Abstract: In this study, the forty Thai medicinal plants were
used to screen the antibacterial activity against Campylobacter jejuni.
Crude 95% ethanolic extracts of each plant were prepared.
Antibacterial activity was investigated by the disc diffusion assay,
and MICs and MBCs were determined by broth microdilution. The
results of antibacterial screening showed that five plants have activity
against C.jejuni including Adenanthera pavonina L., Moringa
oleifera Lam., Annona squamosa L., Hibiscus sabdariffa L. and
Eupotorium odortum L. The extraction of A. pavonina L. and A.
squamosa L. produced an outstanding against C. jejuni, inhibiting
growth at 62.5-125 and 250-500 μg/mL, respectively. The MBCs of
two extracts were just 4-fold higher than MICs against C. jejuni,
suggesting the extracts are bactericidal against this species. These
results indicate that A. pavonina and A. squamosa could potentially
be used in modern applications aimed at treatment or prevention of
foodborne disease from C. jejuni.
Abstract: The purpose of this research is to increase our
knowledge as regards how Small-and-Medium-Sized Enterprises
(SMEs) tackle ERP implementation projects to achieve successful
adoption and use of these systems within the organization. SMEs
have scare resources to handle these kinds of projects which have
proved to be risky and costly. There are several studies focusing on
ERP implementation in larger companies, however, few studies
report on challenges experienced by SMEs. Our research seeks to
bridge this gap. Through a multiple case study of four companies, we
identified challenges and critical elements within the different phases
(pre-implementation, implementation and post-implementation) of
the ERP life cycle. To interpret our findings, we utilize a well-know
ERP life cycle model and critical success factors developed for larger
companies which are reported in former research literature. We
discuss if these models are relevant for SMEs and suggest additional
critical elements identified in this study to make a framework more
adapted to the SME context.
Abstract: The present work deals with analyses of the effects
of bearing curvature and non-Newtonian characteristics on the load capacity of an exponential rectangular squeeze film bearing using
Bingham fluids as lubricants. Bingham fluids are characterized by an
yield value and hence the formation of a “rigid" core in the region
between the plates is justified. The flow is confined to the region
between the core and the plates. The shape of the core has been
identified through numerical means. Further, numerical solutions for
the pressure distribution and load carrying capacity of the bearing
for various values of Bingham number and curvature parameter have
been obtained. The effects of bearing curvature and non-Newtonian
characteristics of the lubricant on the bearing performances have been
discussed.
Abstract: Bone growth factors, such as Bone Morphogenic
Protein-2 (BMP-2) have been approved by the FDA to replace grafting for some surgical interventions, but the high dose requirement limits its use in patients. Noggin, an extracellular protein, blocks the effect of BMP-2 by binding to BMP. Preventing
the BMP-2/noggin interaction will help increase the free
concentration of BMP-2 and therefore should enhance its efficacy to
induce bone formation. The work presented here involves
computational design of novel small molecule inhibitory agents of BMP-2/noggin interaction, based on our current understanding of
BMP-2, and its known putative ligands (receptors and antagonists). A
successful acquisition of such an inhibitory agent of BMP-2/noggin interaction would allow clinicians to reduce the dose required of
BMP-2 protein in clinical applications to promote osteogenesis. The
available crystal structures of the BMPs, its receptors, and the binding partner noggin were analyzed to identify the critical residues
involved in their interaction. In presenting this study, LUDI de novo design method was utilized to perform virtual screening of a large
number of compounds from a commercially available library against the binding sites of noggin to identify the lead chemical compounds
that could potentially block BMP-noggin interaction with a high specificity.
Abstract: The range of the output power is a very important and evident limitation of two-level inverters. In order to overcome this disadvantage, multilevel inverters are introduced. Recently, Cascade H-Bridge inverters have emerged as one of the popular converter topologies used in numerous industrial applications. The modulation switching strategies such as phase shifted carrier based Pulse Width Modulation (PWM) technique and Stair case modulation with Selective Harmonic Elimination (SHE) PWM technique are generally used. NR method is used to solve highly non linear transcendental equations which are formed by SHEPWM method. Generally NR method has a drawback of requiring good initial guess but in this paper a new approach is implemented for NR method with any random initial guess. A three phase CHB 11-level inverter is chosen for analysis. MATLAB/SIMULINK programming environment and harmonic profiles are compared. Finally this paper presents a method at fundamental switching frequency with least % THDV.
