Effects of Bay Leaves on Blood Glucose and Lipid Profiles on the Patients with Type 1 Diabetes
Bay leaves have been shown to improve insulin
function in vitro but the effects on people have not been determined.
The objective of this study was to determine if bay leaves may be
important in the prevention and/or alleviation of type 1 diabetes.
Methods: Fifty five people with type 1 diabetes were divided into
two groups, 45 given capsules containing 3 g of bay leaves per day
for 30 days and 10 given a placebo capsules. Results All the patients
consumed bay leaves shows reduced serum glucose with significant
decreases 27% after 30 d. Total cholesterol decreased, 21 %, after 30
days with larger decreases in low density lipoprotein (LDL) 24%.
High density lipoprotein (HDL) increased 20% and Triglycerides
also decreased 26%. There were no significant changes in the
placebo group. Conclusion, this study demonstrates that consumption
of bay leaves, 3 g/d for 30 days, decreases risk factors for diabetes
and cardiovascular diseases and suggests that bay leaves may be
beneficial for people with type 1 diabetes.
[1] Grundy S.M. Metabolic syndrome: connecting and reconciling
cardiovascular and diabetes worlds. J. Am. Coll. Cardiol. 2006;47:1093-
1100.
[2] Srinivasan K. Plant foods in the management of diabetes mellitus: spices
as beneficial antidiabetic food adjuncts. Int. J. Food Sci. Nutr.
2005;56:399-414.
[3] Khan A., Bryden N.A., Polansky M.M., Anderson R.A. Insulin
potentiating factor and chromium content of selected foods and spices.
Biol. Trace Elem. Res. 1990;24:183-188.
[4] Bailey C.J., Day C. Traditional plant medicines as treatments for
diabetes. Diabetes Care. 1989;12:553-564.
[5] Arteriosclerosis. A report of by the National Heart and Lung Institute
Task force on Arteriosclerosis Department of Health. Education and
welfare Publication (NIA) 1971. 72- 137. Washington DC. National
nstitute of Health, Vol.1.
[6] Coronary Drug Project Research Group. The coronary drug project.
Clofibrate and Niacin in coronary heart disease. JAMA. 1975231:360-
381.
[7] Turpana, O. 1979. Effect of cholesterol lowering diet on mortality from
coronary heart disease and other causes. Circulation. 59:1-7.
[8] Lipid Research Clinics Programme. The Lipid Research Clinics
Coronary Primary Prevention Trial Results. II: The relationships of
reduction in the incidence of coronary heart disease to cholesterol.
JAMA. 1984.25: 365-374.
[9] Shaten, B.J., Kuller, L.H. and Neaton, J.D. Association between baseline
risk factors, cigarette smoking, and CHD mortality after 10.5 years.
Prev. Med. 1991. 20:655-669.
[10] Castelli, W.P., Anderson, K., Wilson, P.W. and Levy, D. Lipid risk of
coronary heart disease: The Framingham Study. Ann. Epidemiol. 1992.
2:23-28.
[11] Wargovich, M.J., Woods, C., Hollis, D.M. and Zander, M.E. 2001.
Herbals, cancer prevention and health. J. Nutr. 131: 3034S-3036S.
[12] Fang Fang, Shengmin Sang, Kuang Y. Chen, Alexander Gosslau, Chi-
Tang Ho, Robert T. Rosen. Isolation and identification of cytotoxic
compounds from Bay leaf (Laurus nobilis) Food Chemistry. 2005. 93
497-501
[13] Yalcin H., Anik M., Sanda M.A., Cakir A. Gas chromatography/mass
spectrometry analysis of Laurus nobilis essential oil composition of
northern Cyprus. J. Med. Food. 2007;10:715-719.
[14] Broadhurst C.L., Polansky M.M., Anderson R.A. Insulin-like biological
activity of culinary and medicinal plant aqueous extracts in vitro. J.
Agric. Food Chem. 2000;48:849-852.
[15] Wall M.E., Wani M.C., Brown D.M., Fullas F. Effect of tannins on
screening of plant extracts for enzyme inhibitory activity and techniques
for their removal. Phytomedicine. 1996;3:281-285.
[16] Anderson R.A. Chromium and polyphenols from cinnamon improve
insulin sensitivity. Proc. Nutr. Soc. 2008;67:48-53.
