Abstract: The paper deals with communication standards for
control and production system. The authors formulate the
requirements for communication security protection. The paper is
focused on application protocols of the industrial networks and their
basic classification. The typical attacks are analysed and the safety
protection, based on requirements for specific industrial network is
suggested and defined in this paper.
Abstract: Natural gas, as one of the most important sources of
energy for many of the industrial and domestic users all over the
world, has a complex, huge supply chain which is in need of heavy
investments in all the phases of exploration, extraction, production,
transportation, storage and distribution. The main purpose of supply
chain is to meet customers’ need efficiently and with minimum cost.
In this study, with the aim of minimizing economic costs, different
levels of natural gas supply chain in the form of a multi-echelon,
multi-period fuzzy linear programming have been modeled. In this
model, different constraints including constraints on demand
satisfaction, capacity, input/output balance and presence/absence of a
path have been defined. The obtained results suggest efficiency of the
recommended model in optimal allocation and reduction of supply
chain costs.
Abstract: The purpose of this project is to carry out an analysis
and determine the profile of actual lean manufacturing processes in
the Metropolitan Area of Bucaramanga. Through the analysis of
qualitative and quantitative variables it was possible to establish how
these manufacturers develop production practices that ensure their
competitiveness and productivity in the market.
In this study, a random sample of metallurgic and wrought iron
companies was applied, following which a quantitative focus and
analysis was used to formulate a qualitative methodology for
measuring the level of lean manufacturing procedures in the industry.
A qualitative evaluation was also carried out through a multivariate
analysis using the Numerical Taxonomy System (NTSYS) program
which should allow for the determination of Lean Manufacturing
profiles.
Through the results it was possible to observe how the companies
in the sector are doing with respect to Lean Manufacturing Practices,
as well as identify the level of management that these companies
practice with respect to this topic. In addition, it was possible to
ascertain that there is no one dominant profile in the sector when it
comes to Lean Manufacturing.
It was established that the companies in the metallurgic and
wrought iron industry show low levels of Lean Manufacturing
implementation. Each one carries out diverse actions that are
insufficient to consolidate a sectoral strategy for developing a
competitive advantage which enables them to tie together a
production strategy.
Abstract: Folic acid (FA) is known to be an important
supplement to prevent neural tube defect (NTD) in pregnant women.
Similar to some commercial formulations, sodium bicarbonate
solution is used as a solvent for FA. This work uses the antisolvent
vapour precipitation (AVP), incorporating ethanol vapour as the
convective drying medium in place of air to produce branch-like
micro-structure FA particles. Interestingly, the dissolution rate of the
resultant particle is 2-3 times better than the particle produce from
conventional air drying due to the higher surface area of particles
produced. The higher dissolution rate could possibly improve the
delivery and absorption of FA in human body. This application could
potentially be extended to other commercial products, particularly in
less soluble drugs to improve its solubility.
Abstract: The purpose of the present work is to review some
data for the management challenges that the aquaculture industry in
Greece is currently facing. The results indicate that Greek
aquaculture fish farms apply Human Resources Management (HRM)
practices which can increase motivation, commitment and job
satisfaction of their personnel. In turn, these practices can increase
the productivity of the business. The Greek fish farms appear to
invest in research and technological innovation with a good record in
research activities and the generation of patents. Interestingly, the
results of the present work were carried out during the period of the
recent economic crisis in Greece. Several sectors of the Greek
economy were severely affected by the financial problems of the
Greek government and the Greek banks. Under the adverse
economical conditions created by the Greek economic crisis, even the
Greek aquaculture industry, which historically is considered as a
thriving national exporting business sector, experienced harsh
economic and market conditions. As a result of the global, European
and national economic crisis, consumption of fish dropped while
companies had to hold most of their stocked fish in order to regulated
the flow to the market and the price. This occurred at a time where
Banks in Greece had their own financial crisis – banking crisis -
which resulted in limited access to lending for the all business sectors
of the national economy including the Greek aquaculture industry. In
spite of these economic conditions, the Greek aquaculture industry,
after a series of mergers and acquisitions, has now stabilized
production and exhibits very good prospects for future growth.
Evidently, the firms had to cut salaries and on some occasions even
pay their staff in arrears. Nevertheless, the results presented in this
paper indicate that during the economic crisis, the surveyed fish
farms maintained their HRM practices, investing in their human
capital and technological input. In fact, human capital and
technological input are the ticket for future success of companies in
any business sector.
