Abstract: With the advancement of knowledge about the utility
and impact of sustainability, its feasibility has been explored into
different walks of life. Scientists, however; have established their
knowledge in four areas viz environmental, economic, social and
cultural, popularly termed as four pillars of sustainability. Aspects of
environmental and economic sustainability have been rigorously
researched and practiced and huge volume of strong evidence of
effectiveness has been founded for these two sub-areas. For the social
and cultural aspects of sustainability, dependable evidence of
effectiveness is still to be instituted as the researchers and
practitioners are developing and experimenting methods across the
globe. Therefore, the present research aimed to identify globally used
practices of social and cultural sustainability and through evidence
synthesis assess their outcomes to determine the effectiveness of
those practices. A PICO format steered the methodology which
included all populations, popular sustainability practices including
walkability/cycle tracks, social/recreational spaces, privacy, health &
human services and barrier free built environment, comparators
included ‘Before’ and ‘After’, ‘With’ and ‘Without’, ‘More’ and
‘Less’ and outcomes included Social well-being, cultural coexistence,
quality of life, ethics and morality, social capital, sense of
place, education, health, recreation and leisure, and holistic
development. Search of literature included major electronic
databases, search websites, organizational resources, directory of
open access journals and subscribed journals. Grey literature,
however, was not included. Inclusion criteria filtered studies on the
basis of research designs such as total randomization, quasirandomization,
cluster randomization, observational or single studies
and certain types of analysis. Studies with combined outcomes were
considered but studies focusing only on environmental and/or
economic outcomes were rejected. Data extraction, critical appraisal
and evidence synthesis was carried out using customized tabulation,
reference manager and CASP tool. Partial meta-analysis was carried
out and calculation of pooled effects and forest plotting were done.
As many as 13 studies finally included for final synthesis explained
the impact of targeted practices on health, behavioural and social
dimensions. Objectivity in the measurement of health outcomes
facilitated quantitative synthesis of studies which highlighted the
impact of sustainability methods on physical activity, Body Mass
Index, perinatal outcomes and child health. Studies synthesized
qualitatively (and also quantitatively) showed outcomes such as
routines, family relations, citizenship, trust in relationships, social
inclusion, neighbourhood social capital, wellbeing, habitability and
family’s social processes. The synthesized evidence indicates slight
effectiveness and efficacy of social and cultural sustainability on the
targeted outcomes. Further synthesis revealed that such results of this
study are due weak research designs and disintegrated implementations. If architects and other practitioners deliver their
interventions in collaboration with research bodies and policy
makers, a stronger evidence-base in this area could be generated.
Abstract: Information technology has been gaining more and
more space whether in industry, commerce or even for personal use,
but the misuse of it brings harm to the environment and human health
as a result. Contribute to the sustainability of the planet is to
compensate the environment, all or part of what withdraws it. The
green computing also came to propose practical for use in IT in an
environmentally correct way in aid of strategic management and
communication. This work focuses on showing how a mobile
application can help businesses reduce costs and reduced
environmental impacts caused by its processes, through a case study
of a public company in Brazil.
Abstract: Large quantities of solid wastes being generated
worldwide from sources such as household, domestic, industrial,
commercial and construction demolition activities, leads to
environmental concerns. Utilization of these wastes in making
building construction materials can reduce the magnitude of the
associated problems. When these waste products are used in place of
other conventional materials, natural resources and energy are
preserved and expensive and/or potentially harmful waste disposal is
avoided. Recycling which is regarded as the third most preferred waste
disposal option, with its numerous environmental benefits, stand as a
viable option to offset the environmental impact associated with the
construction industry. This paper reviews the results of laboratory tests and important
research findings, and the potential of using these wastes in building
construction materials with focus on sustainable development.
Research gaps, which includes; the need to develop standard mix
design for solid waste based building materials; the need to develop
energy efficient method of processing solid waste use in concrete; the
need to study the actual behavior or performance of such building
materials in practical application and the limited real life application
of such building materials have also been identified. A research is being proposed to develop an environmentally
friendly, lightweight building block from recycled waste paper,
without the use of cement, and with properties suitable for use as
walling unit. This proposed research intends to incorporate,
laboratory experimentation and modeling to address the identified
research gaps.
