Abstract: Compacted clay liners (CCLs) are the main materials
used in waste disposal landfills due to their low permeability. In this
study, the effect on the shear resistant of clays with inorganic salt
solutions as permeate fluid was experimentally investigated. For this
purpose, NaCl inorganic salt solution at concentrations of 2, 5, 10%
and deionized water were used. Laboratory direct shear and Vane
shear tests were conducted on three compacted clays with low,
medium and high plasticity. Results indicated that the solutions type
and its concentration affect the shear properties of the mixture. In the
light of this study, the influence magnitude of these inorganic salts in
varies concentrations in different clays were determined and more
suitable compacted clay with the compare of plasticity were found.
Abstract: Modeling of Panel Zone (PZ) seismic behavior,
because of its role in overall ductility and lateral stiffness of steel
moment frames, has been considered a challenge for years. There are
some studies regarding the effects of different doubler plates
thicknesses and geometric properties of PZ on its seismic behavior.
However, there is not much investigation on the effects of number of
provided continuity plates in case of presence of one triangular
haunch, two triangular haunches and rectangular haunch (T shape
haunches) for exterior columns. In this research first detailed finite
element models of 12tested connection of SAC joint venture were
created and analyzed then obtained cyclic behavior backbone curves
of these models besides other FE models for similar tests were used
for neural network training. Then seismic behavior of these data is
categorized according to continuity plate-s arrangements and
differences in type of haunches. PZ with one-sided haunches have
little plastic rotation. As the number of continuity plates increases
due to presence of two triangular haunches (four continuity plate),
there will be no plastic rotation, in other words PZ behaves in its
elastic range. In the case of rectangular haunch, PZ show more plastic
rotation in comparison with one-sided triangular haunch and
especially double-sided triangular haunches. Moreover, the models
that will be presented in case of triangular one-sided and double-
sided haunches and rectangular haunches as a result of this study
seem to have a proper estimation of PZ seismic behavior.
Abstract: Deep cold rolling (DCR) and low plasticity burnishing (LPB) process are cold working processes, which easily produce a smooth and work-hardened surface by plastic deformation of surface irregularities. The present study focuses on the surface roughness and surface hardness aspects of AISI 4140 work material, using fractional factorial design of experiments. The assessment of the surface integrity aspects on work material was done, in order to identify the predominant factors amongst the selected parameters. They were then categorized in order of significance followed by setting the levels of the factors for minimizing surface roughness and/or maximizing surface hardness. In the present work, the influence of main process parameters (force, feed rate, number of tool passes/overruns, initial roughness of the work piece, ball material, ball diameter and lubricant used) on the surface roughness and the hardness of AISI 4140 steel were studied for both LPB and DCR process and the results are compared. It was observed that by using LPB process surface hardness has been improved by 167% and in DCR process surface hardness has been improved by 442%. It was also found that the force, ball diameter, number of tool passes and initial roughness of the workpiece are the most pronounced parameters, which has a significant effect on the work piece-s surface during deep cold rolling and low plasticity burnishing process.
Abstract: Nonlinear finite element method with eight noded
isoparametric quadrilateral element is used for prediction of loaddeformation
behavior including bearing capacity of foundations.
Modified generalized plasticity model with non-associated flow rule
is applied for analysis of soil-footing system. Also Von Mises and
Tresca criterions are used for simulation of soil behavior. Modified
generalized plasticity model is able to simulate load-deformation
including softening behavior. Localization phenomena are considered
by different meshes. Localization phenomena have not been seen in
the examples. Predictions by modified generalized plasticity model
show good agreement with laboratory data and theoretical prediction
in comparison the other models.
Abstract: The present work deals with the stabilisation of
organic clay using hydrated lime. Artificial organic clays were
prepared by adding kaolin and different humic acid contents. Results
given by physical testing show that the presence of humic acid has a
drawback effect on the untreated organic clay. The decrease in
specific gravity value was accompanied by a decrease in dry density
and plasticity of clay at higher humic acid contents. Significant
increase in shear strength at 7 days of curing period is observed in the
lime-treated samples up to 5% lime content. However shear strength
of lime-treated organic clay decreases at longer curing periods. The
results given by laboratory testing is further verified by
microstructure analysis. Based on the results obtained in this study, it
can be concluded that the presence of more than 1.5% humic acid
reduces significantly the efficiency of lime stabilization in organic
clays.
Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: Creep stresses and strain rates have been obtained
for a thin rotating disc having variable density with inclusion by
using Seth-s transition theory. The density of the disc is assumed to
vary radially, i.e. ( ) 0 ¤ü ¤ü r/b m - = ; ¤ü 0 and m being real positive
constants. It has been observed that a disc, whose density increases
radially, rotates at higher angular speed, thus decreasing the
possibility of a fracture at the bore, whereas for a disc whose
density decreases radially, the possibility of a fracture at the bore
increases.
Abstract: Mammals are known to use Interaural Intensity Difference (IID) to determine azimuthal position of high frequency sounds. In the Lateral Superior Olive (LSO) neurons have firing behaviours which vary systematicaly with IID. Those neurons receive excitatory inputs from the ipsilateral ear and inhibitory inputs from the contralateral one. The IID sensitivity of a LSO neuron is thought to be due to delay differences between both ears, delays due to different synaptic delays and to intensity-dependent delays. In this paper we model the auditory pathway until the LSO. Inputs to LSO neurons are at first numerous and differ in their relative delays. Spike Timing-Dependent Plasticity is then used to prune those connections. We compare the pruned neuron responses with physiological data and analyse the relationship between IID-s of teacher stimuli and IID sensitivities of trained LSO neurons.
Abstract: Future astronomical projects on large space x-ray
imaging telescopes require novel substrates and technologies for the
construction of their reflecting mirrors. The mirrors must be
lightweight and precisely shaped to achieve large collecting area with
high angular resolution. The new materials and technologies must be
cost-effective. Currently, the most promising materials are glass or
silicon foils. We focused on precise shaping these foils by thermal
forming process. We studied free and forced slumping in the
temperature region of hot plastic deformation and compared the
shapes obtained by the different slumping processes. We measured
the shapes and the surface quality of the foils. In the experiments, we
varied both heat-treatment temperature and time following our
experiment design. The obtained data and relations we can use for
modeling and optimizing the thermal forming procedure.
Abstract: Many experimental results suggest that more precise spike timing is significant in neural information processing. We construct a self-organization model using the spatiotemporal pat-terns, where Spike-Timing Dependent Plasticity (STDP) tunes the conduction delays between neurons. We show that, for highly syn-chronized inputs, the fluctuation of conduction delays causes globally continuous and locally distributed firing patterns through the self-organization.
Abstract: With the development of the Polyvinyl chloride
(PVC) products in many applications, the challenge of investigating
the raw material composition and reducing the cost have both
become more and more important. Considerable research has been
done investigating the effect of additives on the PVC products. Most
of the PVC composites research investigates only the effect of
single/few factors, at a time. This isolated consideration of the input
factors does not take in consideration the interaction effect of the
different factors. This paper implements a mixture experimental
design approach to find out a cost-effective PVC composition for the
production of electrical-insulation cables considering the ASTM
Designation (D) 6096. The results analysis showed that a minimum
cost can be achieved through using 20% virgin PVC, 18.75%
recycled PVC, 43.75% CaCO3 with participle size 10 microns, 14%
DOP plasticizer, and 3.5% CPW plasticizer. For maximum UTS the
compound should consist of: 17.5% DOP, 62.5% virgin PVC, and
20.0% CaCO3 of particle size 5 microns. Finally, for the highest
ductility the compound should be made of 35% virgin PVC, 20%
CaCO3 of particle size 5 microns, and 45.0% DOP plasticizer.
Abstract: This work deals with the initial applications and formulation of an anisotropic plastic-damage constitutive model proposed for non-linear analysis of reinforced concrete structures submitted to a loading with change of the sign. The original constitutive model is based on the fundamental hypothesis of energy equivalence between real and continuous medium following the concepts of the Continuum Damage Mechanics. The concrete is assumed as an initial elastic isotropic medium presenting anisotropy, permanent strains and bimodularity (distinct elastic responses whether traction or compression stress states prevail) induced by damage evolution. In order to take into account the bimodularity, two damage tensors governing the rigidity in tension or compression regimes are introduced. Then, some conditions are introduced in the original version of the model in order to simulate the damage unilateral effect. The three-dimensional version of the proposed model is analyzed in order to validate its formulation when compared to micromechanical theory. The one-dimensional version of the model is applied in the analyses of a reinforced concrete beam submitted to a loading with change of the sign. Despite the parametric identification problems, the initial applications show the good performance of the model.
