Abstract: Analysis of heart rate variability (HRV) has become a
popular non-invasive tool for assessing the activities of autonomic
nervous system. Most of the methods were hired from techniques
used for time series analysis. Currently used methods are time
domain, frequency domain, geometrical and fractal methods. A new
technique, which searches for pattern repeatability in a time series, is
proposed for quantifying heart rate (HR) time series. These set of
indices, which are termed as pattern repeatability measure and
pattern repeatability ratio are able to distinguish HR data clearly
from noise and electroencephalogram (EEG). The results of analysis
using these measures give an insight into the fundamental difference
between the composition of HR time series with respect to EEG and
noise.
Abstract: Functional near infrared spectroscopy (fNIRS) is a
practical non-invasive optical technique to detect characteristic of
hemoglobin density dynamics response during functional activation of
the cerebral cortex. In this paper, fNIRS measurements were made in
the area of motor cortex from C4 position according to international
10-20 system. Three subjects, aged 23 - 30 years, were participated in
the experiment.
The aim of this paper was to evaluate the effects of different motor
activation tasks of the hemoglobin density dynamics of fNIRS signal.
The chaotic concept based on deterministic dynamics is an important
feature in biological signal analysis. This paper employs the chaotic
properties which is a novel method of nonlinear analysis, to analyze
and to quantify the chaotic property in the time series of the
hemoglobin dynamics of the various motor imagery tasks of fNIRS
signal. Usually, hemoglobin density in the human brain cortex is
found to change slowly in time. An inevitable noise caused by various
factors is to be included in a signal. So, principle component analysis
method (PCA) is utilized to remove high frequency component. The
phase pace is reconstructed and evaluated the Lyapunov spectrum, and
Lyapunov dimensions. From the experimental results, it can be
conclude that the signals measured by fNIRS are chaotic.
Abstract: Several studies have been carried out, using various techniques, including neural networks, to discriminate vigilance states in humans from electroencephalographic (EEG) signals, but we are still far from results satisfactorily useable results. The work presented in this paper aims at improving this status with regards to 2 aspects. Firstly, we introduce an original procedure made of the association of two neural networks, a self organizing map (SOM) and a learning vector quantization (LVQ), that allows to automatically detect artefacted states and to separate the different levels of vigilance which is a major breakthrough in the field of vigilance. Lastly and more importantly, our study has been oriented toward real-worked situation and the resulting model can be easily implemented as a wearable device. It benefits from restricted computational and memory requirements and data access is very limited in time. Furthermore, some ongoing works demonstrate that this work should shortly results in the design and conception of a non invasive electronic wearable device.
Abstract: Laser Doppler flowmetry is a modern method of noninvasive
microcirculation investigation. The aim of our study was to
use this method in the examination of patients with secondary
lymphedema of the lower extremities and obliterating atherosclerosis
of lower extremities. In the analysis of the amplitude-frequency
spectrum of secondary lymphedema patients we have identified
remarkable changes. To describe the changes we used a special
amplitude rate. In both of patients groups this rate was significally
(p
Abstract: In this paper as showed a non-invasive 3D eye tracker
for optometry clinical applications. Measurements of biomechanical
variables in clinical practice have many font of errors associated with
traditional procedments such cover test (CT), near point of
accommodation (NPC), eye ductions (ED), eye vergences (EG) and,
eye versions (ES). Ocular motility should always be tested but all
evaluations have a subjective interpretations by practitioners, the
results is based in clinical experiences, repeatability and accuracy
don-t exist. Optometric-lab is a tool with 3 (tree) analogical video
cameras triggered and synchronized in one acquisition board AD.
The variables globe rotation angle and velocity can be quantified.
Data record frequency was performed with 27Hz, camera calibration
was performed in a know volume and image radial distortion
adjustments.
Abstract: Optical Coherence Tomography (OCT) combined
with the Confocal Microscopy, as a noninvasive method, permits the
determinations of materials defects in the ceramic layers depth. For
this study 256 anterior and posterior metal and integral ceramic fixed
partial dentures were used, made with Empress (Ivoclar), Wollceram
and CAD/CAM (Wieland) technology. For each investigate area 350
slices were obtain and a 3D reconstruction was perform from each
stuck. The Optical Coherent Tomography, as a noninvasive method,
can be used as a control technique in integral ceramic technology,
before placing those fixed partial dentures in the oral cavity. The
purpose of this study is to evaluate the capability of En face Optical
Coherence Tomography (OCT) combined with a fluorescent method
in detection and analysis of possible material defects in metalceramic
and integral ceramic fixed partial dentures. As a conclusion,
it is important to have a non invasive method to investigate fixed
partial prostheses before their insertion in the oral cavity in order to
satisfy the high stress requirements and the esthetic function.
