Abstract: Persea declinata (Bl.) Kosterm is a member of the
Lauraceae family, widely distributed in Southeast Asia. It is from the
same genus with avocado (Persea americana Mill), which is widely
consumed as food and for medicinal purposes. In the present study,
we examined the anticancer properties of Persea declinata (Bl.)
Kosterm bark methanolic crude extract (PDM). PDM exhibited a
potent antiproliferative effect in MCF-7 human breast cancer cells,
with an IC50 value of 16.68 .g/mL after 48h of treatment. We
observed that PDM caused cell cycle arrest and subsequent apoptosis
in MCF-7 cells, as exhibited by increased population at G0/G1 phase,
higher lactate dehydrogenase (LDH) release, and DNA
fragmentation. Mechanistic studies showed that PDM caused
significant elevation in ROS production, leading to perturbation of
mitochondrial membrane potential, cell permeability, and activation
of caspases-3/7. On the other hand, real-time PCR and Western blot
analysis showed that PDM treatment increased the expression of the
proapoptotic molecule, Bax, but decreased the expression of
prosurvival proteins, Bcl-2 and Bcl-xL, in a dose-dependent manner.
These findings imply that PDM could inhibit proliferation in MCF-7
cells via cell cycle arrest and apoptosis induction, indicating its
potential as a therapeutic agent worthy of further development.
Abstract: This article presents summary on preparation and
characterization of zinc, copper, cadmium and cobalt chromite
nanocrystals, embedded in an amorphous silica matrix. The
ZnCr2O4/SiO2, CuCr2O4/SiO2, CdCr2O4/SiO2 and CoCr2O4/SiO2
nanocomposites were prepared by a conventional sol-gel method
under acid catalysis. Final heat treatment of the samples was carried
out at temperatures in the range of 900−1200 ◦C to adjust the
phase composition and the crystallite size, respectively. The resulting
samples were characterized by Powder X-ray diffraction (PXRD),
High Resolution Transmission Electron Microscopy (HRTEM),
Raman/FTIR spectroscopy and magnetic measurements. Formation
of the spinel phase was confirmed in all samples. The average size of
the nanocrystals was determined from the PXRD data and by direct
particle size observation on HRTEM; both results were correlated.
The mean particle size (reviewed by HRTEM) was in the range from
∼4 to 46 nm. The results showed that the sol-gel method can be
effectively used for preparation of the spinel chromite nanoparticles
embedded in the silica matrix and the particle size is driven by the
type of the cation A2+ in the spinel structure and the temperature
of the final heat treatment. Magnetic properties of the nanocrystals
were found to be just moderately modified in comparison to the bulk
phases.
Abstract: The organizations of European and Czech critical
infrastructure have specific position, mission, characteristics and
behaviour in European Union and Czech state/business environments,
regarding specific requirements for regional and global security
environments. They must respect policy of national security and
global rules, requirements and standards in all their inherent and
outer processes of supply - customer chains and networks. A
controlling is generalized capability to have control over situational
policy. This paper aims and purposes are to introduce the controlling
as quite new necessary process attribute providing for critical
infrastructure is environment the capability and profit to achieve its
commitment regarding to the effectiveness of the quality
management system in meeting customer/ user requirements and also
the continual improvement of critical infrastructure organization’s
processes overall performance and efficiency, as well as its societal
security via continual planning improvement via DYVELOP
modelling.
Abstract: This paper attempts to evaluate the effect of fire
damage on concrete by using nonlinear resonance vibration method,
one of the nonlinear nondestructive method. Concrete exhibits not
only nonlinear stress-strain relation but also hysteresis and discrete
memory effect which are contained in consolidated materials.
Hysteretic materials typically show the linear resonance frequency
shift. Also, the shift of resonance frequency is changed according to
the degree of micro damage. The degree of the shift can be obtained
through nonlinear resonance vibration method. Five exposure
scenarios were considered in order to make different internal micro
damage. Also, the effect of post-fire-curing on fire-damaged concrete
was taken into account to conform the change in internal damage.
Hysteretic nonlinearity parameter was obtained by amplitudedependent
resonance frequency shift after specific curing periods. In
addition, splitting tensile strength was measured on each sample to
characterize the variation of residual strength. Then, a correlation
between the hysteretic nonlinearity parameter and residual strength
was proposed from each test result.
