Abstract: The objective of the present study was to evaluate the
potential of hollow microneedles for enhancing the transdermal
delivery of Bovine Serum Albumin (MW~66,000 Da)-Fluorescein
Isothiocyanate (BSA-FITC) conjugate, a hydrophilic large molecular
compound. Moreover, the effect of different formulations was
evaluated. The series of binary mixtures composed of propylene
glycol (PG) and pH 7.4 phosphate buffer solution (PBS) was
prepared and used as a medium for BSA-FITC. The results showed
that there was no permeation of BSA-FITC solution across the
neonatal porcine skin without using hollow microneedles, whereas
the cumulative amount of BSA-FITC released at 8 h through the
neonatal porcine skin was about 60-70% when using hollow
microneedles. Furthermore, the results demonstrated that the higher
volume of PG in binary mixtures injected, the lower cumulative
amount of BSA-FITC released and release rate of BSA-FITC from
skin. These release profiles of BSA-FITC in binary mixtures were
expressed by Fick-s law of diffusion. These results suggest the
utilization of hollow microneedle to enhance transdermal delivery of
protein and provide useful information for designing an effective
hollow microneedle system.
Abstract: We propose that Virtual Learning Environments (VLEs) should be designed by taking into account the characteristics, the special needs and the specific operating rules of the academic institutions in which they are employed. In this context, we describe a VLE module that extends the support of the organization and delivery of course material by including administration activities related to the various stages of teaching. These include the co-ordination, collaboration and monitoring of the course material development process and institution-specific course material delivery modes. Our specialized module, which enhances VLE capabilities by Helping Educators and Learners through a Laboratory Assistance System, is willing to assist the Greek tertiary technological sector, which includes Technological Educational Institutes (T.E.I.).
Abstract: This paper presents a mathematical model and a
methodology to analyze the losses in transmission expansion
planning (TEP) under uncertainty in demand. The methodology is
based on discrete particle swarm optimization (DPSO). DPSO is a
useful and powerful stochastic evolutionary algorithm to solve the
large-scale, discrete and nonlinear optimization problems like TEP.
The effectiveness of the proposed idea is tested on an actual
transmission network of the Azerbaijan regional electric company,
Iran. The simulation results show that considering the losses even for
transmission expansion planning of a network with low load growth
is caused that operational costs decreases considerably and the
network satisfies the requirement of delivering electric power more
reliable to load centers.
Abstract: In this paper a new approach to face recognition is
presented that achieves double dimension reduction, making the
system computationally efficient with better recognition results and
out perform common DCT technique of face recognition. In pattern
recognition techniques, discriminative information of image
increases with increase in resolution to a certain extent, consequently
face recognition results change with change in face image resolution
and provide optimal results when arriving at a certain resolution
level. In the proposed model of face recognition, initially image
decimation algorithm is applied on face image for dimension
reduction to a certain resolution level which provides best
recognition results. Due to increased computational speed and feature
extraction potential of Discrete Cosine Transform (DCT), it is
applied on face image. A subset of coefficients of DCT from low to
mid frequencies that represent the face adequately and provides best
recognition results is retained. A tradeoff between decimation factor,
number of DCT coefficients retained and recognition rate with
minimum computation is obtained. Preprocessing of the image is
carried out to increase its robustness against variations in poses and
illumination level. This new model has been tested on different
databases which include ORL , Yale and EME color database.
Abstract: The overall penumbra is usually defined as the
distance, p20–80, separating the 20% and 80% of the dose on the beam axis at the depth of interest. This overall penumbra accounts
also for the fact that some photons emitted by the distal parts of the source are only partially attenuated by the collimator. Medulloblastoma is the most common type of childhood brain tumor
and often spreads to the spine. Current guidelines call for surgery to remove as much of the tumor as possible, followed by radiation of the brain and spinal cord, and finally treatment with chemotherapy.
The purpose of this paper was to present results on an Uniformity of dose distribution in radiation fields surrounding the spine using film
dosimetry and comparison with 3D treatment planning software.
