Abstract: Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.
Abstract: In this paper, we first introduce the new concept of completely semiprime fuzzy ideals of an ordered semigroup S, which is an extension of completely semiprime ideals of ordered semigroup S, and investigate some its related properties. Especially, we characterize an ordered semigroup that is a semilattice of simple ordered semigroups in terms of completely semiprime fuzzy ideals of ordered semigroups. Furthermore, we introduce the notion of semiprime fuzzy ideals of ordered semigroup S and establish the relations between completely semiprime fuzzy ideals and semiprime fuzzy ideals of S. Finally, we give a characterization of prime fuzzy ideals of an ordered semigroup S and show that a nonconstant fuzzy ideal f of an ordered semigroup S is prime if and only if f is twovalued, and max{f(a), f(b)} = inf f((aSb]), ∀a, b ∈ S.
Abstract: An important technique in stability theory for
differential equations is known as the direct method of Lyapunov. In
this work we deal global stability properties of Leptospirosis
transmission model by age group in Thailand. First we consider the
data from Division of Epidemiology Ministry of Public Health,
Thailand between 1997-2011. Then we construct the mathematical
model for leptospirosis transmission by eight age groups. The
Lyapunov functions are used for our model which takes the forms of
an Ordinary Differential Equation system. The globally
asymptotically for equilibrium states are analyzed.
Abstract: Intelligent Transportation System integrates various modern advanced technologies into the ground transportation system, and it will be the goal of urban transport system in the future because of its comprehensive effects. However, it also brings some problems, such as project performance assessment, fairness of benefiting groups, fund management, which are directly related to its operation and implementation. Wuhan has difficulties in organizing transportation because of its nature feature (river and lake), therefore, calling Service of Taxi plays an important role in transportation. This paper researches on calling Service of Taxi in Wuhan, based on quantitative and qualitative analysis. It analyzes its operations management systematically, including business model, finance, usage analysis and users evaluation. As for business model, it is that the government leads the operation at the initial stage, and the third part dominates the operation at the mature stage, which not only eases the pressure of the third part and benefits the spread of the calling service at the initial stage, but also alleviates financial pressure of government and improve the efficiency of the operation at the mature stage. As for finance, it draws that this service will bring heavy financial burden of equipments, but it will be alleviated in the future because of its spread. As for usage analysis, through data comparison, this service can bring some benefits for taxi drivers, and time and spatial distribution of usage have certain features. As for user evaluation, it analyzes using group and the reason why choosing it. At last, according to the analysis above, the paper puts forward the potentials, limitations, and future development strategies for it.
Abstract: This work presents the first results from the long-term laboratory experiment dealing with impact of drought on soil properties. Three groups of the treatment (A, B and C) with different regime of irrigation were prepared. The soil water content was maintained at 70 % of soil water holding capacity in group A, at 40 % in group B. In group C, soil water regime was maintained in the range of wilting point. Each group of the experiment was divided into three variants (A1 = B1, C1; A2 = B2, C2 etc.) with three repetitions: Variants A1 (B1, C1) were a controls without addition of another fertilizer. Variants A2 (B2, C2) were fertilized with mineral nitrogen fertilizer DAM 390 (0.140 Mg of N per ha) and variants A3 (B3, C3) contained 45 g of Cp per a pot.
The significant differences (ANOVA, P
Abstract: A dissimilarity measure between the empiric
characteristic functions of the subsamples associated to the different
classes in a multivariate data set is proposed. This measure can be
efficiently computed, and it depends on all the cases of each class. It
may be used to find groups of similar classes, which could be joined
for further analysis, or it could be employed to perform an
agglomerative hierarchical cluster analysis of the set of classes. The
final tree can serve to build a family of binary classification models,
offering an alternative approach to the multi-class SVM problem. We
have tested this dendrogram based SVM approach with the oneagainst-
one SVM approach over four publicly available data sets,
three of them being microarray data. Both performances have been
found equivalent, but the first solution requires a smaller number of
binary SVM models.
Abstract: The link between Gröbner basis and linear algebra was
described by Lazard [4,5] where he realized the Gr¨obner basis
computation could be archived by applying Gaussian elimination over
Macaulay-s matrix .
