Abstract: The authors present an algorithm for order reduction of linear time invariant dynamic systems using the combined advantages of the eigen spectrum analysis and the error minimization by particle swarm optimization technique. Pole centroid and system stiffness of both original and reduced order systems remain same in this method to determine the poles, whereas zeros are synthesized by minimizing the integral square error in between the transient responses of original and reduced order models using particle swarm optimization technique, pertaining to a unit step input. It is shown that the algorithm has several advantages, e.g. the reduced order models retain the steady-state value and stability of the original system. The algorithm is illustrated with the help of two numerical examples and the results are compared with the other existing techniques.
Abstract: A new tool path planning method for 5-axis flank
milling of a globoidal indexing cam is developed in this paper. The
globoidal indexing cam is a practical transmission mechanism due
to its high transmission speed, accuracy and dynamic performance.
Machining the cam profile is a complex and precise task. The profile
surface of the globoidal cam is generated by the conjugate contact
motion of the roller. The generated complex profile surface is usually
machined by 5-axis point-milling method. The point-milling method
is time-consuming compared with flank milling. The tool path for
5-axis flank milling of globoidal cam is developed to improve the
cutting efficiency. The flank milling tool path is globally optimized
according to the minimum zone criterion, and high accuracy is
guaranteed. The computational example and cutting simulation finally
validate the developed method.
Abstract: A learning content management system (LCMS) is an
environment to support web-based learning content development.
Primary function of the system is to manage the learning process as
well as to generate content customized to meet a unique requirement
of each learner. Among the available supporting tools offered by
several vendors, we propose to enhance the LCMS functionality to
individualize the presented content with the induction ability. Our
induction technique is based on rough set theory. The induced rules
are intended to be the supportive knowledge for guiding the content
flow planning. They can also be used as decision rules to help
content developers on managing content delivered to individual
learner.
Abstract: This study examined the toxicological effects and
safety of polypeptide k isolated from the seeds of Momordica
charantia in laboratory rats. 30 male Sprague Dawley rats (12 weeks
old, bodyweight 180-200 g) were randomly divided into 3 groups
(1000 mg/kg, 500 mg and 0 mg/kg). Rats were acclimatized to
laboratory conditions for 7 days and at day 8 rats were dosed orally
with polypeptide k (in 2% DMSO/normal saline) and the controls
received the dosed vehicle only. Rats were then observed for 72
hours before sacrificed. Rats were anaesthetized by pentobarbital
(50 mg/kg ip) and 2-3.0 mL of blood was taken by cardiac puncture
and rats were scarified by anaesthetic overdose. Immediately, organs
(heart, lungs, liver, kidneys) were weigh and taken for histology.
Organ sections were then evaluated by a histopathologist. Serum
samples were assayed for liver functions (ALT and γ-GT) and kidney
functions (BUN and creatinine). All rats showed normal behavior
after the dosing and no statistical changes were observed in all blood
parameters and organ weight. Histological examinations revealed
normal organ structures. In conclusion, dosing of rats up to 1000
mg/kg did not have any effects on the rat behavior, liver or kidney
functions nor histology of the selected organs.
Abstract: Knowledge and these notions have become more and
more important and we speak about a knowledge based society
today. A lot of small and big companies have reacted upon these new
challenges. But there is a deep abyss about knowledge conception
and practice between the professional researchers and company - life.
The question of this research was: How can small and mediumsized
companies be equal to the demands of new economy?
Questionnaires were used in this research and a special segment of
the native knowledge based on economy was focused on.
Researchers would have liked to know what the sources of success
are and how they can be in connection with questions of knowledge
acquisition, knowledge transfer, knowledge utilization in small and
medium-sized companies. These companies know that they have to
change their behaviour and thinking, but they are not on the suitable
level that they can compete with bigger or multinational companies.
