Abstract: Calcium is a vital second messenger used in signal transduction. Calcium controls secretion, cell movement, muscular contraction, cell differentiation, ciliary beating and so on. Two theories have been used to simplify the system of reaction-diffusion equations of calcium into a single equation. One is excess buffer approximation (EBA) which assumes that mobile buffer is present in excess and cannot be saturated. The other is rapid buffer approximation (RBA), which assumes that calcium binding to buffer is rapid compared to calcium diffusion rate. In the present work, attempt has been made to develop a model for calcium diffusion under excess buffer approximation in neuron cells. This model incorporates the effect of [Na+] influx on [Ca2+] diffusion,variable calcium and sodium sources, sodium-calcium exchange protein, Sarcolemmal Calcium ATPase pump, sodium and calcium channels. The proposed mathematical model leads to a system of partial differential equations which have been solved numerically using Forward Time Centered Space (FTCS) approach. The numerical results have been used to study the relationships among different types of parameters such as buffer concentration, association rate, calcium permeability.
Abstract: Ultrastructure of duodenum mucosa of irradiated rat
was studied versus dose rate of irradiation following exposure to
gamma rays from 60-Cobalt source. The animals were whole body
irradiated at two dose rates (1 Gy.mn-1 and 1 Gy.h-1) and three total
doses (1, 2 or 4 Gy) for each dose rate. 24 or 48 h after irradiation,
their small intestine was removed and samples of duodenum were
processed for observations under a transmission electron microscopy.
Samples of duodenum mucosa of control rats were processed in the
same way. For the lower dose rate of 1 Gy.h-1, main lesions
characteristic of apoptosis were detected within irradiated enterocytes
at a total dose of 2 Gy and 24 h after exposure. Necrosis was noted in
the samples, 48 h after exposition. For the higher dose rate of 1
Gy.mn-1, fewer changes were detected at all total doses 24 or 48 h
irradiation. Thus, it was shown that the appearance of radiationinduced
alterations varies not only with increasing total dose and
post-irradiation time but especially with decreasing dose rate.
Abstract: Rooted in the study of social functioning of space in architecture, Space Syntax (SS) and the more recent Network Pattern (NP) researches demonstrate the 'spatial structures' of city, i.e. the hierarchical patterns of streets, junctions and alley ends. Applying SS and NP models, planners can conceptualize the real city-s patterns. Although, both models yield the optimal path of the city their underpinning displays of the city-s spatial configuration differ. The Axial Map analyzes the topological non-distance-based connectivity structure, whereas, the Central-Node Map and the Shortcut-Path Map, in contrast, analyze the metrical distance-based structures. This research contrasts and combines them to understand various forms of city-s structures. It concludes that, while they reveal different spatial structures, Space Syntax and Network Pattern urban models support each the other. Combining together they simulate the global access and the locally compact structures namely the central nodes and the shortcuts for the city.
Abstract: The introduction of haptic elements in a graphic user interfaces are becoming more widespread. Since haptics are being introduced rapidly into computational tools, investigating how these models affect Human-Computer Interaction would help define how to integrate and model new modes of interaction. The interest of this paper is to discuss and investigate the issues surrounding Haptic and Graphic User Interface designs (GUI) as separate systems, as well as understand how these work in tandem. The development of these systems is explored from a psychological perspective, based on how usability is addressed through learning and affordances, defined by J.J. Gibson. Haptic design can be a powerful tool, aiding in intuitive learning. The problems discussed within the text is how can haptic interfaces be integrated within a GUI without the sense of frivolity. Juxtaposing haptics and Graphic user interfaces has issues of motivation; GUI tends to have a performatory process, while Haptic Interfaces use affordances to learn tool use. In a deeper view, it is noted that two modes of perception, foveal and ambient, dictate perception. These two modes were once thought to work in tandem, however it has been discovered that these processes work independently from each other. Foveal modes interpret orientation is space which provide for posture, locomotion, and motor skills with variations of the sensory information, which instructs perceptions of object-task performance. It is contended, here, that object-task performance is a key element in the use of Haptic Interfaces because exploratory learning uses affordances in order to use an object, without meditating an experience cognitively. It is a direct experience that, through iteration, can lead to skill-sets. It is also indicated that object-task performance will not work as efficiently without the use of exploratory or kinesthetic learning practices. Therefore, object-task performance is not as congruently explored in GUI than it is practiced in Haptic interfaces.
