Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: Fatigue cracking continues to be the main challenges in
improving the performance of bituminous mixture pavements. The
purpose of this paper is to look at some aspects of the effects of fine
aggregate properties on the fatigue behaviour of hot mixture asphalt.
Two types of sand (quarry and mining sand) with two conventional
bitumen (PEN 50/60 & PEN 80/100) and four polymers modified
bitumen PMB (PM1_82, PM1_76, PM2_82 and PM2_76) were used.
Physical, chemical and mechanical tests were performed on the sands
to determine their effect when incorporated with a bituminous
mixture. According to the beam fatigue results, quarry sand that has
more angularity, rougher, higher shear strength and a higher
percentage of Aluminium oxide presented higher resistance to
fatigue. Also a PMB mixture gives better fatigue results than
conventional mixtures, this is due to the PMB having better viscosity
property than that of the conventional bitumen.
Abstract: This paper presents a hybrid fuzzy-PD plus PID
(HFPP) controller and its application to steam distillation process for
essential oil extraction system. Steam temperature is one of the most
significant parameters that can influence the composition of essential
oil yield. Due to parameter variations and changes in operation
conditions during distillation, a robust steam temperature controller becomes nontrivial to avoid the degradation of essential oil quality.
Initially, the PRBS input is triggered to the system and output of steam temperature is modeled using ARX model structure. The
parameter estimation and tuning method is adopted by simulation
using HFPP controller scheme. The effectiveness and robustness of
proposed controller technique is validated by real time
implementation to the system. The performance of HFPP using 25 and 49 fuzzy rules is compared. The experimental result demonstrates the proposed HFPP using 49 fuzzy rules achieves a
better, consistent and robust controller compared to PID when considering the test on tracking the set point and the effects due to disturbance.
Abstract: This paper argues that networks, such as the ECN and the American network, are affected by certain small events which are inherent to path dependence and preclude the full evolution towards efficiency. It is advocated that the American network is superior to the ECN in many respects due to its greater flexibility and longer history. This stems in particular from the creation of the American network, which was based on a small number of cases. Such a structure encourages further changes and modifications which are not necessarily radical. The ECN, by contrast, was established by legislative action, which explains its rigid structure and resistance to change. This paper is an attempt to transpose the superiority of the American network on to the ECN. It looks at concepts such as judicial cooperation, harmonisation of procedure, peer review and regulatory impact assessments (RIAs), and dispute resolution procedures.
Abstract: We introduce an adaptive technique for the joint mitigation of transients and continuous-wave radio-frequency co-channel interference (CW RFI) in high-frequency (HF) over-the-horizon radars (OTHRs). The performance of this technique is illustrated using data from an operational surface-wave radar (SECAR) and from recent experimental trials with sky-wave (SW) and sky-wave–line-of-sight (SKYLOS) HF OTHRs.
Abstract: In this study, a longitudinal joint connection was
proposed for the short-span slab-type modular bridges with rapid
construction. The slab-type modular bridge consists of a number of
precast slab modules and has the joint connection between the
modules in the longitudinal direction of the bridge. A finite element
based parameter analysis was conducted to design the shape and the
dimensions of the longitudinal joint connection. Numbers of shear
keys within the joint, height and depth of the shear key, tooth angle,
and the spacing were considered as the design parameters. Using the
local cracking load at the corner of the shear key and the
cross-sectional area of the joint, an efficiency factor was proposed to
evaluate the effectiveness of the longitudinal joint connection. The
dimensions of shear key were determined by comparing the cracking
loads and the efficiency factors obtained from the finite element
analysis.
Abstract: In this paper, we investigate the strategic stochastic air traffic flow management problem which seeks to balance airspace capacity and demand under weather disruptions. The goal is to reduce the need for myopic tactical decisions that do not account for probabilistic knowledge about the NAS near-future states. We present and discuss a scenario-based modeling approach based on a time-space stochastic process to depict weather disruption occurrences in the NAS. A solution framework is also proposed along with a distributed implementation aimed at overcoming scalability problems. Issues related to this implementation are also discussed.
Abstract: Many foreign and Lithuanian scientists, analyzing the
evaluation of the tax system in respect of the burden of taxation,
agree that the latter, in principle, depends on how many individuals
and what units of the residents constitute a household. Therefore, the
aim of scientific research is to substantiate or to deny the significance
of a household, but not a resident, as a statistical unit, during the
evaluation of tax system, to be precise, determination of the value of
the burden of taxation. A performed scientific research revealed that
evaluation of the tax system in respect of a household, but not a
resident, as a statistical unit, allows not only to evaluate the
efficiency of the tax system more objectively, but also to forecast
practicably existing poverty line, burden of taxation, and to
capacitate the initiation of efficient decisions in social and tax fields
creating the environment of existence.
