Abstract: Purpose: The study aimed to assess the depressant or
antidepressant effects of several Nonsteroidal Anti-Inflammatory
Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2)
inhibitor meloxicam, and the non-selective COX-1 and COX-2
inhibitors lornoxicam, sodium metamizole, and ketorolac. The
current literature data regarding such effects of these agents are
scarce.
Materials and methods: The study was carried out on NMRI mice
weighing 20-35 g, kept in a standard laboratory environment. The
study was approved by the Ethics Committee of the University of
Medicine and Pharmacy „Carol Davila”, Bucharest. The study agents
were injected intraperitoneally, 10 mL/kg body weight (bw) 1 hour
before the assessment of the locomotor activity by cage testing (n=10
mice/ group) and 2 hours before the forced swimming tests (n=15).
The study agents were dissolved in normal saline (meloxicam,
sodium metamizole), ethanol 11.8% v/v in normal saline (ketorolac),
or water (lornoxicam), respectively. Negative and positive control
agents were also given (amitryptilline in the forced swimming test).
The cage floor used in the locomotor activity assessment was divided
into 20 equal 10 cm squares. The forced swimming test involved
partial immersion of the mice in cylinders (15/9cm height/diameter)
filled with water (10 cm depth at 28C), where they were left for 6
minutes. The cage endpoint used in the locomotor activity assessment
was the number of treaded squares. Four endpoints were used in the
forced swimming test (immobility latency for the entire 6 minutes,
and immobility, swimming, and climbing scores for the final 4
minutes of the swimming session), recorded by an observer that was
„blinded” to the experimental design. The statistical analysis used the
Levene test for variance homogeneity, ANOVA and post-hoc
analysis as appropriate, Tukey or Tamhane tests.
Results: No statistically significant increase or decrease in the
number of treaded squares was seen in the locomotor activity
assessment of any mice group. In the forced swimming test,
amitryptilline showed an antidepressant effect in each experiment, at
the 10 mg/kg bw dosage. Sodium metamizole was depressant at 100
mg/kg bw (increased the immobility score, p=0.049, Tamhane test),
but not in lower dosages as well (25 and 50 mg/kg bw). Ketorolac
showed an antidepressant effect at the intermediate dosage of 5
mg/kg bw, but not so in the dosages of 2.5 and 10 mg/kg bw,
respectively (increased the swimming score, p=0.012, Tamhane test).
Meloxicam and lornoxicam did not alter the forced swimming
endpoints at any dosage level.
Discussion: 1) Certain NSAIDs caused changes in the forced
swimming patterns without interfering with locomotion. 2) Sodium
metamizole showed a depressant effect, whereas ketorolac proved
antidepressant. Conclusion: NSAID-induced mood changes are not
class effects of these agents and apparently are independent of the
type of inhibited cyclooxygenase (COX-1 or COX-2).
Disclosure: This paper was co-financed from the European Social
Fund, through the Sectorial Operational Programme Human Resources Development 2007-2013, project number POSDRU /159
/1.5 /S /138907 "Excellence in scientific interdisciplinary research,
doctoral and postdoctoral, in the economic, social and medical fields
-EXCELIS", coordinator The Bucharest University of Economic
Studies.
Abstract: Verification of vented wooden façade system with
bonded joints is presented in this paper. The potential of bonded
joints is studied and described in more detail. The paper presents the results of an experimental and theoretical research about the effects of freeze cycling on the bonded joint. For the purpose of tests spruce
timber profiles were chosen for the load bearing substructure. Planks from wooden plastic composite and Siberian larch are representing facade cladding. Two types of industrial polyurethane adhesives intended for structural bonding were selected. The article is focused on the preparation as well as on the subsequent curing and conditioning of test samples. All test samples were subjected to 15 cycles that represents sudden temperature changes, i.e. immersion in a water bath at (293.15 ± 3) K for 6 hours and subsequent freezing to (253.15 ± 2) K for 18 hours. Furthermore, the retention of bond strength between substructure and cladding wastested and strength in shear was determined under tensile stress.Research data indicate that little, if any, damage to the bond results from freezingcycles. Additionally, the suitability of selected group of adhesives in combination with timber substructure was confirmed.