Abstract: Software quality issues require special attention
especially in view of the demands of quality software product to meet
customer satisfaction. Software development projects in most
organisations need proper defect management process in order to
produce high quality software product and reduce the number of
defects. The research question of this study is how to produce high
quality software and reducing the number of defects. Therefore, the
objective of this paper is to provide a framework for managing
software defects by following defined life cycle processes. The
methodology starts by reviewing defects, defect models, best
practices, and standards. A framework for defect management life
cycle is proposed. The major contribution of this study is to define a
defect management roadmap in software development. The adoption
of an effective defect management process helps to achieve the
ultimate goal of producing high quality software products and
contributes towards continuous software process improvement.
Abstract: In the past years electric mobility became part of a
public discussion. The trend to fully electrified vehicles instead of
vehicles fueled with fossil energy has notably gained momentum.
Today nearly every big car manufacturer produces and sells fully
electrified vehicles, but electrified vehicles are still not as competitive
as conventional powered vehicles. As the traction battery states the
largest cost driver, lowering its price is a crucial objective. In
addition to improvements in product and production processes a nonnegligible,
but widely underestimated cost driver of production can
be found in logistics, since the production technology is not
continuous yet and neither are the logistics systems. This paper presents an approach to evaluate cost factors on
different designs of load carrier systems. Due to numerous
interdependencies, the combination of costs factors for a particular
scenario is not transparent. This is effecting actions for cost reduction
negatively, but still cost reduction is one of the major goals for
simultaneous engineering processes. Therefore a concurrent and
phase appropriate cost valuation method is necessary to serve cost
transparency. In this paper the four phases of this cost valuation
method are defined and explained, which based upon a new approach
integrating the logistics development process in to the integrated
product and process development.
Abstract: Gastric Cancer (GC) has high morbidity and fatality
rate in various countries. It is still one of the most frequent and
deadly diseases. Gastrokine1 (GKN1) and gastrokine2 (GKN2) genes
are highly expressed in the normal stomach epithelium and play
important roles in maintaining the integrity and homeostasis of
stomach mucosal epithelial cells. In this study, 47 paired samples that
were grouped according to the types of gastric cancer and the clinical
characteristics of the patients, including gender and average of age.
They were investigated with gene expression analysis and mutation
screening by monitoring RT-PCR, SSCP and nucleotide sequencing
techniques. Both GKN1 and GKN2 genes were observed significantly
reduced found by (Wilcoxon signed rank test; p
Abstract: Machine visualization is an area of interest with fast
and progressive development. We present a method of machine
visualization which will be applicable in real industrial conditions
according to current needs and demands. Real factory data were
obtained in a newly built research plant. Methods described in this
paper were validated on a case study. Input data were processed and
the virtual environment was created. The environment contains
information about dimensions, structure, disposition, and function.
Hardware was enhanced by modular machines, prototypes, and
accessories. We added functionalities and machines into the virtual
environment. The user is able to interact with objects such as testing
and cutting machines, he/she can operate and move them. Proposed
design consists of an environment with two degrees of freedom of
movement. Users are in touch with items in the virtual world which
are embedded into the real surroundings. This paper describes development of the virtual environment. We
compared and tested various options of factory layout virtualization
and visualization. We analyzed possibilities of using a 3D scanner in
the layout obtaining process and we also analyzed various virtual
reality hardware visualization methods such as: Stereoscopic (CAVE)
projection, Head Mounted Display (HMD) and augmented reality
(AR) projection provided by see-through glasses.
Abstract: This paper discusses the thematic structure of Yoruba
popular music of Southwest Nigeria. It examines the use of themes
and variations in early and contemporary Juju music. The work is an
outcome of a research developed by the author in his doctoral studies
at the University of Lagos, Nigeria, with the aim of analyzing the
thematic and motivic developments in Yoruba popular genres.
Observations, interviews, live recordings and CDs were used as
methods for eliciting information. Field recordings and CDs of
selected musical samples were also transcribed and notated. The
research established the prevalent use of string of themes by Juju
musicians as a compositional technique in moving from one musical
section to another, as they communicate the verbal messages in their
song. These themes consist of the popular ‘call and response’ form
found in most African music, analogous to the western ‘subject and
answer’ style of the fugue or sonata form, although without the tonic–
dominant relations. Due to the short and repetitive form of African
melodies and rhythms, a theme is restated as a variation, where its
rhythmic and melodic motifs are stylistically developed and repeated,
but still retaining its recognizable core musical structure. The
findings of this study showed that Juju musicians generally often
employ a thematic plan where new themes are used to arrange the
songs into sections, and each theme is developed into variations in
order to further expand the music, eliminate monotony, and create
musical aesthetics, serving as hallmark of its musical identity. The
study established the musical and extra-musical attributes of the
genre, while recommending further research towards analyzing the
various compositional techniques employed in African popular
genres.