Abstract: Crime is a major societal problem for most of the
world's nations. Consequently, the police need to develop new
methods to improve their efficiency in dealing with these ever increasing crime rates. Two of the common difficulties that the police
face in crime control are crime investigation and the provision of crime information to the general public to help them protect themselves. Crime control in police operations involves the use of
spatial data, crime data and the related crime data from different organizations (depending on the nature of the analysis to be made).
These types of data are collected from several heterogeneous sources
in different formats and from different platforms, resulting in a lack of standardization. Moreover, there is no standard framework for
crime data collection, integration and dissemination through mobile
devices. An investigation into the current situation in crime control was carried out to identify the needs to resolve these issues. This
paper proposes and investigates the use of service oriented
architecture (SOA) and the mobile spatial information service in crime control. SOA plays an important role in crime control as an
appropriate way to support data exchange and model sharing from
heterogeneous sources. Crime control also needs to facilitate mobile
spatial information services in order to exchange, receive, share and release information based on location to mobile users anytime and
anywhere.
Abstract: The possibility of using cassava residue containing
49.66% starch, 21.47% cellulose, 12.97% hemicellulose, and 21.86%
lignin as a raw material to produce glucose using enzymatic
hydrolysis was investigated. In the experiment, each reactor
contained the cassava residue, bacteria cells, and production medium.
The effects of particles size (40 mesh and 60 mesh) and strains of
bacteria (A002 and M015) isolated from Thai higher termites,
Microcerotermes sp., on the glucose concentration at 37°C were
focused. High performance liquid chromatography (HPLC) with a
refractive index detector was used to determine the quantity of
glucose. The maximum glucose concentration obtained at 37°C using
strain A002 and 60 mesh of the cassava residue was 1.51 g/L at 10 h.
Abstract: An interesting method to produce calcium carbonate is based in a gas-liquid reaction between carbon dioxide and aqueous solutions of calcium hydroxide. The design parameters for gas-liquid phase are flow regime, individual mass transfer, gas-liquid specific interfacial area. Most studies on gas-liquid phase were devoted to the experimental determination of some of these parameters, and more specifically, of the mass transfer coefficient, kLa which depends fundamentally on the superficial gas velocity and on the physical properties of absorption phase. The principle investigation was directed to study the effect of the vibration on the mass transfer coefficient kLa in gas-liquid phase during absorption of CO2 in the in aqueous solution of calcium hydroxide. The vibration with a higher frequency increase the mass transfer coefficient kLa, but vibration with lower frequency didn-t improve it, the mass transfer coefficient kLa increase with increase the superficial gas velocity.
Abstract: PDMS (Polydimethylsiloxane) polymer is a suitable material for biological and MEMS (Microelectromechanical systems) designers, because of its biocompatibility, transparency and high resistance under plasma treatment. PDMS round channel is always been of great interest due to its ability to confine the liquid with membrane type micro valves. In this paper we are presenting a very simple way to form round shapemicrofluidic channel, which is based on reflow of positive photoresist AZ® 40 XT. With this method, it is possible to obtain channel of different height simply by varying the spin coating parameters of photoresist.
Abstract: Studies on Simultaneous Saccharification and Fermentation (SSF) of corn flour, a major agricultural product as the substrate using starch digesting glucoamylase enzyme derived from Aspergillus niger and non starch digesting and sugar fermenting Saccharomyces cerevisiae in a batch fermentation. Experiments based on Central Composite Design (CCD) were conducted to study the effect of substrate concentration, pH, temperature, enzyme concentration on Ethanol Concentration and the above parameters were optimized using Response Surface Methodology (RSM). The optimum values of substrate concentration, pH, temperature and enzyme concentration were found to be 160 g/l, 5.5, 30°C and 50 IU respectively. The effect of inoculums age on ethanol concentration was also investigated. The corn flour solution equivalent to 16% initial starch concentration gave the highest ethanol concentration of 63.04 g/l after 48 h of fermentation at optimum conditions of pH and temperature. Monod model and Logistic model were used for growth kinetics and Leudeking – Piret model was used for product formation kinetics.
