Abstract: Mendelian Disease Genes represent a collection of single points of failure for the various systems they constitute. Such genes have been shown, on average, to encode longer proteins than 'non-disease' proteins. Existing models suggest that this results from the increased likeli-hood of longer genes undergoing mutations. Here, we show that in saturated mutagenesis experiments performed on model organisms, where the likelihood of each gene mutating is one, a similar relationship between length and the probability of a gene being lethal was observed. We thus suggest an extended model demonstrating that the likelihood of a mutated gene to produce a severe phenotype is length-dependent. Using the occurrence of conserved domains, we bring evidence that this dependency results from a correlation between protein length and the number of functions it performs. We propose that protein length thus serves as a proxy for protein cardinality in different networks required for the organism's survival and well-being. We use this example to argue that the collection of Mendelian Disease Genes can, and should, be used to study the rules governing systems vulnerability in living organisms.
Abstract: A potentially serious problem with current payment systems is that their underlying hard problems from number theory may be solved by either a quantum computer or unanticipated future advances in algorithms and hardware. A new quantum payment system is proposed in this paper. The suggested system makes use of fundamental principles of quantum mechanics to ensure the unconditional security without prior arrangements between customers and vendors. More specifically, the new system uses Greenberger-Home-Zeilinger (GHZ) states and Quantum Key Distribution to authenticate the vendors and guarantee the transaction integrity.
Abstract: This paper deals with dynamic load balancing using PVM. In distributed environment Load Balancing and Heterogeneity are very critical issues and needed to drill down in order to achieve the optimal results and efficiency. Various techniques are being used in order to distribute the load dynamically among different nodes and to deal with heterogeneity. These techniques are using different approaches where Process Migration is basic concept with different optimal flavors. But Process Migration is not an easy job, it impose lot of burden and processing effort in order to track each process in nodes. We will propose a dynamic load balancing technique in which application will intelligently balance the load among different nodes, resulting in efficient use of system and have no overheads of process migration. It would also provide a simple solution to problem of load balancing in heterogeneous environment.
Abstract: Group contribution based models are widely used in
industrial applications for its convenience and flexibility. Although a
number of group contribution models have been proposed, there were
certain limitations inherent to those models. Models based on group
contribution excess Gibbs free energy are limited to low pressures and
models based on equation of state (EOS) cannot properly describe
highly nonideal mixtures including acids without introducing
additional modification such as chemical theory. In the present study
new a new approach derived from quantum chemistry have been used
to calculate necessary EOS group interaction parameters. The
COSMO-RS method, based on quantum mechanics, provides a
reliable tool for fluid phase thermodynamics. Benefits of the group
contribution EOS are the consistent extension to hydrogen-bonded
mixtures and the capability to predict polymer-solvent equilibria up to
high pressures. The authors are confident that with a sufficient
parameter matrix the performance of the lattice EOS can be improved
significantly.
Abstract: QoS Routing aims to find paths between senders and
receivers satisfying the QoS requirements of the application which
efficiently using the network resources and underlying routing
algorithm to be able to find low-cost paths that satisfy given QoS
constraints. The problem of finding least-cost routing is known to be
NP-hard or complete and some algorithms have been proposed to
find a near optimal solution. But these heuristics or algorithms either
impose relationships among the link metrics to reduce the complexity
of the problem which may limit the general applicability of the
heuristic, or are too costly in terms of execution time to be applicable
to large networks. In this paper, we concentrate an algorithm that
finds a near-optimal solution fast and we named this algorithm as
optimized Delay Constrained Routing (ODCR), which uses an
adaptive path weight function together with an additional constraint
imposed on the path cost, to restrict search space and hence ODCR
finds near optimal solution in much quicker time.
