Abstract: Topical photodynamic therapy (PDT) with
5-aminolevulinic acid (ALA) is an alternative therapy for treating
superficial cancer, especially for skin or oral cancer. ALA, a precursor
of the photosensitizer protoporphyrin IX (PpIX), is present as
zwitterions and hydrophilic property which make the low permeability
through the cell membrane. Collagen is a traditional carrier; its
molecular composed various amino acids which bear positive charge
and negative charge. In order to utilize the ion-pairs with ALA and
collagen, the study employed various pH values adjusting the net
charge. The aim of this study was to compare a series collagen form,
including solution, gel and sponge to investigate the topical delivery
behavior of ALA. The in vivo confocal laser scanning microscopy
(CLSM) study demonstrated that PpIX generation ability was different
pattern after apply for 6 h. Gel type could generate high PpIX, and
archived more deep of skin depth.
Abstract: This article experimentally investigates the
thermal performance of thermoelectric air-cooling module
which comprises a thermoelectric cooler (TEC) and an
air-cooling heat sink. The influences of input current and heat
load are determined. And performances under each situation
are quantified by thermal resistance analysis. Since TEC
generates Joule heat, this nature makes construction of thermal
resistance network difficult. To simplify the analysis, this
article emphasizes on the resistance heat load might meet when
passing through the device. Therefore, the thermal resistances
in this paper are to divide temperature differences by heat load.
According to the result, there exists an optimum input current
under every heating power. In this case, the optimum input
current is around 6A or 7A. The performance of the heat sink
would be improved with TEC under certain heating power and
input current, especially at a low heat load. According to the
result, the device can even make the heat source cooler than the
ambient. However, TEC is not always effective at every heat
load and input current. In some situation, the device works
worse than the heat sink without TEC. To determine the
availability of TEC, this study figures out the effective
operating region in which the TEC air-cooling module works
better than the heat sink without TEC. The result shows that
TEC is more effective at a lower heat load. If heat load is too
high, heat sink with TEC will perform worse than without TEC.
The limit of this device is 57W. Besides, TEC is not helpful if
input current is too high or too low. There is an effective range
of input current, and the range becomes narrower when the heat
load grows.
Abstract: The purpose of this study was to study postpartum breastfeeding mothers to determine the impact their psychosocial and spiritual dimensions play in promoting full-term (6 month duration) breastfeeding of their infants. Purposive and snowball sampling methods were used to identify and recruit the study's participants. A total of 23 postpartum mothers, who were breastfeeding within 6 weeks after giving birth, participated in this study. In-depth interviews combined with observations, participant focus groups, and ethnographic records were used for data collection. The Data were then analyzed using content analysis and typology. The results of this study illustrated that postpartum mothers experienced fear and worry that they would lack support from their spouse, family and peers, and that their infant would not get enough milk It was found that the main barrier mothers faced in breastfeeding to full-term was the difficulty of continuing to breastfeed when returning to work. 81.82% of the primiparous mothers and 91.67% of the non-primiparous mothers were able to breastfeed for the desired full-term of 6 months. Factors found to be related to breastfeeding for six months included 1) belief and faith in breastfeeding, 2) support from spouse and family members, 3) counseling from public health nurses and friends. The sample also provided evidence that religious principles such as tolerance, effort, love, and compassion to their infant, and positive thinking, were used in solving their physical, mental and spiritual problems.
Abstract: purpose of this study was to investigate the current status of support services for students with special education needs (SEN) at colleges and universities in Taiwan. Seventy-two college and universities received a questionnaire on its resource room operation process and four resource room staffs each from different areas were interviewed through semi- structured interview forms. The main findings were (1) most colleges and universities did offer sufficient administrative resources; (2) more efforts on preventions for SEN students and establishment of disability awareness should be made for all campus faculties ; (3) more comprehensive services were required to help students to have better transition into post-school life; (4) most schools provided basic administrative resource requirements but qualities of the resource room programs needed to be enhanced; and (5) most resource room staffs lacked of professional knowledge in counseling the SEN students which needed to be strengthened in the future.
