Abstract: Ocimum americanum L (Lamiaceae) is an annual herb
that is native to tropical Africa. The in vitro and in vivo antioxidant
activity of its aqueous extract was carefully investigated by assessing
the DPPH radical scavenging activity, ABTS radical scavenging
activity and hydrogen peroxide radical scavenging activity. The
reducing power, total phenol, total flavonoids and flavonols content
of the extract were also evaluated. The data obtained revealed that the
extract is rich in polyphenolic compounds and scavenged the radicals
in a concentration dependent manner. This was done in comparison
with the standard antioxidants such as BHT and Vitamin C. Also, the
induction of oxidative damage with paracetamol (2000 mg/kg)
resulted in the elevation of lipid peroxides and significant (P < 0.05)
decrease in activities of superoxide dismutase, glutathione
peroxidase, glutathione reductase and catalase in the liver and kidney
of rats. However, the pretreatment of rats with aqueous extract of O.
americanum leaves (200 and 400 mg/kg) and silymarin (100 mg/kg)
caused a significant (P < 0.05) reduction in the values of lipid
peroxides and restored the levels of antioxidant parameters in these
organs. These findings suggest that the leaves of O. americanum have
potent antioxidant properties which may be responsible for its
acclaimed folkloric uses.
Abstract: The present study was undertaken to investigate the
effect of aging parameters (time and temperature) on the mechanical
properties of Be-and/or Zr- treated Al-Mg-Zn (7075) alloys. Ultimate
tensile strength, 0.5% offset yield strength and % elongation
measurements were carried out on specimens prepared from cast and
heat treated 7075 alloys containing Be and/or Zr. Different aging
treatment were carried out for the as solution treated (SHT)
specimens (after quenching in warm water). The specimens were
aged at different conditions; Natural and artificial aging was carried
out at room temperature, 120C, 150C, 180C and 220C for different
periods of time. Duplex aging was performed for SHT conditions
(pre-aged at different time and temperature followed by high
temperature aging). Ultimate tensile strength, yield strength and %
elongation data results as a function of different aging parameters are
analysed. A statistical design of experiments (DOE) approach using
fractional factorial design is applied to acquire an understanding of
the effects of these variables and their interactions on the mechanical
properties of Be- and/or Zr- treated 7075 alloys. Mathematical
models are developed to relate the alloy mechanical properties with
the different aging parameters.
Abstract: The aim of this study is to develop an anterior lumbar
interbody fusion (ALIF) PEEK cage suitable for Korean people. In this
study, CT images were obtained from Korean male (173cm, 71kg) and
3D Korean lumbar models were reconstructed based on the CT images
to investigate anatomical characteristics. Major design parameters of
anterior lumbar interbody fusion (ALIF) PEEK Cage were selected
using the morphological measurement information of the Korean
Lumbar models. Through finite element analysis and mechanical tests,
the developed ALIFPEEK Cage prototype was compared with the
Fidji Cage (Zimmer. Inc, USA) and it was found that the ALIF
prototype showed similar and/or superior mechanical performance
compared to the FidJi Cage. Also, clinical validation for the ALIF
PEEK Cage prototype was carried out to check predictable troubles in
surgical operations. Finally, it is considered that the convenience and
stability of the prototype was clinically verified.
Abstract: The Standard Penetration Test (SPT) is the most
common in situ test for soil investigations. On the other hand, the
Cone Penetration Test (CPT) is considered one of the best
investigation tools. Due to the fast and accurate results that can be
obtained it complaints the SPT in many applications like field
explorations, design parameters, and quality control assessments.
Many soil index and engineering properties have been correlated to
both of SPT and CPT. Various foundation design methods were
developed based on the outcome of these tests. Therefore it is vital to
correlate these tests to each other so that either one of the tests can be
used in the absence of the other, especially for preliminary evaluation
and design purposes.
The primary purpose of this study was to investigate the
relationships between the SPT and CPT for different type of sandy
soils in Florida. Data for this research were collected from number of
projects sponsored by the Florida Department of Transportation
(FDOT), six sites served as the subject of SPT-CPT correlations. The
correlations were established between the cone resistance (qc), sleeve
friction (fs) and the uncorrected SPT blow counts (N) for various
soils.
A positive linear relationship was found between qc, fs and N for
various sandy soils. In general, qc versus N showed higher
correlation coefficients than fs versus N. qc/N ratios were developed
for different soil types and compared to literature values, the results
of this research revealed higher ratios than literature values.