Abstract: Well-designed composite steel and concrete structures
highlight the good material properties and lower the deficiencies of
steel and concrete, in particular they make use of high tensile strength
of steel and high stiffness of concrete. The most common composite
steel and concrete structure is a simply supported beam, which
concrete slab transferring the slab load to a beam is connected to the
steel cross-section. The aim of this paper is to find the most adequate
numerical model of a simply supported composite beam with the
cross-sectional and material parameters based on the results of a
processed parametric study and numerical analysis. The paper also
evaluates the suitability of using compact concrete with the
lightweight aggregates for composite steel and concrete beams. The
most adequate numerical model will be used in the resent future to
compare the results of laboratory tests.
Abstract: The fundamental issues in ICT Governance (ICTG)
implementation for Malaysian Public Sector (MPS) is how ICT be
applied to support improvements in productivity, management
effectiveness and the quality of services offered to its citizens. Our
main concern is to develop and adopt a common definition and
framework to illustrate how ICTG can be used to better align ICT
with government’s operations and strategic focus. In particular, we
want to identify and categorize factors that drive a successful ICTG
process. This paper presents the results of an exploratory study to
identify, validate and refine such Critical Success Factors (CSFs) and
confirmed seven CSFs and nineteen sub-factors as influential factors
that fit MPS after further validated and refined. The Delphi method
applied in validation and refining process before being endorsed as
appropriate for MPS. The identified CSFs reflect the focus areas that
need to be considered strategically to strengthen ICT Governance
implementation and ensure business success.
Abstract: Load Forecasting plays a key role in making today's
and future's Smart Energy Grids sustainable and reliable. Accurate
power consumption prediction allows utilities to organize in advance
their resources or to execute Demand Response strategies more
effectively, which enables several features such as higher
sustainability, better quality of service, and affordable electricity
tariffs. It is easy yet effective to apply Load Forecasting at larger
geographic scale, i.e. Smart Micro Grids, wherein the lower available
grid flexibility makes accurate prediction more critical in Demand
Response applications. This paper analyses the application of
short-term load forecasting in a concrete scenario, proposed within the
EU-funded GreenCom project, which collect load data from single
loads and households belonging to a Smart Micro Grid. Three
short-term load forecasting techniques, i.e. linear regression, artificial
neural networks, and radial basis function network, are considered,
compared, and evaluated through absolute forecast errors and training
time. The influence of weather conditions in Load Forecasting is also
evaluated. A new definition of Gain is introduced in this paper, which
innovatively serves as an indicator of short-term prediction
capabilities of time spam consistency. Two models, 24- and
1-hour-ahead forecasting, are built to comprehensively compare these
three techniques.
Abstract: Metal-enhanced Luminescence of silicon nanocrystals
(SiNCs) was determined using two different particle sizes of silver
nanoparticles (AgNPs). SiNCs have been characterized by scanning
electron microscopy (SEM), high resolution transmission electron
microscopy (HRTEM), Fourier transform infrared spectroscopy
(FTIR) and X-ray photoelectron spectroscopy (XPS). It is found that
the SiNCs are crystalline with an average diameter of 65 nm and FCC
lattice. AgNPs were synthesized using photochemical reduction of
AgNO3 with sodium dodecyl sulphate (SDS). The enhanced
luminescence of SiNCs by AgNPs was evaluated by confocal Raman
microspectroscopy. Enhancement up to x9 and x3 times were
observed for SiNCs that mixed with AgNPs which have an average
particle size of 100 nm and 30 nm, respectively. Silver NPs-enhanced
luminescence of SiNCs occurs as a result of the coupling between the
excitation laser light and the plasmon bands of AgNPs; thus this
intense field at AgNPs surface couples strongly to SiNCs.
Abstract: Artemisia species, which are medically beneficial, are
widespread in temperate regions of both Northern and Southern
hemispheres among which Iran is located. About 35 species of
Artemisia are indigenous in Iran among them some are widespread in
all or most provinces, yet some are restricted to some specific
regions. In this review paper, initially, GC-Mass results of some
experiments done in different provinces of Iran are mentioned among
them some compounds are common among species, some others are
mostly restricted to other species; after that, medical advantages
based on some researches on species of this genus are reviewed;
different qualities such as anti-leishmania, anti-bacteria, antiviral as
well as anti-proliferative could be mentioned.
