Abstract: In the paper, the relative performances on spectral
classification of short exon and intron sequences of the human and
eleven model organisms is studied. In the simulations, all
combinations of sixteen one-sequence numerical representations, four
threshold values, and four window lengths are considered. Sequences
of 150-base length are chosen and for each organism, a total of
16,000 sequences are used for training and testing. Results indicate
that an appropriate combination of one-sequence numerical
representation, threshold value, and window length is essential for
arriving at top spectral classification results. For fixed-length
sequences, the precisions on exon and intron classification obtained
for different organisms are not the same because of their genomic
differences. In general, precision increases as sequence length
increases.
Abstract: Modern managements of water distribution system
(WDS) need water quality models that are able to accurately predict
the dynamics of water quality variations within the distribution system
environment. Before water quality models can be applied to solve
system problems, they should be calibrated. Although former
researchers use GA solver to calibrate relative parameters, it is
difficult to apply on the large-scale or medium-scale real system for
long computational time. In this paper a new method is designed
which combines both macro and detailed model to optimize the water
quality parameters. This new combinational algorithm uses radial
basis function (RBF) metamodeling as a surrogate to be optimized for
the purpose of decreasing the times of time-consuming water quality
simulation and can realize rapidly the calibration of pipe wall reaction
coefficients of chlorine model of large-scaled WDS. After two cases
study this method is testified to be more efficient and promising, and
deserve to generalize in the future.
Abstract: The struggle between modern and postmodern
understanding is also displayed in terms of the superiorities of
quantitative and qualitative methods to each other which are
evaluated within the scope of these understandings. By way of
assuming that the quantitative researches (modern) are able to
account for structure while the qualitative researches (postmodern)
explain the process, these methods are turned into a means for
worldviews specific to a period. In fact, process is not a functioning
independent of structure. In addition to this issue, the ability of
quantitative methods to provide scientific knowledge is also
controversial so long as they exclude the dialectical method. For this
reason, the critiques charged against modernism in terms of
quantitative methods are, in a sense, legitimate. Nevertheless, the
main issue is in which parameters postmodernist critique tries to
legitimize its critiques and whether these parameters represent a point
of view enabling democratic solutions.
In this respect, the scientific knowledge covered in Turkish media
as a means through which ordinary people have access to scientific
knowledge will be evaluated by means of content analysis within a
new objectivity conception.
Abstract: The benefits of rooftop greenery systems (such as
energy savings, reduction of greenhouse gas emission for mitigating
climate change and maintaining sustainable development, indoor
temperature control etc.) in buildings are well recognized, however
there remains very little research conducted for quantifying the
benefits in subtropical climates such as in Australia. This study
mainly focuses on measuring/determining temperature profile and air
conditioning energy savings by implementing rooftop greenery
systems in subtropical Central Queensland in Australia. An
experimental set-up was installed at Rockhampton campus of Central
Queensland University, where two standard shipping containers (6m
x 2.4m x 2.4m) were converted into small offices, one with green
roof and one without. These were used for temperature, humidity and
energy consumption data collection. The study found that an energy
savings of up to 11.70% and temperature difference of up to 4°C can
be achieved in March in subtropical Central Queensland climate in
Australia. It is expected that more energy can be saved in peak
summer days (December/February) as temperature difference
between green roof and non-green roof is higher in December-
February.
Abstract: Adhesion to the human intestinal cell is considered
as one of the main selection criteria of lactic acid bacteria for
probiotic use. The adhesion ability of two Bifidobacteriums strains
Bifidobacterium longum BB536 and Bifidobacterium
psudocatenulatum G4 was done using HT-29 human epithelium
cell line as in vitro study. Four different level of pH were used 5.6,
5.7, 6.6, and 6.8 with four different times 15, 30, 60, and 120 min.
Adhesion was quantified by counting the adhering bacteria after
Gram staining. The adhesion of B. longum BB536 was higher than
B. psudocatenulatum G4. Both species showed significant
different in the adhesion properties at the factors tested. The
highest adhesion for both Bifidobacterium was observed at 120
min and the low adhesion was in 15 min. The findings of this
study will contribute to the introduction of new effective probiotic
strain for future utilization.
