Abstract: Type 2 diabetes mellitus (T2DM) is a complex
metabolic disorder that characterized by the presence of high glucose
in blood that cause from insulin resistance and insufficiency due to
deterioration β-cell Langerhans functions. T2DM is commonly
caused by the combination of inherited genetic variations as well as
our own lifestyle. Metallothionein (MT) is a known cysteine-rich
protein responsible in helping zinc homeostasis which is important in
insulin signaling and secretion as well as protection our body from
reactive oxygen species (ROS). MT scavenged ROS and free
radicals in our body happen to be one of the reasons of T2DM and its
complications. The objective of this study was to investigate the
association of MT1A and MT2A polymorphisms between T2DM and
control subjects among Malay populations. This study involved 150
T2DM and 120 Healthy individuals of Malay ethnic with mixed
genders. The genomic DNA was extracted from buccal cells and
amplified for MT1A and MT2A loci; the 347bp and 238bp banding
patterns were respectively produced by mean of the Polymerase
Chain Reaction (PCR). The PCR products were digested with Mlucl
and Tsp451 restriction enzymes respectively and producing
fragments lengths of (158/189/347bp) and (103/135/238bp)
respectively. The ANOVA test was conducted and it shown that there
was a significant difference between diabetic and control subjects for
age, BMI, WHR, SBP, FPG, HBA1C, LDL, TG, TC and family
history with (P0.05). The genotype
frequency for AA, AG and GG of MT1A polymorphisms was 72.7%,
22.7% and 4.7% in cases and 15%, 55% and 30% in control
respectively. As for MT2A, genotype frequency of GG, GC and CC
was 42.7%, 27.3% and 30% in case and 5%, 40% and 55% for
control respectively. Both polymorphisms show significant difference
between two investigated groups with (P=0.000). The Post hoc test
was conducted and shows a significant difference between the
genotypes within each polymorphism (P=0. 000). The MT1A and
MT2A polymorphisms were believed to be the reliable molecular
markers to distinguish the T2DM subjects from healthy individuals in
Malay populations.
Abstract: A new code synchronization algorithm is proposed in
this paper for the secondary cell-search stage in wideband CDMA
systems. Rather than using the Cyclically Permutable (CP) code in the
Secondary Synchronization Channel (S-SCH) to simultaneously
determine the frame boundary and scrambling code group, the new
synchronization algorithm implements the same function with less
system complexity and less Mean Acquisition Time (MAT). The
Secondary Synchronization Code (SSC) is redesigned by splitting into
two sub-sequences. We treat the information of scrambling code group
as data bits and use simple time diversity BCH coding for further
reliability. It avoids involved and time-costly Reed-Solomon (RS)
code computations and comparisons. Analysis and simulation results
show that the Synchronization Error Rate (SER) yielded by the new
algorithm in Rayleigh fading channels is close to that of the
conventional algorithm in the standard. This new synchronization
algorithm reduces system complexities, shortens the average
cell-search time and can be implemented in the slot-based cell-search
pipeline. By taking antenna diversity and pipelining correlation
processes, the new algorithm also shows its flexible application in
multiple antenna systems.
Abstract: The Internet has become an indispensable part of our lives. Witnessing recent web-based mass collaboration, e.g. Wikipedia, people are questioning whether the Internet has made fundamental changes to the society or whether it is merely a hyperbolic fad. It has long been assumed that collective action for a certain goal yields the problem of free-riding, due to its non-exclusive and non-rival characteristics. Then, thanks to recent technological advances, the on-line space experienced the following changes that enabled it to produce public goods: 1) decrease in the cost of production or coordination 2) externality from networked structure 3) production function which integrates both self-interest and altruism. However, this research doubts the homogeneity of on-line mass collaboration and argues that a more sophisticated and systematical approach is required. The alternative that we suggest is to connect the characteristics of the goal to the motivation. Despite various approaches, previous literature fails to recognize that motivation can be structurally restricted by the characteristic of the goal. First we draw a typology of on-line mass collaboration with 'the extent of expected beneficiary' and 'the existence of externality', and then we examine each combination of motivation using Benkler-s framework. Finally, we explore and connect such typology with its possible dominant participating motivation.