Abstract: Brain Computer Interface (BCI) has been recently
increased in research. Functional Near Infrared Spectroscope (fNIRs)
is one the latest technologies which utilize light in the near-infrared
range to determine brain activities. Because near infrared technology
allows design of safe, portable, wearable, non-invasive and wireless
qualities monitoring systems, fNIRs monitoring of brain
hemodynamics can be value in helping to understand brain tasks. In
this paper, we present results of fNIRs signal analysis indicating that
there exist distinct patterns of hemodynamic responses which
recognize brain tasks toward developing a BCI. We applied two
different mathematics tools separately, Wavelets analysis for
preprocessing as signal filters and feature extractions and Neural
networks for cognition brain tasks as a classification module. We
also discuss and compare with other methods while our proposals
perform better with an average accuracy of 99.9% for classification.
Abstract: This paper describes a new method for extracting the fetal heart rate (fHR) and the fetal heart rate variability (fHRV) signal non-invasively using abdominal maternal electrocardiogram (mECG) recordings. The extraction is based on the fundamental frequency (Fourier-s) theorem. The fundamental frequency of the mother-s electrocardiogram signal (fo-m) is calculated directly from the abdominal signal. The heart rate of the fetus is usually higher than that of the mother; as a result, the fundamental frequency of the fetal-s electrocardiogram signal (fo-f) is higher than that of the mother-s (fo-f > fo-m). Notch filters to suppress mother-s higher harmonics were designed; then a bandpass filter to target fo-f and reject fo-m is implemented. Although the bandpass filter will pass some other frequencies (harmonics), we have shown in this study that those harmonics are actually carried on fo-f, and thus have no impact on the evaluation of the beat-to-beat changes (RR intervals). The oscillations of the time-domain extracted signal represent the RR intervals. We have also shown in this study that zero-to-zero evaluation of the periods is more accurate than the peak-to-peak evaluation. This method is evaluated both on simulated signals and on different abdominal recordings obtained at different gestational ages.
Abstract: The Principal component regression (PCR) is a
combination of principal component analysis (PCA) and multiple linear regression (MLR). The objective of this paper is to revise the
use of PCR in shortwave near infrared (SWNIR) (750-1000nm) spectral analysis. The idea of PCR was explained mathematically and
implemented in the non-destructive assessment of the soluble solid
content (SSC) of pineapple based on SWNIR spectral data. PCR achieved satisfactory results in this application with root mean
squared error of calibration (RMSEC) of 0.7611 Brix°, coefficient of determination (R2) of 0.5865 and root mean squared error of crossvalidation
(RMSECV) of 0.8323 Brix° with principal components
(PCs) of 14.
Abstract: Insulation used in transformer is mostly oil pressboard insulation. Insulation failure is one of the major causes of catastrophic failure of transformers. It is established that partial discharges (PD) cause insulation degradation and premature failure of insulation. Online monitoring of PDs can reduce the risk of catastrophic failure of transformers. There are different techniques of partial discharge measurement like, electrical, optical, acoustic, opto-acoustic and ultra high frequency (UHF). Being non invasive and non interference prone, acoustic emission technique is advantageous for online PD measurement. Acoustic detection of p.d. is based on the retrieval and analysis of mechanical or pressure signals produced by partial discharges. Partial discharges are classified according to the origin of discharges. Their effects on insulation deterioration are different for different types. This paper reports experimental results and analysis for classification of partial discharges using acoustic emission signal of laboratory simulated partial discharges in oil pressboard insulation system using three different electrode systems. Acoustic emission signal produced by PD are detected by sensors mounted on the experimental tank surface, stored on an oscilloscope and fed to computer for further analysis. The measured AE signals are analyzed using discrete wavelet transform analysis and wavelet packet analysis. Energy distribution in different frequency bands of discrete wavelet decomposed signal and wavelet packet decomposed signal is calculated. These analyses show a distinct feature useful for PD classification. Wavelet packet analysis can sort out any misclassification arising out of DWT in most cases.
Abstract: Tumor cells have an invasive and metastatic phenotype
that is the main cause of death for cancer patients. Tumor
establishment and penetration consists of a series of complex
processes involving multiple changes in gene expression. In this study,
intraperitoneal administration of a high concentration of ascorbic acid
inhibited tumor establishment and decreased tumor mass in BALB/C
mice implanted with S-180 sarcoma cancer cells. To identify proteins
involved in the ascorbic acid-mediated inhibition of tumor
progression, changes in the tumor proteome associated with ascorbic
acid treatment of BALB/C mice implanted with S-180 were
investigated using two-dimensional gel electrophoresis and mass
spectrometry. Twenty protein spots were identified whose expression
was different between control and ascorbic acid treatment groups.