Abstract: Soil washing process with a surfactant solution is a potential technology for the rapid removal of hydrophobic organic compound (HOC) from soil. However, large amount of washed water would be produced during operation and this should be treated effectively by proper methods. The soil washed water for complex contaminated site with HOC and heavy metals might contain high amount of pollutants such as HOC and heavy metals as well as used surfactant. The heavy metals in the soil washed water have toxic effects on microbial activities thus these should be removed from the washed water before proceeding to a biological waste-water treatment system. Moreover, the used surfactant solutions are necessary to be recovered for reducing the soil washing operation cost. In order to simultaneously remove the heavy metals and HOC from soil-washed water, activated carbon (AC) was used in the present study. In an anionic-nonionic surfactant mixed solution, the Cd(II) and phenanthrene (PHE) were effectively removed by adsorption on activated carbon. The removal efficiency for Cd(II) was increased from 0.027 mmol-Cd/g-AC to 0.142 mmol-Cd/g-AC as the mole ratio of SDS increased in the presence of PHE. The adsorptive capacity of PHE was also increased according to the SDS mole ratio due to the decrement of molar solubilization ratios (MSR) for PHE in an anionic-nonionic surfactant mixture. The simultaneous adsorption of HOC and cationic heavy metals using activated carbon could be a useful method for surfactant recovery and the reduction of heavy metal toxicity in a surfactant-enhanced soil washing process.
Abstract: In order to perform on-line measuring and detection
of PD signals, a total solution composing of an HFCT, A/D
converter and a complete software package is proposed. The
software package includes compensation of HFCT contribution,
filtering and noise reduction using wavelet transform and soft
calibration routines. The results have shown good performance and
high accuracy.
Abstract: A satured liquid is warmed until boiling in a parallelepipedic boiler. The heat is supplied in a liquid through the horizontal bottom of the boiler, the other walls being adiabatic. During the process of boiling, the liquid evaporates through its free surface by deforming it. This surface which subdivides the boiler into two regions occupied on both sides by the boiled liquid (broth) and its vapor which surmounts it. The broth occupying the region and its vapor the superior region. A two- fluids model is used to describe the dynamics of the broth, its vapor and their interface. In this model, the broth is treated as a monophasic fluid (homogeneous model) and form with its vapor adiphasic pseudo fluid (two-fluid model). Furthermore, the interface is treated as a zone of mixture characterized by superficial void fraction noted α* . The aim of this article is to describe the dynamics of the interface between the boiled fluid and its vapor within a boiler. The resolution of the problem allowed us to show the evolution of the broth and the level of the liquid.
Abstract: Influence of octane and benzene on plant cell
ultrastructure and enzymes of basic metabolism, such as nitrogen
assimilation and energy generation have been studied. Different
plants: perennial ryegrass (Lolium perenne) and alfalfa (Medicago
sativa); crops- maize (Zea mays L.) and bean (Phaseolus vulgaris);
shrubs – privet (Ligustrum sempervirens) and trifoliate orange
(Poncirus trifoliate); trees - poplar (Populus deltoides) and white
mulberry (Morus alba L.) were exposed to hydrocarbons of different
concentrations (1, 10 and 100 mM). Destructive changes in bean and
maize leaves cells ultrastructure under the influence of benzene
vapour were revealed at the level of photosynthetic and energy
generation subcellular organells. Different deviations at the level of
subcellular organelles structure and distribution were observed in
alfalfa and ryegrass root cells under the influence of benzene and
octane, absorbed through roots. The level of destructive changes is
concentration dependent. Benzene at low 1 and 10 mM concentration
caused the increase in glutamate dehydrogenase (GDH) activity in
maize roots and leaves and in poplar and mulberry shoots, though to
higher extent in case of lower, 1mM concentration. The induction
was more intensive in plant roots. The highest tested 100mM
concentration of benzene was inhibitory to the enzyme in all plants.
Octane caused induction of GDH in all grassy plants at all tested
concentrations; however the rate of induction decreased parallel to
increase of the hydrocarbon concentration. Octane at concentration 1
mM caused induction of GDH in privet, trifoliate and white mulberry
shoots. The highest, 100mM octane was characterized by inhibitory
effect to GDH activity in all plants. Octane had inductive effect on
malate dehydrogenase in almost all plants and tested concentrations,
indicating the intensification of Trycarboxylic Acid Cycle.