Abstract: This paper presents effects of distilled water, seawater
and sustained bending strains of 30% and 50% ultimate strain at
room temperature, on the durability of unidirectional pultruded
carbon fiber reinforced polymer (CFRP) plates. In this study,
dynamic mechanical analyzer (DMA) was used to investigate the
synergic effects of the immersions and bending strains on the viscoelastic
properties of (CFRP) such as storage modulus, tan delta and
glass transition temperature. The study reveals that the storage
modulus and glass transition temperature increase while tan delta
peak decreases in the initial stage of both immersions due to the
progression of curing. The storage modulus and Tg subsequently
decrease and tan delta increases due to the matrix plasticization. The
blister induced damages in the unstrained seawater samples enhance
water uptake and cause more serious degradation of Tg and storage
modulus than in water immersion. Increasing sustained bending
decreases Tg and storage modulus in a long run for both immersions
due to resin matrix cracking and debonding. The combined effects of
immersions and strains are not clearly reflected due to the statistical
effects of DMA sample sizes and competing processes of molecular
reorientation and postcuring.
Abstract: Meeting the growth in demand for digital services
such as social media, telecommunications, and business and cloud
services requires large scale data centres, which has led to an increase
in their end use energy demand. Generally, over 30% of data centre
power is consumed by the necessary cooling overhead. Thus energy
can be reduced by improving the cooling efficiency. Air and liquid
can both be used as cooling media for the data centre. Traditional
data centre cooling systems use air, however liquid is recognised as a
promising method that can handle the more densely packed data
centres. Liquid cooling can be classified into three methods; rack heat
exchanger, on-chip heat exchanger and full immersion of the
microelectronics. This study quantifies the improvements of heat
transfer specifically for the case of immersed microelectronics by
varying the CPU and heat sink location. Immersion of the server is
achieved by filling the gap between the microelectronics and a water
jacket with a dielectric liquid which convects the heat from the CPU
to the water jacket on the opposite side. Heat transfer is governed by
two physical mechanisms, which is natural convection for the fixed
enclosure filled with dielectric liquid and forced convection for the
water that is pumped through the water jacket. The model in this
study is validated with published numerical and experimental work
and shows good agreement with previous work. The results show that
the heat transfer performance and Nusselt number (Nu) is improved
by 89% by placing the CPU and heat sink on the bottom of the
microelectronics enclosure.
Abstract: Paints are the most widely used methods of protection
against atmospheric corrosion of metals. The aim of this work was to
determine the protective performance of epoxy coating against sea
water before and after damage.
Investigations are conducted using stationary and non-stationary
electrochemical tools such as electrochemical impedance
spectroscopy has allowed us to characterize the protective qualities of
these films. The application of the EIS on our damaged in-situ
painting shows the existence of several capacitive loops which is an
indicator of the failure of our tested paint. Microscopic analysis
(micrograph) helped bring essential elements in understanding the
degradation of our paint condition and immersion training corrosion
products.
Abstract: This paper outlines the basic installation and operation of magnetic inductive flow velocity sensors on large underground cooling water pipelines. Research on the effects of cathodic protection as well as into other factors that might influence the overall performance of the meter is presented in this paper. The experiments were carried out on an immersion type magnetic meter specially used for flow measurement of cooling water pipeline. An attempt has been made in this paper to outline guidelines that can ensure accurate measurement related to immersion type magnetic meters on underground pipelines.
Abstract: With a long history, dual-task has become one of the
most intriguing research fields regarding human brain functioning
and cognition. However, findings considering effects of taskinterrelations
are limited (especially, in combined motor and
cognitive tasks). Therefore, we aimed at developing a measurement
system in order to analyse interrelation effects of cognitive and motor
tasks. On the one hand, the present study demonstrates the
applicability of the measurement system and on the other hand first
results regarding a systematisation of different task combinations are
shown. Future investigations should combine imagine technologies
and this developed measurement system.
