Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.
Abstract: The objective of this paper is twofold: (1) discuss and
analyze the successful case studies worldwide, and (2) identify the
similarities and differences of case studies worldwide. Design
methodology/approach: The nature of this research is mainly method
qualitative (multi-case studies, literature review). This investigation
uses ten case studies, and the data was mainly collected and
organizational documents from the international countries. Finding:
The finding of this research can help incubator manager, policy
maker and government parties for successful implementation.
Originality/value: This paper contributes to the current literate review
on the best practices worldwide. Additionally, it presents future
perspective for academicians and practitioners.
Abstract: The Neuro-Fuzzy hybridization scheme has become
of research interest in pattern classification over the past decade. The
present paper proposes a novel Modified Adaptive Fuzzy Inference
Engine (MAFIE) for pattern classification. A modified Apriori
algorithm technique is utilized to reduce a minimal set of decision
rules based on input output data sets. A TSK type fuzzy inference
system is constructed by the automatic generation of membership
functions and rules by the fuzzy c-means clustering and Apriori
algorithm technique, respectively. The generated adaptive fuzzy
inference engine is adjusted by the least-squares fit and a conjugate
gradient descent algorithm towards better performance with a
minimal set of rules. The proposed MAFIE is able to reduce the
number of rules which increases exponentially when more input
variables are involved. The performance of the proposed MAFIE is
compared with other existing applications of pattern classification
schemes using Fisher-s Iris and Wisconsin breast cancer data sets and
shown to be very competitive.
Abstract: As an effort to promote wind power industry in Korea,
Korea South-East Power Corporation has been developing 22MW
YeungHeung wind farm consisting of nine 2 to 3MW wind turbines
supplied by three manufacturers. To maximize its availability and
reliability and to solve the difficulty of operating three kinds of
SCADA systems, Korea Electric Power Corporation has been
developing a condition monitoring system integrated with control
functions. This paper presents the developed condition monitoring
system and its application to YeungHeung wind test bed, and the
design of its control functions.
Abstract: This paper presents two different sequential switching hybrid-modulation strategies and implemented for cascaded multilevel inverters. Hybrid modulation strategies represent the combinations of Fundamental-frequency pulse width modulation (FFPWM) and Multilevel sinusoidal-modulation (MSPWM) strategies, and are designed for performance of the well-known Alternative Phase opposition disposition (APOD), Phase shifted carrier (PSC). The main characteristics of these modulations are the reduction of switching losses with good harmonic performance, balanced power loss dissipation among the devices with in a cell, and among the series-connected cells. The feasibility of these modulations is verified through spectral analysis, power loss analysis and simulation.
Abstract: All climate models agree that the temperature in
Greece will increase in the range of 1° to 2°C by the year 2030 and
mean sea level in Mediterranean is expected to rise at the rate of 5
cm/decade. The aim of the present paper is the estimation of the
coastline displacement driven by the climate change and sea level
rise. In order to achieve that, all known statistical and non-statistical
computational methods are employed on some Greek coastal areas.
Furthermore, Kalman filtering techniques are for the first time
introduced, formulated and tested. Based on all the above, shoreline
change signals and noises are computed and an inter-comparison
between the different methods can be deduced to help evaluating
which method is most promising as far as the retrieve of shoreline
change rate is concerned.
Abstract: Road authorities have confronted problems to
maintaining the serviceability of road infrastructure systems by using
various traditional methods of contracting. As a solution to these
problems, many road authorities have started contracting out road
maintenance works to the private sector based on performance
measures. This contracting method is named Performance-Based
Maintenance Contracting (PBMC). It is considered more costeffective
than other traditional methods of contracting. It has a
substantial success records in many developed and developing
countries over the last two decades. This paper discusses and
analyses the potential issues to be considered before the introduction
of PBMC in a country.
Abstract: Crypto System Identification is one of the challenging tasks in Crypt analysis. The paper discusses the possibility of employing Neural Networks for identification of Cipher Systems from cipher texts. Cascade Correlation Neural Network and Back Propagation Network have been employed for identification of Cipher Systems. Very large collection of cipher texts were generated using a Block Cipher (Enhanced RC6) and a Stream Cipher (SEAL). Promising results were obtained in terms of accuracy using both the Neural Network models but it was observed that the Cascade Correlation Neural Network Model performed better compared to Back Propagation Network.
