Variant Polymorphisms of GST and XRCC Genes and the Early Risk of Age Associated Disease in Kazakhstan

It is believed that DNA damaging toxic metabolites contributes to the development of different pathological conditions. To prevent harmful influence of toxic agents, cells developed number of protecting mechanisms, such as enzymatic reaction of detoxification of reactive metabolites and repair of DNA damage. The aim of the study was to examine the association between polymorphism of GSTT1/GSTM1 and XRCC1/3 genes and coronary artery disease (CAD) incidence. To examine a polymorphism of these genes in CAD susceptibility in patients and controls, PCR based genotyping assay was performed. For GST genes, frequency of GSTM1 null genotype among CAD affected group was significantly increased than in control group (P0.1). We found that neither XRCC1 Arg399Gln nor XRCC3 Thr241Met were associated with CAD risk. Obtained data suggests that GSTM1 null genotype carriers are more susceptible to CAD development.

Impact of Reflectors on Solar Energy Systems

The paper aims to show that implementing different types of reflectors in solar energy systems, will dramatically improve energy production by means of concentrating and intensifying more sunlight onto a solar cell. The Solar Intensifier unit is designed to increase efficiency and performance of a set of solar panels. The unit was fabricated and tested. The experimental results show good improvement in the performance of the solar energy system.

Investigating the Impact of Wind Speed on Active and Reactive Power Penetration to the Distribution Network

Wind power is among the most actively developing distributed generation (DG) technology. Majority of the wind power based DG technologies employ wind turbine induction generators (WTIG) instead of synchronous generators, for the technical advantages like: reduced size, increased robustness, lower cost, and increased electromechanical damping. However, dynamic changes of wind speed make the amount of active/reactive power injected/drawn to a WTIG embedded distribution network highly variable. This paper analyzes the effect of wind speed changes on the active and reactive power penetration to the wind energy embedded distribution network. Four types of wind speed changes namely; constant, linear change, gust change and random change of wind speed are considered in the analysis. The study is carried out by three-phase, non-linear, dynamic simulation of distribution system component models. Results obtained from the investigation are presented and discussed.

Seismic Analysis of a S-Curved Viaduct using Stick and Finite Element Models

Stick models are widely used in studying the behaviour of straight as well as skew bridges and viaducts subjected to earthquakes while carrying out preliminary studies. The application of such models to highly curved bridges continues to pose challenging problems. A viaduct proposed in the foothills of the Himalayas in Northern India is chosen for the study. It is having 8 simply supported spans @ 30 m c/c. It is doubly curved in horizontal plane with 20 m radius. It is inclined in vertical plane as well. The superstructure consists of a box section. Three models have been used: a conventional stick model, an improved stick model and a 3D finite element model. The improved stick model is employed by making use of body constraints in order to study its capabilities. The first 8 frequencies are about 9.71% away in the latter two models. Later the difference increases to 80% in 50th mode. The viaduct was subjected to all three components of the El Centro earthquake of May 1940. The numerical integration was carried out using the Hilber- Hughes-Taylor method as implemented in SAP2000. Axial forces and moments in the bridge piers as well as lateral displacements at the bearing levels are compared for the three models. The maximum difference in the axial forces and bending moments and displacements vary by 25% between the improved and finite element model. Whereas, the maximum difference in the axial forces, moments, and displacements in various sections vary by 35% between the improved stick model and equivalent straight stick model. The difference for torsional moment was as high as 75%. It is concluded that the stick model with body constraints to model the bearings and expansion joints is not desirable in very sharp S curved viaducts even for preliminary analysis. This model can be used only to determine first 10 frequency and mode shapes but not for member forces. A 3D finite element analysis must be carried out for meaningful results.

CFD of Oscillating Airfoil Pitch Cycle by using PISO Algorithm

This research paper presents the CFD analysis of oscillating airfoil during pitch cycle. Unsteady subsonic flow is simulated for pitching airfoil at Mach number 0.283 and Reynolds number 3.45 millions. Turbulent effects are also considered for this study by using K-ω SST turbulent model. Two-dimensional unsteady compressible Navier-Stokes code including two-equation turbulence model and PISO pressure velocity coupling is used. Pressure based implicit solver with first order implicit unsteady formulation is used. The simulated pitch cycle results are compared with the available experimental data. The results have a good agreement with the experimental data. Aerodynamic characteristics during pitch cycles have been studied and validated.