Abstract: The objective in this work is to generate and discuss the stability results of fully-immersed end-milling process with parameters; tool mass m=0.0431kg,tool natural frequency ωn = 5700 rads^-1, damping factor ξ=0.002 and workpiece cutting coefficient C=3.5x10^7 Nm^-7/4. Different no of teeth is considered for the end-milling. Both 1-DOF and 2-DOF chatter models of the system are generated on the basis of non-linear force law. Chatter stability analysis is carried out using a modified form (generalized for both 1-DOF and 2-DOF models) of recently developed method called Full-discretization. The full-immersion three tooth end-milling together with higher toothed end-milling processes has secondary Hopf bifurcation lobes (SHBL’s) that exhibit one turning (minimum) point each. Each of such SHBL is demarcated by its minimum point into two portions; (i) the Lower Spindle Speed Portion (LSSP) in which bifurcations occur in the right half portion of the unit circle centred at the origin of the complex plane and (ii) the Higher Spindle Speed Portion (HSSP) in which bifurcations occur in the left half portion of the unit circle. Comments are made regarding why bifurcation lobes should generally get bigger and more visible with increase in spindle speed and why flip bifurcation lobes (FBL’s) could be invisible in the low-speed stability chart but visible in the high-speed stability chart of the fully-immersed three-tooth miller.
Abstract: Activated carbons were produced from olive stones by a chemical process. The activated carbon (AC) were modified by nitric acid and used as adsorbents for the removal of methylene blue dye from aqueous solution. The activated carbons were characterized by nitrogen adsorption and enthalpy of immersion. Batch adsorption experiments were carried out to study the effect of initial different concentrations solution on dye adsorption properties. Isotherms were fitted to Langmuir model, and corresponding parameters were determined. The results showed that the increase of ration of ZnCl2 leads to increase in apparent surface areas and produces activated carbons with pore structure more developed. However, the maximum MB uptakes for all carbons were determined and correlated with activated carbons characteristics.
Abstract: Preparation of hydrogel based on carrageenan
extracted from Kappaphycus alvarezii was conducted with film
immersion in glutaraldehyde solution (GA 4%w/w) for 2min and
then followed by thermal curing at 110°C for 25min. The method of
carrageenan recovery strongly determines the properties of
crosslinked carrageenan. Hydrogel obtained from alkali treated
carrageenan showed higher swelling ability compared to hydrogel
from nonalkali treated carrageenan. Hydrogel from alkali treated
showed the ability of sensitive to pH media.
Abstract: Synchronous cooperative systems (SCS) bring together users that are geographically distributed and connected through a network to carry out a task. Examples of SCS include Tele- Immersion and Tele-Conferences. In SCS, the coordination is the core of the system, and it has been defined as the act of managing interdependencies between activities performed to achieve a goal. Some of the main problems that SCS present deal with the management of constraints between simultaneous activities and the execution ordering of these activities. In order to resolve these problems, orderings based on Lamport-s happened-before relation have been used, namely, causal, Δ-causal, and causal-total orderings. They mainly differ in the degree of asynchronous execution allowed. One of the most important orderings is the causal order, which establishes that the events must be seen in the cause-effect order as they occur in the system. In this paper we show that for certain SCS (e.g. videoconferences, tele-immersion) where some degradation of the system is allowed, ensuring the causal order is still rigid, which can render negative affects to the system. In this paper, we illustrate how a more relaxed ordering, which we call Fuzzy Causal Order (FCO), is useful for such kind of systems by allowing a more asynchronous execution than the causal order. The benefit of the FCO is illustrated by applying it to a particular scenario of intermedia synchronization of an audio-conference system.
Abstract: This paper examines the use of mechanical aerator for
oxidation-ditch process. The rotor, which controls the aeration, is the
main component of the aeration process. Therefore, the objective of
this study is to find out the variations in overall oxygen transfer
coefficient (KLa) and aeration efficiency (AE) for different
configurations of aerator by varying the parameters viz. speed of
aerator, depth of immersion, blade tip angles so as to yield higher
values of KLa and AE. Six different configurations of aerator were
developed and fabricated in the laboratory and were tested for abovementioned
parameters. The curved blade rotor (CBR) emerged as a
potential aerator with blade tip angle of 47°.
The mathematical models are developed for predicting the
behaviour of CBR w.r.t kLa and power. In laboratory studies, the
optimum value of KLa and AE were observed to be 10.33 h-1 and
2.269 kg O2/ kWh.
