Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.
Abstract: The paper deals with determination of electromagnetic
and temperature field distribution of induction heating system used
for pipe brazing. The problem is considered as coupled – time
harmonic electromagnetic and transient thermal field. It has been
solved using finite element method. The detailed maps of
electromagnetic and thermal field distribution have been obtained.
The good understanding of the processes in the considered system
ensures possibilities for control, management and increasing the
efficiency of the welding process.
Abstract: The evaluation of unit cell neutronic parameters and
lifetime for some innovant reactors without on sit-refuling will be
held in this work. the behavior of some small and medium reactors
without on site refueling with triso and cermet fuel. For the FBNR
long life except we propose to change the enrichment of the Cermet
MFE to 9%. For the AFPR reactor we can see that the use of the
Cermet MFE can extend the life of this reactor but to maintain the
same life period for AFPR-SC we most use burnup poison to have the
same slope for Kinf (Burnup). PFPWR50 cell behaves almost in
same way using both fuels Cermet and TRISO. So we can conclude
that PFPWR50 reactor, with CERMET Fuel, is kept among the long
cycle reactors and with the new configuration we avoid subcriticality
at the beginning of cycle. The evaluation of unit cell neutronic
parameters reveals a good agreement with the goal of BWR-PB
concept. It is found out that the Triso fuel assembly lifetime can be
extended for a reasonably long period without being refueled,
approximately up to 48GWd/t burnup. Using coated particles fuels
with the Cermet composition can be more extended the fuel assembly
life time, approximately 52 GWd/t.
Abstract: The application of stability theory has led to detailed studies of different types of vessels; however, the shortage of information relating to multihull vessels demanded further investigation. This study shows that the position of the hulls has a very influential effect on both the transverse and longitudinal stability of the tricore. HSC stability code is applied for the optimisation of the hull configurations. Such optimization criteria would undoubtedly aid the performance of the vessel for both commercial or leisure purposes
Abstract: Over last two decades, due to hostilities of environment
over the internet the concerns about confidentiality of information
have increased at phenomenal rate. Therefore to safeguard the information
from attacks, number of data/information hiding methods have
evolved mostly in spatial and transformation domain.In spatial domain
data hiding techniques,the information is embedded directly on
the image plane itself. In transform domain data hiding techniques the
image is first changed from spatial domain to some other domain and
then the secret information is embedded so that the secret information
remains more secure from any attack. Information hiding algorithms
in time domain or spatial domain have high capacity and relatively
lower robustness. In contrast, the algorithms in transform domain,
such as DCT, DWT have certain robustness against some multimedia
processing.In this work the authors propose a novel steganographic
method for hiding information in the transform domain of the gray
scale image.The proposed approach works by converting the gray
level image in transform domain using discrete integer wavelet
technique through lifting scheme.This approach performs a 2-D
lifting wavelet decomposition through Haar lifted wavelet of the cover
image and computes the approximation coefficients matrix CA and
detail coefficients matrices CH, CV, and CD.Next step is to apply the
PMM technique in those coefficients to form the stego image. The
aim of this paper is to propose a high-capacity image steganography
technique that uses pixel mapping method in integer wavelet domain
with acceptable levels of imperceptibility and distortion in the cover
image and high level of overall security. This solution is independent
of the nature of the data to be hidden and produces a stego image
with minimum degradation.
Abstract: A 3.5-bit stage of the CMOS pipelined ADC is proposed. In this report, the main part of 3.5-bit stage ADC is introduced. How the MDAC, comparator and encoder worked and designed are shown in details. Besides, an OTA which is used in fully differential pipelined ADC was described. Using gain-boost architecture with differential amplifier, this OTA achieve high-gain and high-speed. This design was using CMOS 0.18um process and simulation in Cadence. The result of the simulation shows that the OTA has a gain up to 80dB, the unity gain bandwidth of about 1.138GHz with 2pF load.
Abstract: Human skull is shown to exhibit numerous sexually dimorphic traits. Estimation of sex is a challenging task especially when a part of skull is brought for medicolegal investigation. The present research was planned to evaluate the sexing potential of the dimensions of foramen magnum in forensic identification by craniometric analysis. Length and breadth of the foramen magnum was measured using Vernier calipers and the area of foramen magnum was calculated. The length, breadth, and area of foramen magnum were found to be larger in males than females. Sexual dimorphism index was calculated to estimate the sexing potential of each variable. The study observations are suggestive of the limited utility of the craniometric analysis of foramen magnum during the examination of skull and its parts in estimation of sex.
