Abstract: Single nucleotide polymorphisms (SNPs) hold much promise as a basis for disease-gene association. However, research is limited by the cost of genotyping the tremendous number of SNPs. Therefore, it is important to identify a small subset of informative SNPs, the so-called tag SNPs. This subset consists of selected SNPs of the genotypes, and accurately represents the rest of the SNPs. Furthermore, an effective evaluation method is needed to evaluate prediction accuracy of a set of tag SNPs. In this paper, a genetic algorithm (GA) is applied to tag SNP problems, and the K-nearest neighbor (K-NN) serves as a prediction method of tag SNP selection. The experimental data used was taken from the HapMap project; it consists of genotype data rather than haplotype data. The proposed method consistently identified tag SNPs with considerably better prediction accuracy than methods from the literature. At the same time, the number of tag SNPs identified was smaller than the number of tag SNPs in the other methods. The run time of the proposed method was much shorter than the run time of the SVM/STSA method when the same accuracy was reached.
Abstract: The electrolyte stirring method of anodization etching
process for manufacturing porous silicon (PS) is reported in this work.
Two experimental setups of nature air stirring (PS-ASM) and
electrolyte stirring (PS-ESM) are employed to clarify the influence of
stirring mechanisms on electrochemical etching process. Compared to
traditional fabrication without any stirring apparatus (PS-TM), a large
plateau region of PS surface structure is obtained from samples with
both stirring methods by the 3D-profiler measurement. Moreover, the
light emission response is also improved by both proposed electrolyte
stirring methods due to the cycling force in electrolyte could
effectively enhance etch-carrier distribution while the electrochemical
etching process is made. According to the analysis of statistical
calculation of photoluminescence (PL) intensity, lower standard
deviations are obtained from PS-samples with studied stirring methods,
i.e. the uniformity of PL-intensity is effectively improved. The
calculated deviations of PL-intensity are 93.2, 74.5 and 64,
respectively, for PS-TM, PS-ASM and PS-ESM.
Abstract: The aim of this study is to discuss the relationship between tourist awareness of environmental issues and their own recreational behaviors in the Taipei Guandu Wetland. A total of 392 questionnaires were gathered for data analysis using descriptive statistics, t-testing, one-way analysis of variance (ANOVA) and least significant difference (LSD) post hoc comparisons. The results showed that most of the visitors there enjoying the beautiful scenery are 21 to 30 years old with a college education. The means and standard deviations indicate that tourists express a positive degree of cognition of environmental issues and recreational behaviors. They suggest that polluting the environment is harmful to the natural ecosystem and that the natural resources of ecotourism are fragile, as well as expressing a high degree of recognition of the need to protect wetlands. Most of respondents are cognizant of the regulations proposed by the Guandu Wetland administration which asks that users exercise self-control and follow recommended guidelines when traveling the wetland. There were significant differences in the degree of cognition related to the variables of age, number of visits and reasons for visiting. We found that most respondents with relatively high levels of education would like to learn more about the wetland and are supportive of its conservation.
Abstract: In this article, using finite element analysis (FEA)
and an X-ray diffractometer (XRD), cold-sprayed titanium particles
on a steel substrate is investigated in term of cooling time and the
development of residual strains. Three cooling-down models of
sprayed particles after deposition stage are simulated and discussed:
the first model (m1) considers conduction effect to the substrate only,
the second model (m2) considers both conduction as well as
convection effect to the environment, and the third model (m3) which
is the same as the second model but with the substrate heated to a
near particle temperature before spraying. Thereafter, residual strains
developed in the third model is compared with the experimental
measurement of residual strains, which involved a Bruker D8
Advance Diffractometer using CuKa radiation (40kV, 40mA)
monochromatised with a graphite sample monochromator. For
deposition conditions of this study, a good correlation was found to
exist between the FEA results and XRD measurements of residual
strains.
Abstract: Since polymerase chain reaction (PCR) has been
invented, it has emerged as a powerful tool in genetic analysis. The
PCR products are closely linked with thermal cycles. Therefore, to
reduce the reaction time and make temperature distribution uniform in
the reaction chamber, a novel oscillatory thermal cycler is designed.
The sample is placed in a fixed chamber, and three constant isothermal
zones are established and lined in the system. The sample is oscillated
and contacted with three different isothermal zones to complete
thermal cycles. This study presents the design of the geometric
characteristics of the chamber. The commercial software
CFD-ACE+TM is utilized to investigate the influences of various
materials, heating times, chamber volumes, and moving speed of the
chamber on the temperature distributions inside the chamber. The
chamber moves at a specific velocity and the boundary conditions
with time variations are related to the moving speed. Whereas the
chamber moves, the boundary is specified at the conditions of the
convection or the uniform temperature. The user subroutines compiled
by the FORTRAN language are used to make the numerical results
realistically. Results show that the reaction chamber with a rectangular
prism is heated on six faces; the effects of various moving speeds of
the chamber on the temperature distributions are examined. Regarding
to the temperature profiles and the standard deviation of the
temperature at the Y-cut cross section, the non-uniform temperature
inside chamber is found as the moving speed is larger than 0.01 m/s.
