Abstract: Dietary macro and micro nutrients in their respective proportion and fractions present a practical potential tool to fabricate milk constituents since cells of lactating mammary glands obtain about 80 % of milk synthesis nutrients from blood, reflecting the existence of an isotonic equilibrium between blood and milk. Diverting milk biosynthetic activities through manipulation of nutrients towards producing milk not only keeping in view its significance as natural food but also as food item which prevents or dilutes the adverse effects of some diseases (like cardiovascular problem by saturated milk fat intake) has been area of interest in the last decade. Nutritional modification / supplementation has been reported to enhance conjugated linoleic acid, fatty acid type and concentration, essential fatty acid concentration, vitamin B12& C, Se, Cu, I and Fe which are involved to counter the health threats to human well being. Synchronizing dietary nutrients aimed to modify rumen dynamics towards synthesis of nutrients or their precursors to make their drive towards formulated milk constituents presents a practical option. Formulating dietary constituents to design milk constituents will let the farmers, consumers and investors know about the real potential and profit margins associated with this enterprise. This article briefly recapitulates the ways and means to modify milk constituents keeping an eye on human health and well being issues, which allows milk to serve more than a food item.
Abstract: The relevance of the study of everyday life in Almaty
and Kyzylorda are associated with the emergence of the modern
trends in historiography and socializing areas of government reform.
The relevance is due to the fact that in the early twentieth century
Kyzylorda and Almaty began to develop as a city and this period has
a special place in the life of the state. An interesting aspect of the
everyday life of the inhabitants of the new city, which was built in the
era of Stalin's Five-Year Plans, can be examined through the eyes of
the Soviet people living in a specific environment, reflecting the life
of the citizens. The study of industrialization of the Soviet Union and
the attention paid to new developments in the first five years of
everyday aspects as the impact of the modernization of the 1930s was
one of the decisive factors in the lives of residents. Among these
factors, we would like to highlight the medical field, which is the
basis of all human life, specifically focusing on the state of medicine
in Alma-Ata in the first 20-30-years of the twentieth century, and
analyze the different aspects of human life, determining the quality of
medical care to the population during this period.
Abstract: The main aim of this study is to describe and introduce a method of numerical analysis in obtaining approximate solutions for the SIR-SI differential equations (susceptible-infectiverecovered for human populations; susceptible-infective for vector populations) that represent a model for dengue disease transmission. Firstly, we describe the ordinary differential equations for the SIR-SI disease transmission models. Then, we introduce the numerical analysis of solutions of this continuous time, discrete space SIR-SI model by simplifying the continuous time scale to a densely populated, discrete time scale. This is followed by the application of this numerical analysis of solutions of the SIR-SI differential equations to the estimation of relative risk using continuous time, discrete space dengue data of Kuala Lumpur, Malaysia. Finally, we present the results of the analysis, comparing and displaying the results in graphs, table and maps. Results of the numerical analysis of solutions that we implemented offers a useful and potentially superior model for estimating relative risks based on continuous time, discrete space data for vector borne infectious diseases specifically for dengue disease.
Abstract: Hypertension is characterized with stress on the heart and blood vessels thus increasing the risk of heart attack and renal diseases. The Renin angiotensin system (RAS) plays a major role in blood pressure control. Renin is the enzyme that controls the RAS at the rate-limiting step. Our aim is to develop new drug-like leads which can inhibit renin and thereby emerge as therapeutics for hypertension. To achieve this, molecular dynamics (MD) simulation and receptor-based pharmacophore modeling were implemented, and three rennin-inhibitor complex structures were selected based on IC50 value and scaffolds of inhibitors. Three pharmacophore models were generated considering conformations induced by inhibitor. The compounds mapped to these models were selected and subjected to drug-like screening. The identified hits were docked into the active site of renin. Finally, hit1 satisfying the binding mode and interaction energy was selected as possible lead candidate to be used in novel renin inhibitors.
Abstract: Data mining techniques have been used in medical
research for many years and have been known to be effective. In order
to solve such problems as long-waiting time, congestion, and delayed
patient care, faced by emergency departments, this study concentrates
on building a hybrid methodology, combining data mining techniques
such as association rules and classification trees. The methodology is
applied to real-world emergency data collected from a hospital and is
evaluated by comparing with other techniques. The methodology is
expected to help physicians to make a faster and more accurate
classification of chest pain diseases.