Abstract: Green concrete are generally composed of recycling
materials as hundred or partial percent substitutes for aggregate,
cement, and admixture in concrete. To reduce greenhouse gas
emissions, efforts are needed to develop environmentally friendly
construction materials. Using of fly ash based geopolymer as an
alternative binder can help reduce CO2 emission of concrete. The
binder of geopolymer concrete is different from the ordinary Portland
cement concrete. Geopolymer Concrete specimens were prepared
with different concentration of NaOH solution M10, M14, and, M16
and cured at 60ºC in duration of 24 hours and 8 hours, in addition to
the curing in direct sunlight. Thus, it is necessary to study the effects
of the geopolymer binder on the behavior of concrete. Concrete is
made by using geopolymer technology is environmental friendly and
could be considered as part of the sustainable development. In this
study, the Local Alkaline Activator in Egypt and crashed stone as
coarse aggregate in fly ash based-geopolymer concrete was
investigated. This paper illustrates the development of mechanical
properties. Since the gained compressive strength for geopolymer
concrete at 28 days was in the range of 22.5MPa – 43.9MPa.
Abstract: Mixed-use development is one of the most important
trends in new island house transformation along southeast coastal area
in China. Unique island geographical environment and profound
fishing village culture coexist for a long time in this. With artistic
creation for the purpose of the "live-work" houses are in a large
number of emergence, however, still lack of systematic strategy.
Based on space effect from marine resources to regional human
settlements, this article teases out the evolution regularity of island
settlement context and architectural form, then, puts forward the
formation mechanism and construction model of art island houses.
Thereby, to further explore space design method and site creation
strategy of mixed-use development.
Abstract: Ceramic obtained on the base of aluminum oxide has
wide application range, because it has unique properties, for example,
wear-resistance, dielectric characteristics, and exploitation ability at
high temperatures and in corrosive atmosphere. Low temperature
synthesis of α-Al2O3 is energo-economical process and it is topical
for developing technologies of corundum ceramics fabrication. In the present work possibilities of low temperature transformation
of oxyhydroxides in α-Al2O3, during the presence of small amount of
rare–earth elements compounds (also Th, Re), have been discussed.
Aluminum unstable oxyhydroxides have been obtained by hydrolysis
of aluminium isopropoxide, nitrates, sulphate, and chloride in
alkaline environment at 80-90ºC temperatures. β-Al(OH)3 has been
received from aluminum powder by ultrasonic development. Drying
of oxyhydroxide sol has been conducted with presence of various
types seeds, which amount reaches 0,1-0,2% (mas). Neodymium,
holmium, thorium, lanthanum, cerium, gadolinium, disprosium
nitrates and rhenium carbonyls have been used as seeds and they
have been added to the sol specimens in amount of 0.1-0.2% (mas)
calculated on metals. Annealing of obtained gels is carried out at 70–
1100ºC for 2 hrs. The same specimen transforms in α-Al2O3 at
1100ºC. At this temperature in case of presence of lanthanum and
gadolinium transformation takes place by 70-85%. In case of
presence of thorium stabilization of γ-and θ-phases takes place. It is
established, that thorium causes inhibition of α-phase generation at
1100ºC, and at the time when in all other doped specimens α-phase is
generated at lower temperatures (1000-1050ºC). Synthesis of various
type compounds and simultaneous consolidation has developed in the
furnace of OXY-GON. Composite materials containing oxide and
non-oxide components close to theoretical data have been obtained in
this furnace respectively. During the work the following devices have
been used: X-ray diffractometer DRON-3M (Cu-Kα, Ni filter,
2º/min), High temperature vacuum furnace OXY-GON, electronic
scanning microscopes Nikon ECLIPSE LV 150, NMM-800TRF,
planetary mill Pulverisette 7 premium line, SHIMADZU Dynamic
Ultra Micro Hardness Tester, DUH-211S, Analysette 12 Dyna sizer.
Abstract: The need to merge software artifacts seems inherent
to modern software development. Distribution of development over
several teams and breaking tasks into smaller, more manageable
pieces are an effective means to deal with the kind of complexity. In
each case, the separately developed artifacts need to be assembled as
efficiently as possible into a consistent whole in which the parts still
function as described. In addition, earlier changes are introduced into
the life cycle and easier is their management by designers.
