Abstract: The small interfering RNA (siRNA) alters the
regulatory role of mRNA during gene expression by translational
inhibition. Recent studies show that upregulation of mRNA because
serious diseases like cancer. So designing effective siRNA with good
knockdown effects plays an important role in gene silencing. Various
siRNA design tools had been developed earlier. In this work, we are
trying to analyze the existing good scoring second generation siRNA
predicting tools and to optimize the efficiency of siRNA prediction
by designing a computational model using Artificial Neural Network
and whole stacking energy (%G), which may help in gene silencing
and drug design in cancer therapy. Our model is trained and tested
against a large data set of siRNA sequences. Validation of our results
is done by finding correlation coefficient of experimental versus
observed inhibition efficacy of siRNA. We achieved a correlation
coefficient of 0.727 in our previous computational model and we
could improve the correlation coefficient up to 0.753 when the
threshold of whole tacking energy is greater than or equal to -32.5
kcal/mol.
Abstract: A new approach to determine the machine layout in flexible manufacturing cell, and to find the feasible robot configuration of the robot to achieve minimum cycle time is presented in this paper. The location of the input/output location and the optimal robot configuration is obtained for all sequences of work tasks of the robot within a specified period of time. A more realistic approach has been presented to model the problem using the robot joint space. The problem is formulated as a nonlinear optimization problem and solved using Sequential Quadratic Programming algorithm.
Abstract: Equations on curved manifolds display interesting properties in a number of ways. In particular, the symmetries and, therefore, the conservation laws reduce depending on how curved the manifold is. Of particular interest are the wave and Gordon-type equations; we study the symmetry properties and conservation laws of these equations on the Milne and Bianchi type III metrics. Properties of reduction procedures via symmetries, variational structures and conservation laws are more involved than on the well known flat (Minkowski) manifold.
Abstract: As the performance of the filtering system depends
upon the accuracy of the noise detection scheme, in this paper, we
present a new scheme for impulse noise detection based on two
levels of decision. In this scheme in the first stage we coarsely
identify the corrupted pixels and in the second stage we finally
decide whether the pixel under consideration is really corrupt or not.
The efficacy of the proposed filter has been confirmed by extensive
simulations.
Abstract: A new and cost effective robotic device was designed
for remote tele surgery using dual tone multi frequency technology
(DTMF). Tele system with Dual Tone Multiple Frequency has a large
capability in sending and receiving of data in hardware and software.
The robot consists of DC motors for arm movements and it is
controlled manually through a mobile phone through DTMF
Technology. The system enables the surgeon from base station to
send commands through mobile phone to the patient’s robotic system
which includes two robotic arms that translate the input into actual
instrument manipulation. A mobile phone attached to the
microcontroller 8051 which can activate robot through relays. The
Remote robot-assisted tele surgery eliminates geographic constraints
for getting surgical expertise where it is needed and allows an expert
surgeon to teach or proctor the performance of surgical technique by
real-time intervention.
Abstract: The thermal expansion behaviour of silicon carbide
(SCS-2) fibre reinforced 6061 aluminium matrix composite subjected
to the influenced thermal mechanical cycling (TMC) process were
investigated. The thermal stress has important effect on the
longitudinal thermal expansion coefficient of the composites. The
present paper used experimental data of the thermal expansion
behaviour of a SiC/Al composite for temperatures up to 370°C, in
which their data was used for carrying out modelling of theoretical
predictions.
Abstract: To determine the presence and location of faults in a transmission by the adaptation of protective distance relay based on the measurement of fixed settings as line impedance is achieved by several different techniques. Moreover, a fast, accurate and robust technique for real-time purposes is required for the modern power systems. The appliance of radial basis function neural network in transmission line protection is demonstrated in this paper. The method applies the power system via voltage and current signals to learn the hidden relationship presented in the input patterns. It is experiential that the proposed technique is competent to identify the particular fault direction more speedily. System simulations studied show that the proposed approach is able to distinguish the direction of a fault on a transmission line swiftly and correctly, therefore suitable for the real-time purposes.
