Abstract: The mathematical modeling of different biological
processes is usually used to predict or assess behavior of systems in
which these processes take place. This study deals with mathematical
and computer modeling of bi-substrate enzymatic reactions with
ping-pong mechanism, which play an important role in different
biochemical pathways. Besides that, three models of competitive
inhibition were designed using different software packages. The main
objective of this study is to represent the results from in silico
investigation of bi-substrate enzymatic reactions with ordered pingpong
mechanism in the presence of competitive inhibitors, as well as
to describe in details the inhibition effects. The simulation of the
models with certain kinetic parameters allowed investigating the
behavior of reactions as well as determined some interesting aspects
concerning influence of different cases of competitive inhibition.
Simultaneous presence of two inhibitors, competitive to the S1 and S2
substrates have been studied. Moreover, we have found the pattern of
simultaneous influence of both inhibitors.
Abstract: This paper proposes, for the first time, how the
challenges facing the guard-band designs including the margin
assist-circuits scheme for the screening-test in the coming process
generations should be addressed. The increased screening error
impacts are discussed based on the proposed statistical analysis
models. It has been shown that the yield-loss caused by the
misjudgment on the screening test would become 5-orders of
magnitude larger than that for the conventional one when the
amplitude of random telegraph noise (RTN) caused variations
approaches to that of random dopant fluctuation. Three fitting methods
to approximate the RTN caused complex Gamma mixtures
distributions by the simple Gaussian mixtures model (GMM) are
proposed and compared. It has been verified that the proposed
methods can reduce the error of the fail-bit predictions by 4-orders of
magnitude.
Abstract: The purpose of this study was to investigate the
relationship between parent involvement and preschool disabled
children’s development. Parents of 3 year old disabled children
(N=440) and 5 year old disabled children (N=937) participating in the
Special Needs Education Longitudinal Study were interviewed or
answered the web design questionnaire about their actions in parenting
their disabled children. These children’s developments were also
evaluated by their teachers. Data were analyzed using Structural
Equation Modeling. Results were showed by tables and figures. Based
on the results, the researcher made some suggestions for future studies.
Abstract: Rutting is one of the major load-related distresses in airport flexible pavements. Rutting in paving materials develop gradually with an increasing number of load applications, usually appearing as longitudinal depressions in the wheel paths and it may be accompanied by small upheavals to the sides. Significant research has been conducted to determine the factors which affect rutting and how they can be controlled. Using the experimental design concepts, a series of tests can be conducted while varying levels of different parameters, which could be the cause for rutting in airport flexible pavements. If proper experimental design is done, the results obtained from these tests can give a better insight into the causes of rutting and the presence of interactions and synergisms among the system variables which have influence on rutting. Although traditionally, laboratory experiments are conducted in a controlled fashion to understand the statistical interaction of variables in such situations, this study is an attempt to identify the critical system variables influencing airport flexible pavement rut depth from a statistical DoE perspective using real field data from a full-scale test facility. The test results do strongly indicate that the response (rut depth) has too much noise in it and it would not allow determination of a good model. From a statistical DoE perspective, two major changes proposed for this experiment are: (1) actual replication of the tests is definitely required, (2) nuisance variables need to be identified and blocked properly. Further investigation is necessary to determine possible sources of noise in the experiment.
Abstract: Arsenic in the sediments of the ash lagoons of the coal-fired power plant in Pagbilao, Quezon Province in the Philippines was sequentially extracted to determine its potential for leaching to the groundwater and the adjacent marine environment. Results show that 89% of the As is bound to the quasi-crystalline Fe/Mn oxides and hydroxide matrix in the sediments, whereas, the adsorbed and exchangeable As hosted by the clay minerals, representing those that are easiest to release from the sediment matrix, is below 10% of the acid leachable As. These As in these sediment matrices represent the possible maximum amount of As that can be released and supplied to the groundwater and the adjacent marine environment. Of the 89% reducible As, up to 4% is associated with the easily reducible variety, whereas, the rest is more strongly bonded by the moderately reducible variety. Based on the long-term As content of the lagoon water, the average desorption rate of As is calculated to be very low -- 0.3-0.5% on the average and 0.6% on the maximum. This indicates that As is well-fixed by its sediment matrices in the ash lagoon, attenuating the influx of As into the adjacent groundwater and marine environments.
