Abstract: Single nucleotide polymorphisms (SNPs) hold much promise as a basis for disease-gene association. However, research is limited by the cost of genotyping the tremendous number of SNPs. Therefore, it is important to identify a small subset of informative SNPs, the so-called tag SNPs. This subset consists of selected SNPs of the genotypes, and accurately represents the rest of the SNPs. Furthermore, an effective evaluation method is needed to evaluate prediction accuracy of a set of tag SNPs. In this paper, a genetic algorithm (GA) is applied to tag SNP problems, and the K-nearest neighbor (K-NN) serves as a prediction method of tag SNP selection. The experimental data used was taken from the HapMap project; it consists of genotype data rather than haplotype data. The proposed method consistently identified tag SNPs with considerably better prediction accuracy than methods from the literature. At the same time, the number of tag SNPs identified was smaller than the number of tag SNPs in the other methods. The run time of the proposed method was much shorter than the run time of the SVM/STSA method when the same accuracy was reached.
Abstract: Supplementation of palm vitamin E has been reported
to prevent loss of bone density in ovariectomised female rats. The
mechanism by which palm vitamin E exerts these effects is still
unknown. We hypothesized that palm vitamin E may act by
preventing the protein expression changes. Two dimensional poly
acyrilamide gel electrophoresis (2-D PAGE) and PD Quest software
genomic solutions Investigator (proteomics) was used to analyze the
differential protein expression profile in femoral and humeri bones
harvested from three groups of rats; sham-operated rats (SO),
ovariectomised rats (Ovx) and ovariectomised rats supplemented for
2 months with palm vitamin E. The results showed that there were
over 300 valued spot on each of the groups PVE and OVX as
compared to about 200 in SO. Comparison between the differential
protein expression between OVX and PVE groups showed that ten
spots were down –regulated in OVX but up-regulated in PVE. The
ten differential spots were separately named P1-P10. The
identification and understanding of the pathway of the differential
protein expression among the groups is ongoing and may account for
the molecular mechanism through which palm vitamin E exert its
anti-osteoporotic effect.
Abstract: Traffic enforcement units (the Police) are partly
responsible for the severity and frequency of the traffic accidents via
the effectiveness of their safety measures. The Police claims that the
reductions in accidents and their severities occur largely by their
timely interventions at the black spots, through traffic management
or temporary changes in the road design (guiding, reducing speeds
and eliminating sight obstructions, etc.). Yet, some other external
factors than the Police measures may intervene into which such
claims require a statistical confirmation. In order to test the net
impact of the Police contribution in the reduction of the number of
crashes, Chi square test was applied for 25 spots (streets and
intersections) and an average evaluation was achieved for general
conclusion in the case study of Izmir city. Separately, the net impact
of economic crisis in the reduction of crashes is assessed by the
trend analysis for the case of the economic crisis with the probable
reduction effects on the trip generation or modal choice. Finally, it
was proven that the Police measures were effective to some degree as
they claimed, though the economic crisis might have only negligible
contribution to the reductions in the same period observed.
Abstract: Serial Analysis of Gene Expression is a powerful
quantification technique for generating cell or tissue gene expression
data. The profile of the gene expression of cell or tissue in several
different states is difficult for biologists to analyze because of the large
number of genes typically involved. However, feature selection in
machine learning can successfully reduce this problem. The method
allows reducing the features (genes) in specific SAGE data, and
determines only relevant genes. In this study, we used a genetic
algorithm to implement feature selection, and evaluate the
classification accuracy of the selected features with the K-nearest
neighbor method. In order to validate the proposed method, we used
two SAGE data sets for testing. The results of this study conclusively
prove that the number of features of the original SAGE data set can be
significantly reduced and higher classification accuracy can be
achieved.