Abstract: One of the major disadvantages of the minimally
invasive surgery (MIS) is the lack of tactile feedback to the surgeon.
In order to identify and avoid any damage to the grasped complex
tissue by endoscopic graspers, it is important to measure the local
softness of tissue during MIS. One way to display the measured
softness to the surgeon is a graphical method. In this paper, a new
tactile sensor has been reported. The tactile sensor consists of an
array of four softness sensors, which are integrated into the jaws of a
modified commercial endoscopic grasper. Each individual softness
sensor consists of two piezoelectric polymer Polyvinylidene Fluoride
(PVDF) films, which are positioned below a rigid and a compliant
cylinder. The compliant cylinder is fabricated using a micro molding
technique. The combination of output voltages from PVDF films is
used to determine the softness of the grasped object. The theoretical
analysis of the sensor is also presented.
A method has been developed with the aim of reproducing the
tactile softness to the surgeon by using a graphical method. In this
approach, the proposed system, including the interfacing and the data
acquisition card, receives signals from the array of softness sensors.
After the signals are processed, the tactile information is displayed
by means of a color coding method. It is shown that the degrees of
softness of the grasped objects/tissues can be visually differentiated
and displayed on a monitor.
Abstract: The dynamic speckle or biospeckle is an interference
phenomenon generated at the reflection of a coherent light by an
active surface or even by a particulate or living body surface. The
above mentioned phenomenon gave scientific support to a method
named biospeckle which has been employed to study seed viability,
biological activity, tissue senescence, tissue water content, fruit
bruising, etc. Since the above mentioned method is not invasive and
yields numerical values, it can be considered for possible automation
associated to several processes, including selection and sorting.
Based on these preliminary considerations, this research work
proposed to study the interaction of a laser beam with vegetative
samples by measuring the incident light intensity and the transmitted
light beam intensity at several vegetative slabs of varying thickness.
Tests were carried on fifteen slices of apple tissue divided into three
thickness groups, i.e., 4 mm, 5 mm, 18 mm and 22 mm. A diode laser
beam of 10mW and 632 nm wavelength and a Samsung digital
camera were employed to carry the tests. Outgoing images were
analyzed by comparing the gray gradient of a fixed image column of
each image to obtain a laser penetration scale into the tissue,
according to the slice thickness.
Abstract: This research work proposed a study of fruit bruise detection by means of a biospeckle method, selecting the papaya fruit (Carica papaya) as testing body. Papaya is recognized as a fruit of outstanding nutritional qualities, showing high vitamin A content, calcium, carbohydrates, exhibiting high popularity all over the world, considering consumption and acceptability. The commercialization of papaya faces special problems which are associated to bruise generation during harvesting, packing and transportation. Papaya is classified as climacteric fruit, permitting to be harvested before the maturation is completed. However, by one side bruise generation is partially controlled once the fruit flesh exhibits high mechanical firmness. By the other side, mechanical loads can set a future bruise at that maturation stage, when it can not be detected yet by conventional methods. Mechanical damages of fruit skin leave an entrance door to microorganisms and pathogens, which will cause severe losses of quality attributes. Traditional techniques of fruit quality inspection include total soluble solids determination, mechanical firmness tests, visual inspections, which would hardly meet required conditions for a fully automated process. However, the pertinent literature reveals a new method named biospeckle which is based on the laser reflectance and interference phenomenon. The laser biospeckle or dynamic speckle is quantified by means of the Moment of Inertia, named after its mechanical counterpart due to similarity between the defining formulae. Biospeckle techniques are able to quantify biological activities of living tissues, which has been applied to seed viability analysis, vegetable senescence and similar topics. Since the biospeckle techniques can monitor tissue physiology, it could also detect changes in the fruit caused by mechanical damages. The proposed technique holds non invasive character, being able to generate numerical results consistent with an adequate automation. The experimental tests associated to this research work included the selection of papaya fruit at different maturation stages which were submitted to artificial mechanical bruising tests. Damages were visually compared with the frequency maps yielded by the biospeckle technique. Results were considered in close agreement.