Abstract: In this research, a mathematical model for integrated evaluation of green design and green manufacturing processes is presented. To design a product, there can be alternative options to design the detailed components to fulfill the same product requirement. In the design alternative cases, the components of the product can be designed with different materials and detailed specifications. If several design alternative cases are proposed, the different materials and specifications can affect the manufacturing processes. In this paper, a new concept for integrating green design and green manufacturing processes is presented. A green design can be determined based the manufacturing processes of the designed product by evaluating the green criteria including energy usage and environmental impact, in addition to the traditional criteria of manufacturing cost. With this concept, a mathematical model is developed to find the green design and the associated green manufacturing processes. In the mathematical model, the cost items include material cost, manufacturing cost, and green related cost. The green related cost items include energy cost and environmental cost. The objective is to find the decisions of green design and green manufacturing processes to achieve the minimized total cost. In practical applications, the decision-making can be made to select a good green design case and its green manufacturing processes. In this presentation, an example product is illustrated. It shows that the model is practical and useful for integrated evaluation of green design and green manufacturing processes.
Abstract: Mycophenolic acid “MPA" is a secondary metabolite
of Penicillium bervicompactum with antibiotic and
immunosuppressive properties. In this study, fermentation process
was established for production of mycophenolic acid by Penicillium
bervicompactum MUCL 19011 in shake flask. The maximum MPA
production, product yield and productivity were 1.379 g/L, 18.6 mg/g
glucose and 4.9 mg/L.h respectively. Glucose consumption, biomass
and MPA production profiles were investigated during fermentation
time. It was found that MPA production starts approximately after
180 hours and reaches to a maximum at 280 h. In the next step, the
effects of methionine and acetate concentrations on MPA production
were evaluated. Maximum MPA production, product yield and
productivity (1.763 g/L, 23.8 mg/g glucose and 6.30 mg/L. h
respectively) were obtained with using 2.5 g/L methionine in culture
medium. Further addition of methionine had not more positive effect
on MPA production. Finally, results showed that the addition of
acetate to the culture medium had not any observable effect on MPA
production.
Abstract: Malware is software which was invented and meant for doing harms on computers. Malware is becoming a significant threat in computer network nowadays. Malware attack is not just only involving financial lost but it can also cause fatal errors which may cost lives in some cases. As new Internet Protocol version 6 (IPv6) emerged, many people believe this protocol could solve most malware propagation issues due to its broader addressing scheme. As IPv6 is still new compares to native IPv4, some transition mechanisms have been introduced to promote smoother migration. Unfortunately, these transition mechanisms allow some malwares to propagate its attack from IPv4 to IPv6 network environment. In this paper, a proof of concept shall be presented in order to show that some existing IPv4 malware detection technique need to be improvised in order to detect malware attack in dual-stack network more efficiently. A testbed of dual-stack network environment has been deployed and some genuine malware have been released to observe their behaviors. The results between these different scenarios will be analyzed and discussed further in term of their behaviors and propagation methods. The results show that malware behave differently on IPv6 from the IPv4 network protocol on the dual-stack network environment. A new detection technique is called for in order to cater this problem in the near future.
Abstract: Ringing effect is one of the most annoying visual
artifacts in digital video. It is a significant factor of subjective quality
deterioration. However, there is a widely-accepted misunderstanding
of its cause. In this paper, we propose a reasonable interpretation of the
cause of ringing effect. Based on the interpretation, we suggest further
two methods to reduce ringing effect in DCT-based video coding. The
methods adaptively adjust quantizers according to video features. Our
experiments proved that the methods could efficiently improve
subjective quality with acceptable additional computing costs.
