Abstract: This is a conceptual paper on the application of open
innovation in three case examples of Apple, Nintendo, and Nokia.
Utilizing key concepts from research into managerial and
organizational cognition, we describe how each company overcame
barriers to utilizing open innovation strategy in R&D and
commercialization projects. We identify three levels of barriers:
cognitive, behavioral, and institutional, and describe the companies
balanced between internal and external resources to launch products
that were instrumental in companies reinventing themselves in
mature markets.
Abstract: A rare phenomenon of SDS-induced activation of a latent protease activity associated with the purified silkworm excretory red fluorescent protein (SE-RFP) was noticed. SE-RFP aliquots incubated with SDS for different time intervals indicated that the protein undergoes an obligatory breakdown into a number of subunits which exhibit autoproteolytic (acting upon themselves) and/or heteroproteolytic (acting on other proteins) activities. A strong serine protease activity of SE-RFP subunits on Bombyx mori nucleopolyhedrovirus (BmNPV) polyhedral protein was detected by zymography technique. A complete inhibition of BmNPV infection to silkworms was observed by the oral administration assay of the SE-RFP. Here, it is proposed that the SE-RFP prevents the initial infection of BmNPV to silkworms by obliterating the polyhedral protein. This is the first report on a silkworm red fluorescent protein that exhibits a protease activity on exposure to SDS. The present studies would help in understanding the antiviral mechanism of silkworm red fluorescent proteins.
Abstract: Tourism researchers have recently focused on repeat visitation as a part of destination loyalty. Different models have also considered satisfaction as the main determinant of revisit intention, while findings in many studies show it as a continuous issue. This conceptual paper attempts at evaluating recent empirical studies on satisfaction and revisit intention. Based on limitations and gaps in recent studies, the current paper suggests a new model that would be more comprehensive than those in previous studies. The new model offers new relationships between antecedents (destination image, perceived value, specific novelty seeking, and distance to destination) and both of satisfaction and revisit intention. Revisit intention in turn is suggested to be measured in a temporal approach.
Abstract: The Philosophy of Sufficiency Economy, bestowed
by His Majesty the King Bhumibol Adulyadej to the people of
Thailand, highlights a balanced way of living. Three principles of
moderation reasonableness, and immunity, along with the conditions
for morality and knowledge, can be applied to any level of the
society–from an individual to the nation. The Philosophy of
Sufficiency Economy helps address the current development
challenges, which are issues on institutions, environmental
sustainability, human well-being, and the role of the government.
Abstract: Functioning of a biometric system in large part
depends on the performance of the similarity measure function.
Frequently a generalized similarity distance measure function such as
Euclidian distance or Mahalanobis distance is applied to the task of
matching biometric feature vectors. However, often accuracy of a
biometric system can be greatly improved by designing a customized
matching algorithm optimized for a particular biometric application.
In this paper we propose a tailored similarity measure function for
behavioral biometric systems based on the expert knowledge of the
feature level data in the domain. We compare performance of a
proposed matching algorithm to that of other well known similarity
distance functions and demonstrate its superiority with respect to the
chosen domain.
Abstract: The possible therapeutic effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against acute hepatotoxicity induced by a single oral dose of acetaminophen (500mg/kg) in mice. Cannabidiol (two intraperitoneal injections, 5mg/kg, each) was given 1 hour and 12 hours following acetaminophen administration. Acetaminophen administration caused significant elevations of serum alanine aminotransferase, and hepatic malondialdehyde, and nitric oxide levels, and a significant decrease in hepatic reduced glutathione. Cannabidiol significantly attenuated the deterioration in the measured biochemical parameters resulted from acetaminophen administration. Also, histopathological examination showed that cannabidiol markedly attenuated ameliorated acetaminophen-induced liver tissue damage. These results emphasize that cannabidiol represents a potential therapeutic option to protect against acetaminophen hepartotoxicity which is a common clinical problem.
Abstract: Kwashiorkor is one of nutritional problem in
Indonesia, which lead to decrease immune system. This condition
causes susceptibility to infectious disease, especially tuberculosis.