Abstract: Vickers indentation is used to measure the hardness
of materials. In this study, numerical simulation of Vickers
indentation experiment was performed for Diamond like Carbon
(DLC) coated materials. DLC coatings were deposited on stainless
steel 304 substrates with Chromium buffer layer using RF Magnetron
and T-shape Filtered Cathodic Vacuum Arc Dual system The
objective of this research is to understand the elastic plastic
properties, stress strain distribution, ring and lateral crack growth and
propagation, penetration depth of indenter and delamination of
coating from substrate with effect of buffer layer thickness. The
effect of Poisson-s ratio of DLC coating was also analyzed. Indenter
penetration is more in coated materials with thin buffer layer as
compared to thicker one, under same conditions. Similarly, the
specimens with thinner buffer layer failed quickly due to high
residual stress as compared to the coated materials with reasonable
thickness of 200nm buffer layer. The simulation results suggested the
optimized thickness of 200 nm among the prepared specimens for
durable and long service.
Abstract: Environmental impact assessment (EIA) is a procedure tool of environmental management for identifying, predicting, evaluating and mitigating the adverse effects of development proposals. EIA reports usually analyze how the amounts or concentrations of pollutants obey the relevant standards. Actually, many analytical tools can deepen the analysis of environmental impacts in EIA reports, such as life cycle assessment (LCA) and environmental risk assessment (ERA). Life cycle impact assessment (LCIA) is one of steps in LCA to introduce the causal relationships among environmental hazards and damage. Incorporating the LCIA concept into ERA as an integrated tool for EIA can extend the focus of the regulatory compliance of environmental impacts to determine of the significance of environmental impacts. Sometimes, when using integrated tools, it is necessary to consider fuzzy situations due to insufficient information; therefore, ERA should be generalized to fuzzy risk assessment (FRA). Finally, the use of the proposed methodology is demonstrated through the study case of the expansion plan of the world-s largest plastics processing factory.
Abstract: Transition theory has been used to derive the elasticplastic
and transitional stresses. Results obtained have been discussed
numerically and depicted graphically. It is observed that the rotating
disk made of incompressible material with inclusion require higher
angular speed to yield at the internal surface as compared to disk
made of compressible material. It is seen that the radial and
circumferential stresses are maximum at the internal surface with and
without edge load (for flat disk). With the increase in thickness
parameter (k = 2, 4), the circumferential stress is maximum at the
external surface while the radial stress is maximum at the internal
surface. From the figures drawn the disk with exponentially varying
thickness (k = 2), high angular speed is required for initial yielding at
internal surface as compared to flat disk and exponentially varying
thickness for k = 4 onwards. It is concluded that the disk made of
isotropic compressible material is on the safer side of the design as
compared to disk made of isotropic incompressible material as it
requires higher percentage increase in an angular speed to become
fully plastic from its initial yielding.
Abstract: Evaluation of contact pressure, surface and
subsurface contact stresses are essential to know the functional
response of surface coatings and the contact behavior mainly depends
on surface roughness, material property, thickness of layer and the
manner of loading. Contact parameter evaluation of real rough
surface contacts mostly relies on statistical single asperity contact
approaches. In this work, a three dimensional layered solid rough
surface in contact with a rigid flat is modeled and analyzed using
finite element method. The rough surface of layered solid is
generated by FFT approach. The generated rough surface is exported
to a finite element method based ANSYS package through which the
bottom up solid modeling is employed to create a deformable solid
model with a layered solid rough surface on top. The discretization
and contact analysis are carried by using the same ANSYS package.
The elastic, elastoplastic and plastic deformations are continuous in
the present finite element method unlike many other contact models.
The Young-s modulus to yield strength ratio of layer is varied in the
present work to observe the contact parameters effect while keeping
the surface roughness and substrate material properties as constant.
The contacting asperities attain elastic, elastoplastic and plastic states
with their continuity and asperity interaction phenomena is inherently
included. The resultant contact parameters show that neighboring
asperity interaction and the Young-s modulus to yield strength ratio
of layer influence the bulk deformation consequently affect the
interface strength.