Abstract: Dietary macro and micro nutrients in their respective proportion and fractions present a practical potential tool to fabricate milk constituents since cells of lactating mammary glands obtain about 80 % of milk synthesis nutrients from blood, reflecting the existence of an isotonic equilibrium between blood and milk. Diverting milk biosynthetic activities through manipulation of nutrients towards producing milk not only keeping in view its significance as natural food but also as food item which prevents or dilutes the adverse effects of some diseases (like cardiovascular problem by saturated milk fat intake) has been area of interest in the last decade. Nutritional modification / supplementation has been reported to enhance conjugated linoleic acid, fatty acid type and concentration, essential fatty acid concentration, vitamin B12& C, Se, Cu, I and Fe which are involved to counter the health threats to human well being. Synchronizing dietary nutrients aimed to modify rumen dynamics towards synthesis of nutrients or their precursors to make their drive towards formulated milk constituents presents a practical option. Formulating dietary constituents to design milk constituents will let the farmers, consumers and investors know about the real potential and profit margins associated with this enterprise. This article briefly recapitulates the ways and means to modify milk constituents keeping an eye on human health and well being issues, which allows milk to serve more than a food item.
Abstract: The events of October 2010, where terrorists managed to get explosive devices onboard of three passenger aircrafts and two air freighters, demonstrated weaknesses of the international air cargo and airmail security. Ever since, postal security has gained interest among policymakers and authorities. This study augments the limited body of academic literature on the topic bydemarcating areas of postal security, identifying relevant stakeholders in each area, and investigating why these stakeholders engage in postal security. Research is based on a case study on Swiss Post’s mail service.
Abstract: The purposes of this study are 1) to study the frequent
English writing errors of students registering the course: Reading and
Writing English for Academic Purposes II, and 2) to find out the
results of writing error correction by using coded indirect corrective
feedback and writing error treatments. Samples include 28 2nd year
English Major students, Faculty of Education, Suan Sunandha
Rajabhat University. Tool for experimental study includes the lesson
plan of the course; Reading and Writing English for Academic
Purposes II, and tool for data collection includes 4 writing tests of
short texts. The research findings disclose that frequent English
writing errors found in this course comprise 7 types of grammatical
errors, namely Fragment sentence, Subject-verb agreement, Wrong
form of verb tense, Singular or plural noun endings, Run-ons
sentence, Wrong form of verb pattern and Lack of parallel structure.
Moreover, it is found that the results of writing error correction by
using coded indirect corrective feedback and error treatment reveal
the overall reduction of the frequent English writing errors and the
increase of students’ achievement in the writing of short texts with
the significance at .05.
Abstract: Transpedicular screw fixation in spinal fractures,
degenerative changes, or deformities is a well-established procedure.
However, important rate of fixation failure due to screw bending,
loosening, or pullout are still reported particularly in weak bone stock
in osteoporosis. To overcome the problem, mechanism of failure has
to be fully investigated in vitro. Post-mortem human subjects are less
accessible and animal cadavers comprise limitations due to different
geometry and mechanical properties. Therefore, the development of a
synthetic model mimicking the realistic human vertebra is highly
demanded. A bone surrogate, composed of Polyurethane (PU) foam
analogous to cancellous bone porous structure, was tested for 3
different densities in this study. The mechanical properties were
investigated under uniaxial compression test by minimizing the end
artifacts on specimens. The results indicated that PU foam of 0.32
g.cm-3 density has comparable mechanical properties to human
cancellous bone in terms of young-s modulus and yield strength.
Therefore, the obtained information can be considered as primary
step for developing a realistic cancellous bone of human vertebral
body. Further evaluations are also recommended for other density
groups.
Abstract: The rapid development of manufacturing and information systems has caused significant changes in manufacturing environments in recent decades. Mass production has given way to flexible manufacturing systems, in which an important characteristic is customized or "on demand" production. In this scenario, the seamless and without gaps information flow becomes a key factor for success of enterprises. In this paper we present a framework to support the mapping of features into machining workingsteps compliant with the ISO 14649 standard (known as STEP-NC). The system determines how the features can be made with the available manufacturing resources. Examples of the mapping method are presented for features such as a pocket with a general surface.
Abstract: In this era of competitiveness, there is a growing need for supply chains also to become competitive enough to handle pressures like varying customer’s expectations, low cost high quality products to be delivered at the minimum time and the most important is throat cutting competition at world wide scale. In the recent years, supply chain competitiveness has been, therefore, accepted as one of the most important philosophies in the supply chain literature. Various researchers and practitioners have tried to identify and implement strategies in supply chains which can bring competitiveness in the supply chains i.e. supply chain competitiveness. The purpose of this paper is to suggest select strategies for supply chain competitiveness in the Indian manufacturing sector using an integrated approach of literature review and exploratory interviews with eminent professionals from the supply chain area in various industries, academia and research. The aim of the paper is to highlight the important area of competitiveness in the supply chain and to suggest recommendations to the industry and managers of manufacturing sector.
