Abstract: Hyperglycaemia is a key factor that contributes to the
development of diabetes-related microvascular disease and a major
risk factor for endothelial dysfunction. In the current study, we have
explored glucose-induced abnormal intracellular calcium (Ca2+
i)
homeostasis in mouse microvessel endothelial cells (MMECs) in
high glucose (HG) (40mmol/L) versus control (low glucose, LG) (11
mmol/L). We demonstrated that the exposure of MMECs to HG for 3
days did not change basal Ca2+
i, however, there was a significant
increase of acetylcholine-induced Ca2+ entry. Western blots
illustrated that exposure to HG also increased STIM1 (Stromal
Interaction Molecule 1), but not Orai1 (the pore forming subunit),
protein expression levels. Although the link between HG-induced
changes in STIM1 expression, enhanced Ca2+ entry and endothelial
dysfunction requires further study, the current data are suggestive
that targeting these pathways may reduce the impact of HG on
endothelial function.
Abstract: IEEE 802.15.4a impulse radio-time hopping ultra wide
band (IR-TH UWB) physical layer, due to small duty cycle and very
short pulse widths is robust against multipath propagation. However,
scattering and reflections with the large number of obstacles in indoor
channel environments, give rise to dense multipath fading. It imposes
serious problem to optimum Rake receiver architectures, for which
very large number of fingers are needed. Presence of strong noise
also affects the reception of fine pulses having extremely low power
spectral density. A robust SRake receiver for IEEE 802.15.4a IRTH
UWB in dense multipath and additive white Gaussian noise
(AWGN) is proposed to efficiently recover the weak signals with
much reduced complexity. It adaptively increases the signal to noise
(SNR) by decreasing noise through a recursive least square (RLS)
algorithm. For simulation, dense multipath environment of IEEE
802.15.4a industrial non line of sight (NLOS) is employed. The power
delay profile (PDF) and the cumulative distribution function (CDF)
for the respective channel environment are found. Moreover, the error
performance of the proposed architecture is evaluated in comparison
with conventional SRake and AWGN correlation receivers. The
simulation results indicate a substantial performance improvement
with very less number of Rake fingers.
Abstract: This paper examines the modeling and analysis of a
cruise control system using a Petri net based approach, task graphs,
invariant analysis and behavioral properties. It shows how the
structures used can be verified and optimized.
Abstract: In the last few years, the Semantic Web gained scientific acceptance as a means of relationships identification in knowledge base, widely known by semantic association. Query about complex relationships between entities is a strong requirement for many applications in analytical domains. In bioinformatics for example, it is critical to extract exchanges between proteins. Currently, the widely known result of such queries is to provide paths between connected entities from data graph. However, they do not always give good results while facing the user need by the best association or a set of limited best association, because they only consider all existing paths but ignore the path evaluation. In this paper, we present an approach for supporting association discovery queries. Our proposal includes (i) a query language PmSPRQL which provides a multiparadigm query expressions for association extraction and (ii) some quantification measures making easy the process of association ranking. The originality of our proposal is demonstrated by a performance evaluation of our approach on real world datasets.
Abstract: This paper describes Clinical Document Architecture Release Two (CDA R2) standard and a client application for messaging with SAĞLIK-NET project developed by The Ministry of Health of Turkey. CDA R2 , developed by Health Level 7 (HL7) organization and approved by American National Standards Institute (ANSI) in 2004, to standardize medical information to be able to share semantically and syntactically. In this study, a client application compatible with HL7 V3 for a project named SAĞLIKNET, aimed to build a National Health Information System by Turkey. Moreover, CDA conformance of this application will also be evaluated.
Abstract: Tandem mass spectrometry (MS/MS) is the engine
driving high-throughput protein identification. Protein mixtures possibly
representing thousands of proteins from multiple species are
treated with proteolytic enzymes, cutting the proteins into smaller
peptides that are then analyzed generating MS/MS spectra. The
task of determining the identity of the peptide from its spectrum
is currently the weak point in the process. Current approaches to de
novo sequencing are able to compute candidate peptides efficiently.