Abstract: A power cable is widely used for power supply in
power distributing networks and power transmission lines. Due to
limitations in the production, delivery and setting up power cables,
they are produced and delivered in several separate lengths. Cable
itself, consists of two cable terminations and arbitrary number of
cable joints, depending on the cable route length. Electrical stress
control is needed to prevent a dielectric breakdown at the end of the
insulation shield in both the air and cable insulation. Reliability of
cable joint depends on its materials, design, installation and operating
environment. The paper describes design and performance results for
new modeled cable joints. Design concepts, based on numerical
calculations, must be correct. An Equivalent Electrodes
Method/Boundary Elements Method-hybrid approach that allows
electromagnetic field calculations in multilayer dielectric media,
including inhomogeneous regions, is presented.
Abstract: Increase in using internet makes some problems that
one of them is "internet anxiety". Internet anxiety is a type of anxious
that people may feel during surfing internet or using internet for their
educational purpose, blogging or streaming to digital libraries. The
goal of this study is evaluating of internet anxiety among the
management students. In this research Ealy's internet anxiety
questionnaire, consists of positive and negative items, is completed
by 310 participants. According to the findings, about 64.7% of them
were equal or below to mean anxiety score (50). The distribution of
internet anxiety scores was normal and there was no meaningful
difference between men-s and women's anxiety level in this sample.
Results also showed that there is no meaningful difference of internet
anxiety level between different fields of study in Management. This
evaluation will help managers to perform gap analysis between the
existent level and the desired one. Future work would be providing
techniques for abating human anxiety while using internet via human
computer interaction techniques.
Abstract: A high performance clarification system has been
discussed for advanced aqueous reprocessing of FBR spent fuel.
Dissolver residue gives the cause of troubles on the plant operation of
reprocessing. In this study, the new clarification system based on the
hybrid of centrifuge and filtration was proposed to get the high
separation ability of the component of whole insoluble sludge. The
clarification tests of simulated solid species were carried out to
evaluate the clarification performance using small-scale test apparatus
of centrifuge and filter unit. The density effect of solid species on the
collection efficiency was mainly evaluated in the centrifugal
clarification test. In the filtration test using ceramic filter with pore
size of 0.2μm, on the other hand, permeability and filtration rate
were evaluated in addition to the filtration efficiency. As results, it was
evaluated that the collection efficiency of solid species on the new
clarification system was estimated as nearly 100%. In conclusion, the
high clarification performance of dissolver liquor can be achieved by
the hybrid of the centrifuge and filtration system.
Abstract: People from different cultures favor web pages
characterized by the values of their culture and, therefore, tend to
prefer different characteristics of a website according to their cultural
values in terms of navigation, security, product information, customer
service, shopping and design tools. For a company aiming to
globalize its market it is useful to implement country specific cultural
interfaces and different web sites for countries with different cultures.
This paper, following the conclusions proposed by two models of
Hall and Hofstede, and the studies of Marcus and Gould, defines,
through an empirical analysis, the guidelines of web design for both
the Scandinavian countries and Malaysia.
Abstract: This paper presents a design method of self-tuning
Quantitative Feedback Theory (QFT) by using improved deadbeat
control algorithm. QFT is a technique to achieve robust control with
pre-defined specifications whereas deadbeat is an algorithm that
could bring the output to steady state with minimum step size.
Nevertheless, usually there are large peaks in the deadbeat response.
By integrating QFT specifications into deadbeat algorithm, the large
peaks could be tolerated. On the other hand, emerging QFT with
adaptive element will produce a robust controller with wider
coverage of uncertainty. By combining QFT-based deadbeat
algorithm and adaptive element, superior controller that is called selftuning
QFT-based deadbeat controller could be achieved. The output
response that is fast, robust and adaptive is expected. Using a grain
dryer plant model as a pilot case-study, the performance of the
proposed method has been evaluated and analyzed. Grain drying
process is very complex with highly nonlinear behaviour, long delay,
affected by environmental changes and affected by disturbances.
Performance comparisons have been performed between the
proposed self-tuning QFT-based deadbeat, standard QFT and
standard dead-beat controllers. The efficiency of the self-tuning QFTbased
dead-beat controller has been proven from the tests results in
terms of controller’s parameters are updated online, less percentage
of overshoot and settling time especially when there are variations in
the plant.
