Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.
Abstract: Formulation of biological profile is one of the modern roles of forensic anthropologist. The present study was conducted to estimate height using foot and shoeprint length of Malaysian population. The present work can be very useful information in the process of identification of individual in forensic cases based on shoeprint evidence. It can help to narrow down suspects and ease the police investigation. Besides, stature is important parameters in determining the partial identify of unidentified and mutilated bodies. Thus, this study can help the problem encountered in cases of mass disaster, massacre, explosions and assault cases. This is because it is very hard to identify parts of bodies in these cases where people are dismembered and become unrecognizable. Samples in this research were collected from 200 Malaysian adults (100 males and 100 females) with age ranging from 20 to 45 years old. In this research, shoeprint length were measured based on the print of the shoes made from the flat shoes. Other information like gender, foot length and height of subject were also recorded. The data was analyzed using IBM® SPSS Statistics 19 software. Results indicated that, foot length has a strong correlation with stature than shoeprint length for both sides of the feet. However, in the unknown, where the gender was undetermined have shown a better correlation in foot length and shoeprint length parameter compared to males and females analyzed separately. In addition, prediction equations are developed to estimate the stature using linear regression analysis of foot length and shoeprint length. However, foot lengths give better prediction than shoeprint length.
Abstract: The experiment was performed to study the
relationship between excreta viscosity and Nitrogen-corrected true
metabolisable energy quantities of soybean meals using conventional
addition method (CAM) in adult cockerels for 7 d: a 3-d preexperiment
and a 4-d experiment period. Results indicated that
differences between the excreta viscosity values were (P
Abstract: Previous research has demonstrated that negative
attitudes towards people with physical disabilities and obesity are
predicted by a component of perceived vulnerability to disease; germ
aversion. These findings have been suggested as illustrations of an
evolved but over-active mechanism which promotes the avoidance of
pathogen-carrying individuals. To date, this interpretation of attitude
formation has not been explored with regard to people with
intellectual disability, and no attempts have been made to examine
possible mediating factors. This study examined attitudes in 333
adults and demonstrated that the moderate positive relationship
between germ aversion and negative attitudes toward people with
intellectual disability is fully mediated by social dominance
orientation, a general preference for hierarchies and inequalities
among social groups. These findings have implications for the
design of programs which attempt to promote community acceptance
and inclusion of people with disabilities.
Abstract: Trauma in early life is widely regarded as a cause for
adult mental health problems. This study explores the role of
secondary trauma on later functioning in a sample of 359 university
students enrolled in undergraduate psychology classes in the United
States. Participants were initially divided into four groups based on
1) having directly experienced trauma (assaultive violence), 2)
having directly experienced trauma and secondary traumatization
through the unanticipated death of a close friend or family member
or witnessing of an injury or shocking even), 3) having no
experience of direct trauma but having experienced indirect trauma
(secondary trauma), or 4) reporting no exposure. Participants
completed a battery of measures on concepts associated with
psychological functioning which included measures of
psychological well-being, problem solving, coping and resiliency.
Findings discuss differences in psychological functioning and
resilience based on participants who experienced secondary
traumatization and assaultive violence versus secondary
traumatization alone.
Abstract: The burst of Web 2.0 technology and social
networking tools manifest different styles of learning and managing
knowledge among both knowledge workers and adult learners. In the
Western countries, open-learning concept has been made popular due
to the ease of use and the reach that the technology provides. In
Malaysia, there are still some gaps between the learners- acceptance
of technology and the full implementation of the technology in the
education system. There is a need to understand how adult learners,
who are knowledge workers, manage their personal knowledge via
social networking tools, especially in their learning process. Four
processes of personal knowledge management (PKM) and four
cognitive enablers are proposed supported by analysed data on adult
learners in a university. The model derived from these processes and
enablers is tested and presented, with recommendations on features to be included in adult learners- learning environment.
Abstract: The purpose of this study was to investigate the effectiveness of a recreational workout program for adults with disabilities over two semesters. This investigation was an action study conducted in a naturalistic setting. Participants included equal numbers of adults with severe cognitive impairments (n = 35) and adults without disabilities (n = 35). Adults with disabilities severe cognitive impairments were trained 6 self-initiated workout activities over two semesters by adults without disabilities. The numbers of task-analyzed steps of each activity performed correctly by each participant at the first and last weeks of each semester were used for data analysis. Results of the paired t-tests indicate that across two semesters, significant differences between the first and last weeks were found on 4 out of the 6 task-analyzed workout activities at a statistical level of significance p < .05. The recreational workout program developed in this study was effective.