Abstract: Twenty seven tektites from the Wenchang area, Hainan
province (south China) and five tektites from the Khon Kaen area
(northeast Thailand) were analyzed for major and trace element
contents and Rb-Sr isotopic compositions. All the samples studied are
splash-form tektites. Tektites of this study are characterized by high
SiO2 contents ranging from 71.95 to 74.07 wt% which is consistent
with previously published analyses of Australasian tektites. The trace
element ratios Ba/Rb (avg. 3.89), Th/Sm (avg. 2.40), Sm/Sc (avg.
0.45), Th/Sc (avg. 0.99) and the rare earth elements (REE) contents of
tektites of this study are similar to the average upper continental crust.
Based on the chemical composition, it is suggested that tektites in this
study are derived from similar parental material and are similar to the
post-Archean upper crustal rocks. The major and trace element
abundances of tektites analyzed indicate that the parental material of
tektites may be a terrestrial sedimentary deposit. The tektites from the
Wenchang area, Hainan Island have high positive εSr(0)
values-ranging from 184.5~196.5 which indicate that the parental
material for these tektites have similar Sr isotopic compositions to old
terrestrial sedimentary rocks and they were not dominantly derived
from recent young sediments (such as soil or loess). Based on Rb-Sr
isotopic data, it has been suggested by Blum (1992) [1]that the
depositional age of sedimentary target materials is close to 170Ma
(Jurassic). According to the model suggested by Ho and Chen
(1996)[2], mixing calculations for various amounts and combinations
of target rocks have been carried out. We consider that the best fit for
tektites from the Wenchang area is a mixture of 47% shale, 23%
sandstone, 25% greywacke and 5% quartzite, and the other tektites
from Khon Kaen area is a mixture of 46% shale, 2% sandstone, 20%
greywacke and 32% quartzite.
Abstract: This paper proposes a new design of spatial FIR
filter to automatically detect water level from a video signal of
various river surroundings. A new approach in this report applies
"addition" of frames and a "horizontal" edge detector to distinguish
water region and land region. Variance of each line of a filtered
video frame is used as a feature value. The water level is recognized
as a boundary line between the land region and the water region.
Edge detection filter essentially demarcates between two distinctly
different regions. However, the conventional filters are not
automatically adaptive to detect water level in various lighting
conditions of river scenery. An optimized filter is purposed so that
the system becomes robust to changes of lighting condition. More
reliability of the proposed system with the optimized filter is
confirmed by accuracy of water level detection.
Abstract: Among all mechanical joining processes, welding has
been employed for its advantage in design flexibility, cost saving,
reduced overall weight and enhanced structural performance.
However, for structures made of relatively thin components, welding
can introduce significant buckling distortion which causes loss of
dimensional control, structural integrity and increased fabrication
costs. Different parameters can affect buckling behavior of welded
thin structures such as, heat input, welding sequence, dimension of
structure. In this work, a 3-D thermo elastic-viscoplastic finite
element analysis technique is applied to evaluate the effect of shell
dimensions on buckling behavior and entropy generation of welded
thin shells. Also, in the present work, the approximated longitudinal
transient stresses which produced in each time step, is applied to the
3D-eigenvalue analysis to ratify predicted buckling time and
corresponding eigenmode. Besides, the possibility of buckling
prediction by entropy generation at each time is investigated and it is
found that one can predict time of buckling with drawing entropy
generation versus out of plane deformation. The results of finite
element analysis show that the length, span and thickness of welded
thin shells affect the number of local buckling, mode shape of global
buckling and post-buckling behavior of welded thin shells.