Abstract: Emotions are related with learning processes and
physiological signals can be used to detect them for the
personalization of learning resources and to control the pace of
instruction. A model of relevant emotions has been developed, where
specific combinations of emotions and cognition processes are
connected and integrated with the concept of 'flow', in order to
improve learning. The cardiac pulse is a reliable signal that carries
useful information about the subject-s emotional condition; it is
detected using a classroom chair adapted with non invasive EMFi
sensor and an acquisition system that generates a ballistocardiogram
(BCG), the signal is processed by an algorithm to obtain
characteristics that match a specific emotional condition. The
complete chair system is presented in this work, along with a
framework for the personalization of learning resources.
Abstract: Medical applications are among the most impactful
areas of microrobotics. The ultimate goal of medical microrobots is
to reach currently inaccessible areas of the human body and carry out
a host of complex operations such as minimally invasive surgery
(MIS), highly localized drug delivery, and screening for diseases at
their very early stages. Miniature, safe and efficient propulsion
systems hold the key to maturing this technology but they pose
significant challenges. A new type of propulsion developed recently,
uses multi-flagella architecture inspired by the motility mechanism of
prokaryotic microorganisms. There is a lack of efficient methods for
designing this type of propulsion system. The goal of this paper is to
overcome the lack and this way, a numerical strategy is proposed to
design multi-flagella propulsion systems. The strategy is based on the
implementation of the regularized stokeslet and rotlet theory, RFT
theory and new approach of “local corrected velocity". The effects of
shape parameters and angular velocities of each flagellum on overall
flow field and on the robot net forces and moments are considered.
Then a multi-layer perceptron artificial neural network is designed
and employed to adjust the angular velocities of the motors for
propulsion control. The proposed method applied successfully on a
sample configuration and useful demonstrative results is obtained.
Abstract: This paper presents a novel method for prediction of
the mechanical behavior of proximal femur using the general
framework of the quantitative computed tomography (QCT)-based
finite element Analysis (FEA). A systematic imaging and modeling
procedure was developed for reliable correspondence between the
QCT-based FEA and the in-vitro mechanical testing. A speciallydesigned
holding frame was used to define and maintain a unique
geometrical reference system during the analysis and testing. The
QCT images were directly converted into voxel-based 3D finite
element models for linear and nonlinear analyses. The equivalent
plastic strain and the strain energy density measures were used to
identify the critical elements and predict the failure patterns. The
samples were destructively tested using a specially-designed gripping
fixture (with five degrees of freedom) mounted within a universal
mechanical testing machine. Very good agreements were found
between the experimental and the predicted failure patterns and the
associated load levels.
Abstract: The intention of this lessons is to assess the probability
of optical coherence tomography (OCT) for biometric recognition.
The OCT is the foundation on an optical signal acquisition and
processing method and has the micrometer-resolution. In this study,
we used the porcine skin for verifying the abovementioned means. The
porcine tissue was sound acknowledged for structural and
immunohistochemical similarity with human skin, so it could be
suitable for pre-clinical trial as investigational specimen. For this
reason, it was tattooed by the tattoo machine with the tattoo-pigment.
We detected the pattern of the tattooed skin by the OCT according to
needle speed. The result was consistent with the histology images.
This result showed that the OCT was effective to examine the tattooed
skin section noninvasively. It might be available to identify
morphological changes inside the skin.
Abstract: The fixed partial dentures are mainly used in the frontal
part of the dental arch because of their great esthetics. There are
several factors that are associated with the stress state created in
ceramic restorations, including: thickness of ceramic layers,
mechanical properties of the materials, elastic modulus of the
supporting substrate material, direction, magnitude and frequency of
applied load, size and location of occlusal contact areas, residual
stresses induced by processing or pores, restoration-cement
interfacial defects and environmental defects. The purpose of this
study is to evaluate the capability of Polarization Sensitive Optical
Coherence Tomography (PSOCT) in detection and analysis of
possible material defects in metal-ceramic and integral ceramic fixed
partial dentures. As a conclusion, it is important to have a non
invasive method to investigate fixed partial prostheses before their
insertion in the oral cavity in order to satisfy the high stress
requirements and the esthetic function.
Abstract: Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low grade tumors. This study validates easier and less time-consuming techniques to evaluate the value of combined use of angiogenin and clusterin in comparison and combination with voided urine cytology in the detection of bladder cancer patients. This study includes malignant (bladder cancer patients, n= 50), benign (n=20) and healthy (n=20) groups. The studied groups were subjected to cystoscopic examination, detection of bilharzial antibodies, urine cytology, and estimation of urinary angiogenin and clusterin by ELISA. The overall sensitivity and specificity were 66% and 75% for angiogenin, 70% and 82.5% for clusterin and 46% and 80% for voided urine cytology. Combined sensitivity of angiogenin and clusterin with urine cytology increased from 82 to 88%.