Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) method with fluorescent detector (FLD) was developed and optimized for Norfloxacin determination in human plasma. Mobile phase specifications, extraction method and excitation and emission wavelengths were varied for optimization. HPLC system contained a reverse phase C18 (5 μm, 4.6 mm×150 mm) column with FLD operated at excitation 330 nm and emission 440 nm. The optimized mobile phase consisted of 14% acetonitrile in buffer solution. The aqueous phase was prepared by mixing 2g of citric acid, 2g sodium acetate and 1 ml of triethylamine in 1 L of Milli-Q water was run at a flow rate of 1.2 mL/min. The standard curve was linear for the range tested (0.156–20 μg/mL) and the coefficient of determination was 0.9978. Aceclofenac sodium was used as internal standard. A detection limit of 0.078 μg/mL was achieved. Run time was set at 10 minutes because retention time of norfloxacin was 0.99 min. which shows the rapidness of this method of analysis. The present assay showed good accuracy, precision and sensitivity for Norfloxacin determination in human plasma with a new internal standard and can be applied pharmacokinetic evaluation of Norfloxacin tablets after oral administration in human.
Abstract: This paper presents a cold flow simulation study of a small gas turbine combustor performed using laboratory scale test rig. The main objective of this investigation is to obtain physical insight of the main vortex, responsible for the efficient mixing of fuel and air. Such models are necessary for predictions and optimization of real gas turbine combustors. Air swirler can control the combustor performance by assisting in the fuel-air mixing process and by producing recirculation region which can act as flame holders and influences residence time. Thus, proper selection of a swirler is needed to enhance combustor performance and to reduce NOx emissions. Three different axial air swirlers were used based on their vane angles i.e., 30°, 45°, and 60°. Three-dimensional, viscous, turbulent, isothermal flow characteristics of the combustor model operating at room temperature were simulated via Reynolds- Averaged Navier-Stokes (RANS) code. The model geometry has been created using solid model, and the meshing has been done using GAMBIT preprocessing package. Finally, the solution and analysis were carried out in a FLUENT solver. This serves to demonstrate the capability of the code for design and analysis of real combustor. The effects of swirlers and mass flow rate were examined. Details of the complex flow structure such as vortices and recirculation zones were obtained by the simulation model. The computational model predicts a major recirculation zone in the central region immediately downstream of the fuel nozzle and a second recirculation zone in the upstream corner of the combustion chamber. It is also shown that swirler angles changes have significant effects on the combustor flowfield as well as pressure losses.
Abstract: This article demonstrated development of
controlled release system of an NSAID drug, Diclofenac
sodium employing different ratios of Ethyl cellulose.
Diclofenac sodium and ethyl cellulose in different proportions
were processed by microencapsulation based on phase
separation technique to formulate microcapsules. The
prepared microcapsules were then compressed into tablets to
obtain controlled release oral formulations. In-vitro evaluation
was performed by dissolution test of each preparation was
conducted in 900 ml of phosphate buffer solution of pH 7.2
maintained at 37 ± 0.5 °C and stirred at 50 rpm. At predetermined
time intervals (0, 0.5, 1.0, 1.5, 2, 3, 4, 6, 8, 10, 12,
16, 20 and 24 hrs). The drug concentration in the collected
samples was determined by UV spectrophotometer at 276 nm.
The physical characteristics of diclofenac sodium
microcapsules were according to accepted range. These were
off-white, free flowing and spherical in shape. The release
profile of diclofenac sodium from microcapsules was found to
be directly proportional to the proportion of ethylcellulose and
coat thickness. The in-vitro release pattern showed that with
ratio of 1:1 and 1:2 (drug: polymer), the percentage release of
drug at first hour was 16.91 and 11.52 %, respectively as
compared to 1:3 which is only 6.87 % with in this time. The
release mechanism followed higuchi model for its release
pattern. Tablet Formulation (F2) of present study was found
comparable in release profile the marketed brand Phlogin-SR,
microcapsules showed an extended release beyond 24 h.
Further, a good correlation was found between drug release
and proportion of ethylcellulose in the microcapsules.
Microencapsulation based on coacervation found as good
technique to control release of diclofenac sodium for making
the controlled release formulations.