The problem lies in the limitations of current scoring functions. In this
paper we introduce the concept of proteome signature. By examining
proteins and compiling proteome signatures (amino acid usage) it is
possible to characterize likely combinations of amino acids and better
distinguish between candidate peptides. Our results strongly support
the hypothesis that a scoring function that considers amino acid usage
patterns is better able to distinguish between candidate peptides. This
in turn leads to higher accuracy in peptide prediction.
Abstract: This research presents a system for post processing of
data that takes mined flat rules as input and discovers crisp as well as
fuzzy hierarchical structures using Learning Classifier System
approach. Learning Classifier System (LCS) is basically a machine
learning technique that combines evolutionary computing,
reinforcement learning, supervised or unsupervised learning and
heuristics to produce adaptive systems. A LCS learns by interacting
with an environment from which it receives feedback in the form of
numerical reward. Learning is achieved by trying to maximize the
amount of reward received. Crisp description for a concept usually
cannot represent human knowledge completely and practically. In the
proposed Learning Classifier System initial population is constructed
as a random collection of HPR–trees (related production rules) and
crisp / fuzzy hierarchies are evolved. A fuzzy subsumption relation is
suggested for the proposed system and based on Subsumption Matrix
(SM), a suitable fitness function is proposed. Suitable genetic
operators are proposed for the chosen chromosome representation
method. For implementing reinforcement a suitable reward and
punishment scheme is also proposed. Experimental results are
presented to demonstrate the performance of the proposed system.
Abstract: Bootstrapping has gained popularity in different tests of hypotheses as an alternative in using asymptotic distribution if one is not sure of the distribution of the test statistic under a null hypothesis. This method, in general, has two variants – the parametric and the nonparametric approaches. However, issues on reliability of this method always arise in many applications. This paper addresses the issue on reliability by establishing a reliability measure in terms of quantiles with respect to asymptotic distribution, when this is approximately correct. The test of hypotheses used is Ftest. The simulated results show that using nonparametric bootstrapping in F-test gives better reliability than parametric bootstrapping with relatively higher degrees of freedom.
Abstract: The aim of this paper is to determine Frenet-Serret invariants of non-null curves in Lorentzian 5-space. First, we define a vector product of four vectors, by this way, we present a method to calculate Frenet-Serret invariants of the non-null curves. Additionally, an algebraic example of presented method is illustrated.
Abstract: The counter flow solar air heaters, with four
transverse fins and wire mesh layers are constructed and investigated
experimentally for thermal efficiency at a geographic location of
Cyprus in the city of Famagusta. The absorber plate is replaced by
sixteen steel wire mesh layers, 0.18 x 0.18cm in cross section
opening and a 0.02cm in diameter. The wire mesh layers arranged in
three groups, first and second include 6 layers, while the third include
4 layers. All layers fixed in the duct parallel to the glazing and each
group separated from the others by wood frame thickness of 0.5cm to
reduce the pressure drop. The transverse fins arranged in a way to
force the air to flow through the bed like eight letter path with flow
depth 3cm. The proposed design has increased the heat transfer rate,
but on other hand causes a high pressure drop. The obtained results
show that, for air mass flow rate range between 0.011-0.036kg/s, the
thermal efficiency increases with increasing the air mass flow. The
maximum efficiency obtained is 65.6% for the mass flow rate of
0.036kg/s. Moreover, the temperature difference between the outlet
flow and the ambient temperature, ΔT, reduces as the air mass flow
rate increase. The maximum difference between the outlet and
ambient temperature obtained was 43°C for double pass for minimum
mass flow rate of 0.011kg/s. Comparison with a conventional solar
air heater collector shows a significantly development in the thermal
efficiency.