Abstract: We present a label-free biosensor based on
electrochemical impedance spectroscopy for the detection of proinflammatory
cytokine Tumor Necrosis Factor (TNF-α). Secretion of
TNF-α has been correlated to the onset of various diseases including
rheumatoid arthritis, Crohn-s disease etc. Gold electrodes were
patterned on a silicon substrate and self assembled monolayer of
dithiobis-succinimidyl propionate was used to develop the biosensor
which achieved a detection limit of ~57fM. A linear relationship was
also observed between increasing TNF-α concentrations and chargetransfer
resistance within a dynamic range of 1pg/ml – 1ng/ml.
Abstract: An on-line condition monitoring method for transmission line is proposed using electrical circuit theory and IT technology in this paper. It is reasonable that the circuit parameters such as resistance (R), inductance (L), conductance (g) and capacitance (C) of a transmission line expose the electrical conditions and physical state of the line. Those parameters can be calculated from the linear equation composed of voltages and currents measured by synchro-phasor measurement technique at both end of the line. A set of linear voltage drop equations containing four terminal constants (A, B ,C ,D ) are mathematical models of the transmission line circuits. At least two sets of those linear equations are established from different operation condition of the line, they may mathematically yield those circuit parameters of the line. The conditions of line connectivity including state of connecting parts or contacting parts of the switching device may be monitored by resistance variations during operation. The insulation conditions of the line can be monitored by conductance (g) and capacitance(C) measurements. Together with other condition monitoring devices such as partial discharge, sensors and visual sensing device etc.,they may give useful information to monitor out any incipient symptoms of faults. The prototype of hardware system has been developed and tested through laboratory level simulated transmission lines. The test has shown enough evident to put the proposed method to practical uses.
Abstract: Most real world systems express themselves formally
as a set of nonlinear algebraic equations. As applications grow, the
size and complexity of these equations also increase. In this work, we
highlight the key concepts in using the homotopy analysis method
as a methodology used to construct efficient iteration formulas for
nonlinear equations solving. The proposed method is experimentally
characterized according to a set of determined parameters which
affect the systems. The experimental results show the potential and
limitations of the new method and imply directions for future work.
Abstract: The Želazny Most tailing pond is one of the largest
facilities worldwide for waste disposal from the copper mines located
in South-West Poland. A potential failure of the dam would allow
more than 10 million cubic meters of contaminated slurry to flow to
the valley, causing immense environmental problems to the
surrounding area. Thus, the determination of the strength properties
of the dam's soils and their variability is of utmost importance.
An extensive site investigation consisting of more than 480 cone
penetration tests (CPTs) with or without pore water pressure
measurements were conducted within a period of 13 years to study
the mechanical properties of the tailings body. The present work
investigates the point variability of the soil strength parameters
(effective friction angle
Abstract: Transmission network expansion planning (TNEP) is a basic part of power system planning that determines where, when and how many new transmission lines should be added to the network. Up till now, various methods have been presented to solve the static transmission network expansion planning (STNEP) problem. But in all of these methods, lines adequacy rate has not been considered at the end of planning horizon, i.e., expanded network misses adequacy after some times and needs to be expanded again. In this paper, expansion planning has been implemented by merging lines loading parameter in the STNEP and inserting investment cost into the fitness function constraints using genetic algorithm. Expanded network will possess a maximum adequacy to provide load demand and also the transmission lines overloaded later. Finally, adequacy index could be defined and used to compare some designs that have different investment costs and adequacy rates. In this paper, the proposed idea has been tested on the Garvers network. The results show that the network will possess maximum efficiency economically.
Abstract: This paper describes the performance of TCP Vegas
over the wireless IPv6 network. The performance of TCP Vegas is
evaluated using network simulator (ns-2). The simulation experiment
investigates how packet spacing affects the network delay, network
throughput and network efficiency of TCP Vegas. Moreover, we
investigate how the variable FTP packet sizes affect the network
performance. The result of the simulation experiment shows that as
the packet spacing is implements, the network delay is reduces,
network throughput and network efficiency is optimizes. As the FTP
packet sizes increase, the ratio of delay per throughput decreases.