Abstract: The purpose of the present study was to evaluate the
epidemiology of waterborne diarrhoeal among children aged 6-36
months old in Busia town, western Kenya. The study was carried out
between Feb. 2008 and Feb. 2010. Cases of diarrhoea reported in 385
households were linked to household water handling practices. A
mother with a child of 6-36 months old was also included in the
study. Diarrhoea prevalence among children 6-36 months was 16.7%
in Busia town, Bwamani (19.6%) and Mayenje (10.6%) clustered in
Mayenje sub-location reported the highest and the lowest prevalence
of diarrhoea. There was a positive correlation between the prevalence
of diarrhoea in children and the level of the mother-s education,
29.9% (n= 100). Diarrhoea cases decreased in range from 35.5% (n
=102) to 4.8% (n= 16), corresponding to increase in age from 6-35
months on average. In conclusion, prevalence of diarrhoea in
children of 6-36 months old was 16.7% in Busia town. This was
higher in children whose mother-s age was below 18 years and with
low level of education, the rate decreased with increase in age of
children. Prevalence of diarrhoea in children aged 6-36months in
households was higher in children aged 6-17 and 36 months and
whose mothers were less educated and fell between the ages of 18-24
years. The Influence of human activities at the main source of
drinking water on the prevalence of diarrhoea in these children was
insignificant.
Abstract: Porcine production in China represents approximately
the 50% of the worldwide pig production. Information about pig
husbandry characteristics in China and manure properties from sows
to fatteners in intensive pig farms are not broadly available for
scientific studies as it is a time consuming, expensive task and highly
inaccessible. This study provides a report about solid pig manures
(28% dry matter) in a commercial pig farm located in the peri-urban
area of Beijing as well as a general overview of the current pig
husbandry techniques including pig breeds, feeds, diseases, housing as
well as pig manure and wastewater disposal. The main results are
intended to serve as a literature source for young scientists in order to
understand the main composition of pig manures as well as to identify
the husbandry techniques applied in an intensive pig farm in Beijing.
Abstract: Recently, the health of retired National Football
League players, particularly lineman has been investigated. A
number of studies have reported increased cardiometabolic risk,
premature cardiovascular disease and incidence of type 2 diabetes.
Rugby union players have somatotypes very similar to National
Football League players which suggests that rugby players may have
similar health risks. The International Golden Oldies World Rugby
Festival (GORF) provided a unique opportunity to investigate the
demographics of veteran rugby players. METHODOLOGIES: A
cross-sectional, observational study was completed using an online
web-based questionnaire that consisted of medical history and
physiological measures. Data analysis was completed using a one
sample t-test (50yrs) and Chi-square test. RESULTS:
A total of 216 veteran rugby competitors (response rate = 6.8%)
representing 10 countries, aged 35-72 yrs (mean 51.2, S.D. ±8.0),
participated in the online survey. As a group, the incidence of current
smokers was low at 8.8% (avg 72.4 cigs/wk) whilst the percentage
consuming alcohol was high (93.1% (avg 11.2 drinks/wk).
Competitors reported the following top six chronic
diseases/disorders; hypertension (18.6%), arthritis (OA/RA, 11.5%),
asthma (9.3%), hyperlipidemia (8.2%), diabetes (all types, 7.5%) and
gout (6%), there were significant differences between groups with
regard to cancer (all types) and migraines. When compared to the
Australian general population (Australian Bureau of Statistics data,
n=18,000), GORF competitors had a significantly lower incidence of
anxiety (p
Abstract: It has been shown that pH 7,3 and 37 0C are the optimal condition for the growth of E. coli “ASAP". The cells grow well on Glucose, Lactose, D-Mannitol, D-Sorbitol, (+)-Xylose, L- (+)-Arabinose and Dulcitol. No growth has been observed on Sucrose, Inositol, Phenylalanine, and Tryptophan. The strain is sensitive to a range of antibiotics. The present study has demonstrated that E. coli “ASAP" inhibit the growth of S. enterica ATCC #700931 in vitro. The studies on conjugating activity has revealed no conjugant of E. coli “ASAP" with plasmid strains E. coli G35#59 and S. enterica ATCC #700931. On the other hand, the conjugants with low frequencies were obtained from E. coli “ASAP" with E. coli G35#61, and E. coli “ASAP" with randomly chosen isolate from healthy human gut microflora: E. coli E6. The results of present study have demonstrated improvements in gut microflora condition of patients with different diseases after the administration of “ASAP"
Abstract: This study retrospectively investigated the significance of whole body CT (WCT) for patients with sepsis. A medical chart review was retrospectively performed for all patients with systemic inflammatory response syndrome that were treated initially between April 2011 and March 2012. The subjects were divided into a WCT group that underwent WCT on arrival and a control group. Results of this study suggested that WCT for sepsis was useful for elderly patients whose chief complaint or physiological findings could not suggest the anatomical site of infection, to determine the infectious focus and indications/method for surgery, to diagnose the basic diseases associated with opportunistic infections and to evaluate complicated diseases