Abstract: The present study has been taken to explore the
screening of in vitro antimicrobial activities of D-galactose-binding
sponge lectin (HOL-30). HOL-30 was purified from the marine
demosponge Halichondria okadai by affinity chromatography. The
molecular mass of the lectin was determined to be 30 kDa with a
single polypeptide by SDS-PAGE under non-reducing and reducing
conditions. HOL-30 agglutinated trypsinized and glutaraldehydefixed
rabbit and human erythrocytes with preference for type O
erythrocytes. The lectin was subjected to evaluation for inhibition of
microbial growth by the disc diffusion method against eleven human
pathogenic gram-positive and gram-negative bacteria. The lectin
exhibited strong antibacterial activity against gram-positive bacteria,
such as Bacillus megaterium and Bacillus subtilis. However, it did
not affect against gram-negative bacteria such as Salmonella typhi
and Escherichia coli. The largest zone of inhibition was recorded of
Bacillus megaterium (12 in diameter) and Bacillus subtilis (10 mm in
diameter) at a concentration of the lectin (250 μg/disc). On the other
hand, the antifungal activity of the lectin was investigated against six
phytopathogenic fungi based on food poisoning technique. The lectin
has shown maximum inhibition (22.83%) of mycelial growth of
Botrydiplodia theobromae at a concentration of 100 μg/mL media.
These findings indicate that the lectin may be of importance to
clinical microbiology and have therapeutic applications.
Abstract: A design of communication area for infrared
electronic-toll-collection systems to provide an extended
communication interval in the vehicle traveling direction and
regular boundary between contiguous traffic lanes is proposed.
By utilizing two typical low-cost commercial infrared LEDs with
different half-intensity angles Φ1/2 = 22◦ and 10◦, the radiation
pattern of the emitter is designed to properly adjust the spatial
distribution of the signal power. The aforementioned purpose
can be achieved with an LED array in a three-piece structure
with appropriate mounting angles. With this emitter, the influence
of the mounting parameters, including the mounting height and
mounting angles of the on-board unit and road-side unit, on the
system performance in terms of the received signal strength and
communication area are investigated. The results reveal that, for
our emitter proposed in this paper, the ideal ”long-and-narrow”
characteristic of the communication area is very little affected by
these mounting parameters. An optimum mounting configuration is
also suggested.
Abstract: Streaming Applications usually run in parallel or in
series that incrementally transform a stream of input data. It poses a
design challenge to break such an application into distinguishable
blocks and then to map them into independent hardware processing
elements. For this, there is required a generic controller that
automatically maps such a stream of data into independent processing
elements without any dependencies and manual considerations. In
this paper, Kahn Process Networks (KPN) for such streaming
applications is designed and developed that will be mapped on
MPSoC. This is designed in such a way that there is a generic Cbased
compiler that will take the mapping specifications as an input
from the user and then it will automate these design constraints and
automatically generate the synthesized RTL optimized code for
specified application.
Abstract: In this paper, we provide complete end-to-end delay analyses including the relay nodes for instant messages. Message Session Relay Protocol (MSRP) is used to provide congestion control for large messages in the Instant Messaging (IM) service. Large messages are broken into several chunks. These chunks may traverse through a maximum number of two relay nodes before reaching destination according to the IETF specification of the MSRP relay extensions. We discuss the current solutions of sending large instant messages and introduce a proposal to reduce message flows in the IM service. We consider virtual traffic parameter i.e., the relay nodes are stateless non-blocking for scalability purpose. This type of relay node is also assumed to have input rate at constant bit rate. We provide a new scheduling policy that schedules chunks according to their previous node?s delivery time stamp tags. Validation and analysis is shown for such scheduling policy. The performance analysis with the model introduced in this paper is simple and straight forward, which lead to reduced message flows in the IM service.
Abstract: Color printing proceeds with multiple halftone
separations overlay. Because of separation overlay misalignment in
printing, the percentage of different primary color combination may
vary and it will result in color shift. In traditional printing procedure
with AM halftone, every separation has different screening angle to
make the superposition pattern in a random style, which will reduce
the color shift. To evaluate the color shift of printing with hybrid
halftoning, we simulate printing procedure with halftone images
overlay and calculate the color difference between expected color and
color in different overlay misalignment configurations. The color
difference for hybrid halftone and AM halftone is very close. So the
color shift for hybrid halftone is acceptable with current color printing
procedure.
Abstract: Market based models are frequently used in the resource
allocation on the computational grid. However, as the size of
the grid grows, it becomes difficult for the customer to negotiate
directly with all the providers. Middle agents are introduced to
mediate between the providers and customers and facilitate the
resource allocation process. The most frequently deployed middle
agents are the matchmakers and the brokers. The matchmaking agent
finds possible candidate providers who can satisfy the requirements
of the consumers, after which the customer directly negotiates with
the candidates. The broker agents are mediating the negotiation with
the providers in real time.
In this paper we present a new type of middle agent, the marketmaker.
