Abstract: Viral influenza A subtypes H5N1 and pandemic
H1N1 (pH1N1) have worldwide emerged and transmitted. The most
common anti-influenza drug for treatment of both seasonal and
pandemic influenza viruses is oseltamivir that nowadays becomes
resistance to influenza neuraminidase. The novel long-acting drug,
laninamivir, was discovered for treatment of the patients infected
with influenza B and influenza A viruses. In the present study,
laninamivir complexed with wild-type strain of both H5N1 and
pH1N1 viruses were comparatively determined the structures and
drug-target interactions by means of molecular dynamics (MD)
simulations. The results show that the hydrogen bonding interactions
formed between laninamivir and its binding residues are likely
similar for the two systems. Additionally, the presence of
intermolecular interactions from laninamivir to the residues in the
binding pocket is established through their side chains in accordance
with hydrogen bond interactions.
Abstract: We present a numerical study of the sensitivity of the so called time relaxation family of models of fluid motion with respect to the time relaxation parameter χ on the two dimensional cavity problem. The goal of the study is to compute and compare the sensitivity of the model using finite difference method (FFD) and sensitivity equation method (SEM).
Abstract: Reachability graph (RG) generation suffers from the
problem of exponential space and time complexity. To alleviate the
more critical problem of time complexity, this paper presents the new
approach for RG generation for the Petri net (PN) models of parallel
processes. Independent RGs for each parallel process in the PN
structure are generated in parallel and cross-product of these RGs
turns into the exhaustive state space from which the RG of given
parallel system is determined. The complexity analysis of the
presented algorithm illuminates significant decrease in the time
complexity cost of RG generation. The proposed technique is
applicable to parallel programs having multiple threads with the
synchronization problem.
Abstract: Fingerprint based identification system; one of a well
known biometric system in the area of pattern recognition and has
always been under study through its important role in forensic
science that could help government criminal justice community. In
this paper, we proposed an identification framework of individuals by
means of fingerprint. Different from the most conventional
fingerprint identification frameworks the extracted Geometrical
element features (GEFs) will go through a Discretization process.
The intention of Discretization in this study is to attain individual
unique features that could reflect the individual varianceness in order
to discriminate one person from another. Previously, Discretization
has been shown a particularly efficient identification on English
handwriting with accuracy of 99.9% and on discrimination of twins-
handwriting with accuracy of 98%. Due to its high discriminative
power, this method is adopted into this framework as an independent
based method to seek for the accuracy of fingerprint identification.
Finally the experimental result shows that the accuracy rate of
identification of the proposed system using Discretization is 100%
for FVC2000, 93% for FVC2002 and 89.7% for FVC2004 which is
much better than the conventional or the existing fingerprint
identification system (72% for FVC2000, 26% for FVC2002 and
32.8% for FVC2004). The result indicates that Discretization
approach manages to boost up the classification effectively, and
therefore prove to be suitable for other biometric features besides
handwriting and fingerprint.
Abstract: In order to enhance the aircraft survivability, the
infrared signatures emitted by hot engine parts should be determined
exactly. For its reduction it is necessary for the rear fuselage
temperature to be decreased. In this study, numerical modeling of flow
fields and heat transfer characteristics of an aircraft nozzle is
performed and its temperature distribution along each component wall
is predicted. The radiation shield is expected to reduce the skin
temperature of rear fuselage. The effect of material characteristic of
radiation shield on the heat transfer is also investigated. Through this
numerical analysis, design parameters related to the susceptibility of
aircraft are examined.
Abstract: This purpose of this paper is to present the acceptance single sampling plan when the fraction of nonconforming items is a fuzzy number and being modeled based on the fuzzy Poisson distribution. We have shown that the operating characteristic (oc) curves of the plan is like a band having a high and low bounds whose width depends on the ambiguity proportion parameter in the lot when that sample size and acceptance numbers is fixed. Finally we completed discuss opinion by a numerical example. And then we compared the oc bands of using of binomial with the oc bands of using of Poisson distribution.
Abstract: Website plays a significant role in success of an e-business. It is the main start point of any organization and corporation for its customers, so it's important to customize and design it according to the visitors' preferences. Also, websites are a place to introduce services of an organization and highlight new service to the visitors and audiences. In this paper, we will use web usage mining techniques, as a new field of research in data mining and knowledge discovery, in an Iranian government website. Using the results, a framework for web content layour is proposed. An agent is designed to dynamically update and improve web links locations and layout. Then, we will explain how it is used to directly enable top managers of the organization to influence on the arrangement of web contents and also to enhance customization of web site navigation due to online users' behaviors.