Abstract: Protein-protein interactions (PPI) play a crucial role in many biological processes such as cell signalling, transcription, translation, replication, signal transduction, and drug targeting, etc. Structural information about protein-protein interaction is essential for understanding the molecular mechanisms of these processes. Structures of protein-protein complexes are still difficult to obtain by biophysical methods such as NMR and X-ray crystallography, and therefore protein-protein docking computation is considered an important approach for understanding protein-protein interactions. However, reliable prediction of the protein-protein complexes is still under way. In the past decades, several grid-based docking algorithms based on the Katchalski-Katzir scoring scheme were developed, e.g., FTDock, ZDOCK, HADDOCK, RosettaDock, HEX, etc. However, the success rate of protein-protein docking prediction is still far from ideal. In this work, we first propose a more practical measure for evaluating the success of protein-protein docking predictions,the rate of first success (RFS), which is similar to the concept of mean first passage time (MFPT). Accordingly, we have assessed the ZDOCK bound and unbound benchmarks 2.0 and 3.0. We also createda new benchmark set for protein-protein docking predictions, in which the complexes have experimentally determined binding affinity data. We performed free energy calculation based on the solution of non-linear Poisson-Boltzmann equation (nlPBE) to improve the binding mode prediction. We used the well-studied thebarnase-barstarsystem to validate the parameters for free energy calculations. Besides,thenlPBE-based free energy calculations were conducted for the badly predicted cases by ZDOCK and ZRANK. We found that direct molecular mechanics energetics cannot be used to discriminate the native binding pose from the decoys.Our results indicate that nlPBE-based calculations appeared to be one of the promising approaches for improving the success rate of binding pose predictions.
Abstract: The issue of classifying objects into one of predefined
groups when the measured variables are mixed with different types
of variables has been part of interest among statisticians in many
years. Some methods for dealing with such situation have been
introduced that include parametric, semi-parametric and nonparametric
approaches. This paper attempts to discuss on a problem
in classifying a data when the number of measured mixed variables is
larger than the size of the sample. A propose idea that integrates a
dimensionality reduction technique via principal component analysis
and a discriminant function based on the location model is discussed.
The study aims in offering practitioners another potential tool in a
classification problem that is possible to be considered when the
observed variables are mixed and too large.
Abstract: Work ethic and labour productivity issues are
extremely important for any society. It has been long proven by the
global practice and various scholars that the country promoting the
labour has always been way forward from the other countries. This
paper studies the thoughts suggested by M.Weber, Confucius, Lee
Kuan Yew, Mahathir Mohammad and other prominent thinkers
concerning the issues of work ethics and labour productivity. The
article analyzes why developed nations are way more advanced in
their development compared to other nations.
Abstract: The objectives of this research were to explore factors
influencing knowledge management process in the manufacturing
industry and develop a model to support knowledge management
processes. The studied factors were technology infrastructure, human
resource, knowledge sharing, and the culture of the organization. The
knowledge management processes included discovery, capture,
sharing, and application. Data were collected through questionnaires
and analyzed using multiple linear regression and multiple
correlation. The results found that technology infrastructure, human
resource, knowledge sharing, and culture of the organization
influenced the discovery and capture processes. However, knowledge
sharing had no influence in sharing and application processes. A
model to support knowledge management processes was developed,
which indicated that sharing knowledge needed further improvement
in the organization.
Abstract: The concerns of education and practice of architecture
do not necessarily overlap. Indeed the gap between them could be
seen increasingly and less frequently bridged. We suggest that
changing in architecture education and clarifying the relationship
between these two can help to find and address the opportunities and
unique positions to bridge this gulf.
Abstract: Server provisioning is one of the most attractive topics in virtualization systems. Virtualization is a method of running multiple independent virtual operating systems on a single physical computer. It is a way of maximizing physical resources to maximize the investment in hardware. Additionally, it can help to consolidate servers, improve hardware utilization and reduce the consumption of power and physical space in the data center. However, management of heterogeneous workloads, especially for resource utilization of the server, or so called provisioning becomes a challenge. In this paper, a new concept for managing workloads based on user behavior is presented. The experimental results show that user behaviors are different in each type of service workload and time. Understanding user behaviors may improve the efficiency of management in provisioning concept. This preliminary study may be an approach to improve management of data centers running heterogeneous workloads for provisioning in virtualization system.