In this paper, we indicate how same technique may be used to
SAGBI- Gröbner basis computations in invariant rings.
Abstract: This paper argues that fostering mutual understanding in landscape planning is as much about the planners educating stakeholder groups as the stakeholders educating the planners. In other words it is an epistemological agreement as to the meaning and nature of place, especially where an effort is made to go beyond the quantitative aspects, which can be achieved by the phenomenological experience of the Virtual Reality (VR) environment. This education needs to be a bi-directional process in which distance can be both temporal as well as spatial separation of participants, that there needs to be a common framework of understanding in which neither 'side' is disadvantaged during the process of information exchange and it follows that a medium such as VR offers an effective way of overcoming some of the shortcomings of traditional media by taking advantage of continuing technological advances in Information, Technology and Communications (ITC). In this paper we make particular reference to this as an extension to Geographical Information Systems (GIS). VR as a two-way communication tool offers considerable potential particularly in the area of Public Participation GIS (PPGIS). Information rich virtual environments that can operate over broadband networks are now possible and thus allow for the representation of large amounts of qualitative and quantitative information 'side-by-side'. Therefore, with broadband access becoming standard for households and enterprises alike, distributed virtual reality environments have great potential to contribute to enabling stakeholder participation and mutual learning within the planning context.
Abstract: Adsorption of CS2 vapors has been studied on
different types of activated carbons obtained from different source
raw materials. The activated carbons have different surface areas and
are associated with varying amounts of the carbon-oxygen surface
groups. The adsorption of CS2 vapors is not directly related to surface
area, but is considerably influenced by the presence of carbonoxygen
surface groups. The adsorption decreases on increasing the
amount of carbon-oxygen surface groups on oxidation and increases
when these surface groups are eliminated on degassing. The
adsorption is maximum in case of the 950°-degassed carbon sample
which is almost completely free of any associated oxygen. The
kinetic data as analysed by Empirical diffusion model and Linear
driving force mass transfer model indicate that the adsorption does
not involve Fickian diffusion but may be considered as a pseudo first
order mass transfer process. The activation energy of adsorption and
isosteric enthalpies of adsorption indicate that the adsorption does not
involve interaction between CS2 and carbon-oxygen surface groups,
but hydrophobic interactions between CS2 and C-C atoms in the
carbon lattice.
Abstract: Gastric ulceration is a discontinuity in gastric mucosa, usually occurs due to imbalance between the gastric mucosal protective factors, that is called gastric mucosal barrier, and the aggressive factors, to which the mucosa is exposed. This study was carried out on sixty male Sprague-Dowely rats (12- 16 weeks old) allocated into two groups. The first control group and the second Gastric lesion group which induced by oral administration of a single daily dose of aspirin at a dose of 300 mg/kg body weight for 7 consecutive-days (6% aspirin solution will be prepared and each rat will be given 5 ml of that solution/kg body weight). Blood is collected 1, 2 and 3 weeks after induction of gastric ulceration. Significant increase in serum copper, nitric oxide, and prostaglandin E2 all over the period of experiment. Significant decrease in erythrocyte superoxide dismutase (t-SOD) activities, serum (calcium, phosphorus, glucose and insulin) levels. Non-significant changes in serum sodium and potassium levels are obtained.
Abstract: In this paper, the periodic surveillance scheme has
been proposed for any convex region using mobile wireless sensor
nodes. A sensor network typically consists of fixed number of
sensor nodes which report the measurements of sensed data such as
temperature, pressure, humidity, etc., of its immediate proximity
(the area within its sensing range). For the purpose of sensing an
area of interest, there are adequate number of fixed sensor
nodes required to cover the entire region of interest. It implies
that the number of fixed sensor nodes required to cover a given
area will depend on the sensing range of the sensor as well as
deployment strategies employed. It is assumed that the sensors to
be mobile within the region of surveillance, can be mounted on
moving bodies like robots or vehicle. Therefore, in our
scheme, the surveillance time period determines the number of
sensor nodes required to be deployed in the region of interest.
The proposed scheme comprises of three algorithms namely:
Hexagonalization, Clustering, and Scheduling, The first algorithm
partitions the coverage area into fixed sized hexagons that
approximate the sensing range (cell) of individual sensor node.