Abstract: When considering the development of constitutive
equations describing the behavior of materials under cyclic plastic
strains, different kinds of formulations can be adopted. The primary
intention of this study is to develop computer programming of
plasticity models to accurately predict the life of engineering
components. For this purpose, the energy or cyclic strain is computed
in multi-surface plasticity models in non-proportional loading and to
present their procedures and codes results.
Abstract: Temperature, humidity and precipitation in an area,
are parameters proved influential in the climate of that area, and one
should recognize them so that he can determine the climate of that
area. Climate changes are of primary importance in climatology, and
in recent years, have been of great concern to researchers and even
politicians and organizations, for they can play an important role in
social, political and economic activities. Even though the real cause
of climate changes or their stability is not yet fully recognized, they
are a matter of concern to researchers and their importance for
countries has prompted them to investigate climate changes in
different levels, especially in regional, national and continental level.
This issue has less been investigated in our country. However, in
recent years, there have been some researches and conferences on
climate changes. This study is also in line with such researches and
tries to investigate and analyze the trends of climate changes
(temperature and precipitation) in Sefid-roud (the name of a river)
basin. Three parameters of mean annual precipitation, temperature,
and maximum and minimum temperatures in 36 synoptic and
climatology stations in a statistical period of 49 years (1956-2005) in
the stations of Sefid-roud basin were analyzed by Mann-Kendall test.
The results obtained by data analysis show that climate changes are
short term and have a trend. The analysis of mean temperature
revealed that changes have a significantly rising trend, besides the
precipitation has a significantly falling trend.
Abstract: Deflocculation and gel characterization were
investigated for three different composition of porcelain slips at
specific gravity 1.8. The suspensions were dispersed with sodium
silicate (Na2SiO3) in under-deflocculated slips and fully deflocculated
slips. The rheology characterization of slips was conducted by the
deflocculation curves and the gel curves. The results showed that
decreasing the amount of the ball clay composition in the slips
consumed less dosages of the dispersants. The under-deflocculated
slips tended to have a gelation rate faster than the fully deflocculated
slips.
Abstract: The purpose of the present work was to study the
production and process parameters optimization for the synthesis of
cellulase from Trichoderma viride in solid state fermentation (SSF)
using an agricultural wheat straw as substrates; as fungal conversion
of lignocellulosic biomass for cellulase production is one among the
major increasing demand for various biotechnological applications.
An optimization of process parameters is a necessary step to get
higher yield of product. Several kinetic parameters like pretreatment,
extraction solvent, substrate concentration, initial moisture content,
pH, incubation temperature and inoculum size were optimized for
enhanced production of third most demanded industrially important
cellulase. The maximum cellulase enzyme activity 398.10±2.43
μM/mL/min was achieved when proximally analyzed lignocellulosic
substrate wheat straw inocubated at 2% HCl as pretreatment tool
along with distilled water as extraction solvent, 3% substrate
concentration 40% moisture content with optimum pH 5.5 at 45°C
incubation temperature and 10% inoculum size.
Abstract: With the popularity of the multi-core and many-core architectures there is a great requirement for software frameworks which can support parallel programming methodologies. In this paper we introduce an Eclipse toolkit, JConqurr which is easy to use and provides robust support for flexible parallel progrmaming. JConqurr is a multi-core and many-core programming toolkit for Java which is capable of providing support for common parallel programming patterns which include task, data, divide and conquer and pipeline parallelism. The toolkit uses an annotation and a directive mechanism to convert the sequential code into parallel code. In addition to that we have proposed a novel mechanism to achieve the parallelism using graphical processing units (GPU). Experiments with common parallelizable algorithms have shown that our toolkit can be easily and efficiently used to convert sequential code to parallel code and significant performance gains can be achieved.