Development of new tuberculosis vaccine will be an important
strategy to eliminate tuberculosis in kwashiorkor. Previous research
showed that 38-kDa Mycobacterium tuberculosis protein is one of the
potent immunogen. However, the role of oral immunization with 38-
kDa Mycobacterium tuberculosis protein to the number of
lymphocytes in the rat model of kwashiorkor is still unknown. We
used kwashiorkor rat model groups with 4% and 2% low protein diet.
Oral immunization with 38-kDa Mycobacterium tuberculosis protein
given with 2 booster every week. The lymphocytes number were
measured by flowcytometry. There was no significant difference
between the number of lymphocytes in the normal rat group and the
kwashiorkor rat groups. It may reveal the role of 38-kDa
Mycobacterium tuberculosis protein as a potent immunogen that can
increase the lymphocytes number from kwashiorkor rat model same
as normal rat.
Abstract: Since the presentation of the backpropagation algorithm, a vast variety of improvements of the technique for training a feed forward neural networks have been proposed. This article focuses on two classes of acceleration techniques, one is known as Local Adaptive Techniques that are based on weightspecific only, such as the temporal behavior of the partial derivative of the current weight. The other, known as Dynamic Adaptation Methods, which dynamically adapts the momentum factors, α, and learning rate, η, with respect to the iteration number or gradient. Some of most popular learning algorithms are described. These techniques have been implemented and tested on several problems and measured in terms of gradient and error function evaluation, and percentage of success. Numerical evidence shows that these techniques improve the convergence of the Backpropagation algorithm.
Abstract: The development incompatible with environment cannot be sustainable. Using renewable energy sources such as solar energy, geothermal energy and wind energy can make sustainable development in a region. Iran has a lot of renewable and nonrenewable energy resources. Since Iran has a special geographic position, it has lot of solar and wind energy resources. Both solar and wind energy are free, renewable and adaptable with environment. The study of 10 year wind data in Iranian South coastal and Islands synoptic stations shows that the production of wind power electricity and water pumping is possible in this region. In this research, we studied the local and temporal distribution of wind using three – hour statistics of windspeed in Iranian South coastal and Islands synoptic stations. This research shows that the production of wind power electricity is possible in this region all the year.
Abstract: The paper is included within the framework of a
complex research program, which was initiated from the hypothesis
arguing on the existence of a correlation between pineal indolic and
peptide hormones and the somatic development rhythm, including
thus the epithalamium-epiphysis complex involvement. At birds,
pineal gland contains a circadian oscillator, playing a main role in the
temporal organization of the cerebral functions. The secretion of
pineal indolic hormones is characterized by a high endogenous
rhythmic alternation, modulated by the light/darkness (L/D)
succession and by temperature as well. The research has been carried
out using 100 chicken broilers - “Ross" commercial hybrid,
randomly allocated in two experimental batches: Lc batch, reared
under a 12L/12D lighting schedule and Lexp batch, which was photic
pinealectomised through continuous exposition to light (150 lux, 24
hours, 56 days). Chemical and physical features of the meat issued
from breast fillet and thighs muscles have been studied, determining
the dry matter, proteins, fat, collagen, salt content and pH value, as
well. Besides the variations of meat chemical composition in relation
with lighting schedule, other parameters have been studied: live
weight dynamics, feed intake and somatic development degree. The
achieved results became significant since chickens have 7 days of
age, some variations of the studied parameters being registered,
revealing that the pineal gland physiologic activity, in relation with
the lighting schedule, could be interpreted through the monitoring of
the somatic development technological parameters, usually studied
within the chicken broilers rearing aviculture practice.
Abstract: Model mapping and transformation are important processes in high level system abstractions, and form the cornerstone of model-driven architecture (MDA) techniques. Considerable research in this field has devoted attention to static system abstraction, despite the fact that most systems are dynamic with high frequency changes in behavior. In this paper we provide an overview of work that has been done with regard to behavior model mapping and transformation, based on: (1) the completeness of the platform independent model (PIM); (2) semantics of behavioral models; (3) languages supporting behavior model transformation processes; and (4) an evaluation of model composition to effect the best approach to describing large systems with high complexity.