Abstract: Equal Channel Angular Pressing (ECAP) is currently
being widely investigated because of its potential to produce ultrafine
grained microstructures in metals and alloys. A sound
knowledge of the plastic deformation and strain distribution is
necessary for understanding the relationships between strain
inhomogeneity and die geometry. Considerable research has been
reported on finite element analysis of this process, assuming threedimensional
plane strain condition. However, the two-dimensional
models are not suitable due to the geometry of the dies, especially in
cylindrical ones. In the present work, three-dimensional simulation of
ECAP process was carried out for six outer corner radii (sharp to 10
mm in steps of 2 mm), with channel angle 105¶Çü▒, for strain hardening
aluminium alloy (AA 6101) using ABAQUS/Standard software.
Strain inhomogeneity is presented and discussed for all cases. Pattern
of strain variation along selected radial lines in the body of the workpiece
is presented. It is found from the results that the outer corner
has a significant influence on the strain distribution in the body of
work-piece. Based on inhomogeneity and average strain criteria,
there is an optimum outer corner radius.
Abstract: This work presents the experimental results obtained
at a pilot plant which works with a slow, wet and catalytic pyrolysis
process of dry fowl manure. This kind of process mainly consists in
the cracking of the organic matrix and in the following reaction of
carbon with water, which is either already contained in the organic
feed or added, to produce carbon monoxide and hydrogen. Reactions
are conducted in a rotating reactor maintained at a temperature of
500°C; the required amount of water is about 30% of the dry organic
feed. This operation yields a gas containing about 59% (on a volume
basis) of hydrogen, 17% of carbon monoxide and other products such
as light hydrocarbons (methane, ethane, propane) and carbon
monoxide in lesser amounts. The gas coming from the reactor can be
used to produce not only electricity, through internal combustion
engines, but also heat, through direct combustion in industrial
boilers. Furthermore, as the produced gas is devoid of both solid
particles and pollutant species (such as dioxins and furans), the
process (in this case applied to fowl manure) can be considered as an
optimal way for the disposal and the contemporary energetic
valorization of organic materials, in such a way that is not damaging
to the environment.
Abstract: In metal cutting industries, mathematical/statistical
models are typically used to predict tool replacement time. These
off-line methods usually result in less than optimum replacement
time thereby either wasting resources or causing quality problems.
The few online real-time methods proposed use indirect measurement
techniques and are prone to similar errors. Our idea is based on
identifying the optimal replacement time using an electronic nose to
detect the airborne compounds released when the tool wear reaches
to a chemical substrate doped into tool material during the
fabrication. The study investigates the feasibility of the idea, possible
doping materials and methods along with data stream mining
techniques for detection and monitoring different phases of tool
wear.
Abstract: This paper presents a novel genetic algorithm, termed
the Optimum Individual Monogenetic Algorithm (OIMGA) and
describes its hardware implementation. As the monogenetic strategy
retains only the optimum individual, the memory requirement is
dramatically reduced and no crossover circuitry is needed, thereby
ensuring the requisite silicon area is kept to a minimum.
Consequently, depending on application requirements, OIMGA
allows the investigation of solutions that warrant either larger GA
populations or individuals of greater length. The results given in this
paper demonstrate that both the performance of OIMGA and its
convergence time are superior to those of existing hardware GA
implementations. Local convergence is achieved in OIMGA by
retaining elite individuals, while population diversity is ensured by
continually searching for the best individuals in fresh regions of the
search space.
Abstract: Despite the strong and consistent increase in the use of
electronic payment methods worldwide, the diffusion of electronic
wallets is still far from widespread. Analysis of the failure of
electronic wallet uptake has either focused on technical issues or
chosen to analyse a specific scheme. This article proposes a joint
approach to analysing key factors affecting the adoption of e-wallets
by using the ‘Technology Acceptance Model” [1] which we have
expanded to take into account the cost of using e-wallets. We use this
model to analyse Monéo, the only French electronic wallet still in
operation.
Abstract: In this paper real money demand function is analyzed
within multivariate time-series framework. Cointegration approach is
used (Johansen procedure) assuming interdependence between
money demand determinants, which are nonstationary variables. This
will help us to understand the behavior of money demand in Croatia,
revealing the significant influence between endogenous variables in
vector autoregrression system (VAR), i.e. vector error correction
model (VECM). Exogeneity of the explanatory variables is tested.