Abstract: In order to obtain an accurate result of the heat transfer
of the rib in the internal cooling Rectangular channel, using separation
of variables, analytical solutions of three dimensional steady-state heat
conduction in rectangular ribs are given by solving three dimensional
steady-state function of the rectangular ribs. Therefore, we can get
solution of three dimensional temperature field in the rib. Based on the
solution, we can get how the Bi number affected on heat transfer.
Furthermore, comparisons of the analytical and numerical results
indicate agreement on temperature field in the rib.
Abstract: This paper presents a microstrip meandered open
circuited stub with bandstop characteristic. The proposed structure is
designed on a high frequency laminate with dielectric constant of 4.0
and board thickness of 0.508 millimeters. The scattering parameters
and electromagnetic field distributions at various frequencies are
investigated by modeling the structure with three dimensional
electromagnetic simulation tool. In order to describe the resonant
and bandstop characteristic of the meandered open circuited stub, a
Smith chart as well as electric field at various frequencies and phases
is illustrated accordingly. The structure can be an alternative method
in suppressing the harmonic response of a bandpass filter.
Abstract: Distributed denial-of-service (DDoS) attacks pose a
serious threat to network security. There have been a lot of
methodologies and tools devised to detect DDoS attacks and reduce
the damage they cause. Still, most of the methods cannot
simultaneously achieve (1) efficient detection with a small number of
false alarms and (2) real-time transfer of packets. Here, we introduce
a method for proactive detection of DDoS attacks, by classifying the
network status, to be utilized in the detection stage of the proposed
anti-DDoS framework. Initially, we analyse the DDoS architecture
and obtain details of its phases. Then, we investigate the procedures
of DDoS attacks and select variables based on these features. Finally,
we apply the k-nearest neighbour (k-NN) method to classify the
network status into each phase of DDoS attack. The simulation result
showed that each phase of the attack scenario is classified well and
we could detect DDoS attack in the early stage.
Abstract: This paper investigates the performance of Multiple- Input Multiple-Output (MIMO) feedback system combined with Orthogonal Frequency Division Multiplexing (OFDM). Two types of codebook based channel feedback techniques are used in this work. The first feedback technique uses a combination of both the long-term and short-term channel state information (CSI) at the transmitter, whereas the second technique uses only the short term CSI. The long-term and short-term CSI at the transmitter is used for efficient channel utilization. OFDM is a powerful technique employed in communication systems suffering from frequency selectivity. Combined with multiple antennas at the transmitter and receiver, OFDM proves to be robust against delay spread. Moreover, it leads to significant data rates with improved bit error performance over links having only a single antenna at both the transmitter and receiver. The effectiveness of these techniques has been demonstrated through the simulation of a MIMO-OFDM feedback system. The results have been evaluated for 4x4 MIMO channels. Simulation results indicate the benefits of the MIMO-OFDM channel feedback system over the one without incorporating OFDM. Performance gain of about 3 dB is observed for MIMO-OFDM feedback system as compared to the one without employing OFDM. Hence MIMO-OFDM becomes an attractive approach for future high speed wireless communication systems.
Abstract: The development of the power electronics has allowed
increasing the precision and reliability of the electrical devices, thanks
to the adjustable inverters, as the Pulse Wide Modulation (PWM)
applied to the three level inverters, which is the object of this study.
The authors treat the relation between the law order adopted for a
given system and the oscillations of the electrical and mechanical
parameters of which the tolerance depends on the process with which
they are integrated (paper factory, lifting of the heavy loads,
etc.).Thus, the best choice of the regulation indexes allows us to
achieve stability and safety training without investment (management
of existing equipment). The optimal behavior of any electric device
can be achieved by the minimization of the stored electrical and
mechanical energy.
Abstract: This paper determines most common model of in-pipe
robots to derive its degree of freedom in order to compare with the
necessary degree of freedom required for a system to move inside
pipelines freely in order to derive analytical reason for losing control
of in-pipe robots at branched pipe. DOF of most common mechanism
in in-pipe robots can be calculated by considering the robot as a
parallel manipulator. A new design based on previously researched
in-pipe robot PAROYS has been suggested, and its possibility to
overcome branched section has been simulated.