By reducing the heating faces to four, the standard deviation of the
temperature of the reaction chamber is under 1.4×10-3K with the range
of velocities between 0.0001 m/s and 1 m/s. The nature convective
boundary conditions are set at all boundaries while the chamber moves
between two heaters, the effects of various moving velocities of the
chamber on the temperature distributions are negligible at the assigned
time duration.
Abstract: The autonomic nervous system has a regulatory
structure that helps people adapt to changes in their environment by
adjusting or modifying some functions in response to stress, and regulating involuntary function of human organs. The purpose of this
study was to investigate the effect of combined stimulation, both
far-infrared heating and chiropractic, on the autonomic nervous system
activities using thermal image and heart rate variability. Six healthy subjects participated in this test. We compared the before and after
autonomic nervous system activities through obtaining thermal image
and photoplethysmogram signal. The thermal images showed that the
combined stimulation changed subject-s body temperature more
highly and widely than before. The result of heart rate variability
indicated that LF/HF ratio decreased. We concluded that combined
stimulation activates autonomic nervous system, and expected other
possibilities of this combined stimulation.
Abstract: Traffic enforcement units (the Police) are partly
responsible for the severity and frequency of the traffic accidents via
the effectiveness of their safety measures. The Police claims that the
reductions in accidents and their severities occur largely by their
timely interventions at the black spots, through traffic management
or temporary changes in the road design (guiding, reducing speeds
and eliminating sight obstructions, etc.). Yet, some other external
factors than the Police measures may intervene into which such
claims require a statistical confirmation. In order to test the net
impact of the Police contribution in the reduction of the number of
crashes, Chi square test was applied for 25 spots (streets and
intersections) and an average evaluation was achieved for general
conclusion in the case study of Izmir city. Separately, the net impact
of economic crisis in the reduction of crashes is assessed by the
trend analysis for the case of the economic crisis with the probable
reduction effects on the trip generation or modal choice. Finally, it
was proven that the Police measures were effective to some degree as
they claimed, though the economic crisis might have only negligible
contribution to the reductions in the same period observed.
Abstract: The notion of communicative competence has been deemed fuzzy in communication studies. This fuzziness has led to tensions among engineers across tenures in interpreting what constitutes communicative competence. The study seeks to investigate novice and professional engineers- understanding of the said notion in terms of two main elements of communicative competence: linguistic and rhetorical competence. Novice engineers are final year engineering students, whilst professional engineers represent engineers who have at least 5 years working experience. Novice and professional engineers were interviewed to gauge their perceptions on linguistic and rhetorical features deemed necessary to enhance communicative competence for the profession. Both groups indicated awareness and differences on the importance of the sub-sets of communicative competence, namely, rhetorical explanatory competence, linguistic oral immediacy competence, technical competence and meta-cognitive competence. Such differences, a possible attribute of the learning theory, inadvertently indicate sublime differences in the way novice and professional engineers perceive communicative competence.
Abstract: This paper presents a solution for ceramic cutting tools availability in interrupted machining. Experiments were performed on a special fixture – the interrupted cut simulator. This fixture was constructed at our Department of Machining and Assembly within the scope of a project by the Czech Science Foundation. The goals of the tests were to contribute to the wider usage of these cutting materials in machining, especially in interrupted machining. Through the centuries, producers of ceramic cutting tools have taken big steps forward. Namely, increasing durability in maintaining high levels of strength and hardness lends an advantage. Some producers of these materials advise cutting inserts for interrupted machining at the present time [1, 2].
Abstract: Twenty seven tektites from the Wenchang area, Hainan
province (south China) and five tektites from the Khon Kaen area
(northeast Thailand) were analyzed for major and trace element
contents and Rb-Sr isotopic compositions. All the samples studied are
splash-form tektites. Tektites of this study are characterized by high
SiO2 contents ranging from 71.95 to 74.07 wt% which is consistent
with previously published analyses of Australasian tektites. The trace
element ratios Ba/Rb (avg. 3.89), Th/Sm (avg. 2.40), Sm/Sc (avg.
0.45), Th/Sc (avg. 0.99) and the rare earth elements (REE) contents of
tektites of this study are similar to the average upper continental crust.