Abstract: It was determined that woody biomass and livestock excreta can be utilized as hydrogen resources and hydrogen produced from such sources can be used to fill fuel cell vehicles (FCVs) at hydrogen stations. It was shown that the biomass transport costs for hydrogen production may be reduced the costs for co-generation. In the Tokyo Metropolitan Area, there are only a few sites capable of producing hydrogen from woody biomass in amounts greater than 200 m3/h-the scale required for a hydrogen station to be operationally practical. However, in the case of livestock excreta, it was shown that 15% of the municipalities in this area are capable of securing sufficient biomass to be operationally practical for hydrogen production. The differences in feasibility of practical operation depend on the type of biomass.
Abstract: The paper reports on the results of experimental and
numerical study of nonstationary swirling flow in an isothermal
model of vortex burner. It has been identified that main source of the
instability is related to a precessing vortex core (PVC) phenomenon.
The PVC induced flow pulsation characteristics such as precession
frequency and its variation as a function of flowrate and swirl number
have been explored making use of acoustic probes. Additionally
pressure transducers were used to measure the pressure drops on the
working chamber and across the vortex flow. The experiments have
been included also the mean velocity measurements making use of a
laser-Doppler anemometry. The features of instantaneous flowfield
generated by the PVC were analyzed employing a commercial CFD
code (Star-CCM+) based on Detached Eddy Simulation (DES)
approach. Validity of the numerical code has been checked by
comparison calculated flowfield data with the obtained experimental
results. It has been confirmed particularly that the CFD code applied
correctly reproduces the flow features.
Abstract: Fractional Fourier Transform is a generalization of the
classical Fourier Transform. The Fractional Fourier span in general
depends on the amplitude and phase functions of the signal and varies
with the transform order. However, with the development of the
Fractional Fourier filter banks, it is advantageous in some cases to
have different transform orders for different filter banks to achieve
better decorrelation of the windowed and overlapped time signal. We
present an expression that is useful for finding the perturbation in the
Fractional Fourier span due to the erroneous transform order and the
possible variation in the window shape and length. The expression is
based on the dependency of the time-Fractional Fourier span
Uncertainty on the amplitude and phase function of the signal. We
also show with the help of the developed expression that the
perturbation of span has a varying degree of sensitivity for varying
degree of transform order and the window coefficients.
Abstract: Data mining uses a variety of techniques each of which
is useful for some particular task. It is important to have a deep
understanding of each technique and be able to perform sophisticated
analysis. In this article we describe a tool built to simulate a variation
of the Kohonen network to perform unsupervised clustering and
support the entire data mining process up to results visualization. A
graphical representation helps the user to find out a strategy to
optimize classification by adding, moving or delete a neuron in order
to change the number of classes. The tool is able to automatically
suggest a strategy to optimize the number of classes optimization, but
also support both tree classifications and semi-lattice organizations of
the classes to give to the users the possibility of passing from one
class to the ones with which it has some aspects in common.
Examples of using tree and semi-lattice classifications are given to
illustrate advantages and problems. The tool is applied to classify
macroeconomic data that report the most developed countries- import
and export. It is possible to classify the countries based on their
economic behaviour and use the tool to characterize the commercial
behaviour of a country in a selected class from the analysis of
positive and negative features that contribute to classes formation.
Possible interrelationships between the classes and their meaning are
also discussed.
Abstract: This research proposes an Interactive 3D Experience to
enhance customer value in the fantasy era. As products reach maturity,
they become more similar in the range of functions that they provide.
This leads to competition via reduced retail price and ultimately
reduced profitability. A competitive design method is therefore
needed that can produce higher value products. An Enhanced Value
Experience has been identified that can assist designers to provide
quality products and to give them a unique positioning. On the basis of
this value opportunity, the method of Interactive 3D Experience has
been formulated and applied to the domain of retail furniture. Through
this, customers can create their own personalized styling via the
interactive 3D platform.
Abstract: A direct search approach to determine optimal reservoir operating is proposed with ant colony optimization for continuous domains (ACOR). The model is applied to a system of single reservoir to determine the optimum releases during 42 years of monthly steps. A disadvantage of ant colony based methods and the ACOR in particular, refers to great amount of computer run time consumption. In this study a highly effective procedure for decreasing run time has been developed. The results are compared to those of a GA based model.
Abstract: Air quality in Setapak district of Kuala Lumpur was
studied by analysing the rainwater chemical composition using ion
chromatography method. Twelve sampling sites were selected and
120 rainwater samples were collected in the period of 10 weeks. The
results of this study were compared to the earlier published data and
the evaluation showed that the NO3
- ion concentration increased from
0.41 to 3.32 ppm, while SO4
2- ion concentration increased from 0.39
to 3.26 ppm over the past two decades that is mostly due to rapid
urban development of the city. However, it was found that the
chemical composition for both residential and industrial areas does
not have significant difference. Most of the rainwater samples
showed alkaline pH (pH > 5.6). The possible factors for such alkaline
pH in rainwater samples are assumed to be the marine sources,
biomass burning and alkaline character of soil particles.