Abstract: Nowadays, computer worms, viruses and Trojan horse
become popular, and they are collectively called malware. Those
malware just spoiled computers by deleting or rewriting important
files a decade ago. However, recent malware seems to be born to earn
money. Some of malware work for collecting personal information so
that malicious people can find secret information such as password for
online banking, evidence for a scandal or contact address which relates
with the target. Moreover, relation between money and malware
becomes more complex. Many kinds of malware bear bots to get
springboards. Meanwhile, for ordinary internet users,
countermeasures against malware come up against a blank wall.
Pattern matching becomes too much waste of computer resources,
since matching tools have to deal with a lot of patterns derived from
subspecies. Virus making tools can automatically bear subspecies of
malware. Moreover, metamorphic and polymorphic malware are no
longer special. Recently there appears malware checking sites that
check contents in place of users' PC. However, there appears a new
type of malicious sites that avoids check by malware checking sites. In
this paper, existing protocols and methods related with the web are
reconsidered in terms of protection from current attacks, and new
protocol and method are indicated for the purpose of security of the
web.
Abstract: Based on 276 responses from academic staff in an
evaluation of an online learning environment (OLE), this paper
identifies those elements of the OLE that were most used and valued
by staff, those elements of the OLE that staff most wanted to see
improved, and those factors that most contributed to staff perceptions
that the use of the OLE enhanced their teaching. The most used and
valued elements were core functions, including accessing unit
information, accessing lecture/tutorial/lab notes, and reading online
discussions. The elements identified as most needing attention related
to online assessment: submitting assignments, managing assessment
items, and receiving feedback on assignments. Staff felt that using the
OLE enhanced their teaching when they were satisfied that their
students were able to access and use their learning materials, and
when they were satisfied with the professional development they
received and were confident with their ability to teach with the OLE.
Abstract: The vast amount of information on the World Wide
Web is created and published by many different types of providers.
Unlike books and journals, most of this information is not subject to
editing or peer review by experts. This lack of quality control and the
explosion of web sites make the task of finding quality information
on the web especially critical. Meanwhile new facilities for
producing web pages such as Blogs make this issue more significant
because Blogs have simple content management tools enabling nonexperts
to build easily updatable web diaries or online journals. On
the other hand despite a decade of active research in information
quality (IQ) there is no framework for measuring information quality
on the Blogs yet. This paper presents a novel experimental
framework for ranking quality of information on the Weblog. The
results of data analysis revealed seven IQ dimensions for the Weblog.
For each dimension, variables and related coefficients were
calculated so that presented framework is able to assess IQ of
Weblogs automatically.
Abstract: Educational reforms are focused point of different
nations. New reform movements generally claim that something is
wrong with the current state of affairs, and that the system is deficient in its goals, its accomplishments and it is accused not being
adopted into global changes all over the world. It is the same for
Turkish education system. It is considered those recent reforms of
teacher education in Turkey and the extent to which they reflect a
response to global economic pressures. The paper challenges the
view that such imposes are inevitable determinants of educational
policy and argues that any country will need to develop its own
national approach to modernizing teacher education in light of the
global context and its particular circumstances. It draws on the idea
of reflexive modernization developed by educators and discusses its
implications for teacher education policy. The paper deals with four
themes teacher education in last decade policy in Turkey; the shift
away from the educational disciplines, the shift towards school-based
approaches, and the emergence of more centralized forms of
accountability of teacher competence.
Abstract: In Both developed and developing countries,
governments play a basic role in making policies, programs and
instruments which support the development of micro, small and
medium enterprises. One of the mechanisms employed to nurture
small firms for more than two decades is business incubation. One of
the mechanisms employed to nurture small firms for more than two
decades is technology business incubation. The main aim of this
research was to establish influencing factors in Technology Business
Incubator's effectiveness and their explanatory model. Therefore,
among 56 Technology Business Incubators in Iran, 32 active
incubators were selected and by stratified random sampling, 528
start-ups were chosen. The validity of research questionnaires
was determines by expert consensus, item analysis and factor
analysis; and their reliability calculated by Cronbach-s alpha.
Data analysis was then made through SPSS and LISREL soft wares.
Both organizational procedures and entrepreneurial behaviors were
the meaningful mediators. Organizational procedures with (P < .01, β
=0.45) was stronger mediator for the improvement of Technology
Business Incubator's effectiveness comparing to entrepreneurial
behavior with (P < .01, β =0.36).
Abstract: In this paper, first we introduce the stable distribution, stable process and theirs characteristics. The a -stable distribution family has received great interest in the last decade due to its success in modeling data, which are too impulsive to be accommodated by the Gaussian distribution. In the second part, we propose major applications of alpha stable distribution in telecommunication, computer science such as network delays and signal processing and financial markets. At the end, we focus on using stable distribution to estimate measure of risk in stock markets and show simulated data with statistical softwares.