Abstract: Recently, a great amount of interest has been shown
in the field of modeling and controlling hybrid systems. One of the
efficient and common methods in this area utilizes the mixed logicaldynamical
(MLD) systems in the modeling. In this method, the
system constraints are transformed into mixed-integer inequalities by
defining some logic statements. In this paper, a system containing
three tanks is modeled as a nonlinear switched system by using the
MLD framework. Comparing the model size of the three-tank system
with that of a two-tank system, it is deduced that the number of
binary variables, the size of the system and its complexity
tremendously increases with the number of tanks, which makes the
control of the system more difficult. Therefore, methods should be
found which result in fewer mixed-integer inequalities.
Abstract: Tool Tracker is a client-server based application. It is essentially a catalogue of various network monitoring and management tools that are available online. There is a database maintained on the server side that contains the information about various tools. Several clients can access this information simultaneously and utilize this information. The various categories of tools considered are packet sniffers, port mappers, port scanners, encryption tools, and vulnerability scanners etc for the development of this application. This application provides a front end through which the user can invoke any tool from a central repository for the purpose of packet sniffing, port scanning, network analysis etc. Apart from the tool, its description and the help files associated with it would also be stored in the central repository. This facility will enable the user to view the documentation pertaining to the tool without having to download and install the tool. The application would update the central repository with the latest versions of the tools. The application would inform the user about the availability of a newer version of the tool currently being used and give the choice of installing the newer version to the user. Thus ToolTracker provides any network administrator that much needed abstraction and ease-ofuse with respect to the tools that he can use to efficiently monitor a network.
Abstract: Role of acoustic driving pressure on the
translational-radial dynamics of a moving single bubble
sonoluminescence (m-SBSL) has been numerically
investigated. The results indicate that increase in the
amplitude of the driving pressure leads to increase in the
bubble peak temperature. The length and the shape of the
trajectory of the bubble depends on the acoustic pressure and
because of the spatially dependence of the radial dynamics of
the moving bubble, its peak temperature varies during the
acoustical pulses. The results are in good agreement with the
experimental reports on m-SBSL.
Abstract: EGOTHOR is a search engine that indexes the Web
and allows us to search the Web documents. Its hit list contains URL
and title of the hits, and also some snippet which tries to shortly
show a match. The snippet can be almost always assembled by an
algorithm that has a full knowledge of the original document (mostly
HTML page). It implies that the search engine is required to store
the full text of the documents as a part of the index.
Such a requirement leads us to pick up an appropriate compression
algorithm which would reduce the space demand. One of the solutions
could be to use common compression methods, for instance gzip or
bzip2, but it might be preferable if we develop a new method which
would take advantage of the document structure, or rather, the textual
character of the documents.
There already exist a special compression text algorithms and
methods for a compression of XML documents. The aim of this
paper is an integration of the two approaches to achieve an optimal
level of the compression ratio
Abstract: Polyurethane foam (PUF) were prepared by
reacting polyols synthesized from soy-oil into mixture of 2,4-
Toluene diisocyanate (TDI) with 4,4--Methylene Diamine
Isocyanate (MDI) with ratio of 70:30. The polyols obtained
via esterification reaction were categorize into different
temperature of reaction and by used of varied concentration
of phosphoric acid catalyst. The purpose of catalysts is to
shifting selectivity to a desired and value added of product.
The effect of stoichiometric balance (molar ratio of
epoxide/ethylene glycol) to the concentration of the catalyst
on the final properties was evaluated.
Abstract: The aim of this paper is to express the input-output
matrix as a linear ordering problem which is classified as an NP-hard
problem. We then use a Tabu search algorithm to find the best
permutation among sectors in the input-output matrix that will give
an optimal solution. This optimal permutation can be useful in
designing policies and strategies for economists and government in
their goal of maximizing the gross domestic product.
Abstract: In order to study pressed pile test and ultimate bearing
capacity character of large-diameter steel pipe pile, based on two high-piled wharfs of Zhanjiang Port, pressed pile test and numerical simulation of three large-diameter steel pipe piles are analyzed in this
paper. Anchored pile method is used to pressed pile test, and the
curves of Q-s and ultimate bearing capacity are attained. Then the three piles are numerically simulated by ABAQUS, and results of numerical simulation and those of field test are comparatively analyzed. The results show that settlement value of numerical
simulation is larger than that of field test in the process of loading, the difference value is widening with the increasing of load, and the
ultimate difference value of settlement is 20% to 30%.