Abstract: Corrosion of metallic water pipelines buried below
ground surface is a function of the nature of the surrounding soil and
groundwater. This gives the importance of knowing the physical and
chemical characteristics of the pipe-s surrounding environment. The
corrosion of externally – unprotected metallic water pipelines,
specially ductile iron pipes, in localities with aggressive soil
conditions is becoming a significant problem. Anticorrosive
protection for metallic water pipelines, their fittings and accessories
is very important, because they may be attached by corrosion with
time. The tendency of a metallic substrate to corrode is a function of
the surface characteristics of the metal and of the metal/protective
film interface, the physical, electrical and electrochemical properties
of the film, and the nature of the environment in which the pipelines
system is placed. In this work the authors have looked at corrosion
problems of water pipelines and their control. The corrosive
properties of groundwater and soil environments are reviewed, and
parameters affecting corrosion are discussed. The purpose of this
work is to provide guidelines for materials selection in water and soil
environments, and how the water pipelines can be protected against
metallic corrosion.
Abstract: A number of automated shot-change detection
methods for indexing a video sequence to facilitate browsing and
retrieval have been proposed in recent years. This paper emphasizes
on the simulation of video shot boundary detection using one of the
methods of the color histogram wherein scaling of the histogram
metrics is an added feature. The difference between the histograms of
two consecutive frames is evaluated resulting in the metrics. Further
scaling of the metrics is performed to avoid ambiguity and to enable
the choice of apt threshold for any type of videos which involves
minor error due to flashlight, camera motion, etc. Two sample videos
are used here with resolution of 352 X 240 pixels using color
histogram approach in the uncompressed media. An attempt is made
for the retrieval of color video. The simulation is performed for the
abrupt change in video which yields 90% recall and precision value.
Abstract: As the demand and prices of various petroleum products have been on the rise in recent years, there is a growing need for alternative fuels. Biodiesel, which consists of alkyl monoesters of fatty acids from vegetable oils and animal fats, is considered as an alternative to petroleum diesel. Biodiesel has comparable performance with that of diesel and has lower brake specific fuel consumption than diesel with significant reduction in emissions of CO, hydrocarbons (HC) and smoke with however, a slight increase in NOx emissions. This paper analyzes the effect of cooled exhaust gas recirculation in the combustion characteristics of a direct injection compression ignition engine using biodiesel blended fuel as opposed to the conventional system. The combustion parameters such as cylinder pressure, heat release rate, delay period and peak pressure were analyzed at various loads. The maximum cylinder pressure reduces as the fraction of biodiesel increases in the blend the maximum rate of pressure rise was found to be higher for diesel at higher engine loads.
Abstract: This paper presents a linear stability analysis of
natural convection in a horizontal layer of a viscoelastic
nanofluid. The Oldroyd B model was utilized to describe the
rheological behavior of a viscoelastic nanofluid. The model
used for the nanofluid incorporated the effects of Brownian
motion and thermophoresis. The onset criterion for stationary
and oscillatory convection was derived analytically. The effects
of the Deborah number, retardation parameters, concentration
Rayleigh number, Prandtl number, and Lewis number on the
stability of the system were investigated. Results indicated that
there was competition among the processes of thermophoresis,
Brownian diffusion, and viscoelasticity which caused
oscillatory rather than stationary convection to occur.
Oscillatory instability is possible with both bottom- and
top-heavy nanoparticle distributions. Regimes of stationary and
oscillatory convection for various parameters were derived and
are discussed in detail.
Abstract: Many systems in the natural world exhibit chaos or non-linear behavior, the complexity of which is so great that they appear to be random. Identification of chaos in experimental data is essential for characterizing the system and for analyzing the predictability of the data under analysis. The Lyapunov exponents provide a quantitative measure of the sensitivity to initial conditions and are the most useful dynamical diagnostic for chaotic systems. However, it is difficult to accurately estimate the Lyapunov exponents of chaotic signals which are corrupted by a random noise. In this work, a method for estimation of Lyapunov exponents from noisy time series using unscented transformation is proposed. The proposed methodology was validated using time series obtained from known chaotic maps. In this paper, the objective of the work, the proposed methodology and validation results are discussed in detail.
Abstract: The detection of outliers is very essential because of
their responsibility for producing huge interpretative problem in
linear as well as in nonlinear regression analysis. Much work has
been accomplished on the identification of outlier in linear
regression, but not in nonlinear regression. In this article we propose
several outlier detection techniques for nonlinear regression. The
main idea is to use the linear approximation of a nonlinear model and
consider the gradient as the design matrix. Subsequently, the
detection techniques are formulated. Six detection measures are
developed that combined with three estimation techniques such as the
Least-Squares, M and MM-estimators. The study shows that among
the six measures, only the studentized residual and Cook Distance
which combined with the MM estimator, consistently capable of
identifying the correct outliers.