Based on the chemical composition, it is suggested that tektites in this
study are derived from similar parental material and are similar to the
post-Archean upper crustal rocks. The major and trace element
abundances of tektites analyzed indicate that the parental material of
tektites may be a terrestrial sedimentary deposit. The tektites from the
Wenchang area, Hainan Island have high positive εSr(0)
values-ranging from 184.5~196.5 which indicate that the parental
material for these tektites have similar Sr isotopic compositions to old
terrestrial sedimentary rocks and they were not dominantly derived
from recent young sediments (such as soil or loess). Based on Rb-Sr
isotopic data, it has been suggested by Blum (1992) [1]that the
depositional age of sedimentary target materials is close to 170Ma
(Jurassic). According to the model suggested by Ho and Chen
(1996)[2], mixing calculations for various amounts and combinations
of target rocks have been carried out. We consider that the best fit for
tektites from the Wenchang area is a mixture of 47% shale, 23%
sandstone, 25% greywacke and 5% quartzite, and the other tektites
from Khon Kaen area is a mixture of 46% shale, 2% sandstone, 20%
greywacke and 32% quartzite.
Abstract: The launching nose plays an important role in the
incremental launching construction. The parameters of the launching
nose essentially affect the internal forces of the girder during the
construction. The appropriate parameters can decrease the internal
forces in the girder and save the material and reduce the cost. The
simplified structural model, which is made with displacement method
according to the characteristic of incremental launching construction
and the variation rule of the internal forces, calculates and analyzes the
effect of the length, the rigidity and weight of launch nose on the
internal forces of girder during the incremental launching
construction. The method, which can calculate the launching nose
parameters for the optimum incremental launching construction, is
achieved. This method is simple, reliable and easy for practical use.
Abstract: This paper deals with dynamic load balancing using PVM. In distributed environment Load Balancing and Heterogeneity are very critical issues and needed to drill down in order to achieve the optimal results and efficiency. Various techniques are being used in order to distribute the load dynamically among different nodes and to deal with heterogeneity. These techniques are using different approaches where Process Migration is basic concept with different optimal flavors. But Process Migration is not an easy job, it impose lot of burden and processing effort in order to track each process in nodes. We will propose a dynamic load balancing technique in which application will intelligently balance the load among different nodes, resulting in efficient use of system and have no overheads of process migration. It would also provide a simple solution to problem of load balancing in heterogeneous environment.
Abstract: Understanding how precipitation inter-annually
changes and its implication in agricultural drought and production change in winter wheat (Triticum aestivum L.) growth season is critical for crop production in China. MODIS Temperature-Vegetation Dryness Index (TVDI) and daily mean precipitation time series for the main growth season(Feb. to May) of winter wheat from 2000 to 2010
were used to analyze the distribution of trends of precipitation,
agricultural drought and winter wheat yield change respectively, and
relationships between them in North China region(Huang-huai-hai
region, HHH region), China. The results indicated that the trend of
precipitation in HHH region past 11 years was increasing, which had
induced generally corresponding decreasing trend of agricultural
drought and increasing trend of wheat yield, while the trend of drought
was spatially diverse. The study could provide a basis for agricultural
drought research during winter wheat season in HHH region under the
ground of climate change.
Abstract: Among all mechanical joining processes, welding has
been employed for its advantage in design flexibility, cost saving,
reduced overall weight and enhanced structural performance.
However, for structures made of relatively thin components, welding
can introduce significant buckling distortion which causes loss of
dimensional control, structural integrity and increased fabrication
costs. Different parameters can affect buckling behavior of welded
thin structures such as, heat input, welding sequence, dimension of
structure. In this work, a 3-D thermo elastic-viscoplastic finite
element analysis technique is applied to evaluate the effect of shell
dimensions on buckling behavior and entropy generation of welded
thin shells. Also, in the present work, the approximated longitudinal
transient stresses which produced in each time step, is applied to the
3D-eigenvalue analysis to ratify predicted buckling time and
corresponding eigenmode. Besides, the possibility of buckling
prediction by entropy generation at each time is investigated and it is
found that one can predict time of buckling with drawing entropy
generation versus out of plane deformation. The results of finite
element analysis show that the length, span and thickness of welded
thin shells affect the number of local buckling, mode shape of global
buckling and post-buckling behavior of welded thin shells.