The clustering algorithm groups the cells into clusters, each of
which will be covered by a single sensor node. The later
determines a schedule for each sensor to serve its respective cluster.
Each sensor node traverses all the cells belonging to the cluster
assigned to it by oscillating between the first and the last cell for
the duration of its life time. Simulation results show that our
scheme provides full coverage within a given period of time using
few sensors with minimum movement, less power consumption,
and relatively less infrastructure cost.
Abstract: This paper deals with the effect of a power transformer’s vector group on the basic voltage sag characteristics during unbalanced faults at a meshed or radial power network. Specifically, the propagation of voltage sags through a power transformer is studied with advanced short-circuit analysis. A smart method to incorporate this effect on analytical mathematical expressions is proposed. Based on this methodology, the positive effect of transformers of certain vector groups on the mitigation of the expected number of voltage sags per year (sag frequency) at the terminals of critical industrial customers can be estimated.
Abstract: The objective of current study is to investigate the
differences of winning and losing teams in terms of goal scoring and
passing sequences. Total of 31 matches from UEFA-EURO 2012
were analyzed and 5 matches were excluded from analysis due to
matches end up drawn. There are two groups of variable used in the
study which is; i. the goal scoring variable and: ii. passing sequences
variable. Data were analyzed using Wilcoxon matched pair rank test
with significant value set at p < 0.05. Current study found the timing
of goal scored was significantly higher for winning team at 1st half
(Z=-3.416, p=.001) and 2nd half (Z=-3.252, p=.001). The scoring
frequency was also found to be increase as time progressed and the
last 15 minutes of the game was the time interval the most goals
scored. The indicators that were significantly differences between
winning and losing team were the goal scored (Z=-4.578, p=.000),
the head (Z=-2.500, p=.012), the right foot (Z=-3.788,p=.000),
corner (Z=-.2.126,p=.033), open play (Z=-3.744,p=.000), inside the
penalty box (Z=-4.174, p=.000) , attackers (Z=-2.976, p=.003) and
also the midfielders (Z=-3.400, p=.001). Regarding the passing
sequences, there are significance difference between both teams in
short passing sequences (Z=-.4.141, p=.000). While for the long
passing, there were no significance difference (Z=-.1.795, p=.073).
The data gathered in present study can be used by the coaches to
construct detailed training program based on their objectives.
Abstract: Laser Doppler flowmetry is a modern method of noninvasive
microcirculation investigation. The aim of our study was to
use this method in the examination of patients with secondary
lymphedema of the lower extremities and obliterating atherosclerosis
of lower extremities. In the analysis of the amplitude-frequency
spectrum of secondary lymphedema patients we have identified
remarkable changes. To describe the changes we used a special
amplitude rate. In both of patients groups this rate was significally
(p
Abstract: Technology transfer is a common method for
companies to acquire new technology and presents both challenges
and substantial benefits. In some cases especially in developing
countries, the mere possession of technology does not guarantee a
competitive advantage if the appropriate infrastructure is not in place.
In this paper, we identify the localization factors needed to provide a
better understanding of the conditions necessary for localization in
order to benefit from future technology developments. Our
theoretical and empirical analyses allow us to identify several factors
in the technology transfer process that affect localization and provide
leverage in enhancing capabilities and absorptive capacity.The
impact factors are categorized within different groups of government,
firms, institutes and market, and are verified through the empirical
survey of a technology transfer experience. Moreover, statistical
analysis has allowed a deeper understanding of the importance of
each factor and has enabled each group to prioritize their
organizational policies to effectively localize their technology.
Abstract: Bay leaves have been shown to improve insulin
function in vitro but the effects on people have not been determined.
The objective of this study was to determine if bay leaves may be
important in the prevention and/or alleviation of type 1 diabetes.
Methods: Fifty five people with type 1 diabetes were divided into
two groups, 45 given capsules containing 3 g of bay leaves per day
for 30 days and 10 given a placebo capsules. Results All the patients
consumed bay leaves shows reduced serum glucose with significant
decreases 27% after 30 d. Total cholesterol decreased, 21 %, after 30
days with larger decreases in low density lipoprotein (LDL) 24%.