Abstract: In this research, the main aim is to investigate the
antimicrobial effectiveness of ammonyx solutions finishing on
Sweatshirt Sport with immersion method. 60 Male healthy subjects
(football player) participated in this study. They were dressed in a
Sweatshirt for 14 days and some microbes found on them were
investigated. The antimicrobial effect of different ammonyx
solutions(1/100, 1/500, 1/1000, 1/2000 v/v solutions of Ammonyx)
on the identified microbes was studied by the zone inhabitation
method in vitro. In the next step the Sweatshirt Sports were treated
with the same different solutions of ammonyx and the antimicrobial
effectiveness was assessed by colony count method in different times
and the results were compared whit untreated ones. Some mechanical
properties of treated cotton/polyester yarn that used in Sweatshirt
Sport were measured after 30 days and were compared with
untreated one. Finally after finishing, scanning electron microscopy
(SEM) was used to compare the surfaces of the finished and
unfinished specimens. The results showed the presence of five
pathogenic microbes on Sweatshirt Sports such as Escherichia coli,
Staphylococcus aureus, Aspergillus, Mucor and Candida. The
inhalation time for treated on Sweatshirt Sports improved. The
amount of colony growth on treated clothes reduced considerably
and moreover the mechanical tests results showed no significant
deterioration effect of studies properties in comparison to the
untreated yarn. The visual examination of the SEM indicated that the
antimicrobial treatments were applied usefully to fabrics.
Abstract: The evolution of silica optical fiber strength aged in cetyltrimethylammonium chloride solution (CTAC) has been investigated. If the solution containing surfactants presents appreciable changes in physical and chemical properties at the critical micelle concentration (CMC), a non negligible mechanical behavior fiber change is observed for silica fiber aged in cationic surfactants as CTAC which can lead to optical fiber reliability questioning. The purpose of this work is to study the mechanical behavior of silica coated and naked optical fibers in contact with CTAC solution at different concentrations. Result analysis proves that the immersion in CTAC drastically decreases the fiber strength and specially near the CMC point. Beyond CMC point, a small increase of fiber strength is analyzed and commented.
Abstract: A laboratory study on the influence of compactive
effort on expansive black cotton specimens treated with up to 8%
ordinary Portland cement (OPC) admixed with up to 8% bagasse ash
(BA) by dry weight of soil and compacted using the energies of the
standard Proctor (SP), West African Standard (WAS) or
“intermediate” and modified Proctor (MP) were undertaken. The
expansive black cotton soil was classified as A-7-6 (16) or CL using
the American Association of Highway and Transportation Officials
(AASHTO) and Unified Soil Classification System (USCS),
respectively. The 7day unconfined compressive strength (UCS)
values of the natural soil for SP, WAS and MP compactive efforts are
286, 401 and 515kN/m2 respectively, while peak values of 1019,
1328 and 1420kN/m2 recorded at 8% OPC/ 6% BA, 8% OPC/ 2% BA
and 6% OPC/ 4% BA treatments, respectively were less than the
UCS value of 1710kN/m2 conventionally used as criterion for
adequate cement stabilization. The soaked California bearing ratio
(CBR) values of the OPC/BA stabilized soil increased with higher
energy level from 2, 4 and 10% for the natural soil to Peak values of
55, 18 and 8% were recorded at 8% OPC/4% BA 8% OPC/2% BA
and 8% OPC/4% BA, treatments when SP, WAS and MP compactive
effort were used, respectively. The durability of specimens was
determined by immersion in water. Soils treatment at 8% OPC/ 4%
BA blend gave a value of 50% resistance to loss in strength value
which is acceptable because of the harsh test condition of 7 days
soaking period specimens were subjected instead of the 4 days
soaking period that specified a minimum resistance to loss in strength
of 80%. Finally An optimal blend of is 8% OPC/ 4% BA is
recommended for treatment of expansive black cotton soil for use as
a sub-base material.
Abstract: Simultaneous effects of temperature, immersion time, salt concentration, sucrose concentration, pressure and convective dryer temperature on the combined osmotic dehydration - convective drying of edible button mushrooms were investigated. Experiments were designed according to Central Composite Design with six factors each at five different levels. Response Surface Methodology (RSM) was used to determine the optimum processing conditions that yield maximum water loss and rehydration ratio and minimum solid gain and shrinkage in osmotic-convective drying of edible button mushrooms. Applying surfaces profiler and contour plots optimum operation conditions were found to be temperature of 39 °C, immersion time of 164 min, salt concentration of 14%, sucrose concentration of 53%, pressure of 600 mbar and drying temperature of 40 °C. At these optimum conditions, water loss, solid gain, rehydration ratio and shrinkage were found to be 63.38 (g/100 g initial sample), 3.17 (g/100 g initial sample), 2.26 and 7.15%, respectively.