The Usage of Social Networks in Educational Context

Possible advantages of technology in educational context required the defining boundaries of formal and informal learning. Increasing opportunity to ubiquitous learning by technological support has revealed a question of how to discover the potential of individuals in the spontaneous environments such as social networks. This seems to be related with the question of what purposes in social networks have been being used? Social networks provide various advantages in educational context as collaboration, knowledge sharing, common interests, active participation and reflective thinking. As a consequence of these, the purpose of this study is composed of proposing a new model that could determine factors which effect adoption of social network applications for usage in educational context. While developing a model proposal, the existing adoption and diffusion models have been reviewed and they are thought to be suitable on handling an original perspective instead of using completely other diffusion or acceptance models because of different natures of education from other organizations. In the proposed model; social factors, perceived ease of use, perceived usefulness and innovativeness are determined four direct constructs that effect adoption process. Facilitating conditions, image, subjective norms and community identity are incorporated to model as antecedents of these direct four constructs.

Design and Research of a New Kind Balance Adjusting System of Centrifuge

In order to make environmental test centrifuge balance automatically and accurately, reduce unbalance centrifugal force, balance adjusting system of centrifuge is designed. The new balance adjusting system comprises motor-reducer, timing belt, screw pair, slider-guideway and four rocker force sensors. According to information obtained by the four rocker force sensors, unbalanced value at both ends of the big arm is computed and heavy block is moved to achieve balance adjusting. In this paper, motor power and torque to move the heavy block is calculated. In full load running progress of centrifuge, the stress-strain of screw pair composed by adjusting nut and big arm are analyzed. A successful application of the balance adjusting system is also put forwarded. The results show that the balance adjusting system can satisfy balance require of environmental test centrifuge.

Heritability Estimates of Lactation Traits in Maltese Goat

Data on 657 lactation from 163 Maltese goat, collected over a 5-year period were analyzed by a mixed model to estimate the variance components for heritability. The considered lactation traits were: milk yield (MY) and lactation length (LL). Year, parity and type of birth (single or twin) were significant sources of variation for lactation length; on the other hand milk yield was significantly influenced only by the year. The average MY was 352.34 kg and the average LL was 230 days. Estimates of heritability were 0.21 and 0.15 for MY and LL respectively. These values suggest there is low correlation between genotype and phenotype so it may be difficult to evaluate animals directly on phenotype. So, the genetic improvement of this breed may be quite slow without the support of progeny test aimed to select Maltese breeders.

Retail Inventory Management for Perishable Products with Two Bins Strategy

Perishable goods constitute a large portion of retailer inventory and lose value with time due to deterioration and/or obsolescence. Retailers dealing with such goods required considering the factors of short shelf life and the dependency of sales on inventory displayed in determining optimal procurement policy. Many retailers follow the practice of using two bins - primary bin sales fresh items at a list price and secondary bin sales unsold items at a discount price transferred from primary bin on attaining certain age. In this paper, mathematical models are developed for primary bin and for secondary bin that maximizes profit with decision variables of order quantities, optimal review period and optimal selling price at secondary bin. The demand rates in two bins are assumed to be deterministic and dependent on displayed inventory level, price and age but independent of each other. The validity of the model is shown by solving an example and the sensitivity analysis of the model is also reported.

Microstructural and In-Vitro Characterization of Glass-Reinforced Hydroxyapatite Composites

Commercial hydroxyapatite (HA) was reinforced by adding 2, 5, and 10 wt % of 28.5%CaO-28.5%P2O5-38%Na2 O- 5%CaF2 based glass and then sintered. Although HA shows good biocompatibility with the human body, its applications are limited to non load-bearing areas and coatings due to its poor mechanical properties. These mechanical properties can be improved substantially with addition of glass ceramics by sintering. In this study, the effects of sintering hydroxyapatite with above specified phosphate glass additions are quantified. Each composition was sintered over a range of temperatures. Scanning electron microscopy and x-ray diffraction were used to characterize the microstructure and phases of the composites. The density, microhardness, and compressive strength were measured using Archimedes Principle, Vickers Microhardness Tester (at 0.98 N), and Instron Universal Testing Machine (cross speed of 0.5 mm/min) respectively. These results were used to indicate which composition provided suitable material for use in hard tissue replacement. Composites containing 10 wt % glass additions formed dense HA/TCP (tricalcium phosphate) composite materials possessing good compressive strength and hardness than HA. In-vitro bioactivity was assessed by evaluating changes in pH and Ca2+ ion concentration of SBF-simulated body fluid on immersion of these composites in it for two weeks.