Interaction-based specifications such as UML sequence diagrams
have been found effective in this regard. As a result, sequence
diagrams can be used not only for capturing system behaviors but
also for merging changes in order to create a new version. The
objective of this paper is to suggest a new approach to deal with the
problem of software merging at the level of sequence diagrams by
using the concept of dependence analysis that captures, formally, all
mapping, and differences between elements of sequence diagrams
and serves as a key concept to create a new version of sequence
diagram.
Abstract: Urban areas, as they have been developed and operate
today, are areas of accumulation of a significant amount of people
and a large number of activities that generate desires and reasons for
traveling. The territorial expansion of the cities as well as the need to
preserve the importance of the central city areas lead to the
continuous increase of transportation needs which in the limited
urban space results in creating serious traffic and operational
problems. The modern perception of urban planning is directed towards more
holistic approaches and integrated policies that make it economically
competitive, socially just and more environmentally friendly. Over
the last 25 years, the goal of sustainable transport development has
been central to the agenda of any plan or policy for the city. The
modern planning of urban space takes into account the economic and
social aspects of the city and the importance of the environment to
sustainable urban development. In this context, the European Union
promotes direct or indirect related interventions according to the
cohesion and environmental policies; many countries even had the
chance to actually test them. This paper explores the methods and processes that have been
developed towards this direction and presents a review and
systematic presentation of this work. The ultimate purpose of this
research is to effectively use this review to create a decision making
methodological framework which can be the basis of a useful
operational tool for sustainable urban planning.
Abstract: Salinity is one of the major factors limiting crop
production in an arid environment. Despite its global importance
soybean production suffer the problems of salinity stress causing
damages at plant development. So it is implacable to either search for
salinity enhancement of soybean plants. Therefore, in the current
study we try to clarify the mechanism that might be involved in the
ameliorating effects of osmo-protectants such as proline and glycine
betaine as well as, compost application on soybean plants grown
under salinity stress. The experiment was conducted under
greenhouse conditions at the Graduate School of Biosphere Science
Laboratory of Hiroshima University, Japan in 2011. The experiment
was designed as a spilt-split plot based on randomized complete
block design with four replications. The treatments could be
summarized as follows; (i) salinity concentrations (0 and 15 mM), (ii)
compost treatments (0 and 24 t ha-1) and (iii) the exogenous, proline
and glycine betaine concentrations (0 mM and 25 mM) for each.
Results indicated that salinity stress induced reduction in growth and
physiological aspects (dry weight per plant, chlorophyll content, N
and K+ content) of soybean plant compared with those of the
unstressed plants. On the other hand, salinity stress led to increases in
the electrolyte leakage ratio, Na and proline contents. Special
attention was paid to, the tolerance against salt stress was observed,
the improvement of salt tolerance resulted from proline, glycine
betaine and compost were accompanied with improved K+, and
proline accumulation. While, significantly decreased electrolyte
leakage ratio and Na+ content. These results clearly demonstrate that
harmful effect of salinity could reduce on growth aspects of soybean.
Consequently, exogenous osmoprotectants combine with compost
will effectively solve seasonal salinity stress problem and are a good
strategy to increase salinity resistance of soybean in the drylands.
Abstract: This study aims to increase understanding of the
transition of business models in servitization. The significance of
service in all business has increased dramatically during the past
decades. Service-dominant logic (SDL) describes this change in the
economy and questions the goods-dominant logic on which business
has primarily been based in the past. A business model canvas is one
of the most cited and used tools in defining end developing business
models. The starting point of this paper lies in the notion that the
traditional business model canvas is inherently goods-oriented and
best suits for product-based business. However, the basic differences
between goods and services necessitate changes in business model
representations when proceeding in servitization. Therefore, new
knowledge is needed on how the conception of business model and
the business model canvas as its representation should be altered in
servitized firms in order to better serve business developers and interfirm
co-creation. That is to say, compared to products, services are
intangible and they are co-produced between the supplier and the
customer. Value is always co-created in interaction between a
supplier and a customer, and customer experience primarily depends
on how well the interaction succeeds between the actors. The role of
service experience is even stronger in service business compared to
product business, as services are co-produced with the customer. This paper provides business model developers with a service
business model canvas, which takes into account the intangible,
interactive, and relational nature of service. The study employs a
design science approach that contributes to theory development via
design artifacts. This study utilizes qualitative data gathered in
workshops with ten companies from various industries. In particular,
key differences between Goods-dominant logic (GDL) and SDLbased
business models are identified when an industrial firm
proceeds in servitization. As the result of the study, an updated version of the business
model canvas is provided based on service-dominant logic. The
service business model canvas ensures a stronger customer focus and
includes aspects salient for services, such as interaction between
companies, service co-production, and customer experience. It can be
used for the analysis and development of a current service business
model of a company or for designing a new business model. It
facilitates customer-focused new service design and service
development. It aids in the identification of development needs, and
facilitates the creation of a common view of the business model.