Abstract: In-vitro mouse co-culture of E14 embryonic stem cells
(ESCs) and OP9 stromal cells can recapitulate the earliest stages of
haematopoietic development, not accessible in human embryos,
supporting both haemogenic precursors and their primitive
haematopoietic progeny. 1α, 25-Dihydroxy-vitamin D3 (VD3) has
been demonstrated to be a powerful differentiation inducer for a wide
variety of neoplastic cells, and could enhance early differentiation of
ESCs into blood cells in E14/OP9 co-culture. This study aims to
ascertain whether VD3 is key in promoting differentiation and
suppressing proliferation, by separately investigating the effects of
VD3 on the proliferation phase of the E14 cell line and on stromal
OP9 cells.The results showed that VD3 inhibited the proliferation of
the cells in a dose-dependent manner, quantitatively by decreased cell
number, and qualitatively by alkaline-phosphatase staining that
revealed significant differences between VD3-treated and untreated
cells, characterised by decreased enzyme expression (colourless
cells). Propidium-iodide cell-cycle analyses showed no significant
percentage change in VD3-treated E14 and OP9 cells within their G
and S-phases, compared to the untreated controls, despite the
increased percentage of G-phase compared to the S-phase in a dosedependent
manner. These results with E14 and OP9 cells indicate that
adequate VD3 concentration enhances cellular differentiation and
inhibits proliferation. The results also suggest that if E14 and OP9
cells were co-cultured andVD3-treated, there would be furtherenhanced
differentiation of ESCs into blood cells.
Abstract: Friction Stir Welding (FSW) is a solid state welding
process invented and patented by The Welding Institute (TWI) in the
United Kingdom in 1991 for butt and lap welding of metals and plastics. This paper highlights the benefits of friction stir welding
process as an energy efficient and a green technology process in the
field of welding. Compared to the other conventional welding processes, its benefits, typical applications and its use in joining
similar and dissimilar materials are also presented.
Abstract: Circular tubes have been widely used as structural
members in engineering application. Therefore, its collapse behavior
has been studied for many decades, focusing on its energy absorption
characteristics. In order to predict the collapse behavior of members,
one could rely on the use of finite element codes or experiments.
These tools are helpful and high accuracy but costly and require
extensive running time. Therefore, an approximating model of tubes
collapse mechanism is an alternative for early step of design. This
paper is also aimed to develop a closed-form solution of thin-walled
circular tube subjected to bending. It has extended the Elchalakani et
al.-s model (Int. J. Mech. Sci.2002; 44:1117-1143) to include the
rate of energy dissipation of rolling hinge in the circumferential
direction. The 3-D geometrical collapse mechanism was analyzed by
adding the oblique hinge lines along the longitudinal tube within the
length of plastically deforming zone. The model was based on the
principal of energy rate conservation. Therefore, the rates of internal
energy dissipation were calculated for each hinge lines which are
defined in term of velocity field. Inextensional deformation and
perfect plastic material behavior was assumed in the derivation of
deformation energy rate. The analytical result was compared with
experimental result. The experiment was conducted with a number of
tubes having various D/t ratios. Good agreement between analytical
and experiment was achieved.
Abstract: In pressure vessels contain hydrogen, the role of
hydrogen will be important because of hydrogen cracking problem. It
is difficult to predict what is happened in metallurgical field spite of a
lot of studies have been searched. The main role in controlling the
mass diffusion as driving force is related to stress. In this study, finite
element analysis is implemented to estimate material-s behavior
associated with hydrogen embrittlement. For this purpose, one model
of a pressure vessel is introduced that it has definite boundary and
initial conditions. In fact, finite element is employed to solve the
sequentially coupled mass diffusion with stress near a crack front in a
pressure vessel. Modeling simulation intergrarnular fracture of AISI
4135 steel due to hydrogen is investigated. So, distribution of
hydrogen and stress are obtained and they indicate that their
maximum amounts occur near the crack front. This phenomenon is
happened exactly the region between elastic and plastic field.
Therefore, hydrogen is highly mobile and can diffuse through crystal
lattice so that this zone is potential to trap high volume of hydrogen.
Consequently, crack growth and fast fracture will be happened.