Abstract: In manufacturing industries, development of measurement leads to increase the number of monitoring variables and eventually the importance of multivariate control comes to the fore. Statistical process control (SPC) is one of the most widely used as multivariate control chart. Nevertheless, SPC is restricted to apply in processes because its assumption of data as following specific distribution. Unfortunately, process data are composed by the mixture of several processes and it is hard to estimate as one certain distribution. To alternative conventional SPC, therefore, nonparametric control chart come into the picture because of the strength of nonparametric control chart, the absence of parameter estimation. SVDD based control chart is one of the nonparametric control charts having the advantage of flexible control boundary. However,basic concept of SVDD has been an oversight to the important of data characteristic, density distribution. Therefore, we proposed DW-SVDD (Density Weighted SVDD) to cover up the weakness of conventional SVDD. DW-SVDD makes a new attempt to consider dense of data as introducing the notion of density Weight. We extend as control chart using new proposed SVDD and a simulation study of various distributional data is conducted to demonstrate the improvement of performance.
Abstract: This paper describes a system, in which various methods of text summarizing can be adapted to Polish. A structure of the system is presented. A modular construction of the system and access to the system via the Internet are signaled.
Abstract: Tasks of the work were study the possible E.coli
contamination in red deer meat, identify pathogenic strains from
isolated E.coli, determine their incidence in red deer meat and
determine the presence of VT1, VT2 and eaeA genes for the
pathogenic E.coli. 8 (10%) samples were randomly selected from 80
analysed isolates of E.coli and PCR reaction was performed on them.
PCR was done both on initial materials – samples of red deer meat -
and for already isolated liqueurs. Two of analysed venison samples
contain verotoxin-producing strains of E. coli. It means that this meat
is not safe to consumer. It was proven by the sequestration reaction of
E. coli and by comparison of the obtained results with the database of
microorganism genome available on the internet that the isolated
culture corresponds to region 16S rDNS of E. coli thus presenting
correctness of the microbiological methods.
Abstract: Recordings from recent earthquakes have provided evidence that ground motions in the near field of a rupturing fault differ from ordinary ground motions, as they can contain a large energy, or “directivity" pulse. This pulse can cause considerable damage during an earthquake, especially to structures with natural periods close to those of the pulse. Failures of modern engineered structures observed within the near-fault region in recent earthquakes have revealed the vulnerability of existing RC buildings against pulse-type ground motions. This may be due to the fact that these modern structures had been designed primarily using the design spectra of available standards, which have been developed using stochastic processes with relatively long duration that characterizes more distant ground motions. Many recently designed and constructed buildings may therefore require strengthening in order to perform well when subjected to near-fault ground motions. Fiber Reinforced Polymers are considered to be a viable alternative, due to their relatively easy and quick installation, low life cycle costs and zero maintenance requirements. The objective of this paper is to investigate the adequacy of Artificial Neural Networks (ANN) to determine the three dimensional dynamic response of FRP strengthened RC buildings under the near-fault ground motions. For this purpose, one ANN model is proposed to estimate the base shear force, base bending moments and roof displacement of buildings in two directions. A training set of 168 and a validation set of 21 buildings are produced from FEA analysis results of the dynamic response of RC buildings under the near-fault earthquakes. It is demonstrated that the neural network based approach is highly successful in determining the response.
Abstract: Carbon dioxide capture process has been simulated
and studied under different process conditions. It has been shown
that several process parameters such as lean amine temperature,
number of adsorber stages, number of stripper stages and stripper
pressure affect different process conditions and outputs such as
carbon dioxide removal and reboiler duty. It may be concluded that
the simulation of carbon dioxide capture process can help to estimate
the best process conditions.
