Abstract: The aim of the present study was to evaluate the
mucoadhesion and the release of nicotinamide gel formulations using
in vitro methods. An agar plate technique was used to investigate the
adhesiveness of the gels whereas a diffusion apparatus was employed
to determine the release of nicotinamide from the gels. In this
respect, 10% w/w nicotinamide gels containing bioadhesive
polymers: Carbopol 934P (0.5-2% w/w), hydroxypropylmethyl
cellulose (HPMC) (4-10% w/w), sodium carboxymethyl cellulose
(SCMC) (4-6% w/w) and methylcellulose 4000 (MC) (3-5% w/w)
were prepared. The gel formulations had pH values in the range of
7.14 - 8.17, which were considered appropriate to oral mucosa
application. In general, the rank order of pH values appeared to be
SCMC > MC4000 > HPMC > Carbopol 934P. Types and
concentrations of polymers used somewhat affected the
adhesiveness. It was found that anionic polymers (Carbopol 934 and
SCMC) adhered more firmly to the agar plate than the neutral
polymers (HPMC and MC 4000). The formulation containing 0.5%
Carbopol 934P (F1) showed the highest release rate. With the
exception of the formulation F1, the neutral polymers tended to give
higher relate rates than the anionic polymers. For oral tissue
treatment, the optimum has to be balanced between the residence
time (adhesiveness) of the formulations and the release rate of the
drug. The formulations containing the anionic polymers: Carbopol
934P or SCMC possessed suitable physical properties (appearance,
pH and viscosity). In addition, for anionic polymer formulations,
justifiable mucoadhesive properties and reasonable release rates of
nicotinamide were achieved. Accordingly, these gel formulations
may be applied for the treatment of oral mucosal lesions.
Abstract: The disaster from functional gastrointestinal disorders has detrimental impact on the quality of life of the effected population and imposes a tremendous social and economic burden. There are, however, rare diagnostic methods for the functional gastrointestinal disorders. Our research group identified recently that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders becomes more rigid than healthy people when palpating the abdominal regions overlaying the gastrointestinal tract. Objective of current study is, therefore, identify feasibility of a diagnostic system for the functional gastrointestinal disorders based on ultrasound technique, which can quantify the characteristics above. Two-dimensional finite difference (FD) models (one normal and two rigid model) were developed to analyze the reflective characteristic (displacement) on each soft-tissue layer responded after application of ultrasound signals. The FD analysis was then based on elastic ultrasound theory. Validation of the model was performed via comparison of the characteristic of the ultrasonic responses predicted by FD analysis with that determined from the actual specimens for the normal and rigid conditions. Based on the results from FD analysis, ultrasound system for diagnosis of the functional gastrointestinal disorders was developed and clinically tested via application of it to 40 human subjects with/without functional gastrointestinal disorders who were assigned to Normal and Patient Groups. The FD models were favorably validated. The results from FD analysis showed that the maximum displacement amplitude in the rigid models (0.12 and 0.16) at the interface between the fat and muscle layers was explicitly less than that in the normal model (0.29). The results from actual specimens showed that the maximum amplitude of the ultrasonic reflective signal in the rigid models (0.2±0.1Vp-p) at the interface between the fat and muscle layers was explicitly higher than that in the normal model (0.1±0.2 Vp-p). Clinical tests using our customized ultrasound system showed that the maximum amplitudes of the ultrasonic reflective signals near to the gastrointestinal tract well for the patient group (2.6±0.3 Vp-p) were generally higher than those in normal group (0.1±0.2 Vp-p). Here, maximum reflective signals was appeared at 20mm depth approximately from abdominal skin for all human subjects, corresponding to the location of the boundary layer close to gastrointestinal tract well. These findings suggest that our customized ultrasound system using the ultrasonic reflective signal may be helpful to the diagnosis of the functional gastrointestinal disorders.
Abstract: This paper presents a novel approach to assessing textile porosity by the application of the image analysis techniques. The images of different types of sample fabrics, taken through a microscope when the fabric is placed over a constant light source,transfer the problem into the image analysis domain. Indeed, porosity can thus be expressed in terms of a brightness percentage index calculated on the digital microscope image. Furthermore, it is meaningful to compare the brightness percentage index with the air permeability and the tightness indices of each fabric type. We have experimentally shown that there exists an approximately linear relation between brightness percentage and air permeability indices.