[17] Decker, E.A. The role of phenolics, conjugated linoleic acid, carnosine,
and pyrroloquinoline quinone as nonessential dietary antioxidants. Nutr.
Rev. 1995.53:49-56.
[18] Nofer, J.R., Kehrel, B., Fobker, M., Levkau, B., Assmann, G.and von
Eckardstein, A. HDL and arteriosclerosis:beyond reverse cholesterol
transport. Atherosclerosis. 2002.161:1-16.
[19] Parthasarathy, S., Barnett, J. and Fong, L.G. High-densitylipoprotein
inhibits the oxidative modification of lowdensity lipoprotein. Biochem.
Biophys. Acta. 1990. 1044:275-285.
[20] Mackness, M.I. and Durrington, P.N. HDL, its enzymes and its potential
to influence lipid peroxidation.Atherosclerosis. 1995.115:243-253.
[21] Mackness, M.I., Arrol, S., Abbott, C. and Durrington, P.N. Protection of
low-density lipoprotein against oxidative modification by high-density
lipoprotein associated paraoxonase. Atherosclerosis. 1993. 104:129-135.
[22] Mooradian A D & Morin A M, Brain uptake of glucose in diabetes
mellitus: The role of glucose transporters, Am J Med Sci, 1990. 30. 173.
[23] S Lakshmi Devi, S Kannappan & C V Anuradha. Evaluation of in vitro
antioxidant activity of Indian bay leaf, Cinnamomum tamala (Buch. -
Ham.) T. Nees & Eberm using rat brain synaptosomes as model system.
2007. Indian Journal of Experimental Biology Vol. 45, September. 778-
784.
[24] Draznin B & Eckel RH, Diabetes and atherosclerosis, in Molecular basis
and clinical aspects (Elsevier Publishers, New York) 1993, 203.
[25] Celik S & Ozkaya A, Effects of intraperitoneally administered lipoic
acid, vitamin E and linalool on the level of total lipid and fatty acids in
guinea pig brain with oxidative stress induced by H2O2. J Biochem Mol
Biol, 2002. 35 547.
[1] Grundy S.M. Metabolic syndrome: connecting and reconciling
cardiovascular and diabetes worlds. J. Am. Coll. Cardiol. 2006;47:1093-
1100.
[2] Srinivasan K. Plant foods in the management of diabetes mellitus: spices
as beneficial antidiabetic food adjuncts. Int. J. Food Sci. Nutr.
2005;56:399-414.
[3] Khan A., Bryden N.A., Polansky M.M., Anderson R.A. Insulin
potentiating factor and chromium content of selected foods and spices.
Biol. Trace Elem. Res. 1990;24:183-188.
[4] Bailey C.J., Day C. Traditional plant medicines as treatments for
diabetes. Diabetes Care. 1989;12:553-564.
[5] Arteriosclerosis. A report of by the National Heart and Lung Institute
Task force on Arteriosclerosis Department of Health. Education and
welfare Publication (NIA) 1971. 72- 137. Washington DC. National
nstitute of Health, Vol.1.
[6] Coronary Drug Project Research Group. The coronary drug project.
Clofibrate and Niacin in coronary heart disease. JAMA. 1975231:360-
381.
[7] Turpana, O. 1979. Effect of cholesterol lowering diet on mortality from
coronary heart disease and other causes. Circulation. 59:1-7.
[8] Lipid Research Clinics Programme. The Lipid Research Clinics
Coronary Primary Prevention Trial Results. II: The relationships of
reduction in the incidence of coronary heart disease to cholesterol.
JAMA. 1984.25: 365-374.
[9] Shaten, B.J., Kuller, L.H. and Neaton, J.D. Association between baseline
risk factors, cigarette smoking, and CHD mortality after 10.5 years.
Prev. Med. 1991. 20:655-669.
[10] Castelli, W.P., Anderson, K., Wilson, P.W. and Levy, D. Lipid risk of
coronary heart disease: The Framingham Study. Ann. Epidemiol. 1992.
2:23-28.
[11] Wargovich, M.J., Woods, C., Hollis, D.M. and Zander, M.E. 2001.
Herbals, cancer prevention and health. J. Nutr. 131: 3034S-3036S.
