Improving the Dissolution Rate of Folic Acid via the Antisolvent Vapour Precipitation
Folic acid (FA) is known to be an important
supplement to prevent neural tube defect (NTD) in pregnant women.
Similar to some commercial formulations, sodium bicarbonate
solution is used as a solvent for FA. This work uses the antisolvent
vapour precipitation (AVP), incorporating ethanol vapour as the
convective drying medium in place of air to produce branch-like
micro-structure FA particles. Interestingly, the dissolution rate of the
resultant particle is 2-3 times better than the particle produce from
conventional air drying due to the higher surface area of particles
produced. The higher dissolution rate could possibly improve the
delivery and absorption of FA in human body. This application could
potentially be extended to other commercial products, particularly in
less soluble drugs to improve its solubility.
[1] J. Fife, S. Raniga, P. N. Hider, and F. A. Frizelle, “Folic acid
supplementation and colorectal cancer risk: a meta-analysis,” Colorectal
Disease, vol. 13, no. 2, pp. 132-137, 2011.
[2] K. Kanal, J. Busch-Hallen, T. Cavalli-Sforza, B. Crape, and S. Smitasiri,
“Weekly iron-folic acid supplements to prevent anemia among
Cambodian women in three settings: Process and outcomes of social
marketing and community mobilization,” Nutrition Review, vol. 63, pp.
S126-S133, 2005.
[3] F. V. Van Oort, A. Melse-Boonstra, I. A. Brouwer, R. Clarke, C. E.
West, M. B. Katan, and P. Verhoef, “Folic acid and reduction of plasma
homocysteine concentration in older adults: a dose-response study,” The
American Journal of Clinical Nutrition, vol. 77, no. 5, pp. 1318-1323,
2003.
[4] R. Williamson, “Prevention of birth defects: Folic acid,” Biological
Research for Nursing, vol. 3, no. 1, pp. 33-38, 2001.
[5] Anonymous, “Folic acid fortification,” Nutrition Reviews, vol. 54, no.3,
pp. 94-95, 1996.
[6] H. S. Reisch, and M. A. T. Flynn, ‚Folic acid and the prevention of
neural tube defects (NTDs): Challenges and recommendations for public
health,” Canadian Journal of Public Health, vol. 93, no. 4, pp. 254-258,
2002.
[7] K. Giebe, and C. Counts, “Comparison of prenate advanceTM with other
prescription prenatal vitamins: A folic acid dissolution study,” Adv.
Therapy, vol. 17, no. 4, pp. 179-183, 2000.
[8] S. Mansouri, N. Fu, M. W. Woo, and X. D. Chen, “Uniform amorphous
lactose microspheres formed in simultaneous convective and
dehydration antisolvent precipitation under atmospheric conditions,”
Langmuir, vol. 28, no. 39, pp. 13772-13776, 2012.
[9] S. Mansouri, G. Q. Chin, T. W. Ching, M. W. Woo, N. Fu, and X. D.
Chen, “Precipitating smooth amorphous or pollen structured lactose
microparticles,” Chemical Engineering Journal, vol. 226, no. 0, pp. 312-
318, 2013.
[10] S. Mansouri, M. W. Woo, and X. D. Chen, “Making uniform whey,
lactose, and composite lactose-whey particles from the dehydration of
single droplets with antisolvent vapour,” Drying Technology, vol. 31,
no. 13-14, pp. 1570-1577, 2013.
[11] J. Sun, F. Wang, Y. Sui, Z. She, W. Zhai, C. Wang, and Y. Deng,
“Effect of particle size on solubility, dissolution rates, and oral
bioavailability: Evaluation using coenzyme Q10 as naked nanocrystals,”
International Journal of Nanomedicines, vol. 7, pp. 5733, 2012.
[12] P. Mohanachandran, P. Sindhumol, and T. Kiran, “Enhancement of
solubility and dissolution rate: An overview,” International Journal of
Comprehensive Pharmacy, vol. 4, no. 11, pp. 1-10, 2010.
[13] B. Johnson, and V. Kuna, “Water-soluble folic acid compostions,”
Google Patents US6248361 B1, 2001.
[14] J. Shaw, “Cisplatin and folic acid administered to treat breast cancer,”
Google Patents US6297245 B1, 2001.
[15] S. Qi Lin, X. D. Chen, “Improving the glass-filament method for
accurate measurement of drying kinetics of liquid droplets,” Chemical
Engineering Research and Design, vol. 80, no. 4, pp. 401-410, 2002.
[16] Y. Lin, S. R. Dueker, J. R. Follett, J. G. Fadel, A. Arjomand, P. D.
Schneider, J. W. Miller, R. Green, B. A. Buchholz, J. S. Vogel, R. D.
Phair, and A. J. Clifford, “Quantitative in vivo human folate
metabolism,” The American Journal of Clinical Nutrition, vol. 80, no. 3,
pp. 680-691, 2004.
[1] J. Fife, S. Raniga, P. N. Hider, and F. A. Frizelle, “Folic acid
supplementation and colorectal cancer risk: a meta-analysis,” Colorectal
Disease, vol. 13, no. 2, pp. 132-137, 2011.