Abstract: Identification and selection of appropriate product and
manufacturing technologies are key factors for competitiveness and
market success of technology-based companies. Therefore, many
companies perform technology intelligence (TI) activities to ensure
the identification of evolving technologies at the right time.
Technology monitoring is one of the three base activities of TI,
besides scanning and scouting.
As the technological progress is accelerating, more and more
technologies are being developed. Against the background of limited
resources it is therefore necessary to focus TI activities. In this paper
we propose a concept for defining appropriate search fields for
technology monitoring. This limitation of search space leads to more
concentrated monitoring activities. The concept will be introduced
and demonstrated through an anonymized case study conducted
within an industry project at the Fraunhofer Institute for Production
Technology IPT.
The described concept provides a customized monitoring
approach, which is suitable for use in technology-oriented companies.
It is shown in this paper that the definition of search fields and search
tasks are suitable methods to define topics of interest and thus to
align monitoring activities. Current as well as planned product,
production and material technologies and existing skills, capabilities
and resources form the basis for derivation of relevant search areas.
To further improve the concept of technology monitoring the
proposed concept should be extended during future research e.g. by
the definition of relevant monitoring parameters.
Abstract: Innovations not only contribute to competitiveness of
the company but have also positive effects on revenues. On average,
product innovations account to 14 percent of companies’ sales.
Innovation management has substantially changed during the last
decade, because of growing reliance on external partners. As a
consequence, a new task for purchasing arises, as firms need to
understand which suppliers actually do have high potential
contributing to the innovativeness of the firm and which do not.
Proper organization of the purchasing function is important since
for the majority of manufacturing companies deal with substantial
material costs which pass through the purchasing function. In the past
the purchasing function was largely seen as a transaction-oriented,
clerical function but today purchasing is the intermediate with supply
chain partners contributing to innovations, be it product or process
innovations. Therefore, purchasing function has to be organized
differently to enable firm innovation potential.
However, innovations are inherently risky. There are behavioral
risk (that some partner will take advantage of the other party),
technological risk in terms of complexity of products and processes
of manufacturing and incoming materials and finally market risks,
which in fact judge the value of the innovation. These risks are
investigated in this work. Specifically, technological risks which deal
with complexity of the products, and processes will be investigated
more thoroughly. Buying components or such high edge technologies
necessities careful investigation of technical features and therefore is
usually conducted by a team of experts. Therefore it is hypothesized
that higher the technological risk, higher will be the centralization of
the purchasing function as an interface with other supply chain
members.
Main contribution of this research lies is in the fact that analysis
was performed on a large data set of 1493 companies, from 25
countries collected in the GMRG 4 survey. Most analyses of
purchasing function are done by case study analysis of innovative
firms. Therefore this study contributes with empirical evaluations that
can be generalized.
Abstract: The goal of this article is the analysis of knowledge
transfer at the regional level of the Czech Republic. We show how
goals of enterprises´ innovative activities are related to the rate of
cooperation with different actors within regional innovative systems
as well as in other world regions. The results show that the most
important partners of enterprises are their suppliers and clients in
most Czech regions. The cooperation rate of enterprises correlates
significantly mainly with enterprises´ efforts to enter new markets
and reduce labour costs per unit output. The meaning of this
cooperation decreases with the increase of partner’s distance.
Regarding the type of a cooperating partner, cooperation within an
enterprise had to do with the increase of market share and decrease of
labour costs. On the other hand, cooperation with clients had to do
with efforts to replace outdated products or processes or enter new
markets. We can pay less attention to the cooperation with
government authorities and organizations. The reasons for
marginalization of this cooperation should be submitted to further
detailed investigation.
Abstract: The systematic evaluation of manufacturing
technologies with regard to the potential for product designing
constitutes a major challenge. Until now, conventional evaluation
methods primarily consider the costs of manufacturing technologies.
Thus, the potential of manufacturing technologies for achieving
additional product design features is not completely captured. To
compensate this deficit, final evaluations of new technologies are
mainly intuitive in practice. Therefore, an additional evaluation
dimension is needed which takes the potential of manufacturing
technologies for specific realizable product designs into account. In
this paper, we present the approach of an evaluation method for
selecting manufacturing technologies with regard to their potential
for product designing. This research is done within the Fraunhofer
innovation cluster »AdaM« (Adaptive Manufacturing) which targets
the development of resource efficient and adaptive manufacturing
technology processes for complex turbomachinery components.