[12] Fang Fang, Shengmin Sang, Kuang Y. Chen, Alexander Gosslau, Chi-
Tang Ho, Robert T. Rosen. Isolation and identification of cytotoxic
compounds from Bay leaf (Laurus nobilis) Food Chemistry. 2005. 93
497-501
[13] Yalcin H., Anik M., Sanda M.A., Cakir A. Gas chromatography/mass
spectrometry analysis of Laurus nobilis essential oil composition of
northern Cyprus. J. Med. Food. 2007;10:715-719.
[14] Broadhurst C.L., Polansky M.M., Anderson R.A. Insulin-like biological
activity of culinary and medicinal plant aqueous extracts in vitro. J.
Agric. Food Chem. 2000;48:849-852.
[15] Wall M.E., Wani M.C., Brown D.M., Fullas F. Effect of tannins on
screening of plant extracts for enzyme inhibitory activity and techniques
for their removal. Phytomedicine. 1996;3:281-285.
[16] Anderson R.A. Chromium and polyphenols from cinnamon improve
insulin sensitivity. Proc. Nutr. Soc. 2008;67:48-53.
[17] Decker, E.A. The role of phenolics, conjugated linoleic acid, carnosine,
and pyrroloquinoline quinone as nonessential dietary antioxidants. Nutr.
Rev. 1995.53:49-56.
[18] Nofer, J.R., Kehrel, B., Fobker, M., Levkau, B., Assmann, G.and von
Eckardstein, A. HDL and arteriosclerosis:beyond reverse cholesterol
transport. Atherosclerosis. 2002.161:1-16.
[19] Parthasarathy, S., Barnett, J. and Fong, L.G. High-densitylipoprotein
inhibits the oxidative modification of lowdensity lipoprotein. Biochem.
Biophys. Acta. 1990. 1044:275-285.
[20] Mackness, M.I. and Durrington, P.N. HDL, its enzymes and its potential
to influence lipid peroxidation.Atherosclerosis. 1995.115:243-253.
[21] Mackness, M.I., Arrol, S., Abbott, C. and Durrington, P.N. Protection of
low-density lipoprotein against oxidative modification by high-density
lipoprotein associated paraoxonase. Atherosclerosis. 1993. 104:129-135.
[22] Mooradian A D & Morin A M, Brain uptake of glucose in diabetes
mellitus: The role of glucose transporters, Am J Med Sci, 1990. 30. 173.
[23] S Lakshmi Devi, S Kannappan & C V Anuradha. Evaluation of in vitro
antioxidant activity of Indian bay leaf, Cinnamomum tamala (Buch. -
Ham.) T. Nees & Eberm using rat brain synaptosomes as model system.
2007. Indian Journal of Experimental Biology Vol. 45, September. 778-
784.
[24] Draznin B & Eckel RH, Diabetes and atherosclerosis, in Molecular basis
and clinical aspects (Elsevier Publishers, New York) 1993, 203.
[25] Celik S & Ozkaya A, Effects of intraperitoneally administered lipoic
acid, vitamin E and linalool on the level of total lipid and fatty acids in
guinea pig brain with oxidative stress induced by H2O2. J Biochem Mol
Biol, 2002. 35 547.
@article{"International Journal of Medical, Medicine and Health Sciences:63795", author = "Abdulrahim Aljamal", title = "Effects of Bay Leaves on Blood Glucose and Lipid Profiles on the Patients with Type 1 Diabetes", abstract = "Bay leaves have been shown to improve insulin
function in vitro but the effects on people have not been determined.
The objective of this study was to determine if bay leaves may be
important in the prevention and/or alleviation of type 1 diabetes.
Methods: Fifty five people with type 1 diabetes were divided into
two groups, 45 given capsules containing 3 g of bay leaves per day
for 30 days and 10 given a placebo capsules. Results All the patients
consumed bay leaves shows reduced serum glucose with significant
decreases 27% after 30 d. Total cholesterol decreased, 21 %, after 30
days with larger decreases in low density lipoprotein (LDL) 24%.
High density lipoprotein (HDL) increased 20% and Triglycerides
also decreased 26%. There were no significant changes in the
placebo group. Conclusion, this study demonstrates that consumption
of bay leaves, 3 g/d for 30 days, decreases risk factors for diabetes
and cardiovascular diseases and suggests that bay leaves may be
beneficial for people with type 1 diabetes.", keywords = "bay leave, cholesterol, diabetes, triglycerides", volume = "4", number = "9", pages = "499-4", }