Abstract: Simultaneous effects of temperature, immersion time, salt concentration, sucrose concentration, pressure and convective dryer temperature on the combined osmotic dehydration - convective drying of edible button mushrooms were investigated. Experiments were designed according to Central Composite Design with six factors each at five different levels. Response Surface Methodology (RSM) was used to determine the optimum processing conditions that yield maximum water loss and rehydration ratio and minimum solid gain and shrinkage in osmotic-convective drying of edible button mushrooms. Applying surfaces profiler and contour plots optimum operation conditions were found to be temperature of 39 °C, immersion time of 164 min, salt concentration of 14%, sucrose concentration of 53%, pressure of 600 mbar and drying temperature of 40 °C. At these optimum conditions, water loss, solid gain, rehydration ratio and shrinkage were found to be 63.38 (g/100 g initial sample), 3.17 (g/100 g initial sample), 2.26 and 7.15%, respectively.
Abstract: The Virtual Reality (VR) is becoming increasingly
important for business, education, and entertainment, therefore VR
technology have been applied for training purposes in the areas of
military, safety training and flying simulators. In particular, the
superior and high reliability VR training system is very important in
immersion. Manipulation training in immersive virtual environments
is difficult partly because users must do without the hap contact with
real objects they rely on in the real world to orient themselves and
their manipulated.
In this paper, we create a convincing questionnaire of immersion
and an experiment to assess the influence of immersion on
performance in VR training system. The Immersion Questionnaire
(IQ) included spatial immersion, Psychological immersion, and
Sensory immersion. We show that users with a training system
complete visual attention and detection of signals. Twenty subjects
were allocated to a factorial design consisting of two different VR
systems (Desktop VR and Projector VR). The results indicated that
different VR representation methods significantly affected the
participants- Immersion dimensions.
Abstract: The value of overall oxygen transfer Coefficient
(KLa), which is the best measure of oxygen transfer in water through
aeration, is obtained by a simple approach, which sufficiently
explains the utility of the method to eliminate the discrepancies due
to inaccurate assumption of saturation dissolved oxygen
concentration. The rate of oxygen transfer depends on number of
factors like intensity of turbulence, which in turns depends on the
speed of rotation, size, and number of blades, diameter and
immersion depth of the rotor, and size and shape of aeration tank, as
well as on physical, chemical, and biological characteristic of water.
An attempt is made in this paper to correlate the overall oxygen
transfer Coefficient (KLa), as an independent parameter with other
influencing parameters mentioned above. It has been estimated that
the simulation equation developed predicts the values of KLa and
power with an average standard error of estimation of 0.0164 and
7.66 respectively and with R2 values of 0.979 and 0.989 respectively,
when compared with experimentally determined values. The
comparison of this model is done with the model generated using
Computational fluid dynamics (CFD) and both the models were
found to be in good agreement with each other.
Abstract: One of the essential requirements of a realistic
surgical simulator is to reproduce haptic sensations due to the
interactions in the virtual environment. However, the interaction need
to be performed in real-time, since a delay between the user action
and the system reaction reduces the immersion sensation. In this
paper, a prototype of a coronary stent implant simulator is present;
this system allows real-time interactions with an artery by means of a
specific haptic device. To improve the realism of the simulation, the
building of the virtual environment is based on real patients- images
and a Web Portal is used to search in the geographically remote
medical centres a virtual environment with specific features in terms
of pathology or anatomy. The functional architecture of the system
defines several Medical Centres in which virtual environments built
from the real patients- images and related metadata with specific
features in terms of pathology or anatomy are stored. The searched
data are downloaded from the Medical Centre to the Training Centre
provided with a specific haptic device and with the software
necessary both to manage the interaction in the virtual environment.
After the integration of the virtual environment in the simulation
system it is possible to perform training on the specific surgical
procedure.