Abstract: The current paper presents the findings of a research
study on learners- barriers and motivators engaged into blended
programs in a workplace context. In this study, the participants were
randomly assigned to one of four parallel e-learning courses, each of
which was delivered using a different learning strategy. Data were
collected through web-based and telephone surveys developed by the
researchers. The results showed that vague instruction, time
management, and insufficient feedback were the top-most barriers to
blended learning. The major motivators for blended learning included
content relevance, flexibility in time, and the ability to work at own
pace.
Abstract: Particulate matter (PM) in ambient air is responsible
for adverse health effects in adults and children. Relatively little is
known about the concentrations, sources and health effects of PM in
indoor air. A monitoring study was conducted in Ankara by three
campaigns in order to measure PM levels in indoor and outdoor
environments to identify and quantify associations between sources
and concentrations. Approximately 82 homes (1st campaign for 42,
2nd campaign for 12, and 3rd campaign for 28), three rooms (living
room, baby-s room and living room used as a baby-s room) and
outdoor ambient at each home were sampled with Grimm
Environmental Dust Monitoring (EDM) 107, during different
seasonal periods of 2011 and 2012. In this study, the relationship
between indoor and outdoor PM levels for particulate matter less than
10 micrometer (.m) (PM10), particulate matter less than 2.5.m
(PM2.5) and particulate matter less than 1.0.m (PM1) were
investigated. The mean concentration of PM10, PM2.5, and PM1.0 at
living room used as baby-s room is higher than living and baby-s
room (or bedroom) for three sampling campaigns. It is concluded that
the household activities and environmental conditions are very
important for PM concentrations in the indoor environments during
the sampling periods. The amount of smokers, being near a main
street and/or construction activities increased the PM concentration.
This study is based on the assessment the relationship between indoor
and outdoor PM levels and the household activities and
environmental conditions
Abstract: The Taiwan Health Literacy Scale (THLS) was developed to cope with the need of measuring heath literacy of Chinese-speaking adults in Taiwan. Although the scale was proven having good reliability and validity, it was not popularly adopted by the practitioners due to the length, and the time required completing. Based on the THLS, this research further invited healthcare professionals to review the original scale for a possible shorten work. Under the logic of THLS, the research adopted an analytic hierarchy process technique to consolidate the healthcare experts- assessments to shorten the original scale. There are fifteen items out of the original 66 items were identified having higher loadings. Confirmed by the experts and passed a pilot test with 40 undergraduate students, a short form of THLS is then introduced. This research then used 839 samples from the major cities of the Hua-lien county in the eastern part of Taiwan to test the reliability and validity of this new scale. The reliability of the scale is high and acceptable. The current scale is also highly correlated with the original, of which provide evidence for the validity of the scale.
Abstract: The neurogenic potential of many herbal extracts used
in Indian medicine is hitherto unknown. Extracts derived from
Clitoria ternatea Linn have been used in Indian Ayurvedic system of
medicine as an ingredient of “Medhya rasayana", consumed for
improving memory and longevity in humans and also in treatment of
various neurological disorders. Our earlier experimental studies with
oral intubation of Clitoria ternatea aqueous root extract (CTR) had
shown significant enhancement of learning and memory in postnatal
and young adult Wistar rats. The present study was designed to
elucidate the in vitro effects of 200ng/ml of CTR on proliferation,
differentiation and growth of anterior subventricular zone neural
stem cells (aSVZ NSC-s) derived from prenatal and postnatal rat
pups. Results show significant increase in proliferation and growth of
neurospheres and increase in the yield of differentiated neurons of
aSVZ neural precursor cells (aSVZNPC-s) at 7 days in vitro when
treated with 200ng/ml of CTR as compared to age matched control.
Results indicate that CTR has growth promoting neurogenic effect on
aSVZ neural stem cells and their survival similar to neurotrophic
factors like Survivin, Neuregulin 1, FGF-2, BDNF possibly the basis
for enhanced learning and memory.