Abstract: Repeated observation of a given area over time yields
potential for many forms of change detection analysis. These
repeated observations are confounded in terms of radiometric
consistency due to changes in sensor calibration over time,
differences in illumination, observation angles and variation in
atmospheric effects.
This paper demonstrates applicability of an empirical relative
radiometric normalization method to a set of multitemporal cloudy
images acquired by Resourcesat1 LISS III sensor. Objective of this
study is to detect and remove cloud cover and normalize an image
radiometrically. Cloud detection is achieved by using Average
Brightness Threshold (ABT) algorithm. The detected cloud is
removed and replaced with data from another images of the same
area. After cloud removal, the proposed normalization method is
applied to reduce the radiometric influence caused by non surface
factors. This process identifies landscape elements whose reflectance
values are nearly constant over time, i.e. the subset of non-changing
pixels are identified using frequency based correlation technique. The
quality of radiometric normalization is statistically assessed by R2
value and mean square error (MSE) between each pair of analogous
band.
Abstract: Supplementation of palm vitamin E has been reported
to prevent loss of bone density in ovariectomised female rats. The
mechanism by which palm vitamin E exerts these effects is still
unknown. We hypothesized that palm vitamin E may act by
preventing the protein expression changes. Two dimensional poly
acyrilamide gel electrophoresis (2-D PAGE) and PD Quest software
genomic solutions Investigator (proteomics) was used to analyze the
differential protein expression profile in femoral and humeri bones
harvested from three groups of rats; sham-operated rats (SO),
ovariectomised rats (Ovx) and ovariectomised rats supplemented for
2 months with palm vitamin E. The results showed that there were
over 300 valued spot on each of the groups PVE and OVX as
compared to about 200 in SO. Comparison between the differential
protein expression between OVX and PVE groups showed that ten
spots were down –regulated in OVX but up-regulated in PVE. The
ten differential spots were separately named P1-P10. The
identification and understanding of the pathway of the differential
protein expression among the groups is ongoing and may account for
the molecular mechanism through which palm vitamin E exert its
anti-osteoporotic effect.
Abstract: The notion of communicative competence has been deemed fuzzy in communication studies. This fuzziness has led to tensions among engineers across tenures in interpreting what constitutes communicative competence. The study seeks to investigate novice and professional engineers- understanding of the said notion in terms of two main elements of communicative competence: linguistic and rhetorical competence. Novice engineers are final year engineering students, whilst professional engineers represent engineers who have at least 5 years working experience. Novice and professional engineers were interviewed to gauge their perceptions on linguistic and rhetorical features deemed necessary to enhance communicative competence for the profession. Both groups indicated awareness and differences on the importance of the sub-sets of communicative competence, namely, rhetorical explanatory competence, linguistic oral immediacy competence, technical competence and meta-cognitive competence. Such differences, a possible attribute of the learning theory, inadvertently indicate sublime differences in the way novice and professional engineers perceive communicative competence.
Abstract: This paper presents an adaptive differentiator
of sequential data based on the adaptive control theory. The
algorithm is applied to detect moving objects by estimating a
temporal gradient of sequential data at a specified pixel. We
adopt two nonlinear intensity functions to reduce the influence
of noises. The derivatives of the nonlinear intensity functions
are estimated by an adaptive observer with σ-modification
update law.
Abstract: The neurogenic potential of many herbal extracts used
in Indian medicine is hitherto unknown. Extracts derived from
Clitoria ternatea Linn have been used in Indian Ayurvedic system of
medicine as an ingredient of “Medhya rasayana", consumed for
improving memory and longevity in humans and also in treatment of
various neurological disorders. Our earlier experimental studies with
oral intubation of Clitoria ternatea aqueous root extract (CTR) had
shown significant enhancement of learning and memory in postnatal
and young adult Wistar rats. The present study was designed to
elucidate the in vitro effects of 200ng/ml of CTR on proliferation,
differentiation and growth of anterior subventricular zone neural
stem cells (aSVZ NSC-s) derived from prenatal and postnatal rat
pups. Results show significant increase in proliferation and growth of
neurospheres and increase in the yield of differentiated neurons of
aSVZ neural precursor cells (aSVZNPC-s) at 7 days in vitro when
treated with 200ng/ml of CTR as compared to age matched control.