Abstract: Acute disseminated encephalomyelitis (ADEM) has
been reported to develop after a hymenoptera sting, but its
pathogenesis is not known in detail. Myelin basic protein (MBP)-
specific T cells have been detected in the blood of patients with
ADEM, and a proportion of these patients develop multiple sclerosis
(MS). In an attempt to understand the mechanisms underlying
ADEM, molecular mimicry between hymenoptera venom peptides
and the human immunodominant MBP peptide was scrutinized,
based on the sequence and structural similarities, whether it was the
root of the disease. The results suggest that the three wasp venom
peptides have low sequence homology with the human
immunodominant MBP residues 85-99. Structural similarity analysis
among the three venom peptides and the MS-related HLA-DR2b
(DRA, DRB1*1501)-associated immunodominant MHC
binding/TCR contact residues 88-93, VVHFFK showed that
hyaluronidase residues 7-12, phospholipase A1 residues 98-103, and
antigen 5 residues 109-114 showed a high degree of similarity
83.3%, 100%, and 83.3% respectively. In conclusion, some wasp
venom peptides, particularly phospholipase A1, may potentially act
as the molecular motifs of the human 3HLA-DR2b-associated
immunodominant MBP88-93, and possibly present a mechanism for
induction of wasp sting-associated ADEM.
Abstract: Today, the preferences and participation of the TD groups such as the elderly and disabled is still lacking in decision-making of transportation planning, and their reactions to certain type of policies are not well known. Thus, a clear methodology is needed. This study aimed to develop a method to extract the preferences of the disabled to be used in the policy-making stage that can also guide to future estimations. The method utilizes the combination of cluster analysis and data filtering using the data of the Arao city (Japan). The method is a process that follows: defining the TD group by the cluster analysis tool, their travel preferences in tabular form from the household surveys by policy variableimpact pairs, zones, and by trip purposes, and the final outcome is the preference probabilities of the disabled. The preferences vary by trip purpose; for the work trips, accessibility and transit system quality policies with the accompanying impacts of modal shifts towards public mode use as well as the decreasing travel costs, and the trip rate increase; for the social trips, the same accessibility and transit system policies leading to the same mode shift impact, together with the travel quality policy area leading to trip rate increase. These results explain the policies to focus and can be used in scenario generation in models, or any other planning purpose as decision support tool.
Abstract: This paper presents the theoretical background and
the real implementation of an automated computer system to
introduce machine vision in flower, fruit and vegetable processing
for recollection, cutting, packaging, classification, or fumigation
tasks. The considerations and implementation issues presented in this
work can be applied to a wide range of varieties of flowers, fruits and
vegetables, although some of them are especially relevant due to the
great amount of units that are manipulated and processed each year
over the world. The computer vision algorithms developed in this
work are shown in detail, and can be easily extended to other
applications. A special attention is given to the electromagnetic
compatibility in order to avoid noisy images. Furthermore, real
experimentation has been carried out in order to validate the
developed application. In particular, the tests show that the method
has good robustness and high success percentage in the object
characterization.
Abstract: The B'enard-Marangoni thermal instability problem for
a viscoelastic Jeffreys- fluid layer with internal heat generation is
investigated. The fluid layer is bounded above by a realistic free
deformable surface and by a plane surface below. Our analysis
shows that while the internal heat generation and the relaxation time
both destabilize the fluid layer, its stability may be enhanced by an
increased retardation time.
Abstract: Presented herein is an assessment of current nonlinear
static procedures (NSPs) for seismic evaluation of bucklingrestrained
braced frames (BRBFs) which have become a favorable
lateral-force resisting system for earthquake resistant buildings. The
bias and accuracy of modal, improved modal pushover analysis
(MPA, IMPA) and mass proportional pushover (MPP) procedures
are comparatively investigated when they are applied to BRBF
buildings subjected to two sets of strong ground motions. The
assessment is based on a comparison of seismic displacement
demands such as target roof displacements, peak floor/roof
displacements and inter-story drifts. The NSP estimates are compared
to 'exact' results from nonlinear response history analysis (NLRHA).
The response statistics presented show that the MPP
procedure tends to significantly overestimate seismic demands of
lower stories of tall buildings considered in this study while MPA
and IMPA procedures provide reasonably accurate results in
estimating maximum inter-story drift over all stories of studied BRBF
systems.
Abstract: Innovation is more important in any companies.
However, it is not easy to measure the innovation performance
correctly. Patent is one of measuring index nowadays. This paper
wants to purpose an approach for valuing patents based on market
reaction to patent infringement litigations. The interesting
phenomenon is found from collection of patent infringement litigation
events. That is if any patent litigation event occurs the stock value will
follow changing. The plaintiffs- stock value raises some percentage.
According to this interesting phenomenon, the relationship between
patent litigation and stock value is tested and verified. And then, the
stock value variation is used to deduce the infringed patents- value.
The purpose of this study is providing another concept model to
evaluate the infringed patents. This study can provide a decision assist
system to help drafting patent litigation strategy and determine the
technology value