of tissue engineering scaffolds fabrication using
advanced RP processes, as well as the current limitations and future
trends in scaffold fabrication RP techniques.
Abstract: A Personal Distributed Environment (PDE) is an
example of an IP-based system architecture designed for future
mobile communications. In a single PDE, there exist several Subnetworks
hosting devices located across the infrastructure, which will
inter-work with one another through the coordination of a Device
Management Entity (DME). Some of these Sub-networks are fixed
and some are mobile. In order to support Mobile Sub-networks
mobility in the PDE, the PDE-NEMO protocol was proposed. This
paper discussed the signalling cost analysis of PDE-NEMO by use of
a detailed simulation model. The paper started with the introduction
of the protocol, followed by the experiments and results and then
followed by discussions.
Abstract: This article stands in the context of rural communities
in Brazil, where, like many others emerging countries, the
overwhelming increasing markets and the overcrowded cities are
leaving behind informal settlements based on obsolete agricultural
economies and techniques. The pilot project for the community of
Goiabeira reflects the attempt to imagine a development model that
privileges the actual improvement of living conditions, the education
and training, the social inclusion and participation of the dwellers of
rural communities. Through the inclusion of operative public space,
the aim is for them to become self-sustaining, encouraging the use of
local resources for appropriate architectural, ecological and energy
technologies and devices, that are efficient, affordable and foster
community participation, in the respect of the surrounding
environment.
Abstract: This paper presents a real time force sensing
instrument that is designed for human gait analysis purposes. It is
capable of recording and monitoring ground reaction forces exerted
by human foot during various activities such as walking, running and
jumping in real time. In overall, force sensing mat mainly consists of
three elements: the force sensing mat, signal conditioning circuit and
data acquisition device. Force sensing mat is the mat that contains an
array of force sensing elements. To control and process the incoming
signal from the force sensing mat, Force-Logger and Force-Reloader
are developed using National Instrument Labview. This paper
describes the architecture of the force sensing mat, signal
conditioning circuit and the real time streaming of the incoming data
from the force sensing mat. Additionally, a preliminary experiment
dataset is presented in this paper.
Abstract: Recent advancements in sensor technologies and
Wireless Body Area Networks (WBANs) have led to the
development of cost-effective healthcare devices which can be used
to monitor and analyse a person-s physiological parameters from
remote locations. These advancements provides a unique opportunity
to overcome current healthcare challenges of low quality service
provisioning, lack of easy accessibility to service varieties, high costs
of services and increasing population of the elderly experienced
globally. This paper reports on a prototype implementation of an
architecture that seamlessly integrates Wireless Body Area Network
(WBAN) with Web services (WS) to proactively collect
physiological data of remote patients to recommend diagnostic
services. Technologies based upon WBAN and WS can provide
ubiquitous accessibility to a variety of services by allowing
distributed healthcare resources to be massively reused to provide
cost-effective services without individuals physically moving to the
locations of those resources. In addition, these technologies can
reduce costs of healthcare services by allowing individuals to access
services to support their healthcare. The prototype uses WBAN body
sensors implemented on arduino fio platforms to be worn by the
patient and an android smart phone as a personal server. The
physiological data are collected and uploaded through GPRS/internet
to the Medical Health Server (MHS) to be analysed. The prototype
monitors the activities, location and physiological parameters such as
SpO2 and Heart Rate of the elderly and patients in rehabilitation.
Medical practitioners would have real time access to the uploaded
information through a web application.
Abstract: This paper provides an in-depth study of Wireless
Sensor Network (WSN) application to monitor and control the
swiftlet habitat. A set of system design is designed and developed
that includes the hardware design of the nodes, Graphical User
Interface (GUI) software, sensor network, and interconnectivity for
remote data access and management. System architecture is proposed
to address the requirements for habitat monitoring. Such applicationdriven
design provides and identify important areas of further work
in data sampling, communications and networking. For this
monitoring system, a sensor node (MTS400), IRIS and Micaz radio
transceivers, and a USB interfaced gateway base station of Crossbow
(Xbow) Technology WSN are employed. The GUI of this monitoring
system is written using a Laboratory Virtual Instrumentation
Engineering Workbench (LabVIEW) along with Xbow Technology
drivers provided by National Instrument. As a result, this monitoring
system is capable of collecting data and presents it in both tables and
waveform charts for further analysis. This system is also able to send
notification message by email provided Internet connectivity is
available whenever changes on habitat at remote sites (swiftlet farms)
occur. Other functions that have been implemented in this system
are the database system for record and management purposes; remote
access through the internet using LogMeIn software. Finally, this
research draws a conclusion that a WSN for monitoring swiftlet
habitat can be effectively used to monitor and manage swiftlet
farming industry in Sarawak.
Abstract: Due to the complex network architecture, the mobile
adhoc network-s multihop feature gives additional problems to the
users. When the traffic load at each node gets increased, the
additional contention due its traffic pattern might cause the nodes
which are close to destination to starve the nodes more away from the
destination and also the capacity of network is unable to satisfy the
total user-s demand which results in an unfairness problem. In this
paper, we propose to create an algorithm to compute the optimal
MAC-layer bandwidth assigned to each flow in the network. The
bottleneck links contention area determines the fair time share which
is necessary to calculate the maximum allowed transmission rate used
by each flow. To completely utilize the network resources, we
compute two optimal rates namely, the maximum fair share and
minimum fair share. We use the maximum fair share achieved in
order to limit the input rate of those flows which crosses the
bottleneck links contention area when the flows that are not allocated
to the optimal transmission rate and calculate the following highest
fair share. Through simulation results, we show that the proposed
protocol achieves improved fair share and throughput with reduced
delay.