Abstract: This paper presents the application of discrete-time
variable structure control with sliding mode based on the 'reaching
law' method for robust control of a 'simple inverted pendulum on
moving cart' - a standard nonlinear benchmark system. The
controllers designed using the above techniques are completely
insensitive to parametric uncertainty and external disturbance. The
controller design is carried out using pole placement technique to find
state feedback gain matrix , which decides the dynamic behavior
of the system during sliding mode. This is followed by feedback gain
realization using the control law which is synthesized from 'Gao-s
reaching law'. The model of a single inverted pendulum and the
discrete variable structure control controller are developed, simulated
in MATLAB-SIMULINK and results are presented. The response of
this simulation is compared with that of the discrete linear quadratic
regulator (DLQR) and the advantages of sliding mode controller over
DLQR are also presented
Abstract: The experiments were performed in a batch set up
under different concentrations of Cu (II) (0.2 g.l-1 to 0.9 g.l-1), pH (4-
6), temperatures (20oC – 40oC) with varying teak leaves powder (as
biosorbent) dosage of 0.3 g.l-1 to 0.5 g.l-1. The kinetics of interactions
were tested with pseudo first order Lagergran equation and the value
for k1 was found to be 6.909 x 10-3 min-1. The biosorption data gave
a good fit with Langmuir and Fruendlich isotherms and the Langmuir
monolayer capacity (qm) was found to be 166.78 mg. g-1. Similarly
the Freundlich adsorption capacity (Kf) was estimated as 2.49 l g-1.
The mean values of the thermodynamic parameters ΔH, ΔS, and ΔG
were -62.42 KJ. mol-1, -0.219 KJ.mol-1 K-1 and -1.747 KJ.mol-1 at
293 K from a solution containing 0.4 g l-1 of Cu(II) showing the
biosorption to be thermodynamically favourable. These results show
good potentiality of using teak leaves as a biosorbent for the removal
of Cu(II) from aqueous solutions.
Abstract: Group key management is an important functional
building block for any secure multicast architecture.
Thereby, it has been extensively studied in the literature.
In this paper we present relevant group key management
protocols. Then, we compare them against some pertinent
performance criteria.
Abstract: We successfully developed and tested a new
separation layer solving problems with unmanageable deposits inside the boilers of Zluticka Heating Plant. The deposits are mainly created
by glass-forming melts. We plotted straw ash compositions in K2OCaO-
SiO2 phase diagram and illustrated that they are in the area of low-melting eutectic points. To prevent the melting of ash and the
formation of deposits, we modified ash compositions by injecting additives into biomass fuel, and thus effectively suppressed deposits in a burner.
Abstract: During the last decade ultrafine grained (UFG) and nano-structured (NS) materials have experienced a rapid development. In this research work finite element analysis has been carried out to investigate the plastic strain distribution in equal channel angular process (ECAP). The magnitudes of Standard deviation (S. D.) and inhomogeneity index (Ci) were compared for different ECAP passes. Verification of a three-dimensional finite element model was performed with experimental tests. Finally the mechanical property including impact energy of ultrafine grained pure commercially pure Aluminum produced by severe plastic deformation method has been examined. For this aim, equal channel angular pressing die with the channel angle, outer corner angle and channel diameter of 90°, 20° and 20mm had been designed and manufactured. Commercial pure Aluminum billets were ECAPed up to four passes by route BC at the ambient temperature. The results indicated that there is a great improvement at the hardness measurement, yield strength and ultimate tensile strength after ECAP process. It is found that the magnitudes of HV reach 67HV from 21HV after the final stage of process. Also, about 330% and 285% enhancement at the YS and UTS values have been obtained after the fourth pass as compared to the as-received conditions, respectively. On the other hand, the elongation to failure and impact energy have been reduced by 23% and 50% after imposing four passes of ECAP process, respectively.