Challenges Facing Housing Developers to Deliver Zero Carbon Homes in England

Housebuilders in England have been the target of numerous government policies in recent years promoting increased productivity and affordability. As a result, the housebuilding industry is currently faced with objectives to improve the affordability and sustainability of new homes whilst also increasing production rates to 240,000 per year by 2016.Yet amidst a faltering economic climate, the UK Government is forging ahead with the 'Code for Sustainable Homes', which includes stringent sustainable standards for all new homes and sets ambitious targets for the housebuilding industry, the culmination of which is the production of zero carbon homes by 2016.Great uncertainty exists amongst housebuilders as to the costs, benefits and risks of building zero carbon homes. This paper examines the key barriers to zero carbon homes from housebuilders- perspective. A comprehensive opinion on the challenges to deliver zero carbon homes is gathered through a questionnaire survey issued to the major housing developers in England. The study found that a number of cultural, legislative, and financial barriers stand in the way of the widespread construction of zero carbon homes. The study concludes with several recommendations to both the Government and the housebuilding industry to address the barriers that hinder a successful delivery of zero carbon homes in England.

A New Vector Quantization Front-End Process for Discrete HMM Speech Recognition System

The paper presents a complete discrete statistical framework, based on a novel vector quantization (VQ) front-end process. This new VQ approach performs an optimal distribution of VQ codebook components on HMM states. This technique that we named the distributed vector quantization (DVQ) of hidden Markov models, succeeds in unifying acoustic micro-structure and phonetic macro-structure, when the estimation of HMM parameters is performed. The DVQ technique is implemented through two variants. The first variant uses the K-means algorithm (K-means- DVQ) to optimize the VQ, while the second variant exploits the benefits of the classification behavior of neural networks (NN-DVQ) for the same purpose. The proposed variants are compared with the HMM-based baseline system by experiments of specific Arabic consonants recognition. The results show that the distributed vector quantization technique increase the performance of the discrete HMM system.

A Planning Model for Evacuation in Building

Previous studies mass evacuation route network does not fully reflect the step-by-step behavior and evacuees make routing decisions. Therefore, they do not work as expected when applied to the evacuation route planning is valid. This article describes where evacuees may have to make a direction to select all areas were identified as guiding points to improve evacuation routes network. This improved route network can be used as a basis for the layout can be used to guide the signs indicate that provides the required evacuation direction. This article also describes that combines simulation and artificial bee colony algorithm to provide the proposed routing solutions, to plan an integrated routing mode. The improved network and the model used is the cinema as a case study to assess the floor. The effectiveness of guidance solution in the total evacuation time is significant by verification.

A Neural Network Based Facial Expression Analysis using Gabor Wavelets

Facial expression analysis is rapidly becoming an area of intense interest in computer science and human-computer interaction design communities. The most expressive way humans display emotions is through facial expressions. In this paper we present a method to analyze facial expression from images by applying Gabor wavelet transform (GWT) and Discrete Cosine Transform (DCT) on face images. Radial Basis Function (RBF) Network is used to classify the facial expressions. As a second stage, the images are preprocessed to enhance the edge details and non uniform down sampling is done to reduce the computational complexity and processing time. Our method reliably works even with faces, which carry heavy expressions.

Analysis of Testing and Operational Software Reliability in SRGM based on NHPP

Software Reliability is one of the key factors in the software development process. Software Reliability is estimated using reliability models based on Non Homogenous Poisson Process. In most of the literature the Software Reliability is predicted only in testing phase. So it leads to wrong decision-making concept. In this paper, two Software Reliability concepts, testing and operational phase are studied in detail. Using S-Shaped Software Reliability Growth Model (SRGM) and Exponential SRGM, the testing and operational reliability values are obtained. Finally two reliability values are compared and optimal release time is investigated.