Abstract: Acute disseminated encephalomyelitis (ADEM) has
been reported to develop after a hymenoptera sting, but its
pathogenesis is not known in detail. Myelin basic protein (MBP)-
specific T cells have been detected in the blood of patients with
ADEM, and a proportion of these patients develop multiple sclerosis
(MS). In an attempt to understand the mechanisms underlying
ADEM, molecular mimicry between hymenoptera venom peptides
and the human immunodominant MBP peptide was scrutinized,
based on the sequence and structural similarities, whether it was the
root of the disease. The results suggest that the three wasp venom
peptides have low sequence homology with the human
immunodominant MBP residues 85-99. Structural similarity analysis
among the three venom peptides and the MS-related HLA-DR2b
(DRA, DRB1*1501)-associated immunodominant MHC
binding/TCR contact residues 88-93, VVHFFK showed that
hyaluronidase residues 7-12, phospholipase A1 residues 98-103, and
antigen 5 residues 109-114 showed a high degree of similarity
83.3%, 100%, and 83.3% respectively. In conclusion, some wasp
venom peptides, particularly phospholipase A1, may potentially act
as the molecular motifs of the human 3HLA-DR2b-associated
immunodominant MBP88-93, and possibly present a mechanism for
induction of wasp sting-associated ADEM.
Abstract: A considerable progress has been achieved in transient
stability analysis (TSA) with various FACTS controllers. But, all
these controllers are associated with single transmission line. This
paper is intended to discuss a new approach i.e. a multi-line FACTS
controller which is interline power flow controller (IPFC) for TSA of
a multi-machine power system network. A mathematical model of
IPFC, termed as power injection model (PIM) presented and this
model is incorporated in Newton-Raphson (NR) power flow
algorithm. Then, the reduced admittance matrix of a multi-machine
power system network for a three phase fault without and with IPFC
is obtained which is required to draw the machine swing curves. A
general approach based on L-index has also been discussed to find
the best location of IPFC to reduce the proximity to instability of a
power system. Numerical results are carried out on two test systems
namely, 6-bus and 11-bus systems. A program in MATLAB has
been written to plot the variation of generator rotor angle and speed
difference curves without and with IPFC for TSA and also a simple
approach has been presented to evaluate critical clearing time for test
systems. The results obtained without and with IPFC are compared
and discussed.
Abstract: In this paper, we present an algorithm for computing a
Schur factorization of a real nonsymmetric matrix with ordered diagonal
blocks such that upper left blocks contains the largest magnitude
eigenvalues. Especially in case of multiple eigenvalues, when matrix
is non diagonalizable, we construct an invariant subspaces with few
additional tricks which are heuristic and numerical results shows the
stability and accuracy of the algorithm.
Abstract: Presented herein is an assessment of current nonlinear
static procedures (NSPs) for seismic evaluation of bucklingrestrained
braced frames (BRBFs) which have become a favorable
lateral-force resisting system for earthquake resistant buildings. The
bias and accuracy of modal, improved modal pushover analysis
(MPA, IMPA) and mass proportional pushover (MPP) procedures
are comparatively investigated when they are applied to BRBF
buildings subjected to two sets of strong ground motions. The
assessment is based on a comparison of seismic displacement
demands such as target roof displacements, peak floor/roof
displacements and inter-story drifts. The NSP estimates are compared
to 'exact' results from nonlinear response history analysis (NLRHA).
The response statistics presented show that the MPP
procedure tends to significantly overestimate seismic demands of
lower stories of tall buildings considered in this study while MPA
and IMPA procedures provide reasonably accurate results in
estimating maximum inter-story drift over all stories of studied BRBF
systems.
Abstract: India recognizes the personal laws of the various
religious communities that reside in the country. At the same time all
the institutions of the state in India are committed to the value of
secularism. This paper has been developed on the basis of a case
study that indicates the dynamics of religion in the working of the
lower judiciary in India. Majority of the commentary on religion and
the judiciary has focused on debates surrounding the existence and
application of personal laws. This paper, through a case study in the
lower judiciary, makes an attempt to examine whether the interface
between religion and the judiciary goes beyond personal laws.
The first part of this paper explains the history and application of
personal laws in social, political and legal contexts in India. The
second part examines the case study located in two courts of first
instance, following into the third part which provides an analysis of
the empirical evidence. The fourth part focuses on preliminary
observations about why there is a hesitancy to speak about religion in
relation to the working of the judicial system.