Therefore, the service business model canvas can be regarded as a
boundary object, which facilitates the creation of a common
understanding of the business model between several actors involved.
The study contributes to the business model and service business
development disciplines by providing a managerial tool for
practitioners in service development. It also provides research insight
into how servitization challenges companies’ business models.
Abstract: This study investigated the impact of inflectional and derivational morphemic analysis awareness on ESL secondary school students’ vocabulary learning strategy. The quasi-experimental study was conducted with 106 low proficiency secondary school students in two experimental groups (inflectional and derivational) and one control group. The students’ vocabulary acquisition was assessed through two measures: Morphemic Analysis Test and Vocabulary- Morphemic Test in the pretest and posttest before and after an intervention programme. Results of ANCOVA revealed that both the experimental groups achieved a significant score in Morphemic Analysis Test and Vocabulary-Morphemic Test. However, the inflectional group obtained a fairly higher score than the derivational group. Thus, the results indicated that ESL low proficiency secondary school students performed better on inflectional morphemic awareness as compared to derivatives. The results also showed that the awareness of inflectional morphology contributed more on the vocabulary acquisition. Importantly, learning inflectional morphology can help ESL low proficiency secondary school students to develop both morphemic awareness and vocabulary gain. Theoretically, these findings show that not all morphemes are equally useful to students for their language development. Practically, these findings indicate that morphological instruction should at least be included in remediation and instructional efforts with struggling learners across all grade levels, allowing them to focus on meaning within the word before they attempt the text in large for better comprehension. Also, by methodologically, by conducting individualized intervention and assessment this study provided fresh empirical evidence to support the existing literature on morphemic analysis awareness and vocabulary learning strategy. Thus, a major pedagogical implication of the study is that morphemic analysis awareness strategy is a definite boon for ESL secondary school students in learning English vocabulary.
Abstract: Financial innovations can be regarded as the cause
and the effect of the evolution of the financial system. Most of
financial innovations are created by various financial institutions for
their own purposes and needs. However, due to their diversity,
financial innovations can be also applied by various business entities
(other than financial institutions).
This paper focuses on the potential application of financial
innovations by non-financial companies. It is assumed that financial
innovations may be effectively applied in all fields of corporate
financial decisions integrating financial management with the risk
management process. Appropriate application of financial
innovations may enhance the development of the company and
increase its value by improving its financial situation and reducing
the level of risk. On the other hand, misused financial innovations
may become the source of extra risk for the company threatening its
further operation.
The main objective of the paper is to identify the major types of
financial innovations offered to non-financial companies by the
banking system in Poland. It also aims at identifying the main factors
determining the creation of financial innovations in the banking
system in Poland and indicating future directions of their
development.
This paper consists of conceptual and empirical part. Conceptual
part based on theoretical study is focused on the determinants of the
process of financial innovations and their application by the nonfinancial
companies. Theoretical study is followed by the empirical
research based on the analysis of the actual offer of the 20 biggest
banks operating in Poland with regard to financial innovations
offered to SMEs and large corporations. These innovations are
classified according to the main functions of the integrated financial
management, such as financing, investment, working capital
management and risk management.
Empirical study has proved that the biggest banks operating in the
Polish market offer to their business customers many types and
classes of financial innovations. This offer appears vast and adequate
to the needs and purposes of the Polish non-financial companies. It
was observed that financial innovations pertained to financing
decisions dominate in the banks’ offer. However, due to high
diversification of the offered financial innovations, business
customers may effectively apply them in all fields and areas of
integrated financial management. It should be underlined, that the
banks’ offer is highly dispersed, which may limit the implementation
of financial innovations in the corporate finance. It would be also
recommended for the banks operating in the Polish market to
intensify the education campaign aiming at increasing knowledge
about financial innovations among business customers.
Abstract: This research paper presents the current practices of
teacher professional development, perceived as beneficial by teachers
themselves, in a private secondary school in Brunei Darussalam. This
is part of the findings of a larger qualitative study on teacher
empowerment, using ethnographic methods for data collection, i.e.
participant observation, interviews and document analysis. The field
work was carried out over a period of six months in 2013. An
analysis of the field data revealed multiple pathways of teacher
professional development existing in the school. The results indicate
that school leaders, the teacher community in the school, students,
and the teachers themselves were the agents in a school that
facilitated teacher empowerment. Besides contributing to the
knowledge base on teacher professional development, the results of
this study provide directions for educational policy makers in their
efforts to enhance professional development in secondary schools of
similar characteristics. For school leaders and the teacher community,
these findings offer guidelines for maximizing the opportunities for
these professional development practices, by strengthening
collegiality and by using the existing structures optimally for the
benefit of all concerned.