Abstract: Disordered function of maniphalanx and difficulty with
ambulation will occur insofar as a human has a failure in the spinal
marrow. Cervical spondylotic myelopathy as one of the myelopathy
emanates from not only external factors but also increased age. In
addition, the diacrisis is difficult since cervical spondylotic
myelopathy is evaluated by a doctor-s neurological remark and
imaging findings. As a quantitative method for measuring the degree
of disability, hand-operated triangle step test (for short, TST) has
formulated. In this research, a full automatic triangle step counter
apparatus is designed and developed to measure the degree of
disability in an accurate fashion according to the principle of TST. The
step counter apparatus whose shape is a low triangle pole displays the
number of stepping upon each corner. Furthermore, the apparatus has
two modes of operation. Namely, one is for measuring the degree of
disability and the other for rehabilitation exercise. In terms of
usefulness, clinical practice should be executed before too long.
Abstract: The objective of our work is to develop a new approach for discovering knowledge from a large mass of data, the result of applying this approach will be an expert system that will serve as diagnostic tools of a phenomenon related to a huge information system. We first recall the general problem of learning Bayesian network structure from data and suggest a solution for optimizing the complexity by using organizational and optimization methods of data. Afterward we proposed a new heuristic of learning a Multi-Entities Bayesian Networks structures. We have applied our approach to biological facts concerning hereditary complex illnesses where the literatures in biology identify the responsible variables for those diseases. Finally we conclude on the limits arched by this work.
Abstract: Certifications such as the Passive House Standard aim to reduce the final space heating energy demand of residential buildings. Space conditioning, notably heating, is responsible for nearly 70% of final residential energy consumption in Europe. There is therefore significant scope for the reduction of energy consumption through improvements to the energy efficiency of residential buildings. However, these certifications totally overlook the energy embodied in the building materials used to achieve this greater operational energy efficiency. The large amount of insulation and the triple-glazed high efficiency windows require a significant amount of energy to manufacture. While some previous studies have assessed the life cycle energy demand of passive houses, including their embodied energy, these rely on incomplete assessment techniques which greatly underestimate embodied energy and can lead to misleading conclusions. This paper analyses the embodied and operational energy demands of a case study passive house using a comprehensive hybrid analysis technique to quantify embodied energy. Results show that the embodied energy is much more significant than previously thought. Also, compared to a standard house with the same geometry, structure, finishes and number of people, a passive house can use more energy over 80 years, mainly due to the additional materials required. Current building energy efficiency certifications should widen their system boundaries to include embodied energy in order to reduce the life cycle energy demand of residential buildings.
Abstract: With the implied volatility as an important factor in
financial decision-making, in particular in option pricing valuation,
and also the given fact that the pricing biases of Leland option pricing
models and the implied volatility structure for the options are related,
this study considers examining the implied adjusted volatility smile
patterns and term structures in the S&P/ASX 200 index options using
the different Leland option pricing models. The examination of the
implied adjusted volatility smiles and term structures in the
Australian index options market covers the global financial crisis in
the mid-2007. The implied adjusted volatility was found to escalate
approximately triple the rate prior the crisis.
Abstract: Selection of maize (Zea mays) hybrids with wide adaptability across diverse farming environments is important, prior to recommending them to achieve a high rate of hybrid adoption. Grain yield of 14 maize hybrids, tested in a randomized completeblock design with four replicates across 22 environments in Iran, was analyzed using site regression (SREG) stability model. The biplot technique facilitates a visual evaluation of superior genotypes, which is useful for cultivar recommendation and mega-environment identification. The objectives of this study were (i) identification of suitable hybrids with both high mean performance and high stability (ii) to determine mega-environments for maize production in Iran. Biplot analysis identifies two mega-environments in this study. The first mega-environments included KRM, KSH, MGN, DZF A, KRJ, DRB, DZF B, SHZ B, and KHM, where G10 hybrid was the best performing hybrid. The second mega-environment included ESF B, ESF A, and SHZ A, where G4 hybrid was the best hybrid. According to the ideal-hybrid biplot, G10 hybrid was better than all other hybrids, followed by the G1 and G3 hybrids. These hybrids were identified as best hybrids that have high grain yield and high yield stability. GGE biplot analysis provided a framework for identifying the target testing locations that discriminates genotypes that are high yielding and stable.