Abstract: Authentication of multimedia contents has gained much attention in recent times. In this paper, we propose a secure semi-fragile watermarking, with a choice of two watermarks to be embedded. This technique operates in integer wavelet domain and makes use of semi fragile watermarks for achieving better robustness. A self-recovering algorithm is employed, that hides the image digest into some Wavelet subbands to detect possible malevolent object manipulation undergone by the image (object replacing and/or deletion). The Semi-fragility makes the scheme tolerant for JPEG lossy compression as low as quality of 70%, and locate the tempered area accurately. In addition, the system ensures more security because the embedded watermarks are protected with private keys. The computational complexity is reduced using parameterized integer wavelet transform. Experimental results show that the proposed scheme guarantees the safety of watermark, image recovery and location of the tempered area accurately.
Abstract: The evolution in project management was triggered by
the changes in management philosophy and practices in order to
maintain competitive advantage and continuous success in the field.
The purpose of this paper is to highlight the practicality of cognitive
style and unlearning approach in influencing the achievement of
project success by project managers. It introduces the concept of
planning, knowing and creating style from cognitive style field in the
light of achieving time, cost, quality and stakeholders appreciation in
project success context. Further it takes up a discussion of the
unlearning approach as a moderator in enhancing the relationship
between cognitive style and project success. The paper bases itself on
literature review from established disciplines like psychology,
sociology and philosophy regarding cognitive style, unlearning and
project success in general. The analysis and synthesis of literature in
the subject area a conceptual paper is utilized as the basis of future
research to form a comprehensive framework for project managers in
enhancing the project management competency.
Abstract: This research is intended to develop a raw material allocation model in timber processing industry in Perum Perhutani Unit I, Central Java, Indonesia. The model can be used to determine the quantity of allocation of timber between chain in the supply chain to select supplier considering factors that are log price and the distance. In determining the quantity of allocation of timber between chains in the supply chain, the model considers the optimal inventory in each chain. Whilst the optimal inventory is determined based on demand forecast, the capacity and safety stock. Problem solving allocation is conducted by developing linear programming model that aims to minimize the total cost of the purchase, transportation cost and storage costs at each chain. The results of numerical examples show that the proposed model can generate savings of the purchase cost of 20.84% and select suppliers with mileage closer.
Abstract: Designing modern machine tools is a complex task. A
simulation tool to aid the design work, a virtual machine, has
therefore been developed in earlier work. The virtual machine
considers the interaction between the mechanics of the machine
(including structural flexibility) and the control system. This paper
exemplifies the usefulness of the virtual machine as a tool for product
development. An optimisation study is conducted aiming at
improving the existing design of a machine tool regarding weight and
manufacturing accuracy at maintained manufacturing speed. The
problem can be categorised as constrained multidisciplinary multiobjective
multivariable optimisation. Parameters of the control and
geometric quantities of the machine are used as design variables. This
results in a mix of continuous and discrete variables and an
optimisation approach using a genetic algorithm is therefore
deployed. The accuracy objective is evaluated according to
international standards. The complete systems model shows nondeterministic
behaviour. A strategy to handle this based on statistical
analysis is suggested. The weight of the main moving parts is reduced
by more than 30 per cent and the manufacturing accuracy is
improvement by more than 60 per cent compared to the original
design, with no reduction in manufacturing speed. It is also shown
that interaction effects exist between the mechanics and the control,
i.e. this improvement would most likely not been possible with a
conventional sequential design approach within the same time, cost
and general resource frame. This indicates the potential of the virtual
machine concept for contributing to improved efficiency of both
complex products and the development process for such products.
Companies incorporating such advanced simulation tools in their
product development could thus improve its own competitiveness as
well as contribute to improved resource efficiency of society at large.
Abstract: Unlike general-purpose processors, digital signal
processors (DSP processors) are strongly application-dependent. To
meet the needs for diverse applications, a wide variety of DSP
processors based on different architectures ranging from the
traditional to VLIW have been introduced to the market over the
years. The functionality, performance, and cost of these processors
vary over a wide range. In order to select a processor that meets the
design criteria for an application, processor performance is usually
the major concern for digital signal processing (DSP) application
developers. Performance data are also essential for the designers of
DSP processors to improve their design. Consequently, several DSP
performance benchmarks have been proposed over the past decade or
so. However, none of these benchmarks seem to have included recent
new DSP applications.