From the result of experiment, we propose the appropriate packet size
in transmitting file transfer protocol application using TCP Vegas
with packet spacing enhancement over wireless IPv6 environment in
ns-2. Additionally, we suggest the appropriate ratio in determining
the appropriate RTT and buffer size in a network.
Abstract: Realistic 3D face model is more precise in representing
pose, illumination, and expression of face than 2D face model so that it
can be utilized usefully in various applications such as face recognition,
games, avatars, animations, and etc.
In this paper, we propose a 3D face modeling method based on 3D
dense morphable shape model. The proposed 3D modeling method
first constructs a 3D dense morphable shape model from 3D face scan
data obtained using a 3D scanner. Next, the proposed method extracts
and matches facial landmarks from 2D image sequence containing a
face to be modeled, and then reconstructs 3D vertices coordinates of
the landmarks using a factorization-based SfM technique. Then, the
proposed method obtains a 3D dense shape model of the face to be
modeled by fitting the constructed 3D dense morphable shape model
into the reconstructed 3D vertices. Also, the proposed method makes a
cylindrical texture map using 2D face image sequence. Finally, the
proposed method generates a 3D face model by rendering the 3D dense
face shape model using the cylindrical texture map. Through building
processes of 3D face model by the proposed method, it is shown that
the proposed method is relatively easy, fast and precise.
Abstract: In this paper we introduce new data oriented modeling
of uniform random variable well-matched with computing systems. Due to this conformity with current computers structure, this modeling will be efficiently used in statistical inference.
Abstract: Facing the concern of the population to its environment and to climatic change, city planners are now considering the urban climate in their choices of planning. The urban climate, representing different urban morphologies across central Bangkok metropolitan area (BMA), are used to investigates the effects of both the composition and configuration of variables of urban morphology indicators on the summer diurnal range of urban climate, using correlation analyses and multiple linear regressions. Results show first indicate that approximately 92.6% of the variation in the average maximum daytime near-surface air temperature (Ta) was explained jointly by the two composition variables of urban morphology indicators including open space ratio (OSR) and floor area ratio (FAR). It has been possible to determine the membership of sample areas to the local climate zones (LCZs) using these urban morphology descriptors automatically computed with GIS and remote sensed data. Finally result found the temperature differences among zones of large separation, such as the city center could be respectively from 35.48±1.04ºC (Mean±S.D.) warmer than the outskirt of Bangkok on average for maximum daytime near surface temperature to 28.27±0.21ºC for extreme event and, can exceed as 8ºC. A spatially disaggregation of urban thermal responsiveness map would be helpful for several reasons. First, it would localize urban areas concerned by different climate behavior over summer daytime and be a good indicator of urban climate variability. Second, when overlaid with a land cover map, this map may contribute to identify possible urban management strategies to reduce heat wave effects in BMA.
Abstract: Plackett-Burman statistical screening of media
constituents and operational conditions for extracellular lipase
production from isolate Trichoderma viride has been carried out in
submerged fermentation. This statistical design is used in the early
stages of experimentation to screen out unimportant factors from a
large number of possible factors. This design involves screening of
up to 'n-1' variables in just 'n' number of experiments. Regression
coefficients and t-values were calculated by subjecting the
experimental data to statistical analysis using Minitab version 15.
The effects of nine process variables were studied in twelve
experimental trials. Maximum lipase activity of 7.83 μmol /ml /min
was obtained in the 6th trail. Pareto chart illustrates the order of
significance of the variables affecting the lipase production. The
present study concludes that the most significant variables affecting
lipase production were found to be palm oil, yeast extract, K2HPO4,
MgSO4 and CaCl2.
