Abstract: Serial Analysis of Gene Expression is a powerful
quantification technique for generating cell or tissue gene expression
data. The profile of the gene expression of cell or tissue in several
different states is difficult for biologists to analyze because of the large
number of genes typically involved. However, feature selection in
machine learning can successfully reduce this problem. The method
allows reducing the features (genes) in specific SAGE data, and
determines only relevant genes. In this study, we used a genetic
algorithm to implement feature selection, and evaluate the
classification accuracy of the selected features with the K-nearest
neighbor method. In order to validate the proposed method, we used
two SAGE data sets for testing. The results of this study conclusively
prove that the number of features of the original SAGE data set can be
significantly reduced and higher classification accuracy can be
achieved.