In this paper, we use a new benchmark that we recently developed
to compare the performance of popular DSP processors from Texas
Instruments and StarCore. The new benchmark is based on the
Selectable Mode Vocoder (SMV), a speech-coding program from the
recent third generation (3G) wireless voice applications. All
benchmark kernels are compiled by the compilers of the respective
DSP processors and run on their simulators. Weighted arithmetic
mean of clock cycles and arithmetic mean of code size are used to
compare the performance of five DSP processors.
In addition, we studied how the performance of a processor is
affected by code structure, features of processor architecture and
optimization of compiler. The extensive experimental data gathered,
analyzed, and presented in this paper should be helpful for DSP
processor and compiler designers to meet their specific design goals.
Abstract: Artemia is one of the most conspicuous invertebrates
associated with aquaculture. It can be considered as a model
organism, offering numerous advantages for comprehensive and
multidisciplinary studies using morphologic or molecular methods.
Since DNA extraction is an important step of any molecular
experiment, a new and a rapid method of DNA extraction from adult
Artemia was described in this study. Besides, the efficiency of this
technique was compared with two widely used alternative techniques,
namely Chelex® 100 resin and SDS-chloroform methods. Data
analysis revealed that the new method is the easiest and the most cost
effective method among the other methods which allows a quick and
efficient extraction of DNA from the adult animal.
Abstract: Security is an interesting and significance issue for
popular virtual platforms, such as virtualization cluster and cloud
platforms. Virtualization is the powerful technology for cloud
computing services, there are a lot of benefits by using virtual machine
tools which be called hypervisors, such as it can quickly deploy all
kinds of virtual Operating Systems in single platform, able to control
all virtual system resources effectively, cost down for system platform
deployment, ability of customization, high elasticity and high
reliability. However, some important security problems need to take
care and resolved in virtual platforms that include terrible viruses, evil
programs, illegal operations and intrusion behavior. In this paper, we
present useful Intrusion Detection Mechanism (IDM) software that not
only can auto to analyze all system-s operations with the accounting
journal database, but also is able to monitor the system-s state for
virtual platforms.
Abstract: n-CdO/p-Si heterojunction diode was fabricated using
sol-gel spin coating technique which is a low cost and easily scalable
method for preparing of semiconductor films. The structural and
morphological properties of CdO film were investigated. The X-ray
diffraction (XRD) spectra indicated that the film was of
polycrystalline nature. The scanning electron microscopy (SEM)
images indicate that the surface morphology CdO film consists of the
clusters formed with the coming together of the nanoparticles. The
electrical characterization of Au/n-CdO/p–Si/Al heterojunction diode
was investigated by current-voltage. The ideality factor of the diode
was found to be 3.02 for room temperature. The reverse current of
the diode strongly increased with illumination intensity of 100
mWcm-2 and the diode gave a maximum open circuit voltage Voc of
0.04 V and short-circuits current Isc of 9.92×10-9 A.
Abstract: This paper presents an environmental and technoeconomic
evaluation of light duty vehicles in Iran. A comprehensive
well-to-wheel (WTW) analysis is applied to compare different
automotive fuel chains, conventional internal combustion engines and
innovative vehicle powertrains. The study examines the
competitiveness of 15 various pathways in terms of energy
efficiencies, GHG emissions, and levelized cost of different energy
carriers. The results indicate that electric vehicles including battery
electric vehicles (BEV), fuel cell vehicles (FCV) and plug-in hybrid
electric vehicles (PHEV) increase the WTW energy efficiency by
54%, 51% and 46%, respectively, compared to common internal
combustion engines powered by gasoline. On the other hand,
greenhouse gas (GHG) emissions per kilometer of FCV and BEV
would be 48% lower than that of gasoline engines. It is concluded
that BEV has the lowest total cost of energy consumption and
external cost of emission, followed by internal combustion engines
(ICE) fueled by CNG. Conventional internal combustion engines
fueled by gasoline, on the other hand, would have the highest costs.