High density lipoprotein (HDL) increased 20% and Triglycerides
also decreased 26%. There were no significant changes in the
placebo group. Conclusion, this study demonstrates that consumption
of bay leaves, 3 g/d for 30 days, decreases risk factors for diabetes
and cardiovascular diseases and suggests that bay leaves may be
beneficial for people with type 1 diabetes.
Abstract: Today-s children, who are born into a more colorful,
more creative, more abstract and more accessible communication
environment than their ancestors as a result of dizzying advances in
technology, have an interesting capacity to perceive and make sense
of the world. Millennium children, who live in an environment where
all kinds of efforts by marketing communication are more intensive
than ever are, from their early childhood on, subject to all kinds of
persuasive messages. As regards advertising communication, it
outperforms all the other marketing communication efforts in
creating little consumer individuals and, as a result of processing of
codes and signs, plays a significant part in building a world of seeing,
thinking and understanding for children. Children who are raised with
metaphorical expressions such as tales and riddles also meet that fast
and effective meaning communication in advertisements.
Children-s perception of metaphors, which help grasp the “product
and its promise" both verbally and visually and facilitate association
between them is the subject of this study. Stimulating and activating
imagination, metaphors have unique advantages in promoting the
product and its promise especially in regard to print advertisements,
which have certain limitations. This study deals comparatively with
both literal and metaphoric versions of print advertisements
belonging to various product groups and attempts to discover to what
extent advertisements are liked, recalled, perceived and are
persuasive. The sample group of the study, which was conducted in
two elementary schools situated in areas that had different socioeconomic
features, consisted of children aged 12.
Abstract: The aim of the present study was to analyze and
distinguish playing pattern between winning and losing field hockey
team in Delhi 2012 tournament. The playing pattern is focus to the D
penetration (right, center, left.) and to distinguish D penetration
linking to end shot made from it. The data was recorded and analyzed
using Sportscode elite computer software. 12 matches were analyzed
from the tournament. Two groups of performance indicators are used
to analyze, that is D penetration right, center, and left. The type of
shot chosen is hit, push, flick, drag, drag flick, deflect sweep, deflect
push, scoop, sweep, and reverse hit. This is to distinguish the pattern
of play between winning and losing, only 2 performance indicator
showed high significant differences from right (Z=-2.87, p=.004,
p
Abstract: This study examined the toxicological effects and
safety of polypeptide k isolated from the seeds of Momordica
charantia in laboratory rats. 30 male Sprague Dawley rats (12 weeks
old, bodyweight 180-200 g) were randomly divided into 3 groups
(1000 mg/kg, 500 mg and 0 mg/kg). Rats were acclimatized to
laboratory conditions for 7 days and at day 8 rats were dosed orally
with polypeptide k (in 2% DMSO/normal saline) and the controls
received the dosed vehicle only. Rats were then observed for 72
hours before sacrificed. Rats were anaesthetized by pentobarbital
(50 mg/kg ip) and 2-3.0 mL of blood was taken by cardiac puncture
and rats were scarified by anaesthetic overdose. Immediately, organs
(heart, lungs, liver, kidneys) were weigh and taken for histology.
Organ sections were then evaluated by a histopathologist. Serum
samples were assayed for liver functions (ALT and γ-GT) and kidney
functions (BUN and creatinine). All rats showed normal behavior
after the dosing and no statistical changes were observed in all blood
parameters and organ weight. Histological examinations revealed
normal organ structures. In conclusion, dosing of rats up to 1000
mg/kg did not have any effects on the rat behavior, liver or kidney
functions nor histology of the selected organs.
Abstract: Anxiety is a common disorder that attacks many people in society and often accompanied by physiological sensations such as tachycardia, chest pain, shortness of breath, insensitivity and etc. The purpose of this study is to characterize the putative anxiolytic-like effects of DEV (dichloromethane extracts of valerian) using the elevated plus maze (EPM) in rats. DEV was dissolved in DMSO and orally administered at different doses to adult male wistar rats, 0.5, 1.5 and 3 hours before behavioral evaluation in an EPM respectively. Control rats were treated with an equal volume of DMSO. Single treatment of DEV (at 0.1,0.2. 0.3, and 0.4 g/kg) significantly increased time-spent and arm entries into open arms of EPM versus control groups (p