Abstract: This paper describes the design and implementation of cyber video consultation systems(CVCS) using hybrid P2P for video consultation between remote sites. The proposed system is based on client-server and P2P(Peer to Peer) architecture, where client-server is used for communication with the MCU(Multipoint Control Unit) and P2P is used for the cyber video consultation. The developed video consultation system decreases server traffic, and cuts down network expenses, as the multimedia data decentralizes to the client by hybrid P2P architecture. Also the developed system is tested by the group-type video consultation system using communication protocol and application software through Ethernet networks.
Abstract: In this paper, we propose a hardware and software
design method for automotive Electronic Control Units (ECU)
considering the functional safety. The proposed ECU is considered for
the application to Electro-Mechanical Actuator systems and the
validity of the design method is shown by the application to the
Electro-Mechanical Brake (EMB) control system which is used as a
brake actuator in Brake-By-Wire (BBW) systems. The importance of a
functional safety-based design approach to EMB ECU design has been
emphasized because of its safety-critical functions, which are executed
with the aid of many electric actuators, sensors, and application
software. Based on hazard analysis and risk assessment according to
ISO26262, the EMB system should be ASIL-D-compliant, the highest
ASIL level. To this end, an external signature watchdog and an
Infineon 32-bit microcontroller TriCore are used to reduce risks
considering common-cause hardware failure. Moreover, a software
design method is introduced for implementing functional
safety-oriented monitoring functions based on an asymmetric dual
core architecture considering redundancy and diversity. The validity
of the proposed ECU design approach is verified by using the EMB
Hardware-In-the-Loop (HILS) system, which consists of the EMB
assembly, actuator ECU, a host PC, and a few debugging devices.
Furthermore, it is shown that the existing sensor fault tolerant control
system can be used more effectively for mitigating the effects of
hardware and software faults by applying the proposed ECU design
method.
Abstract: Modular multiplication is the basic operation
in most public key cryptosystems, such as RSA, DSA, ECC,
and DH key exchange. Unfortunately, very large operands
(in order of 1024 or 2048 bits) must be used to provide
sufficient security strength. The use of such big numbers
dramatically slows down the whole cipher system, especially
when running on embedded processors.
So far, customized hardware accelerators - developed on
FPGAs or ASICs - were the best choice for accelerating
modular multiplication in embedded environments. On the
other hand, many algorithms have been developed to speed
up such operations. Examples are the Montgomery modular
multiplication and the interleaved modular multiplication
algorithms. Combining both customized hardware with
an efficient algorithm is expected to provide a much faster
cipher system.
This paper introduces an enhanced architecture for computing
the modular multiplication of two large numbers X
and Y modulo a given modulus M. The proposed design is
compared with three previous architectures depending on
carry save adders and look up tables. Look up tables should
be loaded with a set of pre-computed values. Our proposed
architecture uses the same carry save addition, but replaces
both look up tables and pre-computations with an enhanced
version of sign detection techniques. The proposed architecture
supports higher frequencies than other architectures.
It also has a better overall absolute time for a single operation.
Abstract: 4G Communication Networks provide heterogeneous
wireless technologies to mobile subscribers through IP based
networks and users can avail high speed access while roaming across
multiple wireless channels; possible by an organized way to manage
the Quality of Service (QoS) functionalities in these networks. This
paper proposes the idea of developing a novel QoS optimization
architecture that will judge the user requirements and knowing peak
times of services utilization can save the bandwidth/cost factors. The
proposed architecture can be customized according to the network
usage priorities so as to considerably improve a network-s QoS
performance.
Abstract: A real time distributed computing has
heterogeneously networked computers to solve a single problem. So
coordination of activities among computers is a complex task and
deadlines make more complex. The performances depend on many
factors such as traffic workloads, database system architecture,
underlying processors, disks speeds, etc. Simulation study have been
performed to analyze the performance under different transaction
scheduling: different workloads, arrival rate, priority policies,
altering slack factors and Preemptive Policy. The performance metric
of the experiments is missed percent that is the percentage of
transaction that the system is unable to complete. The throughput of
the system is depends on the arrival rate of transaction. The
performance can be enhanced with altering the slack factor value.
Working on slack value for the transaction can helps to avoid some
of transactions from killing or aborts. Under the Preemptive Policy,
many extra executions of new transactions can be carried out.
Abstract: The intermittent connectivity modifies the “always
on" network assumption made by all the distributed query processing
systems. In modern- day systems, the absence of network
connectivity is considered as a fault. Since the last upload, it might
not be feasible to transmit all the data accumulated right away over
the available connection. It is possible that vital information may be
delayed excessively when the less important information takes place
of the vital information. Owing to the restricted and uneven
bandwidth, it is vital that the mobile nodes make the most
advantageous use of the connectivity when it arrives. Hence, in order
to select the data that needs to be transmitted first, some sort of data
prioritization is essential. A continuous query processing system for
intermittently connected mobile networks that comprises of a delaytolerant
continuous query processor distributed across the mobile
hosts has been proposed in this paper. In addition, a mechanism for
prioritizing query results has been designed that guarantees enhanced
accuracy and reduced delay. It is illustrated that our architecture
reduces the client power consumption, increases query efficiency by
the extensive simulation results.