Abstract: Two geometrically nonlinear plate theories, based either on first- or third-order transverse shear deformation theory are used for finite element modeling and simulation of the transient response of smart structures incorporating piezoelectric layers. In particular the time histories of nonlinear vibrations and sensor voltage output of a thin beam with a piezoelectric patch bonded to the surface due to an applied step force are studied.
Abstract: This paper presents the comparative study of coded
data methods for finding the benefit of concealing the natural data
which is the mercantile secret. Influential parameters of the number
of replicates (rep), treatment effects (τ) and standard deviation (σ)
against the efficiency of each transformation method are investigated.
The experimental data are generated via computer simulations under
the specified condition of the process with the completely
randomized design (CRD). Three ways of data transformation consist
of Box-Cox, arcsine and logit methods. The difference values of F
statistic between coded data and natural data (Fc-Fn) and hypothesis
testing results were determined. The experimental results indicate
that the Box-Cox results are significantly different from natural data
in cases of smaller levels of replicates and seem to be improper when
the parameter of minus lambda has been assigned. On the other hand,
arcsine and logit transformations are more robust and obviously,
provide more precise numerical results. In addition, the alternate
ways to select the lambda in the power transformation are also
offered to achieve much more appropriate outcomes.
Abstract: A key element of many distribution systems is the
routing and scheduling of vehicles servicing a set of customers. A
wide variety of exact and approximate algorithms have been
proposed for solving the vehicle routing problems (VRP). Exact
algorithms can only solve relatively small problems of VRP, which is
classified as NP-Hard. Several approximate algorithms have proven
successful in finding a feasible solution not necessarily optimum.
Although different parts of the problem are stochastic in nature; yet,
limited work relevant to the application of discrete event system
simulation has addressed the problem. Presented here is optimization
using simulation of VRP; where, a simplified problem has been
developed in the ExtendSimTM simulation environment; where,
ExtendSimTM evolutionary optimizer is used to minimize the total
transportation cost of the problem. Results obtained from the model
are very satisfactory. Further complexities of the problem are
proposed for consideration in the future.
Abstract: Deoxyribonucleic Acid or DNA computing has
emerged as an interdisciplinary field that draws together chemistry,
molecular biology, computer science and mathematics. Thus, in this
paper, the possibility of DNA-based computing to solve an absolute
1-center problem by molecular manipulations is presented. This is
truly the first attempt to solve such a problem by DNA-based
computing approach. Since, part of the procedures involve with
shortest path computation, research works on DNA computing for
shortest path Traveling Salesman Problem, in short, TSP are reviewed.
These approaches are studied and only the appropriate one is adapted
in designing the computation procedures. This DNA-based
computation is designed in such a way that every path is encoded by
oligonucleotides and the path-s length is directly proportional to the
length of oligonucleotides. Using these properties, gel electrophoresis
is performed in order to separate the respective DNA molecules
according to their length. One expectation arise from this paper is that
it is possible to verify the instance absolute 1-center problem using
DNA computing by laboratory experiments.
Abstract: To help overcome limits to the density of conventional SRAMs and leakage current of SRAM cell in nanoscaled CMOS technology, we have developed a four-transistor SRAM cell. The newly developed CMOS four-transistor SRAM cell uses one word-line and one bit-line during read/write operation. This cell retains its data with leakage current and positive feedback without refresh cycle. The new cell size is 19% smaller than a conventional six-transistor cell using same design rules. Also the leakage current of new cell is 60% smaller than a conventional sixtransistor SRAM cell. Simulation result in 65nm CMOS technology shows new cell has correct operation during read/write operation and idle mode.
Abstract: International trade involves both large and small firms
engaged in business overseas. Possible drivers that force companies
to enter international markets include increasing competition at the
domestic market, maturing domestic markets, and limited domestic
market opportunities. Technology is an important driving factor in
shaping international marketing strategy as well as in driving force
towards a more global marketplace, especially technology in
communication. It includes telephones, the internet, computer
systems and e-mail. There are three main marketing strategy choices,
namely standardization approach, adaptation approach and middleof-
the-road approach that companies implement to overseas markets.
The decision depends on situations and factors facing the companies
in the international markets. In this paper, the contingency concept is
considered that no single strategy can be effective in all contexts.