Abstract: Immunomodulators are substances that alter immune
system via dynamic regulation of messenger molecules. It can be
divided into immunostimulant and immunosuppressant. It can help to
increase immunity of people with a low immune system, and also can
help to normalize an overactive immune system. Aim of this study is
to investigate the effects of in vitro exposure to low and high doses of
several immunomodulators which include caffeine, kaloba and
quercetin on antigen-stimulated whole blood culture cytokine
production. Whole blood samples were taken from 5 healthy males
(age: 32 ± 12 years; weight: 75.7 ± 6.1 kg; BMI: 24.3 ± 1.5 kg/m2)
following an overnight fast with no vigorous activity during the
preceding 24 h. The whole blood was then stimulated with 50 μl of
100 x diluted Pediacel vaccine and low or high dose of
immunomodulators in the culture plate. After 20 h incubation (5%
CO2, 37°C), it was analysed using the Evidence Investigator to
determine the production of cytokines including IL-2, IL-4, IL-10,
IFN-γ, and IL-1α. Caffeine and quercetin showed a tendency towards
decrease cytokine production as the doses were increased. On the
other hand, an upward trend was evident with kaloba, where a high
dose of kaloba seemed to increase the cytokine production. In
conclusion, we found that caffeine and quercetin have potential as
immunosuppressant and kaloba as immunostimulant.
Abstract: This paper involved the performance of a hightemperature
X-Ray powder diffraction analysis (XRD) of a sample of
chemical gypsum generated in the production of titanium white; this
gypsum originates by neutralizing highly acidic water with limestone
suspension. Specifically, it was gypsum formed in the first stage of
neutralization when the resulting material contains, apart from
gypsum, a number of waste products resulting from the
decomposition of ilmenite by sulphuric acid. So it can be described as
red titanogypsum. By conducting the experiment using XRD
apparatus Bruker D8 Advance with a Cu anode (λkα=1.54184 Å)
equipped with high-temperature chamber Anton Paar HTK 16, it was
possible to identify clearly in the sample each phase transition in the
system of CaSO4·xH2O.
Abstract: Caused by shorter product life cycles and higher
product variety the importance of production ramp ups is increasing.
Even though companies are aware of that fact, up to 40% of the ramp
up projects still miss technical and economical requirements. The
success of a ramp up depends on the planning of human factors,
organizational aspects and technological solutions. Since only partly
considered in scientific literature, this paper lays its focus on the
human factor during production ramp up. There are only incoherent
methods which address the problems in this area. A systematic and
holistic method to improve the capabilities of the employees during
ramp up is missing. The Harada Method is a relatively young
approach for developing highly-skilled workers. It consists of
different worksheets which help employees to set guidelines and
reach overall objectives. This approach is going to be transferred into
a tool for ramp up management.
Abstract: OEE has been used in many industries as measure of
performance. However due to limitations of original OEE, it has been
modified by various researchers. OEE for mining application is
special version of classic equation, carries these limitation over. In
this paper it has been aimed to modify the OEE for mining
application by introducing the weights to the elements of it and
termed as Mine Production index (MPi). As a special application of
new index MPishovel has been developed by authors. This can be used
for evaluating the shovel effectiveness. Based on analysis, utilization
followed by performance and availability were ranked in this order.
To check the applicability of this index, a case study was done on
four electrical and one hydraulic shovel in a Swedish mine. The
results shows that MPishovel can evaluate production effectiveness of
shovels and can determine effectiveness values in optimistic view
compared to OEE. MPi with calculation not only give the
effectiveness but also can predict which elements should be focused
for improving the productivity.
Abstract: The majority of contemporary insulation materials
commonly used in the building industry is made from non-renewable
raw materials; furthermore, their production often brings high energy
costs. A long-term trend as far as sustainable development is
concerned has been the reduction of energy and material demands of
building material production. One of the solutions is the possibility of
using easily renewable natural raw material sources which are
considerably more ecological and their production is mostly less
energy-consuming compared to the production of normal insulations
(mineral wool, polystyrene). The paper describes the results of
research focused on the development of thermal and acoustic
insulation materials based on natural fibres intended for floor
constructions. Given the characteristic open porosity of natural fibre
materials, the hygrothermal behaviour of the developed materials was
studied. Especially the influence of relative humidity and temperature
on thermal insulation properties was observed.