Abstract: “Dengue" is an African word meaning “bone
breaking" because it causes severe joint and muscle pain that feels
like bones are breaking. It is an infectious disease mainly transmitted
by female mosquito, Aedes aegypti, and causes four serotypes of
dengue viruses. In recent years, a dramatic increase in the dengue
fever confirmed cases around the equator-s belt has been reported.
Several conventional indices have been designed so far to monitor the
transmitting vector populations known as House Index (HI),
Container Index (CI), Breteau Index (BI). However, none of them
describes the adult mosquito population size which is important to
direct and guide comprehensive control strategy operations since
number of infected people has a direct relationship with the vector
density. Therefore, it is crucial to know the population size of the
transmitting vector in order to design a suitable and effective control
program. In this context, a study is carried out to report a new
statistical index, ABURAS Index, using Poisson distribution based
on the collection of vector population in Jeddah Governorate, Saudi Arabia.
Abstract: 28 healthy adult Maradi bucks were used to evaluate
sperm production and sperm storage capacity in the breed. Daily
sperm production (DSP) averaged 0.55±0.05x109, while the daily
sperm production/g (DSP/g) was 1.37±0.12 x107. Gonadal sperm
reserve was 1.99±0.18 x109, while the caput, upper corpus and lower
corpus averaged 0.58±0.04 x109, 0.36±0.02 x109 and 0.33±0.08 x109
respectively. The proximal cauda, mid cauda, distal cauda and ductus
deferens had values of 0.68±0.10 x109, 1.23±0.16 x109,1.87±0.
x109and 0.17±0.05 x109 respectively. The relative contributions of
the respective epididymal sections and ductus deferens to the total
extragonadal sperm reserves were, 11.11%, 6.89%, 6.32%, 13.03%,
23.56%, 35.82% and 3.26% respectively. Gonadal sperm reserves
were significantly higher (p0.05) to
mid cauda and distal cauda epididymal reserves.
Abstract: Automatic detection of syllable repetition is one of the
important parameter in assessing the stuttered speech objectively.
The existing method which uses artificial neural network (ANN)
requires high levels of agreement as prerequisite before attempting to
train and test ANNs to separate fluent and nonfluent. We propose
automatic detection method for syllable repetition in read speech for
objective assessment of stuttered disfluencies which uses a novel
approach and has four stages comprising of segmentation, feature
extraction, score matching and decision logic. Feature extraction is
implemented using well know Mel frequency Cepstra coefficient
(MFCC). Score matching is done using Dynamic Time Warping
(DTW) between the syllables. The Decision logic is implemented by
Perceptron based on the score given by score matching. Although
many methods are available for segmentation, in this paper it is done
manually. Here the assessment by human judges on the read speech
of 10 adults who stutter are described using corresponding method
and the result was 83%.
Abstract: Portuguese diet has been gradually diverging from the basic principles of healthy eating, leading to an unbalanced dietary pattern which, associated with increasing sedentary lifestyle, has a negative impact on public health. The main objective of this work was to characterize the dietary habits of university students in Viseu, Portugal. The study consisted of a sample of 80 university students, aged between 18 and 28 years. Anthropometric data (weight (kg) and height (m)) were collected and Body Mass Index (BMI) was calculated. The dietary habits were assessed through a three-day food record and the software Medpoint was used to convert food into energy and nutrients. The results showed that students present a normal body mass index. Female university students made a higher number of daily meals than male students, and these last skipped breakfast more frequently. The values of average daily intake of energy, macronutrients and calcium were higher in males. The food pattern was characterized by a predominant consumption of meat, cereal, fats and sugar. Dietary intake of dairy products, fruits, vegetables and legumes does not meet the recommendations, revealing inadequate food habits such as hypoglycemic, hyperprotein and hyperlipidemic diet. Our findings suggest that preventive interventions should be focus in promoting healthy eating habits and physical activity in adulthood.