Abstract: This paper deals with the problem of non-uniform
torsion in thin-walled elastic beams with asymmetric cross-section,
removing the basic concept of a fixed center of twist, necessary in the
Vlasov-s and Benscoter-s theories to obtain a warping stress field
equivalent to zero. In this new torsion/flexure theory, despite of the
classical ones, the warping function will punctually satisfy the first
indefinite equilibrium equation along the beam axis and it wont- be
necessary to introduce the classical congruence condition, to take into
account the effect of the beam restraints. The solution, based on the
Fourier development of the displacement field, is obtained assuming
that the applied external torque is constant along the beam axis and
on both beam ends the unit twist angle and the warping axial
displacement functions are totally restrained.
Finally, in order to verify the feasibility of the proposed method
and to compare it with the classical theories, two applications are
carried out. The first one, relative to an open profile, is necessary to
test the numerical method adopted to find the solution; the second
one, instead, is relative to a simplified containership section,
considered as full restrained in correspondence of two adjacent
transverse bulkheads.
Abstract: Enterprises need a strategic plan to retain their skillful employees and provide their career management, sustain their existence, to have growth and leadership qualities, to reach the objectives to increase the value of the enterprise and to not to be affected from changing demographic structure. In the cases when the long term career expectations of skillful employees are in integrity with the enterprise’s interests, skill management process is directly related to the career management. With a long term plan, the enterprises should cover the labor force need that may arise in the future by using systematic career development programs and be prepared against developments for all times. Skill management is considered as a practice with which career mobility is planned for the skillful employee to be prepared for high level positions. Career planning is the planning of an employee’s progress or promotion within an organization for which he works by developing his knowledge, skills, abilities and motives. Career planning is considered as an individual’s planning his future and the position which he wants to have, the area which he want to work in, the objectives which he want to reach. With the aim of contributing the abovementioned discussion process, career management concept and its perception manner are examined in this study in a comparative manner.
Abstract: Measures of complexity and entropy have not converged to a single quantitative description of levels of organization of complex systems. The need for such a measure is increasingly necessary in all disciplines studying complex systems. To address this problem, starting from the most fundamental principle in Physics, here a new measure for quantity of organization and rate of self-organization in complex systems based on the principle of least (stationary) action is applied to a model system - the central processing unit (CPU) of computers. The quantity of organization for several generations of CPUs shows a double exponential rate of change of organization with time. The exact functional dependence has a fine, S-shaped structure, revealing some of the mechanisms of self-organization. The principle of least action helps to explain the mechanism of increase of organization through quantity accumulation and constraint and curvature minimization with an attractor, the least average sum of actions of all elements and for all motions. This approach can help describe, quantify, measure, manage, design and predict future behavior of complex systems to achieve the highest rates of self organization to improve their quality. It can be applied to other complex systems from Physics, Chemistry, Biology, Ecology, Economics, Cities, network theory and others where complex systems are present.
Abstract: This research studied recycled waste by the Recyclable Material Bank Project of 4 universities in the central region of Thailand for the evaluation of reducing greenhouse gas emissions compared with landfilling activity during July 2012 to June 2013. The results showed that the projects collected total amount of recyclable wastes of about 911,984.80 kilograms. Office paper had the largest amount among these recycled wastes (50.68% of total recycled waste). Groups of recycled waste can be prioritized from high to low according to their amount as paper, plastic, glass, mixed recyclables, and metal, respectively. The project reduced greenhouse gas emissions equivalent to about 2814.969 metric tons of carbon dioxide. The most significant recycled waste that affects the reduction of greenhouse gas emissions is office paper which is 70.16% of total reduced greenhouse gasses emission. According to amount of reduced greenhouse gasses emission, groups of recycled waste can be prioritized from high to low significances as paper, plastic, metals, mixed recyclables, and glass, respectively.
Abstract: The 15-a-side Fiji rugby team trains well in preparations for any rugby competition but rarely performs to expectations. In order to help the Fiji local based rugby players to identify some key basic areas in improving their performance, a series of workshops were conducted to assess their nutritional status and dietary habits in relation to energy demand during rugby matches. The nutrition workshop included the administration of questionnaires to 19 local based rugby players, requesting the following information: usual food intakes, training camp food intakes, carbohydrate loading, pre-game meals and post-game meals. The study revealed that poor eating habits of the players resulted in the low carbohydrate intake, which may have contributed to increase levels of fatigue leading to loss of stamina even before the second half of the game. It appears that the diet of most 15-a-side players does not provide enough energy to enable them to last the full eightyminutes of the game.
Abstract: Both the minimum energy consumption and
smoothness, which is quantified as a function of jerk, are generally
needed in many dynamic systems such as the automobile and the
pick-and-place robot manipulator that handles fragile equipments.