Abstract: Physical properties of uranium dinitride (UN2) were
investigated in detail using first principle calculations based on
density functional theory (DFT). To study the strong correlation
effects due to 5f uranium valence electrons, the on-site coulomb
interaction correction U via the Hubbard-like term (DFT+U) was
employed. The UN2 structural, mechanical and thermodynamic
properties were calculated within DFT and Various U of DFT+U
approach.
The Perdew–Burke–Ernzerhof (PBE.5.2) version of the
generalized gradient approximation (GGA) is used to describe the
exchange-correlation with the projector-augmented wave (PAW)
pseudo potentials.
A comparative study shows that results are improved by using the
Hubbard formalism for a certain U value correction like the structural
parameter. For some physical properties the variation versus
Hubbard-U is strong like Young modulus but for others it is weakly
noticeable such as bulk modulus.
We noticed also that from U=7.5 eV, elastic results don’t agree
with the cubic cell because of the C44 values which turn out to be
negative.
Abstract: An analysis is carried out to investigate the effect of
magnetic field and heat source on the steady boundary layer flow and
heat transfer of a Casson nanofluid over a vertical cylinder stretching
exponentially along its radial direction. Using a similarity
transformation, the governing mathematical equations, with the
boundary conditions are reduced to a system of coupled, non –linear
ordinary differential equations. The resulting system is solved
numerically by the fourth order Runge – Kutta scheme with shooting
technique. The influence of various physical parameters such as
Reynolds number, Prandtl number, magnetic field, Brownian motion
parameter, thermophoresis parameter, Lewis number and the natural
convection parameter are presented graphically and discussed for non
– dimensional velocity, temperature and nanoparticle volume
fraction. Numerical data for the skin – friction coefficient, local
Nusselt number and the local Sherwood number have been tabulated
for various parametric conditions. It is found that the local Nusselt
number is a decreasing function of Brownian motion parameter Nb
and the thermophoresis parameter Nt.
Abstract: Verification and Validation of Simulated Process
Model is the most important phase of the simulator life cycle.
Evaluation of simulated process models based on Verification and
Validation techniques checks the closeness of each component model
(in a simulated network) with the real system/process with respect to
dynamic behaviour under steady state and transient conditions. The
process of Verification and Validation helps in qualifying the process
simulator for the intended purpose whether it is for providing
comprehensive training or design verification. In general, model
verification is carried out by comparison of simulated component
characteristics with the original requirement to ensure that each step
in the model development process completely incorporates all the
design requirements. Validation testing is performed by comparing
the simulated process parameters to the actual plant process
parameters either in standalone mode or integrated mode.
A Full Scope Replica Operator Training Simulator for PFBR -
Prototype Fast Breeder Reactor has been developed at IGCAR,
Kalpakkam, INDIA named KALBR-SIM (Kalpakkam Breeder
Reactor Simulator) where in the main participants are
engineers/experts belonging to Modeling Team, Process Design and
Instrumentation & Control design team. This paper discusses about
the Verification and Validation process in general, the evaluation
procedure adopted for PFBR operator training Simulator, the
methodology followed for verifying the models, the reference
documents and standards used etc. It details out the importance of
internal validation by design experts, subsequent validation by
external agency consisting of experts from various fields, model
improvement by tuning based on expert’s comments, final
qualification of the simulator for the intended purpose and the
difficulties faced while co-coordinating various activities.
Abstract: This study is concerned with the optimization of
fermentation parameters for the hyper production of mannanase from
Fusarium oxysporum SS-25 employing two step statistical strategy
and kinetic characterization of crude enzyme preparation. The
Plackett-Burman design used to screen out the important factors in
the culture medium revealed 20% (w/w) wheat bran, 2% (w/w) each
of potato peels, soyabean meal and malt extract, 1% tryptone, 0.14%
NH4SO4, 0.2% KH2PO4, 0.0002% ZnSO4, 0.0005% FeSO4, 0.01%
MnSO4, 0.012% SDS, 0.03% NH4Cl, 0.1% NaNO3 in brewer’s spent
grain based medium with 50% moisture content, inoculated with
2.8×107 spores and incubated at 30oC for 6 days to be the main
parameters influencing the enzyme production. Of these factors, four
variables including soyabean meal, FeSO4, MnSO4 and NaNO3 were
chosen to study the interactive effects and their optimum levels in
central composite design of response surface methodology with the
final mannanase yield of 193 IU/gds. The kinetic characterization
revealed the crude enzyme to be active over broader temperature and
pH range. This could result in 26.6% reduction in kappa number with
4.93% higher tear index and 1% increase in brightness when used to
treat the wheat straw based kraft pulp. The hydrolytic potential of
enzyme was also demonstrated on both locust bean gum and guar
gum.