Long-run money demand function is estimated indicating slow speed
of adjustment of removing the disequilibrium. Empirical results
provide the evidence that real industrial production and exchange
rate explains the most variations of money demand in the long-run,
while interest rate is significant only in short-run.
Abstract: Radiofrequency (RF) lesioning of nerves have been commonly used to alleviate chronic pain, where RF current preventing transmission of pain signals through the nerve by heating the nerve causing the pain. There are some factors that affect the temperature distribution and the nerve lesion size, one of these factors is the inhomogeneities in the tissue medium. Our objective is to calculate the temperature distribution and the nerve lesion size in an inhomogeneous medium surrounding the RF electrode. A two 3-D finite element models are used to compare the temperature distribution in the homogeneous and inhomogeneous medium. Also the effect of temperature-dependent electric conductivity on maximum temperature and lesion size is observed. Results show that the presence of an inhomogeneous medium around the RF electrode has a valuable effect on the temperature distribution and lesion size. The dependency of electric conductivity on tissue temperature increased lesion size.
Abstract: The proof of concept experiments were conducted to
determine the feasibility of using small amounts of Dissolved
Sulphur (DS) from the gaseous phase to precipitate platinum ions in
chloride media. Two sets of precipitation experiments were
performed in which the source of sulphur atoms was either a
thiosulphate solution (Na2S2O3) or a sulphur dioxide gas (SO2). In
liquid-liquid (L-L) system, complete precipitation of Pt was achieved
at small dosages of Na2S2O3 (0.01 – 1.0 M) in a time interval of 3-5
minutes. On the basis of this result, gas absorption tests were carried
out mainly to achieve sulphur solubility equivalent to 0.018 M. The
idea that huge amounts of precious metals could be recovered
selectively from their dilute solutions by utilizing the waste SO2
streams at low pressure seemed attractive from the economic and
environmental point of views. Therefore, mass transfer characteristics
of SO2 gas associated with reactive absorption across the gas-liquid
(G-L) interface were evaluated under different conditions of pressure
(0.5 – 2 bar), solution temperature ranges from 20 – 50 oC and acid
strength (1 – 4 M, HCl). This paper concludes with information about
selective precipitation of Pt in the presence of cations (Fe2+, Co2+,
and Cr3+) in a CSTR and recommendation to scale up laboratory data
to industrial pilot scale operations.
Abstract: Accurate timing alignment and stability is important
to maximize the true counts and minimize the random counts in
positron emission tomography So signals output from detectors must
be centering with the two isotopes to pre-operation and fed signals
into four units of pulse-processing units, each unit can accept up to
eight inputs. The dual source computed tomography consist two units
on the left for 15 detector signals of Cs-137 isotope and two units on
the right are for 15 detectors signals of Co-60 isotope. The gamma
spectrum consisting of either single or multiple photo peaks. This
allows for the use of energy discrimination electronic hardware
associated with the data acquisition system to acquire photon counts
data with a specific energy, even if poor energy resolution detectors
are used. This also helps to avoid counting of the Compton scatter
counts especially if a single discrete gamma photo peak is emitted by
the source as in the case of Cs-137. In this study the polyenergetic
version of the alternating minimization algorithm is applied to the
dual energy gamma computed tomography problem.
Abstract: There exists an injective, information-preserving function
that maps a semantic network (i.e a directed labeled network)
to a directed network (i.e. a directed unlabeled network). The edge
label in the semantic network is represented as a topological feature
of the directed network. Also, there exists an injective function that
maps a directed network to an undirected network (i.e. an undirected
unlabeled network). The edge directionality in the directed network
is represented as a topological feature of the undirected network.
Through function composition, there exists an injective function that
maps a semantic network to an undirected network. Thus, aside from
space constraints, the semantic network construct does not have any
modeling functionality that is not possible with either a directed
or undirected network representation. Two proofs of this idea will
be presented. The first is a proof of the aforementioned function
composition concept. The second is a simpler proof involving an
undirected binary encoding of a semantic network.