Abstract: Hydrothermally synthesized high silica borosilicates
with the MFI structure was subjected to several characterization
techniques. The effect of boron on the structure and acidity of
HZSM-5 catalyst were studied by XRD, SEM, N2 adsorption, solid
state NMR, NH3-TPD. It was confirmed that boron had entered the
framework in the boron samples. The results also revealed that strong
acidity was weakened and weak acidity was strengthened by the
boron added zeolite framework compared with parent catalyst. The
catalytic performance was carried out in a fixed bed at 460°C for
methanol to propylene (MTP) reaction. The results of MTP reaction
showed a great increment of the propylene selectivity and excellent
stability for the B-HZSM-5. The catalyst exhibited about 81%
selectivity to C2
= - C4
= olefins with 40% selectivity of propylene as
major component at near 100% methanol conversion, and the stable
performance in the studied period was 100h.
Abstract: Effective knowledge support relies on providing
operation-relevant knowledge to workers promptly and accurately. A
knowledge flow represents an individual-s or a group-s
knowledge-needs and referencing behavior of codified knowledge
during operation performance. The flow has been utilized to facilitate
organizational knowledge support by illustrating workers-
knowledge-needs systematically and precisely. However,
conventional knowledge-flow models cannot work well in cooperative
teams, which team members usually have diverse knowledge-needs in
terms of roles. The reason is that those models only provide one single
view to all participants and do not reflect individual knowledge-needs
in flows. Hence, we propose a role-based knowledge-flow view model
in this work. The model builds knowledge-flow views (or virtual
knowledge flows) by creating appropriate virtual knowledge nodes
and generalizing knowledge concepts to required concept levels. The
customized views could represent individual role-s knowledge-needs
in teamwork context. The novel model indicates knowledge-needs in
condensed representation from a roles perspective and enhances the
efficiency of cooperative knowledge support in organizations.
Abstract: The authors report a case of swine urolithiasis caused
by improper administration of sulfamonomethoxine and which was
diagnosed by examination of urinary sediments and analyzing the
composition of the uroliths. The chemical composition of urinary
calculi obtained from affected pigs with urolithiasis was further
confimed as sulfamonomethoxine by fourier transform infrared
(FTIR). It is suggested that appearance of typical fanlike or wheat
bunchy crystals in urinary sediments under observation of lightmicroscope
and determination by FTIR for the crystals are helpful in
diagnosing sulfa calculi causced swine urolithiasis.
Abstract: This paper studies the mean square exponential synchronization problem of a class of stochastic neutral type chaotic neural networks with mixed delay. On the Basis of Lyapunov stability theory, some sufficient conditions ensuring the mean square exponential synchronization of two identical chaotic neural networks are obtained by using stochastic analysis and inequality technique. These conditions are expressed in the form of linear matrix inequalities (LMIs), whose feasibility can be easily checked by using Matlab LMI Toolbox. The feedback controller used in this paper is more general than those used in previous literatures. One simulation example is presented to demonstrate the effectiveness of the derived results.
Abstract: Electrocardiogram (ECG) segmentation is necessary to help reduce the time consuming task of manually annotating ECG's. Several algorithms have been developed to segment the ECG automatically. We first review several of such methods, and then present a new single lead segmentation method based on Adaptive piecewise constant approximation (APCA) and Piecewise derivative dynamic time warping (PDDTW). The results are tested on the QT database. We compared our results to Laguna's two lead method. Our proposed approach has a comparable mean error, but yields a slightly higher standard deviation than Laguna's method.