Its operation is based on two parallel operations - through
the investment process the marketmaker is acquiring resources and
resource reservations in large quantities, while through the resale process
it sells them to the customers. The operation of the marketmaker
is based on the fact that through its global view of the grid it can
perform a more efficient resource allocation than the one possible in
one-to-one negotiations between the customers and providers.
We present the operation and algorithms governing the operation
of the marketmaker agent, contrasting it with the matchmaker and
broker agents. Through a series of simulations in the task oriented
domain we compare the operation of the three agents types. We find
that the use of marketmaker agent leads to a better performance in the
allocation of large tasks and a significant reduction of the messaging
overhead.
Abstract: In this paper, genetic algorithm (GA) is proposed for
the design of an optimization algorithm to achieve the bandwidth
allocation of ATM network. In Broadband ISDN, the ATM is a highbandwidth;
fast packet switching and multiplexing technique. Using
ATM it can be flexibly reconfigure the network and reassign the
bandwidth to meet the requirements of all types of services. By
dynamically routing the traffic and adjusting the bandwidth
assignment, the average packet delay of the whole network can be
reduced to a minimum. M/M/1 model can be used to analyze the
performance.
Abstract: Attachment of the circulating monocytes to the
endothelium is the earliest detectable events during formation of
atherosclerosis. The adhesion molecules, chemokines and matrix
proteases genes were identified to be expressed in atherogenesis.
Expressions of these genes may influence structural integrity of the
luminal endothelium. The aim of this study is to relate changes in the
ultrastructural morphology of the aortic luminal surface and gene
expressions of the endothelial surface, chemokine and MMP-12 in
normal and hypercholesterolemic rabbits. Luminal endothelial
surface from rabbit aortic tissue was examined by scanning electron
microscopy (SEM) using low vacuum mode to ascertain
ultrastructural changes in development of atherosclerotic lesion. Gene
expression of adhesion molecules, MCP-1 and MMP-12 were studied
by Real-time PCR. Ultrastructural observations of the aortic luminal
surface exhibited changes from normal regular smooth intact
endothelium to irregular luminal surface including marked globular
appearance and ruptures of the membrane layer. Real-time PCR
demonstrated differentially expressed of studied genes in
atherosclerotic tissues. The appearance of ultrastructural changes in
aortic tissue of hypercholesterolemic rabbits is suggested to have
relation with underlying changes of endothelial surface molecules,
chemokine and MMP-12 gene expressions.
Abstract: In-vitro mouse co-culture of E14 embryonic stem cells
(ESCs) and OP9 stromal cells can recapitulate the earliest stages of
haematopoietic development, not accessible in human embryos,
supporting both haemogenic precursors and their primitive
haematopoietic progeny. 1α, 25-Dihydroxy-vitamin D3 (VD3) has
been demonstrated to be a powerful differentiation inducer for a wide
variety of neoplastic cells, and could enhance early differentiation of
ESCs into blood cells in E14/OP9 co-culture. This study aims to
ascertain whether VD3 is key in promoting differentiation and
suppressing proliferation, by separately investigating the effects of
VD3 on the proliferation phase of the E14 cell line and on stromal
OP9 cells.The results showed that VD3 inhibited the proliferation of
the cells in a dose-dependent manner, quantitatively by decreased cell
number, and qualitatively by alkaline-phosphatase staining that
revealed significant differences between VD3-treated and untreated
cells, characterised by decreased enzyme expression (colourless
cells). Propidium-iodide cell-cycle analyses showed no significant
percentage change in VD3-treated E14 and OP9 cells within their G
and S-phases, compared to the untreated controls, despite the
increased percentage of G-phase compared to the S-phase in a dosedependent
manner. These results with E14 and OP9 cells indicate that
adequate VD3 concentration enhances cellular differentiation and
inhibits proliferation. The results also suggest that if E14 and OP9
cells were co-cultured andVD3-treated, there would be furtherenhanced
differentiation of ESCs into blood cells.
Abstract: Support vector machines (SVMs) have shown
superior performance compared to other machine learning techniques,
especially in classification problems. Yet one limitation of SVMs is
the lack of an explanation capability which is crucial in some
applications, e.g. in the medical and security domains. In this paper, a
novel approach for eclectic rule-extraction from support vector
machines is presented. This approach utilizes the knowledge acquired
by the SVM and represented in its support vectors as well as the
parameters associated with them. The approach includes three stages;
training, propositional rule-extraction and rule quality evaluation.
Results from four different experiments have demonstrated the value
of the approach for extracting comprehensible rules of high accuracy
and fidelity.