The data could be suggested for elaboration of criteria for plant
selection for phytoremediation of oil hydrocarbons contaminated
soils.
Abstract: We have developed a microfluidic device system for the continuous producting of nanoparticles, and we have clarified the relationship between the mixing performance of reactors and the particle size. First, we evaluated the mixing performance of reactors by carring out the Villermaux–Dushman reaction and determined the experimental conditions for producing AgCl nanoparticles. Next, we produced AgCl nanoparticles and evaluated the mixing performance and the particle size. We found that as the mixing performance improves the size of produced particles decreases and the particle size distribution becomes sharper. We produced AgCl nanoparticles with a size of 86 nm using the microfluidic device that had the best mixing performance among the three reactors we tested in this study; the coefficient of variation (Cv) of the size distribution of the produced nanoparticles was 26.1%.
Abstract: Given the motivation of maps impact in enhancing the
perception of the quality of life in a region, this work examines the
use of spatial analytical techniques in exploring the role of space in
shaping human development patterns in Assiut governorate.
Variations of human development index (HDI) of the governorate-s
villages, districts and cities are mapped using geographic information
systems (GIS). Global and local spatial autocorrelation measures are
employed to assess the levels of spatial dependency in the data and to
map clusters of human development. Results show prominent
disparities in HDI between regions of Assiut. Strong patterns of
spatial association were found proving the presence of clusters on the
distribution of HDI. Finally, the study indicates several "hot-spots" in
the governorate to be area of more investigations to explore the
attributes of such levels of human development. This is very
important for accomplishing the development plan of poorest regions
currently adopted in Egypt.
Abstract: In most of the cases, natural disasters lead to the
necessity of evacuating people. The quality of evacuation
management is dramatically improved by the use of information
provided by decision support systems, which become indispensable
in case of large scale evacuation operations. This paper presents a
best practice case study. In November 2007, officers from the
Emergency Situations Inspectorate “Crisana" of Bihor County from
Romania participated to a cross-border evacuation exercise, when
700 people have been evacuated from Netherlands to Belgium. One
of the main objectives of the exercise was the test of four different
decision support systems. Afterwards, based on that experience,
software system called TEVAC (Trans Border Evacuation) has been
developed “in house" by the experts of this institution. This original
software system was successfully tested in September 2008, during
the deployment of the international exercise EU-HUROMEX 2008,
the scenario involving real evacuation of 200 persons from Hungary
to Romania. Based on the lessons learned and results, starting from
April 2009, the TEVAC software is used by all Emergency
Situations Inspectorates all over Romania.
Abstract: A major requirement for Grid application developers is ensuring performance and scalability of their applications. Predicting the performance of an application demands understanding its specific features. This paper discusses performance modeling and prediction of multi-agent based simulation (MABS) applications on the Grid. An experiment conducted using a synthetic MABS workload explains the key features to be included in the performance model. The results obtained from the experiment show that the prediction model developed for the synthetic workload can be used as a guideline to understand to estimate the performance characteristics of real world simulation applications.
Abstract: The purposes of this paper are to (1) promote excellence in computer science by suggesting a cohesive innovative approach to fill well documented deficiencies in current computer science education, (2) justify (using the authors' and others anecdotal evidence from both the classroom and the real world) why this approach holds great potential to successfully eliminate the deficiencies, (3) invite other professionals to join the authors in proof of concept research. The authors' experiences, though anecdotal, strongly suggest that a new approach involving visual modeling technologies should allow computer science programs to retain a greater percentage of prospective and declared majors as students become more engaged learners, more successful problem-solvers, and better prepared as programmers. In addition, the graduates of such computer science programs will make greater contributions to the profession as skilled problem-solvers. Instead of wearily rememorizing code as they move to the next course, students will have the problem-solving skills to think and work in more sophisticated and creative ways.