Abstract: Age at first marriage is a basic temporal term that is
culturally constructed for marriage relationship between an adult
male and an adult female intended to have sex, to reproduce and to
adapt to environment from one generation to another around the
world. Cross-cultural evidences suggest that age at first marriage for
both male and female not only varies across the cultures, but also
varies among the subcultures of the same society. The purpose of the
study was to compare age at first marriage for husband and wife
including age differences between them between Muslim and Santal
communities in rural Bangladesh. For this we hypothesized that (1)
there were significant differences in age at first marriage and age
interval between husband and wife between Muslim and Santal
communities in rural Bangladesh. In so doing, 288 couples (145 pairs
of couples for Muslim and 143 pairs of couples for Santal) were
selected by cluster random sampling from the Kalna village situated
in the Tanore Upazila of Rajshahi district, Bangladesh, whose
current mean age range was 36.59 years for husband and 28.85 years
for wife for the Muslim and 31.74 years for husband and 25.21 years
for wife for the Santal respectively. The results of Independent
Sample t test showed that mean age at first marriage for the Muslim
samples was 23.05 years for husbands and 15.11 years for wives,
while mean age at first marriage for the Santal samples was 20.71
years for husbands and 14.34 years for wives respectively that were
significantly different at p0.05) among the selected husbands
and wives between the two communities. This study recommends
that further cross-cultural researches should be done on the causeeffect
relationships between socio-cultural factors and age at
marriage between the two communities in Bangladesh.
Abstract: This paper presents a model for the characterization
and selection of beeswaxes for use as base substitute tissue for the
manufacture of objects suitable for external radiotherapy using
megavoltage photon beams. The model of characterization was
divided into three distinct stages: 1) verification of aspects related to
the origin of the beeswax, the bee species, the flora in the vicinity of
the beehives and procedures to detect adulterations; 2) evaluation of
physical and chemical properties; and 3) evaluation of beam
attenuation capacity. The chemical composition of the beeswax
evaluated in this study was similar to other simulators commonly
used in radiotherapy. The behavior of the mass attenuation coefficient
in the radiotherapy energy range was comparable to other simulators.
The proposed model is efficient and enables convenient assessment
of the use of any particular beeswax as a base substitute tissue for
radiotherapy.
Abstract: This case study investigates the effects of reactive
focus on form through negotiation on the linguistic development of
an adult EFL learner in an exclusive private EFL classroom. The
findings revealed that in this classroom negotiated feedback occurred
significantly more often than non-negotiated feedback. However, it
was also found that in the long run the learner was significantly more
successful in correcting his own errors when he had received nonnegotiated
feedback than negotiated feedback. This study, therefore,
argues that although negotiated feedback seems to be effective for
some learners in the short run, it is non-negotiated feedback which
seems to be more effective in the long run. This long lasting effect
might be attributed to the impact of schooling system which is itself
indicative of the dominant culture, or to the absence of other
interlocutors in the course of interaction.
Abstract: Leptospirosis occurs worldwide (except the
poles of the earth), urban and rural areas, developed and
developing countries, especially in Thailand. It can be
transmitted to the human by rats through direct and indirect
ways. Human can be infected by either touching the infected rats
or contacting with water, soil containing urine from the infected
rats through skin, eyes and nose. The data of the people who
are infected with this disease indicates that most of the
patients are adults. The transmission of this disease is studied
through mathematical model. The population is separated into human
and rat. The human is divided into two classes, namely juvenile
and adult. The model equation is constructed for each class. The
standard dynamical modeling method is then used for
analyzing the behaviours of solutions. In addition, the
conditions of the parameters for the disease free and endemic
states are obtained. Numerical solutions are shown to support the
theoretical predictions. The results of this study guide the way to
decrease the disease outbreak.
Abstract: The nanosized polymeric micelles release the drug
due to acoustic cavitation, which is enhanced in dual frequency
ultrasonic fields. In this study, adult female Balb/C mice were
transplanted with spontaneous breast adenocarcinoma tumors and
were injected with a dose of 1.3 mg/kg doxorubicin in one of three
forms: free doxorubicin, micellar doxorubicin without sonication and
micellar doxorubicin with sonication. To increase cavitation yield,
the tumor region was sonicated with low level dual frequency of 3
MHz and 28 kHz. The animals were sacrificed 24 h after injection,
and their tumor, heart, spleen, liver, kidneys and plasma were
separated and homogenized. The drug content in their tumor, heart,
spleen, liver, kidneys and plasma was determined using tissue
fluorimetry. The results show that in the group that received micellar
doxorubicin with sonication, the drug concentration in the tumor
tissue was nine and three times higher than in the free doxorubicin
group and the micellar doxorubicin without sonication group,
respectively. In the micellar doxorubicin with sonication group, the
drug concentration in other tissues was lower than other groups
(p