Abstract: Small tanks, the ancient man-made rain water storage
systems, support the pheasant life and agriculture of the dry zone of
Sri Lanka. Many small tanks were abandoned with time due to
various reasons. Such tanks, rehabilitated in the recent past, were
found to be less sustainable and most of these rehabilitation
approaches have failed. The objective of this research is to assess the
impact of the rehabilitation approaches in the management of small
tanks in the Kurunegala District of Sri Lanka with respect to eight
small tanks. A Sustainability index was developed using seven
indicators representing the ability and commitment of the villagers to
maintain these tanks. The sustainability index of the eight tanks
varied between 79.2 and 47.2 out of a total score of 100. The
conclusion is that, the approaches used for tank rehabilitation have a
significant effect on the sustainability of the management of these
small tanks.
Abstract: The operation performance of a valveless micro-pump
is strongly dependent on the shape of connected nozzle/diffuser and
Reynolds number. The aims of present work are to compare the
performance curves of micropump with the original straight
nozzle/diffuser and contoured nozzle/diffuser under different back
pressure conditions. The tested valveless micropumps are assembled
of five pieces of patterned PMMA plates with hot-embracing
technique. The structures of central chamber, the inlet/outlet
reservoirs and the connected nozzle/diffuser are fabricated with laser
cutting machine. The micropump is actuated with circular-type PZT
film embraced on the bottom of central chamber. The deformation of
PZT membrane with various input voltages is measured with a
displacement laser probe. A simple testing facility is also constructed
to evaluate the performance curves for comparison.
In order to observe the evaluation of low Reynolds number
multiple vortex flow patterns within the micropump during suction
and pumping modes, the unsteady, incompressible laminar
three-dimensional Reynolds-averaged Navier-Stokes equations are
solved. The working fluid is DI water with constant thermo-physical
properties. The oscillating behavior of PZT film is modeled with the
moving boundary wall in way of UDF program. With the dynamic
mesh method, the instants pressure and velocity fields are obtained
and discussed.Results indicated that the volume flow rate is not
monotony increased with the oscillating frequency of PZT film,
regardless of the shapes of nozzle/diffuser. The present micropump
can generate the maximum volume flow rate of 13.53 ml/min when
the operation frequency is 64Hz and the input voltage is 140 volts.
The micropump with contoured nozzle/diffuser can provide 7ml/min
flow rate even when the back pressure is up to 400 mm-H2O. CFD
results revealed that the flow central chamber was occupied with
multiple pairs of counter-rotating vortices during suction and
pumping modes. The net volume flow rate over a complete
oscillating periodic of PZT
Abstract: In this paper we present a novel approach for human
Body configuration based on the Silhouette. We propose to address
this problem under the Bayesian framework. We use an effective
Model based MCMC (Markov Chain Monte Carlo) method to solve
the configuration problem, in which the best configuration could be
defined as MAP (maximize a posteriori probability) in Bayesian
model. This model based MCMC utilizes the human body model to
drive the MCMC sampling from the solution space. It converses the
original high dimension space into a restricted sub-space constructed
by the human model and uses a hybrid sampling algorithm. We
choose an explicit human model and carefully select the likelihood
functions to represent the best configuration solution. The
experiments show that this method could get an accurate
configuration and timesaving for different human from multi-views.
Abstract: Ethanol is generally used as a therapeutic reagent against Hepatocellular carcinoma (HCC or hepatoma) worldwide, as it can induce Hepatocellular carcinoma cell apoptosis at low concentration through a multifactorial process regulated by several unknown proteins. This paper provides a simple and available proteomic strategy for exploring differentially expressed proteins in the apoptotic pathway. The appropriate concentrations of ethanol required to induce HepG2 cell apoptosis were first assessed by MTT assay, Gisma and fluorescence staining. Next, the central proteins involved in the apoptosis pathway processs were determined using 2D-PAGE, SDS-PAGE, and bio-software analysis. Finally the downregulation of two proteins, AFP and survivin, were determined by immunocytochemistry and reverse transcriptase PCR (RT-PCR) technology. The simple, useful method demonstrated here provides a new approach to proteomic analysis in key bio-regulating process including proliferation, differentiation, apoptosis, immunity and metastasis.