Abstract: According to the statistics, the prevalence of congenital hearing loss in Taiwan is approximately six thousandths; furthermore, one thousandths of infants have severe hearing impairment. Hearing ability during infancy has significant impact in the development of children-s oral expressions, language maturity, cognitive performance, education ability and social behaviors in the future. Although most children born with hearing impairment have sensorineural hearing loss, almost every child more or less still retains some residual hearing. If provided with a hearing aid or cochlear implant (a bionic ear) timely in addition to hearing speech training, even severely hearing-impaired children can still learn to talk. On the other hand, those who failed to be diagnosed and thus unable to begin hearing and speech rehabilitations on a timely manner might lose an important opportunity to live a complete and healthy life. Eventually, the lack of hearing and speaking ability will affect the development of both mental and physical functions, intelligence, and social adaptability. Not only will this problem result in an irreparable regret to the hearing-impaired child for the life time, but also create a heavy burden for the family and society. Therefore, it is necessary to establish a set of computer-assisted predictive model that can accurately detect and help diagnose newborn hearing loss so that early interventions can be provided timely to eliminate waste of medical resources. This study uses information from the neonatal database of the case hospital as the subjects, adopting two different analysis methods of using support vector machine (SVM) for model predictions and using logistic regression to conduct factor screening prior to model predictions in SVM to examine the results. The results indicate that prediction accuracy is as high as 96.43% when the factors are screened and selected through logistic regression. Hence, the model constructed in this study will have real help in clinical diagnosis for the physicians and actually beneficial to the early interventions of newborn hearing impairment.
Abstract: The Influence Diagrams (IDs) is a kind of Probabilistic Belief Networks for graphic modeling. The usage of IDs can improve the communication among field experts, modelers, and decision makers, by showing the issue frame discussed from a high-level point of view. This paper enhances the Time-Sliced Influence Diagrams (TSIDs, or called Dynamic IDs) based formalism from a Discrete Event Systems Modeling and Simulation (DES M&S) perspective, for Exploring Analysis (EA) modeling. The enhancements enable a modeler to specify times occurred of endogenous events dynamically with stochastic sampling as model running and to describe the inter- influences among them with variable nodes in a dynamic situation that the existing TSIDs fails to capture. The new class of model is named Dynamic-Stochastic Influence Diagrams (DSIDs). The paper includes a description of the modeling formalism and the hiberarchy simulators implementing its simulation algorithm, and shows a case study to illustrate its enhancements.
Abstract: The Information and Communication Technologies
(ICTs), and the Wide World Web (WWW) have fundamentally
altered the practice of teaching and learning world wide. Many
universities, organizations, colleges and schools are trying to apply
the benefits of the emerging ICT. In the early nineties the term
learning object was introduced into the instructional technology
vernacular; the idea being that educational resources could be broken
into modular components for later combination by instructors,
learners, and eventually computes into larger structures that would
support learning [1]. However in many developing countries, the use
of ICT is still in its infancy stage and the concept of learning object
is quite new. This paper outlines the learning object design
considerations for developing countries depending on learning
environment.
Abstract: Exclusive breastfeeding is the feeding of a baby on no other milk apart from breast milk. Exclusive breastfeeding during the first 6 months of life is very important as it supports optimal growth and development during infancy and reduces the risk of obliterating diseases and problems. Moreover, it helps to reduce the incidence and/or severity of diarrhea, lower respiratory infection and urinary tract infection. In this paper, we make a survey of the factors that influence exclusive breastfeeding and use two dispersed statistical models to analyze data. The models are the Generalized Poisson regression model and the Com-Poisson regression models.
Abstract: In this study Vitaton (an organic supplement which
contains fermentative β-carotene) and synthetic astaxanthin
(CAROPHYLL® Pink) were evaluated as pro-growth factors in
Rainbow trout diet. An 8 week feeding trial was conducted to
determine the effects of Vitaton versus astaxanthin on rearing factors,
survival rate and visual flesh color of Rainbow trout
(Oncorhnchynchus mykiss) with initial weight of 196±5. Four
practical diets were formulated to contain 50 and 80 (ppm) of β-
carotene and astaxanthin and also a control diet was prepared without
any pigment. Each diet was fed to triplicate groups of fish rearing in
fresh water. Fish were fed twice daily. The water temperature
fluctuated from 12 to 15 (C˚) and also dissolved oxygen content was
between 7 to 7.5 (mg/lit) during the experimental period. At the end
of the experiment, growth and food utilization parameters and
survival rate were unaffected by dietary treatments (p>0.05). Also,
there was no significant difference between carcass yield within
treatments (p>0.05). No significant difference recognized between
visual flesh color (SalmoFan score) of fish fed Vitaton-containing
diets. On the contrary, feeding on diets containing 50 and 80 (ppm)
of astaxanthin, increased SalmoFan score (flesh astaxanthin
concentration) from
Abstract: The fuel cost of the motor vehicle operating on its
common route is an important part of the operating cost. Therefore,
the importance of the fuel saving is increasing day by day. One of the
parameters which improve fuel saving is the regulation of driving
characteristics. The number and duration of stop is increased by the
heavy traffic load. It is possible to improve the fuel saving with
regulation of traffic flow and driving characteristics. The researches
show that the regulation of the traffic flow decreases fuel
consumption, but it is not enough to improve fuel saving without the
regulation of driving characteristics. This study analyses the fuel
consumption of two trips of city bus operating on its common route
and determines the effect of traffic density and driving characteristics
on fuel consumption. Finally it offers some suggestions about
regulation of driving characteristics to improve the fuel saving. Fuel
saving is determined according to the results obtained from
simulation program. When experimental and simulation results are
compared, it has been found that the fuel saving was reached up the
to 40 percent ratios.