Abstract: Although automotive industry has brought different beneficiaries to human life, it is being pointed out as one of the major cause of global air pollution which resulted in climate change, smog, green house gases (GHGs), and human diseases by many reasons. Since auto industry is one of the largest consumers of fossil fuels, the realization of green innovations is becoming a crucial choice to meet the challenges towards sustainable development. Recently, many auto manufacturers have embarked on green technology initiatives to gain a competitive advantage in the global market; however, innovative manufacturing systems and technologies can enhance operational performance only if the human resource management is in place to elicit the motivation of the employees and develop their organizational expertise. No organization can perform at peak levels unless each employee is committed to the company goals and works as an effective team member. Strategic human resource practices are the primary means by which firms can shape the skills, attitudes, and behavior of individuals to align with the business strategic objectives. This study investigates on the comprehensive approach of multiple advanced technology innovations and human resource management at Toyota Motor Corporation as the market leader of full hybrid technology in the automotive industry. Then, HRM framework of the company is described and three sets of human resource practices that support the innovation-oriented HR system, presented. Finally, a conceptual framework for innovativeness in green technology in automotive industry by applying a deliberate strategic HR management system and knowledge management with the intervening factors of organizational culture, knowledge application and knowledge sharing is proposed.
Abstract: The study of proteomics reached unexpected levels of
interest, as a direct consequence of its discovered influence over some
complex biological phenomena, such as problematic diseases like
cancer. This paper presents the latest authors- achievements regarding
the analysis of the networks of proteins (interactome networks), by
computing more efficiently the betweenness centrality measure. The
paper introduces the concept of betweenness centrality, and then
describes how betweenness computation can help the interactome net-
work analysis. Current sequential implementations for the between-
ness computation do not perform satisfactory in terms of execution
times. The paper-s main contribution is centered towards introducing
a speedup technique for the betweenness computation, based on
modified shortest path algorithms for sparse graphs. Three optimized
generic algorithms for betweenness computation are described and
implemented, and their performance tested against real biological
data, which is part of the IntAct dataset.
Abstract: Case based reasoning (CBR) methodology presents a foundation for a new technology of building intelligent computeraided diagnoses systems. This Technology directly addresses the problems found in the traditional Artificial Intelligence (AI) techniques, e.g. the problems of knowledge acquisition, remembering, robust and maintenance. This paper discusses the CBR methodology, the research issues and technical aspects of implementing intelligent medical diagnoses systems. Successful applications in cancer and heart diseases developed by Medical Informatics Research Group at Ain Shams University are also discussed.
Abstract: Hemorrhage Disease of Grass Carp (HDGC) is a kind
of commonly occurring illnesses in summer, and the extremely high
death rate result in colossal losses to aquaculture. As the complex
connections among each factor which influences aquiculture diseases,
there-s no quit reasonable mathematical model to solve the problem at
present.A BP neural network which with excellent nonlinear mapping
coherence was adopted to establish mathematical model;
Environmental factor, which can easily detected, such as breeding
density, water temperature, pH and light intensity was set as the main
analyzing object. 25 groups of experimental data were used for
training and test, and the accuracy of using the model to predict the
trend of HDGC was above 80%. It is demonstrated that BP neural
network for predicating diseases in HDGC has a particularly
objectivity and practicality, thus it can be spread to other aquiculture
disease.
Abstract: The study of proteomics reached unexpected levels of
interest, as a direct consequence of its discovered influence over
some complex biological phenomena, such as problematic diseases
like cancer. This paper presents a new technique that allows for an
accurate analysis of the human interactome network. It is basically
a two-step analysis process that involves, at first, the detection of
each protein-s absolute importance through the betweenness centrality
computation. Then, the second step determines the functionallyrelated
communities of proteins. For this purpose, we use a community
detection technique that is based on the edge betweenness
calculation. The new technique was thoroughly tested on real biological
data and the results prove some interesting properties of those proteins that are involved in the carcinogenesis process. Apart from its
experimental usefulness, the novel technique is also computationally
effective in terms of execution times. Based on the analysis- results, some topological features of cancer mutated proteins are presented
and a possible optimization solution for cancer drugs design is suggested.