Abstract: Radio frequency identification (RFID) applications have grown rapidly in many industries, especially in indoor location identification. The advantage of using received signal strength indicator (RSSI) values as an indoor location measurement method is a cost-effective approach without installing extra hardware. Because the accuracy of many positioning schemes using RSSI values is limited by interference factors and the environment, thus it is challenging to use RFID location techniques based on integrating positioning algorithm design. This study proposes the location estimation approach and analyzes a scheme relying on RSSI values to minimize location errors. In addition, this paper examines different factors that affect location accuracy by integrating the backpropagation neural network (BPN) with the LANDMARC algorithm in a training phase and an online phase. First, the training phase computes coordinates obtained from the LANDMARC algorithm, which uses RSSI values and the real coordinates of reference tags as training data for constructing an appropriate BPN architecture and training length. Second, in the online phase, the LANDMARC algorithm calculates the coordinates of tracking tags, which are then used as BPN inputs to obtain location estimates. The results show that the proposed scheme can estimate locations more accurately compared to LANDMARC without extra devices.
Abstract: Attempts to add fibre and polyphenols (PPs) into
popular beverages present challenges related to the properties of
finished products such as smoothies. Consumer acceptability,
viscosity and phenolic composition of smoothies containing high
levels of fruit fibre (2.5-7.5 g per 300 mL serve) and PPs (250-750
mg per 300 mL serve) were examined. The changes in total
extractable PP, vitamin C content, and colour of selected smoothies
over a storage stability trial (4°C, 14 days) were compared. A set of
acidic aqueous model beverages were prepared to further examine
the effect of two different heat treatments on the stability and
extractability of PPs. Results show that overall consumer
acceptability of high fibre and PP smoothies was low, with average
hedonic scores ranging from 3.9 to 6.4 (on a 1-9 scale). Flavour,
texture and overall acceptability decreased as fibre and polyphenol
contents increased, with fibre content exerting a stronger effect.
Higher fibre content resulted in greater viscosity, with an elevated PP
content increasing viscosity only slightly. The presence of fibre also
aided the stability and extractability of PPs after heating. A reduction
of extractable PPs, vitamin C content and colour intensity of
smoothies was observed after a 14-day storage period at 4°C. Two
heat treatments (75°C for 45 min or 85°C for 1 min) that are
normally used for beverage production, did not cause significant
reduction of total extracted PPs. It is clear that high levels of added
fibre and PPs greatly influence the consumer appeal of smoothies,
suggesting the need to develop novel formulation and processing
methods if a satisfactory functional beverage is to be developed
incorporating these ingredients.
Abstract: It is estimated that the total cost of abnormal
conditions to US process industries is around $20 billion dollars in
annual losses. The hydrotreatment (HDT) of diesel fuel in petroleum
refineries is a conversion process that leads to high profitable
economical returns. However, this is a difficult process to control
because it is operated continuously, with high hydrogen pressures
and it is also subject to disturbances in feed properties and catalyst
performance. So, the automatic detection of fault and diagnosis plays
an important role in this context. In this work, a hybrid approach
based on neural networks together with a pos-processing
classification algorithm is used to detect faults in a simulated HDT
unit. Nine classes (8 faults and the normal operation) were correctly
classified using the proposed approach in a maximum time of 5
minutes, based on on-line data process measurements.
Abstract: The reduction of hexavalent chromium by scrap iron
was investigated in continuous system, using long-term column
experiments, for aqueous Cr(VI) solutions having low buffering
capacities, over the Cr(VI) concentration range of 5 – 40 mg/L. The
results showed that the initial Cr(VI) concentration significantly
affects the reduction capacity of scrap iron. Maximum reduction
capacity of scrap iron was observed at the beginning of the column
experiments; the lower the Cr(VI) concentration, the greater the
experiment duration with maximum scrap iron reduction capacity.
However, due to passivation of active surface, scrap iron reduction
capacity continuously decreased in time, especially after Cr(VI)
breakthrough. The experimental results showed that highest
reduction capacity recorded until Cr(VI) breakthrough was 22.8 mg
Cr(VI)/g scrap iron, at CI = 5 mg/L, and decreased with increasing
Cr(VI) concentration. In order to assure total reduction of greater
Cr(VI) concentrations for a longer period of time, either the mass of
scrap iron filling, or the hydraulic retention time should be increased.