Abstract: We describe an effective method for image encryption
which employs magnitude and phase manipulation using carrier
images. Although it involves traditional methods like magnitude and
phase encryptions, the novelty of this work lies in deploying the
concept of carrier images for encryption purpose. To this end, a
carrier image is randomly chosen from a set of stored images. One
dimensional (1-D) discrete Fourier transform (DFT) is then carried
out on the original image to be encrypted along with the carrier
image. Row wise spectral addition and scaling is performed between
the magnitude spectra of the original and carrier images by randomly
selecting the rows. Similarly, row wise phase addition and scaling is
performed between the original and carrier images phase spectra by
randomly selecting the rows. The encrypted image obtained by these
two operations is further subjected to one more level of magnitude
and phase manipulation using another randomly chosen carrier image
by 1-D DFT along the columns. The resulting encrypted image is
found to be fully distorted, resulting in increasing the robustness
of the proposed work. Further, applying the reverse process at the
receiver, the decrypted image is found to be distortionless.
Abstract: The studying of enzymatic esterification of carboxylic
acids and higher alcohols was performed by esterase Saccharomyces
cerevisiae in water-organic medium. Investigation of the enzyme
specificity to acetic substrates showed the best result with acetic acid
in esterification reactions with ethanol whereas within other
carboxylic acids the esterification decreased with acids: hexanoic >
pentanoic > butyric > decanoic. In relation to higher alcohols C3-C5,
esterification increased with alcohols propanol < butanol < amylol.
Also it was determined that esterase was more specific to alcohols
with branched chain such as isobutyl alcohol and isoamyl alcohol.
Data obtained may have important practical implications, for
example, for application of yeast esterase in producing various
volatile esters as well as in enzymatic transformation of volatile acids
and toxic fusel alcohols into volatile esters by providing the
production of the high quality alcoholic beverages with redused
content of higher alcohols as well as with improved degustational and
hygienic properties.
Abstract: Banyan networks are really attractive for serving as
the optical switching architectures due to their unique properties of
small depth and absolute signal loss uniformity. The fact has been
established that the limitations of blocking nature and the nonavailability
of proper connections due to non-rearrangeable property
can be easily ruled out using electro-optic MZI switches as basic
switching elements. Combination of the horizontal expansion and
vertical stacking of optical banyan networks is an appropriate scheme
for constructing non-blocking banyan-based optical switching
networks. The interconnected banyan switching fabrics (IBSF) have
been considered and analyzed to best serve the purpose of optical
switching with electro-optic MZI basic elements. The cross/bar state
interchange for the switches has been facilitated by appropriate
voltage switching or the by the switching of operating wavelength.
The paper is dedicated to the modification of the basic switching
element being used as well as the architecture of the switching
network.
Abstract: Palm methyl ester (PME) is one of the alternative
biomass fuels to liquid fossil fuels. To investigate the combustion
characteristics of PME as an alternative fuel for gas turbines, combustion experiments using two types of burners under atmospheric
pressure were performed. One of the burners has a configuration
making strong non-premixed flame, whereas the other has a
configuration promoting prevaporization of fuel droplets. The results
show that the NOx emissions can be reduced by employing the latter burner without accumulation of soot when PME is used as a fuel. A
burner configuration promoting prevaporzation of fuel droplets is
recommended for PME.
Abstract: Constant amplitude fatigue crack growth (FCG) tests
were performed on dissimilar metal welded plates of Type 316L
Stainless Steel (SS) and IS 2062 Grade A Carbon steel (CS). The
plates were welded by TIG welding using SS E309 as electrode. FCG
tests were carried on the Side Edge Notch Tension (SENT)
specimens of 5 mm thickness, with crack initiator (notch) at base
metal region (BM), weld metal region (WM) and heat affected zones
(HAZ). The tests were performed at a test frequency of 10 Hz and at
load ratios (R) of 0.1 & 0.6. FCG rate was found to increase with
stress ratio for weld metals and base metals, where as in case of
HAZ, FCG rates were almost equal at high ΔK. FCG rate of HAZ of
stainless steel was found to be lowest at low and high ΔK. At
intermediate ΔK, WM showed the lowest FCG rate. CS showed
higher crack growth rate at all ΔK. However, the scatter band of data
was found to be narrow. Fracture toughness (Kc) was found to vary
in different locations of weldments. Kc was found lowest for the
weldment and highest for HAZ of stainless steel. A novel method of
characterizing the FCG behavior using an Infrared thermography
(IRT) camera was attempted. By monitoring the temperature rise at
the fast moving crack tip region, the amount of plastic deformation
was estimated.