Nevertheless, many researchers come up with either solely
concerning on the minimum energy consumption or minimum jerk
trajectory. This research paper considers the indirect minimum Jerk
method for higher order differential equation in dynamics
optimization proposes a simple yet very interesting indirect jerks
approaches in designing the time-dependent system yielding an
alternative optimal solution. Extremal solutions for the cost functions
of indirect jerks are found using the dynamic optimization methods
together with the numerical approximation. This case considers the
linear equation of a simple system, for instance, mass, spring and
damping. The simple system uses two mass connected together by
springs. The boundary initial is defined the fix end time and end
point. The higher differential order is solved by Galerkin-s methods
weight residual. As the result, the 6th higher differential order shows
the faster solving time.
Abstract: This paper presents a method for the detection of OD in the retina which takes advantage of the powerful preprocessing techniques such as the contrast enhancement, Gabor wavelet transform for vessel segmentation, mathematical morphology and Earth Mover-s distance (EMD) as the matching process. The OD detection algorithm is based on matching the expected directional pattern of the retinal blood vessels. Vessel segmentation method produces segmentations by classifying each image pixel as vessel or nonvessel, based on the pixel-s feature vector. Feature vectors are composed of the pixel-s intensity and 2D Gabor wavelet transform responses taken at multiple scales. A simple matched filter is proposed to roughly match the direction of the vessels at the OD vicinity using the EMD. The minimum distance provides an estimate of the OD center coordinates. The method-s performance is evaluated on publicly available DRIVE and STARE databases. On the DRIVE database the OD center was detected correctly in all of the 40 images (100%) and on the STARE database the OD was detected correctly in 76 out of the 81 images, even in rather difficult pathological situations.
Abstract: Brassinosteroids (BRs) regulate cell elongation,
vascular differentiation, senescence, and stress responses. BRs signal
through the BES1/BZR1 family of transcription factors, which
regulate hundreds of target genes involved in this pathway. In this
research a comprehensive genome-wide analysis was carried out in
BES1/BZR1 gene family in Arabidopsis thaliana, Cucumis sativus,
Vitis vinifera, Glycin max and Brachypodium distachyon.
Specifications of the desired sequences, dot plot and hydropathy plot
were analyzed in the protein and genome sequences of five plant
species. The maximum amino acid length was attributed to protein
sequence Brdic3g with 374aa and the minimum amino acid length
was attributed to protein sequence Gm7g with 163aa. The maximum
Instability index was attributed to protein sequence AT1G19350
equal with 79.99 and the minimum Instability index was attributed to
protein sequence Gm5g equal with 33.22. Aliphatic index of these
protein sequences ranged from 47.82 to 78.79 in Arabidopsis
thaliana, 49.91 to 57.50 in Vitis vinifera, 55.09 to 82.43 in Glycin
max, 54.09 to 54.28 in Brachypodium distachyon 55.36 to 56.83 in
Cucumis sativus. Overall, data obtained from our investigation
contributes a better understanding of the complexity of the
BES1/BZR1 gene family and provides the first step towards directing
future experimental designs to perform systematic analysis of the
functions of the BES1/BZR1 gene family.
Abstract: Segmenting the lungs in medical images is a
challenging and important task for many applications. In particular,
automatic segmentation of lung cavities from multiple magnetic
resonance (MR) images is very useful for oncological applications
such as radiotherapy treatment planning. However, distinguishing of
the lung areas is not trivial due to largely changing lung shapes, low
contrast and poorly defined boundaries. In this paper, we address
lung segmentation problem from pulmonary magnetic resonance
images and propose an automated method based on a robust regionaided
geometric snake with a modified diffused region force into the
standard geometric model definition. The extra region force gives the
snake a global complementary view of the lung boundary
information within the image which along with the local gradient
flow, helps detect fuzzy boundaries. The proposed method has been
successful in segmenting the lungs in every slice of 30 magnetic
resonance images with 80 consecutive slices in each image. We
present results by comparing our automatic method to manually
segmented lung cavities provided by an expert radiologist and with
those of previous works, showing encouraging results and high
robustness of our approach.
Abstract: The building of a factory can be a strategic investment
owing to its long service life. An evaluation that only focuses, for
example, on payments for the building, the technical equipment of
the factory, and the personnel for the enterprise is – considering the
complexity of the system factory – not sufficient for this long-term
view. The success of an investment is secured, among other things,
by the attainment of nonmonetary goals, too, like transformability.
Such aspects are not considered in traditional investment calculations
like the net present value method. This paper closes this gap with the
enhanced economic evaluation (EWR) for factory planning. The
procedure and the first results of an application in a project are
presented.