Abstract: The progress of industry integrated circuits in recent
years has been pushed by continuous miniaturization of transistors.
With the reduction of dimensions of components at 0.1 micron and
below, new physical effects come into play as the standard simulators
of two dimensions (2D) do not consider. In fact the third dimension
comes into play because the transverse and longitudinal dimensions
of the components are of the same order of magnitude. To describe
the operation of such components with greater fidelity, we must
refine simulation tools and adapted to take into account these
phenomena. After an analytical study of the static characteristics of
the component, according to the different operating modes, a
numerical simulation is performed of field-effect transistor with
submicron gate MESFET GaInP. The influence of the dimensions of
the gate length is studied. The results are used to determine the
optimal geometric and physical parameters of the component for their
specific applications and uses.
Abstract: Advanced head and neck cancers are aggressive
tumours, which require aggressive treatment. Treatment efficiency is
often hindered by cancer cell repopulation during radiotherapy,
which is due to various mechanisms triggered by the loss of tumour
cells and involves both stem and differentiated cells. The aim of the
current paper is to present in silico simulations of radiotherapy
schedules on a virtual head and neck tumour grown with biologically
realistic kinetic parameters. Using the linear quadratic formalism of
cell survival after radiotherapy, altered fractionation schedules
employing various treatment breaks for normal tissue recovery are
simulated and repopulation mechanism implemented in order to
evaluate the impact of various cancer cell contribution on tumour
behaviour during irradiation. The model has shown that the timing of
treatment breaks is an important factor influencing tumour control in
rapidly proliferating tissues such as squamous cell carcinomas of the
head and neck. Furthermore, not only stem cells but also
differentiated cells, via the mechanism of abortive division, can
contribute to malignant cell repopulation during treatment.
Abstract: The design and plantwide control of an integrated
plant where the endothermic 1,4-butanediol dehydrogenation and the
exothermic furfural hydrogenation is simultaneously performed in a
single reactor is studied. The reactions can be carried out in an
adiabatic reactor using small hydrogen excess and with reduced
parameter sensitivity. The plant is robust and flexible enough to
allow different production rates of γ-butyrolactone and 2-methyl
furan, keeping high product purities. Rigorous steady state and
dynamic simulations performed in AspenPlus and AspenDynamics to
support the conclusions.
Abstract: The emerging Cognitive Radio is combo of both the
technologies i.e. Radio dynamics and software technology. It involve
wireless system with efficient coding, designing, and making them
artificial intelligent to take the decision according to the surrounding
environment and adopt themselves accordingly, so as to deliver the
best QoS. This is the breakthrough from fixed hardware and fixed
utilization of the spectrum. This software-defined approach of
research is centralized at user-definition and application driven
model, various software method are used for the optimization of the
wireless communication. This paper focused on the Spectrum
allocation technique using genetic algorithm GA to evolve radio,
represented by chromosomes. The chromosomes gene represents the
adjustable parameters in given radio and by using GA, evolving over
the generations, the optimized set of parameters are evolved, as per
the requirement of user and availability of the spectrum, in our
prototype the gene consist of 6 different parameters, and the best set
of parameters are evolved according to the application need and
availability of the spectrum holes and thus maintaining best QoS for
user, simultaneously maintaining licensed user rights. The analyzing
tool Matlab is used for the performance of the prototype.
Abstract: Exact solution of an unsteady flow of elastico-viscous
fluid through a porous media in a tube of spherical cross section
under the influence of constant pressure gradient has been obtained in
this paper. Initially, the flow is generated by a constant pressure
gradient. After attaining the steady state, the pressure gradient is
suddenly withdrawn and the resulting fluid motion in a tube of
spherical cross section by taking into account of the porosity factor of
the bounding surface is investigated. The problem is solved in twostages
the first stage is a steady motion in tube under the influence of
a constant pressure gradient, the second stage concern with an
unsteady motion. The problem is solved employing separation of
variables technique. The results are expressed in terms of a nondimensional
porosity parameter (K) and elastico-viscosity parameter
(β), which depends on the Non-Newtonian coefficient. The flow
parameters are found to be identical with that of Newtonian case as
elastic-viscosity parameter tends to zero and porosity tends to
infinity. It is seen that the effect of elastico-viscosity parameter,
porosity parameter of the bounding surface has significant effect on
the velocity parameter.