Abstract: The objective of this paper is to investigate a new
approach based on the idea of pictograms for food portion size. This
approach adopts the model of the United States Pharmacopeia- Drug
Information (USP-DI). The representation of each food portion size
composed of three parts: frame, the connotation of dietary portion
sizes and layout. To investigate users- comprehension based on this
approach, two experiments were conducted, included 122 Taiwanese
people, 60 male and 62 female with ages between 16 and 64 (divided
into age groups of 16-30, 31-45 and 46-64). In Experiment 1, the mean
correcting rate of the understanding level of food items is 48.54%
(S.D.= 95.08) and the mean response time 2.89sec (S.D.=2.14). The
difference on the correct rates for different age groups is significant
(P*=0.00
Abstract: In this paper, free vibration analysis of carbon nanotube (CNT) reinforced laminated composite panels is presented. Three types of panels such as flat, concave and convex are considered for study. Numerical simulation is carried out using commercially available finite element analysis software ANSYS. Numerical homogenization is employed to calculate the effective elastic properties of randomly distributed carbon nanotube reinforced composites. To verify the accuracy of the finite element method, comparisons are made with existing results available in the literature for conventional laminated composite panels and good agreements are obtained. The results of the CNT reinforced composite materials are compared with conventional composite materials under different boundary conditions.
Abstract: The problem of lot sizing, sequencing and scheduling
multiple products in flow line production systems has been studied
by several authors. Almost all of the researches in this area assumed
that setup times and costs are sequence –independent even though
sequence dependent setups are common in practice. In this paper we
present a new mixed integer non linear program (MINLP) and a
heuristic method to solve the problem in sequence dependent case.
Furthermore, a genetic algorithm has been developed which applies
this constructive heuristic to generate initial population. These two
proposed solution methods are compared on randomly generated
problems. Computational results show a clear superiority of our
proposed GA for majority of the test problems.
Abstract: Harmonic pollution and low power factor in power
systems caused by power converters have been of great concern. To
overcome these problems several converter topologies using
advanced semiconductor devices and control schemes have been
proposed. This investigation is to identify a low cost, small size,
efficient and reliable ac to dc converter to meet the input performance
index of UPS. The performance of single phase and three phase ac to
dc converter along with various control techniques are studied and
compared. The half bridge converter topology with linear current
control is identified as most suitable. It is simple, energy efficient
because of single switch power loss and transformer-less operation of
UPS. The results are validated practically using a prototype built
using IGBT and analog controller. The performance for both single
and three-phase system is verified. Digital implementation of closed
loop control achieves higher reliability. Its cost largely depends on
chosen bit precision. The minimal bit precision for optimum
converter performance is identified as 16-bit with fixed-point
operation. From the investigation and practical implementation it is
concluded that half bridge ac – dc converter along with digital linear
controller meets the performance index of UPS for single and three
phase systems.
Abstract: Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV.
Abstract: Data warehouse is a dedicated database used for querying and reporting. Queries in this environment show special characteristics such as multidimensionality and aggregation. Exploiting the nature of queries, in this paper we propose a query driven design framework. The proposed framework is general and allows a designer to generate a schema based on a set of queries.
Abstract: Numerical parametric study is conducted to study the effects of ampoule rotation on the flows and the dopant segregation in vertical bridgman (vb) crystal growth. Calculations were performed in unsteady state. The extended darcy model, which includes the time derivative and coriolis terms, has been employed in the momentum equation. It’s found that the convection, and dopant segregation can be affected significantly by ampoule rotation, and the effect is similar to that by an axial magnetic field. Ampoule rotation decreases the intensity of convection and stretches the flow cell axially. When the convection is weak, the flow can be suppressed almost completely by moderate ampoule rotation and the dopant segregation becomes diffusion-controlled. For stronger convection, the elongated flow cell by ampoule rotation may bring dopant mixing into the bulk melt reducing axial segregation at the early stage of the growth. However, if the cellular flow cannot be suppressed completely, ampoule rotation may induce larger radial segregation due to poor mixing.
Abstract: One of the most important parameters to develop and
manage urban areas is appropriate selection of land surface to
develop green spaces in these areas. In this study, in order to identify
the most appropriate sites and areas cultivated for ornamental species
in Jiroft, Landsat Enhanced Thematic Mapper Plus (ETM+) images
due to extract the most important effective climatic and adaphic
parameters for growth ornamental species were used. After geometric
and atmospheric corrections applied, to enhance accuracy of multi
spectral (XS) bands, the fusion of Landsat XS bands by IRS-1D
panchromatic band (PAN) was performed. After field sampling to
evaluate the correlation between different factors in surface soil
sampling location and different bands digital number (DN) of ETM+
sensor on the same points, correlation tables formed using the best
computational model and the map of physical and chemical
parameters of soil was produced. Then the accuracy of them was
investigated by using kappa coefficient. Finally, according to
produced maps, the best areas for cultivation of recommended
species were introduced.