Abstract: The authors have been developing several models
based on artificial neural networks, linear regression models, Box-
Jenkins methodology and ARIMA models to predict the time series
of tourism. The time series consist in the “Monthly Number of Guest
Nights in the Hotels" of one region. Several comparisons between the
different type models have been experimented as well as the features
used at the entrance of the models. The Artificial Neural Network
(ANN) models have always had their performance at the top of the
best models. Usually the feed-forward architecture was used due to
their huge application and results. In this paper the author made a
comparison between different architectures of the ANNs using
simply the same input. Therefore, the traditional feed-forward
architecture, the cascade forwards, a recurrent Elman architecture and
a radial based architecture were discussed and compared based on the
task of predicting the mentioned time series.
Abstract: The Navier–Stokes equations for unsteady, incompressible, viscous fluids in the axisymmetric coordinate system are solved using a control volume method. The volume-of-fluid (VOF) technique is used to track the free-surface of the liquid. Model predictions are in good agreement with experimental measurements. It is found that the dynamic processes after impact are sensitive to the initial droplet velocity and the liquid pool depth. The time evolution of the crown height and diameter are obtained by numerical simulation. The critical We number for splashing (Wecr) is studied for Oh (Ohnesorge) numbers in the range of 0.01~0.1; the results compares well with those of the experiments.
Abstract: The objective of the present paper is a numerical
analysis of the flow forces acting on spool surfaces of a pressure
regulated valve. The transient, compressible and turbulent flow
structures inside the valve are simulated using ANSYS FLUENT
coupled with a special UDF. Here, valve inlet pressure is varied in a
stepwise manner. For every value of inlet pressure, transient analysis
leads to a quasi-static flow through the valve. Spool forces are
calculated based on different pressures at inlet. From this information
of spool forces, pressure characteristic of the passive control circuit
has been derived.
Abstract: The incorporation of computational fluid dynamics in the design of modern hydraulic turbines appears to be necessary in order to improve their efficiency and cost-effectiveness beyond the traditional design practices. A numerical optimization methodology is developed and applied in the present work to a Turgo water turbine. The fluid is simulated by a Lagrangian mesh-free approach that can provide detailed information on the energy transfer and enhance the understanding of the complex, unsteady flow field, at very small computing cost. The runner blades are initially shaped according to hydrodynamics theory, and parameterized using Bezier polynomials and interpolation techniques. The use of a limited number of free design variables allows for various modifications of the standard blade shape, while stochastic optimization using evolutionary algorithms is implemented to find the best blade that maximizes the attainable hydraulic efficiency of the runner. The obtained optimal runner design achieves considerably higher efficiency than the standard one, and its numerically predicted performance is comparable to a real Turgo turbine, verifying the reliability and the prospects of the new methodology.
Abstract: Information sharing and gathering are important in the rapid advancement era of technology. The existence of WWW has caused rapid growth of information explosion. Readers are overloaded with too many lengthy text documents in which they are more interested in shorter versions. Oil and gas industry could not escape from this predicament. In this paper, we develop an Automated Text Summarization System known as AutoTextSumm to extract the salient points of oil and gas drilling articles by incorporating statistical approach, keywords identification, synonym words and sentence-s position. In this study, we have conducted interviews with Petroleum Engineering experts and English Language experts to identify the list of most commonly used keywords in the oil and gas drilling domain. The system performance of AutoTextSumm is evaluated using the formulae of precision, recall and F-score. Based on the experimental results, AutoTextSumm has produced satisfactory performance with F-score of 0.81.
Abstract: This paper will provide the kinematic and dynamic
analysis of a lower limb exoskeleton. The forward and inverse
kinematics of proposed exoskeleton is performed using Denevit and
Hartenberg method. The torques required for the actuators will be
calculated using Lagrangian formulation technique. This research can
be used to design the control of the proposed exoskeleton.
Abstract: In this paper, a residue number arithmetic is used in
direct sequence spread spectrum system, this system is evaluated and
the bit error probability of this system is compared to that of non
residue number system. The effect of channel bandwidth, PN
sequences, multipath effect and modulation scheme are studied. A
Matlab program is developed to measure the signal-to-noise ratio
(SNR), and the bit error probability for the various schemes.