Abstract: The California Bearing Ratio (CBR) has been
acknowledged as an important parameter to characterize the bearing
capacity of earth structures, such as earth dams, road embankments,
airport runways, bridge abutments and pavements. Technically, the
CBR test can be carried out in the laboratory or in the field. The CBR
test is time-consuming and is infrequently performed due to the
equipment needed and the fact that the field moisture content keeps
changing over time. Over the years, many correlations have been
developed for the prediction of CBR by various researchers,
including the dynamic cone penetrometer, undrained shear strength
and Clegg impact hammer. This paper reports and discusses some of
the results from a study on the prediction of CBR. In the current
study, the CBR test was performed in the laboratory on some finegrained
subgrade soils collected from various locations in Victoria.
Based on the test results, a satisfactory empirical correlation was
found between the CBR and the physical properties of the
experimental soils.
Abstract: In this report we have discussed the theoretical aspects
of the flow transformation, occurring through a series of bifurcations.
The parameters and their continuous diversion, the intermittent bursts
in the transition zone, variation of velocity and pressure with time,
effect of roughness in turbulent zone, and changes in friction factor
and head loss coefficient as a function of Reynolds number for a
transverse flow across a cylinder have been discussed. An analysis of
the variation in the wake length with Reynolds number was done in
FORTRAN.
Abstract: A parametric study on circular thin-walled pipes
subjected to pure bending is performed. Both straight and curved
pipes are considered. Ratio D/t, initial pipe curvature and internal
pressure are the parameters varying in the analyses. The study is
mainly FEA-based.
It is found that negative curvatures (opposite to bending moment)
considerably increase stiffness and buckling limit of the pipe when no
internal pressure is acting and, similarly, positive curvatures decrease
the stiffness and buckling limit. For internal pressurised pipes the
effects of initial pipe curvature are less relevant. Results show that
this phenomenon is in relationship with the cross-section deformation
due to bending moment, which undergoes relevant ovalisation for no
pressurised pipes and little ovalisation for pressurised pipes.
Abstract: Recent research in neural networks science and
neuroscience for modeling complex time series data and statistical
learning has focused mostly on learning from high input space and
signals. Local linear models are a strong choice for modeling local
nonlinearity in data series. Locally weighted projection regression is
a flexible and powerful algorithm for nonlinear approximation in
high dimensional signal spaces. In this paper, different learning
scenario of one and two dimensional data series with different
distributions are investigated for simulation and further noise is
inputted to data distribution for making different disordered
distribution in time series data and for evaluation of algorithm in
locality prediction of nonlinearity. Then, the performance of this
algorithm is simulated and also when the distribution of data is high
or when the number of data is less the sensitivity of this approach to
data distribution and influence of important parameter of local
validity in this algorithm with different data distribution is explained.
Abstract: The present study was undertaken to investigate the
effect of pre-aging and aging parameters (time and temperature) on
the mechanical properties of Al-Mg-Zn (7075) alloys. Ultimate
tensile strength, 0.5% offset yield strength and % elongation
measurements were carried out on specimens prepared from cast and
heat treated 7075 alloys. Aging treatments were carried out for the as
solution treated (SHT) specimens (after quenching in warm water).
The specimens were aged at different conditions; Natural aging was
carried out at room temperature for different periods of time. Double
aging was performed for SHT conditions (pre-aged at different time
and temperature followed by high temperature aging). Ultimate
tensile strength, yield strength and % elongation as a function of
different pre-aging and aging parameters are analyzed to acquire an
understanding of the effects of these variables and their interactions
on the mechanical properties of Be-treated 7075 alloys.
Abstract: Parameters of flow are calculated in vaneless diffusers
with relative width 0,014–0,10. Inlet angles of flow and similarity
criteria were varied. There is information on flow separation,
boundary layer development, configuration of streamlines.
Polytrophic efficiency, loss coefficient and recovery coefficient are
used to compare effectiveness of diffusers. The sample of
optimization of narrow diffuser with conical walls is presented. Three
wide diffusers with narrowing walls are compared. The work is made
in the R&D laboratory “Gas dynamics of turbo machines” of the TU
SPb.
Abstract: There is an evident trend to elevate pressure ratio of a
single stage of a turbo compressors - axial compressors in particular.
Whilst there was an opinion recently that a pressure ratio 1,9 was a
reasonable limit, later appeared information on successful modeling
tested of stages with pressure ratio up to 2,8. The authors recon that
lack of information on high pressure stages makes actual a study of
rational choice of design parameters before high supersonic flow
problems solving. The computer program of an engineering type was
developed. Below is presented a sample of its application to study
possible parameters of the impeller of the stage with pressure ratio
3,0. Influence of two main design parameters on expected efficiency,
periphery blade speed and flow structure is demonstrated. The results
had lead to choose a variant for further analysis and improvement by
CFD methods.