Abstract: In this paper, a mathematical model for data object replication in ad hoc networks is formulated. The derived model is general, flexible and adaptable to cater for various applications in ad hoc networks. We propose a game theoretical technique in which players (mobile hosts) continuously compete in a non-cooperative environment to improve data accessibility by replicating data objects. The technique incorporates the access frequency from mobile hosts to each data object, the status of the network connectivity, and communication costs. The proposed technique is extensively evaluated against four well-known ad hoc network replica allocation methods. The experimental results reveal that the proposed approach outperforms the four techniques in both the execution time and solution quality
Abstract: Adaptive observers used in sensorless control of induction motors suffer from instability especally in regenerating mode. In this paper, an optimal feed back gain design is proposed, it can reduce the instability region in the torque speed plane .
Abstract: Studying literature theme in the fields of tourism and
sustainable development and its importance in today world and their
criteria in architecture, here in this article we will also study the area
where the selected site is located; beside the Aab-Ask Village located
in Larijan region in Mazandaran province on the way to Haraz – one
of the tourism routes of Iran. After these studies by analyzing the
site, its strong potentials – such as mineral water springs (hot
springs), geothermal, landscapes and ideal climate - as a tourist
attraction spot in the region, and considering sustainable
development criteria – with regard to limits and available facilities –
a plan was offered that could change the region to provide the needs
of local people and in addition change it to a place where tourism
services is offered to the visitors and make it an acceptable sample of
stable building in Iran. Finally the reason to make design for this
complex is recovery of natural and historical values of Aab-Ask area
regarding development and sustainable architecture criteria in the
form of a functional sample which can be a suitable place to fulfill
this goal for having lots of strong points in attracting cultural and
sustainable tourist.
Abstract: Toxic and bloom-forming cyanobacterium Microcystis
aeruginosa was exposed to antialgal allelochemical gramine (0, 0.5, 1,
2, 4, 8 mg·L-1), The effects of gramine on photosynthetic pigments
(lipid soluble: chlorophyll a and β-carotene; water soluble:
phycocyanin, allophycocyanin, phycoerythrin, and total phycobilins)
and absorption spectra were studied in order to identify the most
sensitive pigment probe implicating the crucial suppression site on
photosynthetic apparatus. The results obtained indicated that all
pigment parameters were decreased with gramine concentration
increasing and exposure time extending. The above serious bleaching
of pigments was also reflected on the scanning results of absorption
spectra. Phycoerytherin exhibited the highest sensitivity to gramine
added, following by the largest relative decrease. It was concluded that
gramine seriously influenced algal photosynthetic activity by
destroying photosynthetic pigments and phycoerythrin most sensitive
to gramine might be contributed to its placing the outside of
phycobilins.
Abstract: A son in every Hindu society pays his own father the debt and he owes him for his own life whereas a girl child is treated as a burden mainly in case of first child. Even today in India we have many societies which does not welcome girl child. Although there is an increase in overall sex ratio, there is a continuous decline in child sex ratio. This paper focuses on issues of sex selective abortion in Rajasthan based on secondary data. It is found that 90.0 percentages of women in Rajasthan wants at least one son. Around 34.3 percentages of women wants more sons than daughters and only 1.5 percentages of women wants more daughters than sons. It is very common among the rich and educated people.
Abstract: The main aim of this study is to describe and introduce a method of numerical analysis in obtaining approximate solutions for the SIR-SI differential equations (susceptible-infectiverecovered for human populations; susceptible-infective for vector populations) that represent a model for dengue disease transmission. Firstly, we describe the ordinary differential equations for the SIR-SI disease transmission models. Then, we introduce the numerical analysis of solutions of this continuous time, discrete space SIR-SI model by simplifying the continuous time scale to a densely populated, discrete time scale. This is followed by the application of this numerical analysis of solutions of the SIR-SI differential equations to the estimation of relative risk using continuous time, discrete space dengue data of Kuala Lumpur, Malaysia. Finally, we present the results of the analysis, comparing and displaying the results in graphs, table and maps. Results of the numerical analysis of solutions that we implemented offers a useful and potentially superior model for estimating relative risks based on continuous time, discrete space data for vector borne infectious diseases specifically for dengue disease.
Abstract: The control of oxygen flow rate during growth of
titanium dioxide by mass flow controller in DC plasma sputtering
growth system is studied. The impedance of TiO2 films for inductance
effect is influenced by annealing time and oxygen flow rate. As
annealing time is increased, the inductance of TiO2 film is the more.
The growth condition of optimum and maximum inductance for TiO2
film to serve as sensing device are oxygen flow rate of 15 sccm and
large annealing time. The large inductance of TiO2 film will be
adopted to fabricate the biosensor to obtain the high sensitivity of
sensing in biology.