Abstract: In this article two algorithms, one based on variation iteration method and the other on Adomian's decomposition method, are developed to find the numerical solution of an initial value problem involving the non linear integro differantial equation where R is a nonlinear operator that contains partial derivatives with respect to x. Special cases of the integro-differential equation are solved using the algorithms. The numerical solutions are compared with analytical solutions. The results show that these two methods are efficient and accurate with only two or three iterations
Abstract: Intuitionistic fuzzy sets as proposed by Atanassov,
have gained much attention from past and latter researchers for
applications in various fields. Similarity measures between
intuitionistic fuzzy sets were developed afterwards. However, it does
not cater the conflicting behavior of each element evaluated. We
therefore made some modification to the similarity measure of IFS
by considering conflicting concept to the model. In this paper, we
concentrate on Zhang and Fu-s similarity measures for IFSs and
some examples are given to validate these similarity measures. A
simple modification to Zhang and Fu-s similarity measures of IFSs
was proposed to find the best result according to the use of degree of
indeterminacy. Finally, we mark up with the application to real
decision making problems.
Abstract: An exploratory computational investigation using
RANS & URANS was carried out to understand the aerodynamics
around an isolatedsingle rotating wheel with decreasing ground
proximity. The wheel was initially modeled in free air conditions,
then with decreasing ground proximity and increased yaw angle with
rotational speeds. Three speeds of rotation were applied to the wheel
so that the effect of different angular velocities can be investigated. In
addition to rotation, three different yaw angles were applied to the
rotating wheel in order to understand how these two variables
combined affect the aerodynamic flow field around the wheel.
Abstract: Thrombosis can be life threatening, necessitating therefore its instant treatment. Hydergine, a nootropic agent is used as a cognition enhancer in stroke patients but relatively little is known about its anti-thrombolytic effect. To investigate this aspect, in vivo and ex vivo experiments were designed and conducted. Three groups of rats were injected 1.5mg, 3.0mg and 4.5mg hydergine intraperitonealy with and without prior exposure to fresh plasma. Positive and negative controls were run in parallel. Animals were sacrificed after 1.5hrs and BT, CT, PT, INR, APTT, plasma calcium levels were estimated. For ex vivo analyses, each 1ml blood aspirated was exposed to 0.1mg, 0.2mg, 0.3mg dose of hydergine with parallel controls. Parameters analyzed were as above. Statistical analysis was through one-way ANOVA. Dunken-s and Tukey-s tests provided intra-group variance. BT, CT, PT, INR and APTT increased while calcium levels dropped significantly (P
Abstract: This work presents a numerical model developed to
simulate the dynamics and vibrations of a multistage tractor gearbox.
The effect of time varying mesh stiffness, time varying frictional
torque on the gear teeth, lateral and torsional flexibility of the shafts
and flexibility of the bearings were included in the model. The model
was developed by using the Lagrangian method, and it was applied to
study the effect of three design variables on the vibration and stress
levels on the gears. The first design variable, module, had little effect
on the vibration levels but a higher module resulted to higher bending
stress levels. The second design variable, pressure angle, had little
effect on the vibration levels, but had a strong effect on the stress
levels on the pinion of a high reduction ratio gear pair. A pressure
angle of 25o resulted to lower stress levels for a pinion with 14 teeth
than a pressure angle of 20o. The third design variable, contact ratio,
had a very strong effect on both the vibration levels and bending
stress levels. Increasing the contact ratio to 2.0 reduced both the
vibration levels and bending stress levels significantly. For the gear
train design used in this study, a module of 2.5 and contact ratio of
2.0 for the various meshes was found to yield the best combination
of low vibration levels and low bending stresses. The model can
therefore be used as a tool for obtaining the optimum gear design
parameters for a given multistage spur gear train.
Abstract: In this paper, genetic algorithm (GA) opmization technique is applied to design Flexible AC Transmission System (FACTS)-based damping controllers. Two types of controller structures, namely a proportional-integral (PI) and a lead-lag (LL) are considered. The design problem of the proposed controllers is formulated as an optimization problem and GA is employed to search for optimal controller parameters. By minimizing the time-domain based objective function, in which the deviation in the oscillatory rotor speed of the generator is involved; stability performance of the system is improved. The proposed controllers are tested on a weakly connected power system subjected to different disturbances. The non-linear simulation results are presented to show the effectiveness of the proposed controller and their ability to provide efficient damping of low frequency oscillations. It is also observed that the proposed SSSC-based controllers improve greatly the voltage profile of the system under severe disturbances. Further, the dynamic performances of both the PI and LL structured FACTS-controller are analyzed at different loading conditions and under various disturbance condition as well as under unbalanced fault conditions..