Abstract: The aim of this investigation is to study the
performance of the new generation of the PVD coated grade and to
map the influence of cutting conditions on the tool life in milling of
ADI (Austempered Ductile Iron). The results show that chipping is
the main wear mechanism which determines the tool life in dry
condition and notch wear in wet condition for this application. This
due to the different stress mechanisms and preexisting cracks in the
coating. The wear development shows clearly that the new PVD
coating (C20) has the best ability to delay the chipping growth. It
was also found that a high content of Al in the new coating (C20)
was especially favorable compared to a TiAlN multilayer with lower
Al content (C30) or CVD coating. This is due to fine grains and low
compressive stress level in the coating which increase the coating
ability to withstand the mechanical and thermal impact. It was also
found that the use of coolant decreases the tool life with 70-80%
compare to dry milling.
Abstract: The purpose of this paper is to summarize the
following protection of scouring countermeasures by using
Bentonite-Enhanced Sand (BES) mixtures. The concept of
underground improvement is being used in this study to reduce the
void of the sand. The sand bentonite mixture was used to bond the
ground soil conditions surrounding the pile of integral bridge. The
right composition of sand bentonite mixture was proposed based on
previous findings. The swelling effect of bentonite also was
investigated to ensure there is no adverse impact to the structure of
the integral bridge. ScourScour, another name for severe erosion,
occurs when the erosive capacity of water resulting from natural and
manmade events exceeds the ability of earth materials to resist its
effects. According to AASHTO LRFD Specifications (Section
C3.7.5), scour is the most common reason for the collapse of
highway bridges in the United States
Abstract: Background Contact lens (CL) wear can cause
changes in blinking and corneal staining. Aims and Objectives To
determine the effects of CL materials (HEMA and SiHy) on
spontaneous blink rate, blinking patterns and corneal staining after 2
months of wear. Methods Ninety subjects in 3 groups (control,
HEMA and SiHy) were assessed at baseline and 2-months. Blink rate
was recorded using a video camera. Blinking patterns were assessed
with digital camera and slit lamp biomicroscope. Corneal staining
was graded using IER grading scale Results There were no significant
differences in all parameters at baseline. At 2 months, CL wearers
showed significant increment in average blink rate (F1.626, 47.141 =
7.250, p = 0.003; F2,58 = 6.240, p = 0.004) and corneal staining (χ2
2,
n=30 = 31.921, p < 0.001; χ2
2, n=30 = 26.909, p < 0.001). Conclusion
Blinking characteristics and corneal staining were not influence by
soft CL materials.
Abstract: This paper propose a new circuit design which
monitor total leakage current during standby mode and generates the
optimal reverse body bias voltage, by using the adaptive body bias
(ABB) technique to compensate die-to-die parameter variations.
Design details of power monitor are examined using simulation
framework in 65nm and 32nm BTPM model CMOS process.
Experimental results show the overhead of proposed circuit in terms
of its power consumption is about 10 μW for 32nm technology and
about 12 μW for 65nm technology at the same power supply voltage
as the core power supply. Moreover the results show that our
proposed circuit design is not far sensitive to the temperature
variations and also process variations. Besides, uses the simple
blocks which offer good sensitivity, high speed, the continuously
feedback loop.
Abstract: The agricultural organic farming is different from
conventional farming in a way that is aimed at providing a balanced
and constructive action in agricultural systems. With the increase in
intensive agriculture, undesirable changes were being observed in
ecosystems with irreparable damage being caused to the natural
equilibrium. This is the reason for the increasing interest in organic
farming as an environment friendly agricultural production method.
In the present work three red fruits produced in organic farming were
analyzed, namely raspberry, gooseberry and blueberry. The samples
were harvested in a local farm when at plain maturation. The results
obtained allowed to conclude that the blueberry contained higher
amounts of phenolic compounds, total tannins and total anthocyanins
than raspberry and gooseberry. Furthermore, the HPLC analysis
allowed to identify monomeric anthocyanins and phenolic acids in
the three fruits studied.