Abstract: In Mauritius, much emphasis is put on measures to
combat the high prevalence of non-communicable diseases (NCDs).
Health promotion campaigns for the adoption of healthy behaviors
and screening programs are done regularly by local authorities and
NCD surveys are carried out at intervals. However, the health
behaviors of the poor have not been investigated so far. This study
aims to give an insight on the perceptions of health status and
lifestyle health behaviors of poor people in Mauritius. A crosssectional
study among 83 persons benefiting from social aid in a
selected urban district was carried out. Results showed that 51.8% of
respondents perceived that they had good health status. 57.8% had no
known NCD whilst 25.3% had hypertension, followed by diabetes
(16.9%), asthma (9.6%) and heart disease (7.2%).They had low
smoking (10.8%) and alcohol consumption (6.0%) as well as high
physical activity prevalence (54.2%). These results were significantly
different from the NCD survey carried out in the general population.
Consumption of vegetables in the study was high. Overweight and
obesity trends were however similar to the NCD survey report 2009.
These findings contrast with other international studies showing poor
people having poor perceptions of health status and unhealthy
behavioral choices. Whether these positive health behaviors of poor
people in Mauritius arise out of choice or whether it is because the
alternative behavior is too costly remains to be investigated further.
Abstract: The Integrated Management of Child illnesses (IMCI) and the surveillance Health Information Systems (HIS) are related strategies that are designed to manage child illnesses and community practices of diseases. However, both strategies do not function well together because of classification incompatibilities and, as such, are difficult to use by health care personnel in rural areas where a majority of people lack the basic knowledge of interpreting disease classification from these methods. This paper discusses a single approach on how a stand-alone expert system can be used as a prompt diagnostic tool for all cases of illnesses presented. The system combines the action-oriented IMCI and the disease-oriented HIS approaches to diagnose malaria and typhoid fever in the rural areas of the Niger-delta region.
Abstract: The small interfering RNA (siRNA) alters the
regulatory role of mRNA during gene expression by translational
inhibition. Recent studies show that upregulation of mRNA because
serious diseases like cancer. So designing effective siRNA with good
knockdown effects plays an important role in gene silencing. Various
siRNA design tools had been developed earlier. In this work, we are
trying to analyze the existing good scoring second generation siRNA
predicting tools and to optimize the efficiency of siRNA prediction
by designing a computational model using Artificial Neural Network
and whole stacking energy (%G), which may help in gene silencing
and drug design in cancer therapy. Our model is trained and tested
against a large data set of siRNA sequences. Validation of our results
is done by finding correlation coefficient of experimental versus
observed inhibition efficacy of siRNA. We achieved a correlation
coefficient of 0.727 in our previous computational model and we
could improve the correlation coefficient up to 0.753 when the
threshold of whole tacking energy is greater than or equal to -32.5
kcal/mol.
Abstract: The paper proposes a methodology to process the signals coming from the Transcranial Magnetic Stimulation (TMS) in order to identify the pathology and evaluate the therapy to treat the patients affected by demency diseases. In particular, a fuzzy model is developed to identify the demency of the patients affected by Subcortical Ischemic Vascular Dementia (SIVD) and to measure the effect of a repetitive TMS on their motor performances. A tool is also presented to support the mentioned analysis.
Abstract: Huge losses in apple production are caused by pathogens that cannot be seen shortly after harvest. After-harvest thermotherapy treatments can considerably improve control of storage diseases on apples and become an alternative to chemical pesticides. In the years 2010-2012 carried out research in this area. Apples of 'Topaz' cultivar were harvested at optimal maturity time for long storage and subject to water bath treatment at 45, 50, 52, 55°C for 60, 120, 180 and 240 seconds. The control was untreated fruits. After 12 and 24 weeks and during so called simulated trade turnover the fruits were checked for their condition and the originators of diseases were determined by using the standard phytopathological methods. The most common originator of 'Topaz' apple infection during storage were the fungi of genus Gloeosporium. In this paper it was proven that for effective protection of 'Topaz' apples against diseases, thermotherapy by using water treatments at temperature range of 50-52°C is quite sufficient.