Abstract: In order to meet the limits imposed on automotive
emissions, engine control systems are required to constrain air/fuel
ratio (AFR) in a narrow band around the stoichiometric value, due to
the strong decay of catalyst efficiency in case of rich or lean mixture.
This paper presents a model of a sample spark ignition engine and
demonstrates Simulink-s capabilities to model an internal combustion
engine from the throttle to the crankshaft output. We used welldefined
physical principles supplemented, where appropriate, with
empirical relationships that describe the system-s dynamic behavior
without introducing unnecessary complexity. We also presents a PID
tuning method that uses an adaptive fuzzy system to model the
relationship between the controller gains and the target output
response, with the response specification set by desired percent
overshoot and settling time. The adaptive fuzzy based input-output
model is then used to tune on-line the PID gains for different
response specifications. Experimental results demonstrate that better
performance can be achieved with adaptive fuzzy tuning relative to
similar alternative control strategies. The actual response
specifications with adaptive fuzzy matched the desired response
specifications.
Abstract: Innovation is more important in any companies.
However, it is not easy to measure the innovation performance
correctly. Patent is one of measuring index nowadays. This paper
wants to purpose an approach for valuing patents based on market
reaction to patent infringement litigations. The interesting
phenomenon is found from collection of patent infringement litigation
events. That is if any patent litigation event occurs the stock value will
follow changing. The plaintiffs- stock value raises some percentage.
According to this interesting phenomenon, the relationship between
patent litigation and stock value is tested and verified. And then, the
stock value variation is used to deduce the infringed patents- value.
The purpose of this study is providing another concept model to
evaluate the infringed patents. This study can provide a decision assist
system to help drafting patent litigation strategy and determine the
technology value
Abstract: Although a picture can be automatically a graphic
work, but especially in the field of graphics and images based on the
idea of advertising and graphic design will be prepared and
photographers to realize the design using his own knowledge and
skills to help does. It is evident that knowledge of photography,
photographer and designer of the facilities, fields of reaching a
higher level of quality offers. At the same time do not have a graphic
designer is also skilled photographer, but can execute your idea may
delegate to an expert photographer. Using technology and methods in
all fields of photography, graphic art may be applicable. But most of
its application in Iran, in works such as packaging, posters, Bill
Board, advertising, brochures and catalogs are. In this study, we
review how the images and techniques in the chart should be used in
Iranian graphic photo what impact has left. Using photography
techniques and procedures can be designed and helped advance the
goals graphic. Technique could not determine the idea. But what is
important to think about design and photography and his creativity
can flourish as a tool to be effective graphic designer in mind.
Computer software to help it's very promotes creativity techniques
shall graphic designer but also it is as a tool. Using images in various
fields, especially graphic arts and only because it is not being
documented, but applications are beautiful. As to his photographic
style from today is graphics. Graphic works try to affect impacts on
their audience. Hence the photo as an important factor is attention.
The other hand saw the man with the extent of forgiving and
understanding people's image, instead of using the word to your files,
allows large messages and concepts should be sent in the shortest
time. Posters, advertisements, brochures, catalog and packaging
products very diverse agricultural, industrial and food could not be
self-image. Today, the use of graphic images for a big score and the
photos to richen the role graphic design plays a major.
Abstract: In this paper, we evaluate the choice of suitable
quantization characteristics for both the decoder messages and the
received samples in Low Density Parity Check (LDPC) coded
systems using M-QAM (Quadrature Amplitude Modulation)
schemes. The analysis involves the demapper block that provides
initial likelihood values for the decoder, by relating its quantization
strategy of the decoder. A mapping strategy refers to the grouping of
bits within a codeword, where each m-bit group is used to select a
2m-ary signal in accordance with the signal labels. Further we
evaluate the system with mapping strategies like Consecutive-Bit
(CB) and Bit-Reliability (BR). A new demapper version, based on
approximate expressions, is also presented to yield a low complexity
hardware implementation.