Abstract: Although in sustainable development field, innovative
solutions have been sought worldwide by environmental groups,
academia, governments and companies for many years, recently,
citizens and communities have emerged as a new group and taken
more and more active role in this field. Many scholars call for more
research on the role of community and community innovation in
sustainable development. This paper is to respond to the calls. In
this paper, we first summarize a comprehensive set of innovation
principles. Then, we do a qualitative cross case study by comparing
three community innovation cases in three different areas of sustainable
development according to the innovation principles. Finally,
we summarize the case comparison and discuss the implications
to sustainable development. A unified role model and innovation
distribution map of community innovation are developed to better
understand community innovation in sustainable development..
Abstract: Using neural network we try to model the unknown function f for given input-output data pairs. The connection strength of each neuron is updated through learning. Repeated simulations of crisp neural network produce different values of weight factors that are directly affected by the change of different parameters. We propose the idea that for each neuron in the network, we can obtain quasi-fuzzy weight sets (QFWS) using repeated simulation of the crisp neural network. Such type of fuzzy weight functions may be applied where we have multivariate crisp input that needs to be adjusted after iterative learning, like claim amount distribution analysis. As real data is subjected to noise and uncertainty, therefore, QFWS may be helpful in the simplification of such complex problems. Secondly, these QFWS provide good initial solution for training of fuzzy neural networks with reduced computational complexity.
Abstract: The notion of Next Generation Network (NGN) is
based on the Network Convergence concept which refers to
integration of services (such as IT and communication services) over
IP layer. As the most popular implementation of Service Oriented
Architecture (SOA), Web Services technology is known to be the
base for service integration. In this paper, we present a platform to
deliver communication services as web services. We also implement
a sample service to show the simplicity of making composite web
and communication services using this platform. A Service Logic
Execution Environment (SLEE) is used to implement the
communication services. The proposed architecture is in agreement
with Service Oriented Architecture (SOA) and also can be integrated
to an Enterprise Service Bus to make a base for NGN Service
Delivery Platform (SDP).
Abstract: The distribution, enrichment, and accumulation of zinc
(Zn) in the sediments of Kaohsiung Ocean Disposal Site (KODS),
Taiwan were investigated. Sediment samples from two outer disposal
site stations and nine disposed stations in the KODS were collected per
quarterly in 2009 and characterized for Zn, aluminum, organic matter,
and grain size. Results showed that the mean Zn concentrations varied
from 48 mg/kg to 456 mg/kg. Results from the enrichment factor (EF)
and geo-accumulation index (Igeo) analyses imply that the sediments
collected from the KODS can be characterized between moderate and
moderately severe degree enrichment and between none and none to
medium accumulation of Zn, respectively. However, results of
potential ecological risk index indicate that the sediment has low
ecological potential risk. The EF, Igeo, and Zn concentrations at the
disposed stations were slightly higher than those at outer disposal site.
This indicated that the disposed area centers may be subjected to the
disposal impaction of harbor dredged sediments.
Abstract: The main objective of this paper is applying a
comparison between the Wolf Pack Search (WPS) as a newly
introduced intelligent algorithm with several other known algorithms
including Particle Swarm Optimization (PSO), Shuffled Frog
Leaping (SFL), Binary and Continues Genetic algorithms. All
algorithms are applied on two benchmark cost functions. The aim is
to identify the best algorithm in terms of more speed and accuracy in
finding the solution, where speed is measured in terms of function
evaluations. The simulation results show that the SFL algorithm with
less function evaluations becomes first if the simulation time is
important, while if accuracy is the significant issue, WPS and PSO
would have a better performance.
Abstract: Since Cloud environment has appeared as the most powerful
keyword in the computing industry, the growth in VDI (Virtual Desktop
Infrastructure) became remarkable in domestic market. In recent years, with the trend
that mobile devices such as smartphones and pads spread so rapidly, the strengths of
VDI that allows people to access and perform business on the move along with
companies' office needs expedite more rapid spread of VDI.
In this paper, mobile OTP (One-Time Password) authentication method is proposed
to secure mobile device portability through rapid and secure authentication using
mobile devices such as mobile phones or pads, which does not require additional
purchase or possession of OTP tokens of users. To facilitate diverse and wide use of
Services in the future, service should be continuous and stable, and above all, security
should be considered the most important to meet advanced portability and user
accessibility, the strengths of VDI.