Abstract: Class cohesion is a key object-oriented software
quality attribute that is used to evaluate the degree of relatedness of
class attributes and methods. Researchers have proposed several class
cohesion measures. However, the effect of considering the special
methods (i.e., constructors, destructors, and access and delegation
methods) in cohesion calculation is not thoroughly theoretically
studied for most of them. In this paper, we address this issue for three
popular connectivity-based class cohesion measures. For each of the
considered measures we theoretically study the impact of including
or excluding special methods on the values that are obtained by
applying the measure. This study is based on analyzing the
definitions and formulas that are proposed for the measures. The
results show that including/excluding special methods has a
considerable effect on the obtained cohesion values and that this
effect varies from one measure to another. For each of the three
connectivity-based measures, the proposed theoretical study
recommended excluding the special methods in cohesion
measurement.
Abstract: Nonalcoholic fatty liver disease (NAFLD) has
increased in conjunction with obesity. The accuracy of risk factors
for detecting NAFLD in obese adolescents has not undergone a
formal evaluation. The aim of this study was to evaluate predictors of
NAFLD among Egyptian female obese adolescents. The study
included 162 obese female adolescents. All were subjected to
anthropometry, biochemical analysis and abdominal ultrasongraphic
assessment. Metabolic syndrome (MS) was diagnosed according to
the IDF criteria. Significant association between presence of MS and
NAFLD was observed. Obese adolescents with NAFLD had
significantly higher levels of ALT, triglycerides, fasting glucose,
insulin, blood pressure and HOMA-IR, whereas decreased HDL-C
levels as compared with obese cases without NAFLD. Receiver–
operating characteristic (ROC) curve analysis shows that ALT is a
sensitive predictor for NAFLD, confirming that ALT can be used as a
marker of NAFLD.
Abstract: Due to reduced stiffness, research on second
generation titanium alloys for implant applications, like the
metastable β-titanium alloy Ti-15Mo, become more and more
important in the recent years. The machinability of these alloys is
generally poor leading to problems during implant production and
comparably large production costs. Therefore, in the present study,
Ti-15Mo was alloyed with 0.8 wt.-% of the rare earth metals
lanthanum (Ti-15Mo+0.8La) and neodymium (Ti-15Mo+0.8Nd) to
improve its machinability. Their microstructure consisted of a
titanium matrix and micrometer-size particles of the rare earth metals
and two of their oxides. The particles stabilized the microstructure as
grain growth was minimized. As especially the ductility might be
affected by the precipitates, the behavior of Ti-15Mo+0.8La and Ti-
15Mo+0.8Nd was investigated during static and dynamic
deformation at elevated temperature to develop a processing route.
The resulting mechanical properties (static strength and ductility)
were similar in all investigated alloys.
Abstract: In the present work, the effect of load and sliding
distance on the performance tribology of commercially used
aluminium-silicon engine block and piston was evaluated at ambient
conditions with humidity of 80% under dry sliding conditions using a
pin-on-disc with two different loads of 5N and 20N yielding applied
pressure of 0.30MPa and 1.4MPa, respectively, at sliding velocity of
0.29ms-1 and with varying sliding distance ranging from 260m-
4200m. Factors and conditions that had significant effect were
identified. The results showed that the load and the sliding distance
affect the wear rate of the alloys and the wear rate increased with
increasing load for both the alloys. Wear rate also increases almost
linearly at low loads and increase to a maximum then attain a plateau
with increasing sliding distance. For both applied loads the piston
alloy showed the better performance due to higher Ni and Mg
content. The worn surface and wear debris was characterized by
optical microscope, SEM and EDX analyzer. The worn surface was
characterized by surface with shallow grooves at loads while the
groove width and depth increased as the loads increases. Oxidative
wear was found to be the predominant mechanisms in the dry sliding
of Al-Si alloys at low loads.
Abstract: Heavy metals are one of the major groups of
contaminants in the environment and many of them are toxic even at
very low concentration in plants and animals. However, some metals
play important roles in the biological function of many enzymes in
living organisms. Metals such as zinc, iron, and cooper are important
for survival and activity of enzymes in plants, however heavy metals
can inhibit enzyme which is responsible for defense system of plants.
Polyphenol oxidase (PPO) is a copper-containing metalloenzyme
which is responsible for enzymatic browning reaction of plants.