Abstract: Verapamil has been shown to inhibit fentanyl uptake in vitro and is a potent P-glycoprotein inhibitor. Tissue partitioning of loperamide, a commercially available opioid, is closely controlled by the P-gp efflux transporter. The following studies were designed to evaluate the effect of opioids on verapamil partitioning in the lung and brain, in vivo. Opioid (fentanyl or loperamide) was administered by intravenous infusion to Sprague Dawley rats alone or in combination with verapamil and plasma, with lung and brain tissues were collected at 1, 5, 6, 8, 10 and 60 minutes. Drug dispositions were modeled by recirculatory pharmacokinetic models. Fentanyl slightly increased the verapamil lung (PL) partition coefficient yet decreased the brain (PB) partition coefficient. Furthermore, loperamide significantly increased PLand PB. Fentanyl reduced the verapamil volume of distribution (V1) and verapamil elimination clearance (ClE). Fentanyl decreased verapamil brain partitioning, yet increased verapamil lung partitioning. Also, loperamide increased lung and brain partitioning in vivo. These results suggest that verapamil and fentanyl may be substrates of an unidentified inward transporter in brain tissue and confirm that verapamil and loperamide are substrates of the efflux transporter P-gp.
Abstract: Viral influenza A subtypes H5N1 and pandemic
H1N1 (pH1N1) have worldwide emerged and transmitted. The most
common anti-influenza drug for treatment of both seasonal and
pandemic influenza viruses is oseltamivir that nowadays becomes
resistance to influenza neuraminidase. The novel long-acting drug,
laninamivir, was discovered for treatment of the patients infected
with influenza B and influenza A viruses. In the present study,
laninamivir complexed with wild-type strain of both H5N1 and
pH1N1 viruses were comparatively determined the structures and
drug-target interactions by means of molecular dynamics (MD)
simulations. The results show that the hydrogen bonding interactions
formed between laninamivir and its binding residues are likely
similar for the two systems. Additionally, the presence of
intermolecular interactions from laninamivir to the residues in the
binding pocket is established through their side chains in accordance
with hydrogen bond interactions.
Abstract: In this paper, an intelligent algorithm for optimal
document archiving is presented. It is kown that electronic archives
are very important for information system management. Minimizing
the size of the stored data in electronic archive is a main issue to
reduce the physical storage area. Here, the effect of different types of
Arabic fonts on electronic archives size is discussed. Simulation
results show that PDF is the best file format for storage of the Arabic
documents in electronic archive. Furthermore, fast information
detection in a given PDF file is introduced. Such approach uses fast
neural networks (FNNs) implemented in the frequency domain. The
operation of these networks relies on performing cross correlation in
the frequency domain rather than spatial one. It is proved
mathematically and practically that the number of computation steps
required for the presented FNNs is less than that needed by
conventional neural networks (CNNs). Simulation results using
MATLAB confirm the theoretical computations.
Abstract: Grid environments consist of the volatile integration
of discrete heterogeneous resources. The notion of the Grid is to
unite different users and organisations and pool their resources into
one large computing platform where they can harness, inter-operate,
collaborate and interact. If the Grid Community is to achieve this
objective, then participants (Users and Organisations) need to be
willing to donate or share their resources and permit other
participants to use their resources. Resources do not have to be
shared at all times, since it may result in users not having access to
their own resource. The idea of reward-based computing was
developed to address the sharing problem in a pragmatic manner.
Participants are offered a reward to donate their resources to the
Grid. A reward may include monetary recompense or a pro rata share
of available resources when constrained. This latter point may imply
a quality of service, which in turn may require some globally agreed
reservation mechanism. This paper presents a platform for economybased
computing using the WebCom Grid middleware. Using this
middleware, participants can configure their resources at times and
priority levels to suit their local usage policy. The WebCom system
accounts for processing done on individual participants- resources
and rewards them accordingly.