Abstract: Protection system hidden failures have been identified as one of the main causes of system cascading collapse resulting to power system instability. In this paper, a systematic approach is presented in order to identify the probability of a system cascading collapse by taking into consideration the effect of protection system hidden failure. This includes the accurate calculation of the probability of hidden failure as it will provide significant impinge on the findings of the probability of system cascading collapse. The probability of a system cascading collapse is then used to identify the initial tripping of sensitive transmission lines which will contribute to a critical system cascading collapse. Based on the results obtained from this study, it is important to decide on the accurate value of the hidden failure probability as it will affect the probability of a system cascading collapse.
Abstract: Composite nanostructures of metal
core/semiconductor shell (Au/CdS) configuration were prepared
using organometalic method. UV-Vis spectra for the Au/CdS colloids
show initially two well separated bands, corresponding to surface
plasmon of the Au core, and the exciton of CdS shell. The absorption
of CdS shell is enhanced, while the Au plasmon band is suppressed
as the shell thickness increases. The shell sizes were estimated from
the optical spectra using the effective mass approximation model
(EMA), and compared to the sizes of the Au core and CdS shell
measured by high resolution transmission electron microscope
(HRTEM). The changes in the absorption features are discussed in
terms of gradual increase in the coupling strength of the Au core
surface plasmon and the exciton in the CdS. leading to charge
transfer and modification of electron oscillation in Au core.
Abstract: Aeration by a plunging water jet is an energetically attractive way to effect oxygen-transfer than conventional oxygenation systems. In the present study, a new type of conical shaped plunging aeration device is fabricated to generate hollow inclined ined plunging jets (jet plunge angle of π/3 ) to investigate its oxygen transfer capacity. The results suggest that the volumetric oxygen-transfer coefficient and oxygen-transfer efficiency of the conical plunging jet aerator are competitive with other types of aeration systems. Relationships of volumetric oxygen-transfer coefficient with jet power per unit volume and jet parameters are also proposed. The suggested relationships predict the volumetric oxygentransfer coefficient within a scatter of ± 15% . Further, the application of Support Vector Machines on the experimental data revealed its utility in the prediction of volumetric oxygen-transfer coefficient and development of conical plunging jet aerators.
Abstract: We describe a novel method for removing noise (in wavelet domain) of unknown variance from microarrays. The method is based on the following procedure: We apply 1) Bidimentional Discrete Wavelet Transform (DWT-2D) to the Noisy Microarray, 2) scaling and rounding to the coefficients of the highest subbands (to obtain integer and positive coefficients), 3) bit-slicing to the new highest subbands (to obtain bit-planes), 4) then we apply the Systholic Boolean Orthonormalizer Network (SBON) to the input bit-plane set and we obtain two orthonormal otput bit-plane sets (in a Boolean sense), we project a set on the other one, by means of an AND operation, and then, 5) we apply re-assembling, and, 6) rescaling. Finally, 7) we apply Inverse DWT-2D and reconstruct a microarray from the modified wavelet coefficients. Denoising results compare favorably to the most of methods in use at the moment.
Abstract: The modern world is experiencing fundamental and dynamic changes. The transformation of international relations; the end of confrontation and successive overcoming of the Cold War consequences have expanded possible international cooperation. The global nuclear conflict threat has been minimized, while a tendency to establish a unipolar world structure with the U.S. economic and power domination is growing. The current world system of international relations, apparently is secular. However, the religious beliefs of one or another nations play a certain (sometimes a key) role, both in the domestic affairs of the individual countries and in the development of bilateral ties. Political situation in Central Asia has been characterized by new factors such as international terrorism; religious extremism and radicalism; narcotrafficking and illicit arms trade of a global character immediately threaten to peace and political stability in Central Asia. The role and influence of Islamic fundamentalism is increasing; political ethnocentrism and the associated aggravation of inter-ethnic relations, the ambiguity of national interests and objectives of major geo-political groups in the Central Asian region regarding the division the political influence, emerge. This article approaches the following issues: the role of Islam in Central Asia; destabilizing factors in Central Asia; Islamic movements in Central Asia, Western Europe and the United States; the United States, Western Europe and Central Asia: religion, politics, ideology, and the US-Central Asia antiterrorism and religious extremism cooperation.