Abstract: This paper reports work done to improve the modeling of complex processes when only small experimental data sets are available. Neural networks are used to capture the nonlinear underlying phenomena contained in the data set and to partly eliminate the burden of having to specify completely the structure of the model. Two different types of neural networks were used for the application of pulping problem. A three layer feed forward neural networks, using the Preconditioned Conjugate Gradient (PCG) methods were used in this investigation. Preconditioning is a method to improve convergence by lowering the condition number and increasing the eigenvalues clustering. The idea is to solve the modified odified problem M-1 Ax= M-1b where M is a positive-definite preconditioner that is closely related to A. We mainly focused on Preconditioned Conjugate Gradient- based training methods which originated from optimization theory, namely Preconditioned Conjugate Gradient with Fletcher-Reeves Update (PCGF), Preconditioned Conjugate Gradient with Polak-Ribiere Update (PCGP) and Preconditioned Conjugate Gradient with Powell-Beale Restarts (PCGB). The behavior of the PCG methods in the simulations proved to be robust against phenomenon such as oscillations due to large step size.
Abstract: We have measured the pressure drop and convective
heat transfer coefficient of water – based AL(25nm),AL2O3(30nm)
and CuO(50nm) Nanofluids flowing through a uniform heated
circular tube in the fully developed laminar flow regime. The
experimental results show that the data for Nanofluids friction factor
show a good agreement with analytical prediction from the Darcy's
equation for single-phase flow. After reducing the experimental
results to the form of Reynolds, Rayleigh and Nusselt numbers. The
results show the local Nusselt number and temperature have
distribution with the non-dimensional axial distance from the tube
entry. Study decided that thenNanofluid as Newtonian fluids through
the design of the linear relationship between shear stress and the rate
of stress has been the study of three chains of the Nanofluid with
different concentrations and where the AL, AL2O3 and CuO – water
ranging from (0.25 - 2.5 vol %). In addition to measuring the four
properties of the Nanofluid in practice so as to ensure the validity of
equations of properties developed by the researchers in this area and
these properties is viscosity, specific heat, and density and found that
the difference does not exceed 3.5% for the experimental equations
between them and the practical. The study also demonstrated that the
amount of the increase in heat transfer coefficient for three types of
Nano fluid is AL, AL2O3, and CuO – Water and these ratios are
respectively (45%, 32%, 25%) with insulation and without insulation
(36%, 23%, 19%), and the statement of any of the cases the best
increase in heat transfer has been proven that using insulation is
better than not using it. I have been using three types of Nano
particles and one metallic Nanoparticle and two oxide Nanoparticle
and a statement, whichever gives the best increase in heat transfer.
Abstract: In this paper, a novel approach for the multidisciplinary design optimization (MDO) of complex mechatronic systems. This approach, which is a part of a global project aiming to include the MDO aspect inside an innovative design process. As a first step, the paper considers the MDO as a redesign approach which is limited to the parametric optimization. After defining and introducing the different keywords, the proposed method which is based on the V-Model which is commonly used in mechatronics.
Abstract: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor.
Abstract: The effect of extraction solvent upon properties
of carrageenan from Eucheuma cottonii was studied. The
distilled water and KOH solution (concentration 0.1- 0.5N) were
used as the solvent. Extraction process was carried out in water
bath equipped by stirrer with constant speed of 275 rpm with a
constant ratio of seaweed weight to solvent volume ( 1:50 g/mL)
at 86oC for 45 minutes. The extract was then precipitated in 3
volume of 90% ethanol, oven dried at 60oC. Based on
experimental data, alkali significantly influenced yield and
properties of extracted carrageenan. The extracted carrageenan
was found to have essentially identical FTIR spectra to the
reference samples of kappa-carrageenan. Increasing the KOH
concentration led to carrageenan containing less sulfate content
and intrinsic viscosity. The gel strength increased along with the
increasing of KOH concentration. The decreasing of intrinsic
viscosity value indicates that a polymer degradation occurs
during alkali extraction.
Abstract: For the first incumbent operator it is very important
to understand how to react when the second operator comes to the
market. In this paper which is prepared for preliminary study of
GSM market in Iran, we have studied five MENA markets
according to the similarity point of view. This paper aims at
analyzing the impact of second entrants in selected markets on
certain marketing key performance indicators (KPI) such as:
Market shares (by operator), prepaid share, minutes of use (MoU),
Price and average revenue per user (ARPU) (for total market
each).