Abstract: Advances technology in the field of photogrammetry
replaces analog cameras with reflection on aircraft GPS/IMU system
with a digital aerial camera. In this system, when determining the
position of the camera with the GPS, camera rotations are also
determined by the IMU systems. All around the world, digital aerial
cameras have been used for the photogrammetry applications in the
last ten years. In this way, in terms of the work done in
photogrammetry it is possible to use time effectively, costs to be
reduced to a minimum level, the opportunity to make fast and
accurate.
Geo-referencing techniques that are the cornerstone of the GPS /
INS systems, photogrammetric triangulation of images required for
balancing (interior and exterior orientation) brings flexibility to the
process. Also geo-referencing process; needed in the application of
photogrammetry targets to help to reduce the number of ground
control points. In this study, the use of direct and indirect georeferencing
techniques on the accuracy of the points was investigated
in the production of photogrammetric mapping.
Abstract: Persea declinata (Bl.) Kosterm is a member of the
Lauraceae family, widely distributed in Southeast Asia. It is from the
same genus with avocado (Persea americana Mill), which is widely
consumed as food and for medicinal purposes. In the present study,
we examined the anticancer properties of Persea declinata (Bl.)
Kosterm bark methanolic crude extract (PDM). PDM exhibited a
potent antiproliferative effect in MCF-7 human breast cancer cells,
with an IC50 value of 16.68 .g/mL after 48h of treatment. We
observed that PDM caused cell cycle arrest and subsequent apoptosis
in MCF-7 cells, as exhibited by increased population at G0/G1 phase,
higher lactate dehydrogenase (LDH) release, and DNA
fragmentation. Mechanistic studies showed that PDM caused
significant elevation in ROS production, leading to perturbation of
mitochondrial membrane potential, cell permeability, and activation
of caspases-3/7. On the other hand, real-time PCR and Western blot
analysis showed that PDM treatment increased the expression of the
proapoptotic molecule, Bax, but decreased the expression of
prosurvival proteins, Bcl-2 and Bcl-xL, in a dose-dependent manner.
These findings imply that PDM could inhibit proliferation in MCF-7
cells via cell cycle arrest and apoptosis induction, indicating its
potential as a therapeutic agent worthy of further development.
Abstract: The fundamental issues in ICT Governance (ICTG)
implementation for Malaysian Public Sector (MPS) is how ICT be
applied to support improvements in productivity, management
effectiveness and the quality of services offered to its citizens. Our
main concern is to develop and adopt a common definition and
framework to illustrate how ICTG can be used to better align ICT
with government’s operations and strategic focus. In particular, we
want to identify and categorize factors that drive a successful ICTG
process. This paper presents the results of an exploratory study to
identify, validate and refine such Critical Success Factors (CSFs) and
confirmed seven CSFs and nineteen sub-factors as influential factors
that fit MPS after further validated and refined. The Delphi method
applied in validation and refining process before being endorsed as
appropriate for MPS. The identified CSFs reflect the focus areas that
need to be considered strategically to strengthen ICT Governance
implementation and ensure business success.
Abstract: Diabetes is a growing health problem in worldwide.
Especially, the patients with Type 1 diabetes need strict glycemic
control because they have deficiency of insulin production. This
paper attempts to control blood glucose based on body mathematical
body model. The Bergman minimal mathematical model is used to
develop the nonlinear controller. A novel back-stepping based sliding
mode control (B-SMC) strategy is proposed as a solution that
guarantees practical tracking of a desired glucose concentration. In
order to show the performance of the proposed design, it is compared
with conventional linear and fuzzy controllers which have been done
in previous researches. The numerical simulation result shows the
advantages of sliding mode back stepping controller design to linear
and fuzzy controllers.
Abstract: Due to reduced stiffness, research on second
generation titanium alloys for implant applications, like the
metastable β-titanium alloy Ti-15Mo, become more and more
important in the recent years. The machinability of these alloys is
generally poor leading to problems during implant production and
comparably large production costs. Therefore, in the present study,
Ti-15Mo was alloyed with 0.8 wt.-% of the rare earth metals
lanthanum (Ti-15Mo+0.8La) and neodymium (Ti-15Mo+0.8Nd) to
improve its machinability. Their microstructure consisted of a
titanium matrix and micrometer-size particles of the rare earth metals
and two of their oxides. The particles stabilized the microstructure as
grain growth was minimized. As especially the ductility might be
affected by the precipitates, the behavior of Ti-15Mo+0.8La and Ti-
15Mo+0.8Nd was investigated during static and dynamic
deformation at elevated temperature to develop a processing route.
The resulting mechanical properties (static strength and ductility)
were similar in all investigated alloys.