The effect of strategy on performance depends on specific situational
variables. Strategic fit is employed to investigate export marketing
strategy adaptation under certain environmental conditions, which in
turn can lead to superior performance.
Abstract: The structural interpretation of a part of eastern Potwar
(Missa Keswal) has been carried out with available seismological,
seismic and well data. Seismological data contains both the source
parameters and fault plane solution (FPS) parameters and seismic data
contains ten seismic lines that were re-interpreted by using well data.
Structural interpretation depicts two broad types of fault sets namely,
thrust and back thrust faults. These faults together give rise to pop up
structures in the study area and also responsible for many structural
traps and seismicity. Seismic interpretation includes time and depth
contour maps of Chorgali Formation while seismological interpretation
includes focal mechanism solution (FMS), depth, frequency,
magnitude bar graphs and renewal of Seismotectonic map. The Focal
Mechanism Solutions (FMS) that surrounds the study area are
correlated with the different geological and structural maps of the area
for the determination of the nature of subsurface faults. Results of
structural interpretation from both seismic and seismological data
show good correlation. It is hoped that the present work will help in
better understanding of the variations in the subsurface structure and
can be a useful tool for earthquake prediction, planning of oil field and
reservoir monitoring.
Abstract: In this study, an analysis has been performed for
conjugate heat and mass transfer of a steady laminar boundary-layer
mixed convection of magnetic hydrodynamic (MHD) flow with
radiation effect of second grade subject to suction past a stretching
sheet. Parameters E Nr, Gr, Gc, Ec and Sc represent the dominance of
the viscoelastic fluid heat and mass transfer effect which have
presented in governing equations, respectively. The similar
transformation and the finite-difference method have been used to
analyze the present problem. The conjugate heat and mass transfer
results show that the non-Newtonian viscoelastic fluid has a better heat
transfer effect than the Newtonian fluid. The free convection with a
larger r G or c G has a good heat transfer effect better than a smaller
r G or c G , and the radiative convection has a good heat transfer
effect better than non-radiative convection.
Abstract: The purpose of this paper is to examine the financing
practices of SMEs in Libya in two different phases of business life
cycle: start-up and matured stages. Moreover, SMEs- accessing bank
loan issues is also identified. The study was conducted by taking into
account the aspect of demand. The findings are based on a sample of
76 SMEs in Libya through the adoption of questionnaires. The results
have pinpointed several things- evidently, SMEs use informal
financing sources which prefer personal savings; SME owners are
willing to apply for bank loan, that the most pressing problem has
been identified, not to apply bank loan is loan with interest (religion
factor).
Abstract: When the shock front (SF) hits the central electrode
axis of plasma focus device, a reflected shock wave moves radially
outwards. The current sheath (CS) results from ionization of filled
gas between two electrodes continues to compress inwards until it
hits the out-going reflected shock front. In this paper the Lagrangian
equations are solved for a parabolic shock trajectory yielding a first
and second approximation for the CS path. To determine the
accuracy of the approximation, the same problem is solved for a
straight shock.
Abstract: In this paper, we proposed an invention of an
accessory into a communication device that will help humans to be
connected universally. Generally, this device will be made up of
crystal and will combine many technologies that will enable the user
to run various applications and software anywhere and everywhere.
Bringing up the concept of from being user friendly, we had used the
crystal as the main material of the device that will trap the
surrounding lights to produce projection of its screen. This leads to a
lesser energy consumption and allows smaller sized battery to be
used, making the device less bulky. Additionally, we proposed the
usage of micro batteries as our energy source. Thus, researches
regarding crystal were made along with explanations in details of
specification and function of the technology used in the device.
Finally, we had also drawn several views of the invention from
different sides to be visualized.
Abstract: Accurate modeling of high speed RLC interconnects
has become a necessity to address signal integrity issues in current
VLSI design. To accurately model a dispersive system of interconnects
at higher frequencies; a full-wave analysis is required.
However, conventional circuit simulation of interconnects with full
wave models is extremely CPU expensive. We present an algorithm
for reducing large VLSI circuits to much smaller ones with similar
input-output behavior. A key feature of our method, called Frequency
Shift Technique, is that it is capable of reducing linear time-varying
systems. This enables it to capture frequency-translation and sampling
behavior, important in communication subsystems such as mixers,
RF components and switched-capacitor filters. Reduction is obtained
by projecting the original system described by linear differential
equations into a lower dimension. Experiments have been carried out
using Cadence Design Simulator cwhich indicates that the proposed
technique achieves more % reduction with less CPU time than the
other model order reduction techniques existing in literature. We
also present applications to RF circuit subsystems, obtaining size
reductions and evaluation speedups of orders of magnitude with
insignificant loss of accuracy.