Abstract: Indonesia has experienced annual forest fires that have
rapidly destroyed and degraded its forests. Fires in the peat swamp
forests of Riau Province, have set the stage for problems to worsen,
this being the ecosystem most prone to fires (which are also the most
difficult, to extinguish). Despite various efforts to curb deforestation,
and forest degradation processes, severe forest fires are still
occurring. To find an effective solution, the basic causes of the
problems must be identified. It is therefore critical to have an indepth
understanding of the underlying causal factors that have
contributed to deforestation and forest degradation as a whole, in
order to attain reductions in their rates. An assessment of the drivers of deforestation and forest
degradation was carried out, in order to design and implement
measures that could slow these destructive processes. Research was
conducted in Giam Siak Kecil–Bukit Batu Biosphere Reserve
(GSKBB BR), in the Riau Province of Sumatera, Indonesia. A
biosphere reserve was selected as the study site because such reserves
aim to reconcile conservation with sustainable development. A
biosphere reserve should promote a range of local human activities,
together with development values that are in line spatially and
economically with the area conservation values, through use of a
zoning system. Moreover, GSKBB BR is an area with vast peatlands,
and is experiencing forest fires annually. Various factors were
analysed to assess the drivers of deforestation and forest degradation
in GSKBB BR; data were collected from focus group discussions
with stakeholders, key informant interviews with key stakeholders,
field observation and a literature review. Landsat satellite imagery was used to map forest-cover changes
for various periods. Analysis of landsat images, taken during the
period 2010-2014, revealed that within the non-protected area of core
zone, there was a trend towards decreasing peat swamp forest areas,
increasing land clearance, and increasing areas of community oilpalm
and rubber plantations. Fire was used for land clearing and most
of the forest fires occurred in the most populous area (the transition
area). The study found a relationship between the deforested/
degraded areas, and certain distance variables, i.e. distance from
roads, villages and the borders between the core area and the buffer
zone. The further the distance from the core area of the reserve, the
higher was the degree of deforestation and forest degradation. Research findings suggested that agricultural expansion may be
the direct cause of deforestation and forest degradation in the reserve,
whereas socio-economic factors were the underlying driver of forest
cover changes; such factors consisting of a combination of sociocultural,
infrastructural, technological, institutional (policy and governance), demographic (population pressure) and economic
(market demand) considerations. These findings indicated that local
factors/problems were the critical causes of deforestation and
degradation in GSKBB BR. This research therefore concluded that
reductions in deforestation and forest degradation in GSKBB BR
could be achieved through ‘local actor’-tailored approaches such as
community empowerment.
Abstract: Effects of nicotine on pre-partum body weight and
preimplantation embryonic development has been reported
previously. Present study was conducted to determine the effects of
annatto (Bixa orellana)-derived delta-tocotrienol (TCT) (with
presence of 10% gamma-TCT isomer) on the nicotine-induced
reduction in body weight and 8-cell embryonic growth in mice.
Twenty-four 6-8 weeks old (23-25g) female balb/c mice were
randomly divided into four groups (G1-G4; n=6). Those groups were
subjected to the following treatments for 7 consecutive days: G1
(control) were gavaged with 0.1 ml tocopherol stripped corn oil. G2
was subcutaneously (s.c.) injected with 3 mg/kg/day of nicotine. G3
received concurrent treatment of nicotine (3 mg/kg/day) and 60
mg/kg/day of δ-TCT mixture (contains 90% delta & 10% gamma
isomers) and G4 was given 60 mg/kg/day of δ-TCT mixture alone.
Body weights were recorded daily during the treatment. On Day 8,
females were superovulated with 5 IU Pregnant Mare’s Serum
Gonadotropin (PMSG) for 48 hours followed with 5 IU human
Chorionic Gonadotropin (hCG) before mated with males at the ratio
of 1:1. Females were sacrificed by cervical dislocation for embryo
collection 48 hours post-coitum. Collected embryos were cultured in
vitro. Results showed that throughout Day 1 to Day 7, the body
weight of nicotine treated group (G2) was significantly lower
(p