Abstract: The brain MR imaging-based clinical research and analysis system were specifically built and the development for a large-scale data was targeted. We used the general clinical data available for building large-scale data. Registration period for the selection of the lesion ROI and the region growing algorithm was used and the Mesh-warp algorithm for matching was implemented. The accuracy of the matching errors was modified individually. Also, the large ROI research data can accumulate by our developed compression method. In this way, the correctly decision criteria to the research result was suggested. The experimental groups were age, sex, MR type, patient ID and smoking which can easily be queries. The result data was visualized of the overlapped images by a color table. Its data was calculated by the statistical package. The evaluation for the utilization of this system in the chronic ischemic damage in the area has done from patients with the acute cerebral infarction. This is the cause of neurologic disability index location in the center portion of the lateral ventricle facing. The corona radiate was found in the position. Finally, the system reliability was measured both inter-user and intra-user registering correlation.
Abstract: The results show that the bridge equipped with seismic isolation bearing system shows a high amount of energy dissipation. The purpose of the present study is to analyze the overall performance of continuous curved highway viaducts with different bearing supports, with an emphasis on the effectiveness of seismic isolation based on lead rubber bearing and hedge reaction force bearing system consisted of friction sliding bearing and rubber bearing. The bridge seismic performance has been evaluated on six different cases with six bearing models. The effects of the different arrangement of bearing on the deck superstructure displacements, the seismic damage at the bottom of the piers, movement track at the pier-s top and the total and strain energies absorbed by the structure are evaluated. In conclusion, the results provide sufficient evidence of the effectiveness on the use of seismic isolation on steel curved highway bridges.
Abstract: Various intelligences and inspirations have been
adopted into the iterative searching process called as meta-heuristics.
They intelligently perform the exploration and exploitation in the
solution domain space aiming to efficiently seek near optimal
solutions. In this work, the bee algorithm, inspired by the natural
foraging behaviour of honey bees, was adapted to find the near
optimal solutions of the transportation management system, dynamic
multi-zone dispatching. This problem prepares for an uncertainty and
changing customers- demand. In striving to remain competitive,
transportation system should therefore be flexible in order to cope
with the changes of customers- demand in terms of in-bound and outbound
goods and technological innovations. To remain higher service
level but lower cost management via the minimal imbalance scenario,
the rearrangement penalty of the area, in each zone, including time
periods are also included. However, the performance of the algorithm
depends on the appropriate parameters- setting and need to be
determined and analysed before its implementation. BEE parameters
are determined through the linear constrained response surface
optimisation or LCRSOM and weighted centroid modified simplex
methods or WCMSM. Experimental results were analysed in terms
of best solutions found so far, mean and standard deviation on the
imbalance values including the convergence of the solutions
obtained. It was found that the results obtained from the LCRSOM
were better than those using the WCMSM. However, the average
execution time of experimental run using the LCRSOM was longer
than those using the WCMSM. Finally a recommendation of proper
level settings of BEE parameters for some selected problem sizes is
given as a guideline for future applications.
Abstract: Vertical Double Gate (DG) Metal Oxide Semiconductor Field Effect Transistor (MOSFET) is believed to suppress various short channel effect problems. The gate to channel coupling in vertical DG-MOSFET are doubled, thus resulting in higher current density. By having two gates, both gates are able to control the channel from both sides and possess better electrostatic control over the channel. In order to ensure that the transistor possess a superb turn-off characteristic, the subs-threshold swing (SS) must be kept at minimum value (60-90mV/dec). By utilizing SILVACO TCAD software, an n-channel vertical DG-MOSFET was successfully designed while keeping the sub-threshold swing (SS) value as minimum as possible. From the observation made, the value of sub-threshold swing (SS) was able to be varied by adjusting the height of the silicon pillar. The minimum value of sub-threshold swing (SS) was found to be 64.7mV/dec with threshold voltage (VTH) of 0.895V. The ideal height of the vertical DG-MOSFET pillar was found to be at 0.265 µm.