Abstract: During the last decade ultrafine grained (UFG) and nano-structured (NS) materials have experienced a rapid development. In this research work finite element analysis has been carried out to investigate the plastic strain distribution in equal channel angular process (ECAP). The magnitudes of Standard deviation (S. D.) and inhomogeneity index (Ci) were compared for different ECAP passes. Verification of a three-dimensional finite element model was performed with experimental tests. Finally the mechanical property including impact energy of ultrafine grained pure commercially pure Aluminum produced by severe plastic deformation method has been examined. For this aim, equal channel angular pressing die with the channel angle, outer corner angle and channel diameter of 90°, 20° and 20mm had been designed and manufactured. Commercial pure Aluminum billets were ECAPed up to four passes by route BC at the ambient temperature. The results indicated that there is a great improvement at the hardness measurement, yield strength and ultimate tensile strength after ECAP process. It is found that the magnitudes of HV reach 67HV from 21HV after the final stage of process. Also, about 330% and 285% enhancement at the YS and UTS values have been obtained after the fourth pass as compared to the as-received conditions, respectively. On the other hand, the elongation to failure and impact energy have been reduced by 23% and 50% after imposing four passes of ECAP process, respectively.
Abstract: The aim of this investigation is to study the
performance of the new generation of the PVD coated grade and to
map the influence of cutting conditions on the tool life in milling of
ADI (Austempered Ductile Iron). The results show that chipping is
the main wear mechanism which determines the tool life in dry
condition and notch wear in wet condition for this application. This
due to the different stress mechanisms and preexisting cracks in the
coating. The wear development shows clearly that the new PVD
coating (C20) has the best ability to delay the chipping growth. It
was also found that a high content of Al in the new coating (C20)
was especially favorable compared to a TiAlN multilayer with lower
Al content (C30) or CVD coating. This is due to fine grains and low
compressive stress level in the coating which increase the coating
ability to withstand the mechanical and thermal impact. It was also
found that the use of coolant decreases the tool life with 70-80%
compare to dry milling.
Abstract: Glazing is a process used to reduce undesirable drying or dehydration of fish during frozen or cold storage. To evaluate the effect of the time/ temperature binomial of the cryogenic frozen tunnel in the amount of glazing watera Central Composite Rotatable Design was used, with application of the Response Surface Methodology. The results reveal that the time/ temperature obtained for pink cusk-eel in experimental conditions for glazing water are similar to the industrial process, but for red fish and merluza the industrial process needs some adjustments. Control charts were established and implementedto control the amount of glazing water on sardine and merluza. They show that the freezing process was statistically controlled but there were some tendencies that must be analyzed, since the trend of sample mean values approached either of the limits, mainly in merluza. Thus, appropriate actions must be taken, in order to improve the process.
Abstract: One of the common problems encountered in software
engineering is addressing and responding to the changing nature of
requirements. While several approaches have been devised to address
this issue, ranging from instilling resistance to changing requirements
in order to mitigate impact to project schedules, to developing an
agile mindset towards requirements, the approach discussed in this
paper is one of conceptualizing the delta in requirement and
modeling it, in order to plan a response to it. To provide some
context here, change is first formally identified and categorized as
either formal change or informal change. While agile methodology
facilitates informal change, the approach discussed in this paper
seeks to develop the idea of facilitating formal change. To collect,
document meta-requirements that represent the phenomena of change
would be a pro-active measure towards building a realistic cognition
of the requirements entity that can further be harnessed in the
software engineering process.
Abstract: Government spending is categorized into consumption spending and capital spending. Three categories of private consumption are used: food consumption, nonfood consumption, and services consumption. The estimated model indicates substitution effects of government consumption spending on budget shares of private nonfood consumption and of government capital spending on budget share of private food consumption. However, the results do not indicate whether the negative effects of changes in the budget shares of the nonfood and the food consumption equates to reduce total private consumption. The concept of aggregate demand comprising consumption, investment, government spending (consumption spending and capital spending), export, and import are used to estimate their relationship by using the Vector Error Correction Mechanism. The study found no effect of government capital spending on either the private consumption or the growth of GDP while the government consumption spending has negative effect on the growth of GDP.