Abstract: Headphones and earphones have many extremely small
holes or narrow slits; they use sound-absorbing or porous material (i.e.,
dampers) to suppress vibratory system resonance. The air viscosity in
these acoustic paths greatly affects the acoustic properties. Simulation
analyses such as the finite element method (FEM) therefore require
knowledge of the material properties of sound-absorbing or porous
materials, such as the characteristic impedance and propagation
constant. The transfer function method using acoustic tubes is a widely
known measuring method, but there is no literature on taking
measurements up to the audible range. To measure the acoustic
properties at high-range frequencies, the acoustic tubes that form the
measuring device need to be narrowed, and the distance between the
two microphones needs to be reduced. However, when the tubes are
narrowed, the characteristic impedance drops below the air impedance.
In this study, we considered the effect of air viscosity in an acoustical
tube, introduced a theoretical formula for this effect in the form of
complex density and complex sonic velocity, and verified the
theoretical formula. We also conducted an experiment and observed
the effect from air viscosity in the actual measurements.
Abstract: In this paper, our concern is the management of mobile transactions in the shared area among many servers, when the mobile user moves from one cell to another in online partiallyreplicated distributed mobile database environment. We defined the concept of transaction and classified the different types of transactions. Based on this analysis, we propose an algorithm that handles the disconnection due to moving among sites.
Abstract: Green home rating has emerged as an important
agenda to practice the principles of sustainability. In Malaysia, the
establishment of the 'Green Building Index ' Residential New
Construction- (GBI-RNC) has brought this agenda closer to the
stakeholders of the local green building industry. GBI-RNC focuses
on the evaluation of the environmental impacts posed by houses
rather than assessing the Triple-Bottom-Line (TBL) of Sustainability
which also include socio-economic factors. Therefore, as part of a
wider study, a survey was conducted to gather the backgrounds of
green building stakeholders in Malaysia and their responses to a
number of exploratory questions regarding the setting up of a
framework to rate green homes against the TBL. This paper reports
the findings from Section A and B from this survey and discusses
them accordingly with a conclusion that forms part of the basis for a
new generation green home rating framework specifically for use in
Malaysia.
Abstract: For a spatiotemporal database management system,
I/O cost of queries and other operations is an important performance
criterion. In order to optimize this cost, an intense research on
designing robust index structures has been done in the past decade.
With these major considerations, there are still other design issues
that deserve addressing due to their direct impact on the I/O cost.
Having said this, an efficient buffer management strategy plays a key
role on reducing redundant disk access. In this paper, we proposed an
efficient buffer strategy for a spatiotemporal database index
structure, specifically indexing objects moving over a network of
roads. The proposed strategy, namely MONPAR, is based on the data
type (i.e. spatiotemporal data) and the structure of the index
structure. For the purpose of an experimental evaluation, we set up a
simulation environment that counts the number of disk accesses
while executing a number of spatiotemporal range-queries over the
index. We reiterated simulations with query sets with different
distributions, such as uniform query distribution and skewed query
distribution. Based on the comparison of our strategy with wellknown
page-replacement techniques, like LRU-based and Prioritybased
buffers, we conclude that MONPAR behaves better than its
competitors for small and medium size buffers under all used query-distributions.
Abstract: The contribution deals with problem of take-off phase of back somersault with twisting with various numbers of twists along longitudinal body axis. The aim was to evaluate the changes in angles during transition phase from back handspring to back somersault using 3D kinematic analysis of the somersaults. We used Simi Motion System for the 3D kinematic analysis of the observed gymnastic element performed by Czech Republic female representative and 2008 Summer Olympic Games participant. The results showed that the higher the number of twists, the smaller the touchdown angle in which the gymnasts lands on the pad in the beginning of take-off phase. In back somersault with one twist (180°) the average angle is 54°, in 1080° back somersault the average angle is 45.9°. These results may help to improve technical training of sports gymnasts.