Enzymatic browning is a major problem for the handling of
vegetables and fruits in food industry. It can be increased and
effected with many different futures such as metals in the nature and
ground. In the present work, PPO was isolated and characterized
from green leaves of red poppy plant (Papaverr hoeas). Then, the
effect of some known antibrowning agents which can form
complexes with metals and metals were investigated on the red poppy
PPO activity. The results showed that glutathione was the most
potent inhibitory effect on PPO activity. Cu(II) and Fe(II) metals
increased the enzyme activities however, Sn(II) had the maximum
inhibitory effect and Zn(II) and Pb(II) had no significant effect on the
enzyme activity. In order to reduce the effect of heavy metals, the
effects of metal-antibrowning agent complexes on the PPO activity
were determined. EDTA and metal complexes had no significant
effect on the enzyme. L-ascorbic acid and metal complexes decreased
but L-ascorbic acid-Cu(II)-complex had no effect. Glutathione–metal
complexes had the best inhibitory effect on Red poppy leaf PPO
activity.
Abstract: The mathematical analysis on radiation obtained and
the development of the solar photovoltaic (PV) array groundwater
pumping is needed in the rural areas of Thohoyandou for sizing and
power performance subject to the climate conditions within the area.
A simple methodology approach is developed for the directed
coupled solar, controller and submersible ground water pump system.
The system consists of a PV array, pump controller and submerged
pump, battery backup and charger controller. For this reason, the
theoretical solar radiation is obtained for optimal predictions and
system performance in order to achieve different design and
operating parameters. Here the examination of the PV schematic
module in a Direct Current (DC) application is used for obtainable
maximum solar power energy for water pumping. In this paper, a
simple efficient photovoltaic water pumping system is presented with
its theoretical studies and mathematical modeling of photovoltaics
(PV) system.
Abstract: This paper presents a comparison of reference
management software between RefWorks and Zotero. The results
were drawn by comparing two software and the novelty of this paper
is the comparative analysis of software and it has shown that
ReftWorks can import more information from the Google Scholar for
the researchers. This finding could help to know researchers to use
the reference management software.
Abstract: This paper is about method to produce a stable and
accurate constant output pulse width regardless of the amplitude,
period and pulse width variation of the input signal source. The pulse
generated is usually being used in numerous applications as the
reference input source to other circuits in the system. Therefore, it is
crucial to produce a clean and constant pulse width to make sure the
system is working accurately as expected.
Abstract: To mimic the natural circumstances of cell growth in an organism, we present three-dimensional (3D) scaffolds fabricated by microfluidics for cultivation. This work investigates the cellular behaviors of rat cardiomyocytes in gelatin 3D scaffolds compared to those on 2D control, such as proliferation, viability and morphology. We found that the scaffolds may induce skeletal differentiation of H9c2 cells.
Abstract: In Capitalism all economic activity rests upon a set of
core institutional foundations, main from which are privately owned
capital assets and profit. How these core institutional foundations are
working in former soviet countries, in particular in Travel and
Tourism Industry of Georgia?
The role of Travel and Tourism as a key pillar of economic growth
is being increasingly recognized by governments in all regions of the
world. For the last few years Georgia succeeded in the World Bank
and IFC “Doing Business” rankings. Despite of that, during decades
totally different statistical data of the tourism sector were provided by
the different State bodies; economic parameters were published few,
or not published at all.
The frequency and extent of property rights violation in Georgia
has repeatedly been the subject of concern for the last decade. Total
value of abrogated by the former Georgian Government private
property is estimated approximately in US$4-5 billion.
Thus, if economic profitability is unknown and property rights are
not protected – that means that the main institutional foundations of
capitalism in Georgia, are not working properly yet, that cause
management problems at all levels of the national Travel and
Tourism industry of Georgia.
Abstract: The purpose of this research is to study of consumer
perception and understanding consumer buying behavior that related
between satisfied and factors affecting the purchasing. Methodology
can be classified between qualitative and quantitative approaches for
the qualitative research were interviews from middlemen who bought
organic vegetables, and middlemen related to production and
marketing system. A questionnaire was utilized as a tool to collect
data. Statistics utilized in this research included frequency,
percentage, mean, standard deviation, and multiple regression
analysis. The result show the reason to decision buying motives is
Fresh products of organic vegetables is the most significant factor on
individuals’ income, with a b of –.143, t = –2.470, the price of
organic vegetables is the most significant factor on individuals’
income, with a b of .176, t = 2.561, p value = .011. The results show
that most people with higher income think about the organic products
are expensive and have negative attitudes towards organic vegetable
as individuals with low and medium income level. Therefore,
household income had a significant influence on the purchasing
decision.