Results indicate that CTR has growth promoting neurogenic effect on
aSVZ neural stem cells and their survival similar to neurotrophic
factors like Survivin, Neuregulin 1, FGF-2, BDNF possibly the basis
for enhanced learning and memory.
Abstract: Location selection is one of the most important
decision making process which requires to consider several criteria
based on the mission and the strategy. This study-s object is to
provide a decision support model in order to help the bank selecting
the most appropriate location for a bank-s branch considering a case
study in Turkey. The object of the bank is to select the most
appropriate city for opening a branch among six alternatives in the
South-Eastern of Turkey. The model in this study was consisted of
five main criteria which are Demographic, Socio-Economic, Sectoral
Employment, Banking and Trade Potential and twenty one subcriteria
which represent the bank-s mission and strategy. Because of
the multi-criteria structure of the problem and the fuzziness in the
comparisons of the criteria, fuzzy AHP is used and for the ranking of
the alternatives, TOPSIS method is used.
Abstract: Shadows add great amount of realism to a scene and
many algorithms exists to generate shadows. Recently, Shadow
volumes (SVs) have made great achievements to place a valuable
position in the gaming industries. Looking at this, we concentrate on
simple but valuable initial partial steps for further optimization in SV
generation, i.e.; model simplification and silhouette edge detection
and tracking. Shadow volumes (SVs) usually takes time in generating
boundary silhouettes of the object and if the object is complex then
the generation of edges become much harder and slower in process.
The challenge gets stiffer when real time shadow generation and
rendering is demanded. We investigated a way to use the real time
silhouette edge detection method, which takes the advantage of
spatial and temporal coherence, and exploit the level-of-details
(LOD) technique for reducing silhouette edges of the model to use
the simplified version of the model for shadow generation speeding
up the running time. These steps highly reduce the execution time of
shadow volume generations in real-time and are easily flexible to any
of the recently proposed SV techniques. Our main focus is to exploit
the LOD and silhouette edge detection technique, adopting them to
further enhance the shadow volume generations for real time
rendering.
Abstract: Effect of oral administration of “Gadagi" tea on liver
function was assessed on 50 healthy male albino rats which were
grouped and administered with different doses(mg/kg) i.e low dose
(380mg/kg, 415mg/kg, 365mg/kg, 315mg/kg for “sak", “sada" and
“magani" respectively), standard dose ( 760mg/kg, 830mg/kg,
730mg/kg for “sak-, “sada" and “magani" respectively) and high dose
(1500mg/kg, 1700mg/kg and 1460mg/kg for “sak--,"sada" and
“magani" groups respectively) for a period of four weeks. Animals
that were not administered with the tea constituted the control group.
At the end of fourth week, the animals were sacrificed and their
serum alanine aminotransferase (ALT), aspartate aminotransferase
(AST), alkaline phosphatase (ALP), total protein (TP), albumin
(ALB), and globulins (GLO) were determined. Mean serum ALT and
ALP activities were significantly higher (P
Abstract: During recent years, the traditional learning
approaches have undergone fundamental changes due to the
emergence of new technologies such as multimedia, hypermedia and
telecommunication. E-learning is a modern world phenomenon that
has come into existence in the information age and in a knowledgebased
society. E-learning has developed significantly within a short
period of time. Thus it is of a great significant to secure information,
allow a confident access and prevent unauthorized accesses. Making
use of individuals- physiologic or behavioral (biometric) properties is
a confident method to make the information secure. Among the
biometrics, fingerprint is more acceptable and most countries use it as
an efficient methods of identification. This article provides a new
method to compare the fingerprint comparison by pattern recognition
and image processing techniques. To verify fingerprint, the shortest
distance method is used together with perceptronic multilayer neural
network functioning based on minutiae. This method is highly
accurate in the extraction of minutiae and it accelerates comparisons
due to elimination of false minutiae and is more reliable compared
with methods that merely use directional images.