[2] K. Kanal, J. Busch-Hallen, T. Cavalli-Sforza, B. Crape, and S. Smitasiri,
“Weekly iron-folic acid supplements to prevent anemia among
Cambodian women in three settings: Process and outcomes of social
marketing and community mobilization,” Nutrition Review, vol. 63, pp.
S126-S133, 2005.
[3] F. V. Van Oort, A. Melse-Boonstra, I. A. Brouwer, R. Clarke, C. E.
West, M. B. Katan, and P. Verhoef, “Folic acid and reduction of plasma
homocysteine concentration in older adults: a dose-response study,” The
American Journal of Clinical Nutrition, vol. 77, no. 5, pp. 1318-1323,
2003.
[4] R. Williamson, “Prevention of birth defects: Folic acid,” Biological
Research for Nursing, vol. 3, no. 1, pp. 33-38, 2001.
[5] Anonymous, “Folic acid fortification,” Nutrition Reviews, vol. 54, no.3,
pp. 94-95, 1996.
[6] H. S. Reisch, and M. A. T. Flynn, ‚Folic acid and the prevention of
neural tube defects (NTDs): Challenges and recommendations for public
health,” Canadian Journal of Public Health, vol. 93, no. 4, pp. 254-258,
2002.
[7] K. Giebe, and C. Counts, “Comparison of prenate advanceTM with other
prescription prenatal vitamins: A folic acid dissolution study,” Adv.
Therapy, vol. 17, no. 4, pp. 179-183, 2000.
[8] S. Mansouri, N. Fu, M. W. Woo, and X. D. Chen, “Uniform amorphous
lactose microspheres formed in simultaneous convective and
dehydration antisolvent precipitation under atmospheric conditions,”
Langmuir, vol. 28, no. 39, pp. 13772-13776, 2012.
[9] S. Mansouri, G. Q. Chin, T. W. Ching, M. W. Woo, N. Fu, and X. D.
Chen, “Precipitating smooth amorphous or pollen structured lactose
microparticles,” Chemical Engineering Journal, vol. 226, no. 0, pp. 312-
318, 2013.
[10] S. Mansouri, M. W. Woo, and X. D. Chen, “Making uniform whey,
lactose, and composite lactose-whey particles from the dehydration of
single droplets with antisolvent vapour,” Drying Technology, vol. 31,
no. 13-14, pp. 1570-1577, 2013.
[11] J. Sun, F. Wang, Y. Sui, Z. She, W. Zhai, C. Wang, and Y. Deng,
“Effect of particle size on solubility, dissolution rates, and oral
bioavailability: Evaluation using coenzyme Q10 as naked nanocrystals,”
International Journal of Nanomedicines, vol. 7, pp. 5733, 2012.
[12] P. Mohanachandran, P. Sindhumol, and T. Kiran, “Enhancement of
solubility and dissolution rate: An overview,” International Journal of
Comprehensive Pharmacy, vol. 4, no. 11, pp. 1-10, 2010.
[13] B. Johnson, and V. Kuna, “Water-soluble folic acid compostions,”
Google Patents US6248361 B1, 2001.
[14] J. Shaw, “Cisplatin and folic acid administered to treat breast cancer,”
Google Patents US6297245 B1, 2001.
[15] S. Qi Lin, X. D. Chen, “Improving the glass-filament method for
accurate measurement of drying kinetics of liquid droplets,” Chemical
Engineering Research and Design, vol. 80, no. 4, pp. 401-410, 2002.
[16] Y. Lin, S. R. Dueker, J. R. Follett, J. G. Fadel, A. Arjomand, P. D.
Schneider, J. W. Miller, R. Green, B. A. Buchholz, J. S. Vogel, R. D.
Phair, and A. J. Clifford, “Quantitative in vivo human folate
metabolism,” The American Journal of Clinical Nutrition, vol. 80, no. 3,
pp. 680-691, 2004.
@article{"International Journal of Chemical, Materials and Biomolecular Sciences:68356", author = "J. Y. Tan and L. C. Lum and M. G. Lee and S. Mansouri and K. Hapgood and X. D. Chen and M. W. Woo", title = "Improving the Dissolution Rate of Folic Acid via the Antisolvent Vapour Precipitation", abstract = "Folic acid (FA) is known to be an important
supplement to prevent neural tube defect (NTD) in pregnant women.
Similar to some commercial formulations, sodium bicarbonate
solution is used as a solvent for FA. This work uses the antisolvent
vapour precipitation (AVP), incorporating ethanol vapour as the
convective drying medium in place of air to produce branch-like
micro-structure FA particles. Interestingly, the dissolution rate of the
resultant particle is 2-3 times better than the particle produce from
conventional air drying due to the higher surface area of particles
produced. The higher dissolution rate could possibly improve the
delivery and absorption of FA in human body. This application could
potentially be extended to other commercial products, particularly in
less soluble drugs to improve its solubility.
", keywords = "Absorption, antisolvent vapour precipitation,
dissolution rate, folic acid.", volume = "8", number = "12", pages = "1299-4", }