Abstract: Many single or multispan arch bridges are
strengthened with the addition of some kind of structural support
between adjacent arches of multispan or beside the arch barrel of a
single span to increase the strength of the overall structure. It was
traditionally formed by either placing loose rubble masonry blocks
between the arches and beside the arches or using mortar or concrete
to construct a more substantial structural bond between the spans. On
the other hand backing materials are present in some existing bridges.
Existing arch assessment procedures generally ignore the effects of
backing materials. In this paper an investigation of the effects of
backing on ratings for masonry arch bridges is carried out. It is
observed that increasing the overall lateral stability of the arch
system through the inclusion of structural backing results in an
enhanced failure load by reducing the likelihood of any tension
occurring at the top of the arch.
Abstract: The nature of adsorbed species on catalytic surface
over an industrial precipitated iron-based high temperature catalyst
during FTS was investigated by in-situ DRIFTS and chemical
trapping. The formulation of the mechanism of oxygenates formation
and key intermediates were also discussed. Numerous oxygenated
precursors and crucial intermediates were found by in-situ DRIFTS,
such as surface acetate, acetyl and methoxide. The results showed that
adsorbed molecules on surface such as methanol or acetaldehyde
could react with basic sites such as lattice oxygen or free surface
hydroxyls. Adsorbed molecules also had reactivity of oxidizing.
Moreover, acetyl as a key intermediate for oxygenates was observed
by investigation of CH3OH + CO and CH3I + CO + H2. Based on the
nature of surface properties, the mechanism of oxygenates formation
on precipitated iron-based high temperature catalyst was discussed.
Abstract: In this Letter, a class of impulsive switched cellular neural networks with time-varying delays is investigated. At the same time, parametric uncertainties assumed to be norm bounded are considered. By dividing the network state variables into subgroups according to the characters of the neural networks, some sufficient conditions guaranteeing exponential stability for all admissible parametric uncertainties are derived via constructing appropriate Lyapunov functional. One numerical example is provided to illustrate the validity of the main results obtained in this paper.
Abstract: Many companies have switched their processes to project-oriented in the last years. This brings new possibilities and effectiveness not only in the field of external processes connected with the product delivery but also the internal processes as well. However centralized project organization which is based on the role of project manager in the team has proved insufficient in some cases. Agile methods of project organization are trying to solve this problem by bringing new view on the project organization, roles, processes and competences. Scrum is one of these methods which builds on the principles of knowledge management to drive the project to effectiveness from all view angles. Using this method to organize internal and delivery projects helps the organization to create and share knowledge throughout the company. It also supports forming unique competences of individuals and project teams and drives innovations in the company.
Abstract: In this paper, an ultra low power and low jitter 12bit
CMOS digitally controlled oscillator (DCO) design is presented.
Based on a ring oscillator implemented with low power Schmitt
trigger based inverters. Simulation of the proposed DCO using 32nm
CMOS Predictive Transistor Model (PTM) achieves controllable
frequency range of 550MHz~830MHz with a wide linearity and high
resolution. Monte Carlo simulation demonstrates that the time-period
jitter due to random power supply fluctuation is under 31ps and the
power consumption is 0.5677mW at 750MHz with 1.2V power
supply and 0.53-ps resolution. The proposed DCO has a good
robustness to voltage and temperature variations and better linearity
comparing to the conventional design.