Abstract: The changing economic climate has made global
manufacturing a growing reality over the last decade, forcing
companies from east and west and all over the world to
collaborate beyond geographic boundaries in the design,
manufacture and assemble of products. The ISO10303 and
ISO14649 Standards (STEP and STEP-NC) have been
developed to introduce interoperability into manufacturing
enterprises so as to meet the challenge of responding to
production on demand. This paper describes and illustrates a
STEP compliant CAD/CAPP/CAM System for the manufacture
of rotational parts on CNC turning centers. The information
models to support the proposed system together with the data
models defined in the ISO14649 standard used to create the NC
programs are also described. A structured view of a STEP
compliant CAD/CAPP/CAM system framework supporting the
next generation of intelligent CNC controllers for turn/mill
component manufacture is provided. Finally a proposed
computational environment for a STEP-NC compliant system
for turning operations (SCSTO) is described. SCSTO is the
experimental part of the research supported by the specification
of information models and constructed using a structured
methodology and object-oriented methods. SCSTO was
developed to generate a Part 21 file based on machining
features to support the interactive generation of process plans
utilizing feature extraction. A case study component has been
developed to prove the concept for using the milling and turning
parts of ISO14649 to provide a turn-mill CAD/CAPP/CAM
environment.
Abstract: The demand on High voltage (HV) infrastructures is growing due to the corresponding growth in industries and population. New or upgraded HV infrastructure has safety implications since Transmission mains usually occupy the same easement in the vicinity of neighbouring residents. Transmission mains consist of underground (UG) and overhead (OH) sections and the transition between the UG and OH section is known as the UGOH pole. The existence of two transmission mains in the same easement can dictate to resort to more complicated earthing design in order to mitigate the effect of AC interference, and in some cases it can also necessitates completing a Split Study of the system. This paper provides an overview of the AC interference, Split Study and the earthing of an underground feeder including the UGOH pole .In addition, this paper discusses the use of different link boxes on the UG feeder and presents a case study that represent a clear example of the Ac interference and Split factor. Finally, a few recommendations are provided to achieve a safety zone in the area beyond the boundary of the HV system.
Abstract: This paper presents an iterative algorithm to find a
inverse kinematic solution of 5-DOF robot. The algorithm is to
minimize the iteration number. Since the 5-DOF robot cannot give full
orientation of tool. Only z-direction of tool is satisfied while rotation
of tool is determined by kinematic constraint. This work therefore
described how to specify the tool direction and let the tool rotation free.
The simulation results show that this algorithm effectively worked.
Using the proposed iteration algorithm, error due to inverse kinematics
converged to zero rapidly in 5 iterations. This algorithm was applied in
real welding robot and verified through various practical works.
Abstract: As a multicultural country, Indonesia has many subcultures
with unique performing arts. Some of them are well-known
to international tourists, such as music ensemble (known as gamelan)
in Bali and Java, shadow puppet play (wayang) in Java, and martial
arts (known as pencak silat) in Sumatra. Some examples of famous
traditional dances in Indonesia are Srimpi from Yogyakarta and Solo,
Legong from Bali, and Gong dance from Kalimantan. Performing arts
show the identity of a nation. However, they are a complex subject,
especially when they are addressed to children. The performing arts,
e.g. music, dance theatre, and opera are experiential, experimental,
and emotionally charged. Therefore, the right strategy and promotion
need to be developed to engage children to appreciate and preserve
traditional dances. This study aims to explore and identify
possibilities of internet usage as a medium to promote traditional
dances, especially to children in Indonesia.
Abstract: Decision Support System (DSS) are interactive
software systems that are built to assist the management of an
organization in the decision making process when faced with nonroutine
problems in a specific application domain. Non-functional
requirements (NFRs) for a DSS deal with the desirable qualities and
restrictions that the DSS functionalities must satisfy. Unlike the
functional requirements, which are tangible functionalities provided
by the DSS, NFRs are often hidden and transparent to DSS users but
affect the quality of the provided functionalities. NFRs are often
overlooked or added later to the system in an ad hoc manner, leading
to a poor overall quality of the system. In this paper, we discuss the
development of NFRs as part of the requirements engineering phase
of the system development life cycle of DSSs. To help eliciting
NFRs, we provide a comprehensive taxonomy of NFRs for DSSs.