The Role of the Shamanistic Music in the Kazakh Folk Culture

The relics of traditional folk culture in Kazakhstan are ceremonies or their fragments - such as weddings, funerals, shamanism. The world of spiritual creatures, spirits-protectors, spirits-helpers, injury spirits, spirits of illnesses, etc., is described in detail in shamanic rites (in Kazakh culture it is called bakslyk). The study of these displays of folk culture, which reflect the peoples` ethnic mentality or notions about the structure, values and hierarchies of the universe, includes collection and recording of the field materials and their interpretation, i.e. reconstruction of those meanings which were initially embodied or “coded" in folklore. A distinctive feature of Kazakh nomadic culture is its self-preservation and actualization, almost untouched the ancient mythologies of the world, in particular, the mythologies connected with music, musical instruments and the creator of music. Within the frameworks of the traditional culture the word and the music keep the sacral meaning. The ritual melodies and what they carry – the holly, and at the same time unexplored, powerful and threatening, uncontrolled by people world – keep on attributing the soul to all, connected with culture.

The Evolution of Quality Improvement Methodology in Malaysia-s IT Industry: The Past, Current and Future

There are various approaches to implement quality improvements. Organizations aim for a management standard which is capable of providing customers with quality assurance on their product/service via continuous process improvement. Carefully planned steps are necessary to ensure the right quality improvement methodology (QIM) and business operations are consistent, reliable and truly meet the customers' needs. This paper traces the evolution of QIM in Malaysia-s Information Technology (IT) industry in the past, current and future; and highlights some of the thought of researchers who contributed to the science and practice of quality, and identifies leading methodologies in use today. Some of the misconceptions and mistakes leading to quality system failures will also be examined and discussed. This paper aims to provide a general overview of different types of QIMs available for IT businesses in maximizing business advantages, enhancing product quality, improving process routines and increasing performance earnings.

Analysis of Foaming Flow Instabilities for Dynamic Liquid Saturation in Trickle Bed Reactor

The effects of different parameters on the hydrodynamics of trickle bed reactors were discussed for Newtonian and non-Newtonian foaming systems. The varying parameters are varying liquid velocities, gas flow velocities and surface tension. The range for gas velocity is particularly large, thanks to the use of dense gas to simulate very high pressure conditions. This data bank has been used to compare the prediction accuracy of the different trendlines and transition points from the literature. More than 240 experimental points for the trickle flow (GCF) and foaming pulsing flow (PF/FPF) regime were obtained for present study. Hydrodynamic characteristics involving dynamic liquid saturation significantly influenced by gas and liquid flow rates. For 15 and 30 ppm air-aqueous surfactant solutions, dynamic liquid saturation decreases with higher liquid and gas flow rates considerably in high interaction regime. With decrease in surface tension i.e. for 45 and 60 ppm air-aqueous surfactant systems, effect was more pronounced with decreases dynamic liquid saturation very sharply during regime transition significantly at both low liquid and gas flow rates.

Green Lean TQM Human Resource Management Practices in Malaysian Automotive Companies

Green Lean Total Quality Management (LTQM) Human Resource Management (HRM) System is a system comprises of HRM in Environmental Management System (EMS) practices which is integrated to TQM with Lean Manufacturing (LM) principles. HRM is essential especially in dealing with low motivation and less productive employees. The ultimate goal of this system is to focus on achieving total human resource development that is motivated and capable to optimize their creativity to be a part of Green and Lean TQM organization. A survey questionnaire was developed and distributed to 30 highly active automotive vendors in Malaysia and analyzed by Minitab v16 and SPSS v17. It was found out companies that are practicing Green LTQM HRM practices have generated more revenue and have RND capability. However, years of company establishment do not affect the openness of the company to adapt new initiatives that can help to improve the effectiveness of the operations. It was also found out the importance of training, communication and rewards for employees. The Green LTQM HRM practices framework model established in this study hopefully will give preliminary insight especially to companies that are still looking for system that can improve their productivity from managing human resource. This is preliminary study that combined 4 awards practices, ISO/TS16949, Toyota Production System SAEJ4000, MAJAICO Lean Production System and EMS focusing on highly active companies that have been involved in MAJAICO Program and Proton Vendor Development Program. Future study can be conducted to know the status at other industry as well as case study pertaining to this system.

The Radial Pulse Wave and Blood Viscosity

The aim of this study was to investigate the effect of blood viscosity on the radial pulse wave. For this, we obtained the radial pulse wave of 15 males with abnormal high hematocrit level and 47 males with normal hematocrit level at the age of thirties and forties. Various variables of the radial pulse wave between two groups were analyzed and compared by Student's T test. There are significant differences in several variables about height, time and area of the pulse wave. The first peak of the radial pulse wave was higher in abnormal high hematocrit group, but the third peak was higher and longer in normal hematocrit group. Our results suggest that the radial pulse wave can be used for diagnosis of high blood viscosity and more clinical application.