Abstract: With drug resistance becoming widespread in
Plasmodium falciparum infections, the development of the alternative
drugs is the desired strategy for prevention and cure of malaria. Three
drug targets were selected to screen promising drug molecules from
the GSK library of 13469 molecules. Using an in silico structure-based
drug designing approach, the differences in binding energies of
the substrate and inhibitor were exploited between target sites of
parasite and human to design a drug molecule against Plasmodium.
The docking studies have shown several promising molecules from
GSK library with more effective binding as compared to the already
known inhibitors for the drug targets. Though stronger interaction has
been shown by several molecules as compared to the reference, few
molecules have shown the potential as drug candidates though in
vitro studies are required to validate the results. In case of
thymidylate synthase-dihydrofolatereductase (TS-DHFR), three
compounds have shown promise for future studies as potential drugs.
Abstract: The impact of Special Economic Zones (SEZs) has
been analyzed for many years by researchers. There are lot of
theoretical studies proving the SEZs importance for regional
development, however, there is lack of empirical studies (and they
are mainly focused on China market) that are based on available data.
The theoretical studies indicate the various impacts of enterprises
operating within SEZs on the economy. The article proves that, in
case of Poland, locating SEZs in municipalities is an important part
of increasing municipalities’ income. Therefore SEZs have a positive
impact on regional development. Municipality income is understood
as taxes paid by taxpayers who depend on SEZ companies’
performance. The analysis includes the Corporate Income Tax (CIT),
Personal Income Tax (PIT) and real estate tax. The effects of SEZs
on regional development were narrowed to a few variables that are
most significant for the financial system. The analysis indicates the
significant impact of SEZs on the amount of taxes influencing the
municipality budget.
Abstract: This paper presents the results and findings from a
parametric study on the water surface elevation at upstream of bridge
constriction for subcritical flow. In this study, the influence of
Manning's Roughness Coefficient of main channel (nmc) and
floodplain (nfp), and bridge opening (b) flow rate (Q), contraction
(kcon) and expansion coefficients (kexp) were investigated on
backwater level. The DECK bridge models with different span widths
and without any pier were investigated within the two stage channel
having various roughness conditions. One of the most commonly
used commercial one-dimensional HEC-RAS model was used in this
parametric study. This study showed that the effects of main channel
roughness (nmc) and flow rate (Q) on the backwater level are much
higher than those of the floodplain roughness (nfp). Bridge opening
(b) with contraction (kcon) and expansion coefficients (kexp) have very
little effect on the backwater level within this range of parameters.
Abstract: A new concept of response system is proposed for
filling the gap that exists in reducing vulnerability during immediate
response to natural disasters. Real Time Early Response Systems
(RTERSs) incorporate real time information as feedback data for
closing control loop and for generating real time situation assessment.
A review of the state of the art on works that fit the concept of
RTERS is presented, and it is found that they are mainly focused on
manmade disasters. At the same time, in response phase of natural
disaster management many works are involved in creating early
warning systems, but just few efforts have been put on deciding what
to do once an alarm is activated. In this context a RTERS arises as a
useful tool for supporting people in their decision making process
during natural disasters after an event is detected, and also as an
innovative context for applying well-known automation technologies
and automatic control concepts and tools.
Abstract: Nowadays, it is a globalization era which social media
plays an important role to the lifestyle as an information source, tools
to connect people together and etc. This research is object to find out
about the significant level of the social media as a distribution
channel to the agriculture product of Thailand. In this research, the
agriculture product is the Rice Berry which is the cross-bred unmilled
rice producing dark violet grain, is a combination of Hom Nin Rice
and Thai Jasmine/ Fragrant Rice 105. Rice Berry has a very high
nutrition and nice aroma so the product is in the growth stage of the
product cycle. The problem for the Rice Berry product in Thailand is
the production and the distribution channel. This study is to confirm
that the social media is another option as the distribution channel for
the product which is not a mass production product. This will be the
role model for the other niche market product to select the
distribution channel.
Abstract: Learning Management System (LMS) is the system
which uses to manage the learning in order to grouping the content
and learning activity between the lecturer and learner including
online examination and evaluation. Nowadays, it is the borderless
learning era so the learning activities can be accessed from
everywhere in the world and also anytime via the information
technology and media. The learner can easily access to the
knowledge so the different in time and distance is not a constraint for
learning anymore.
The learning pattern which was used in this research is the
integration of the in-class learning and online learning via internet
and will be able to monitor the progress by the Learning management
system which will create the fast response and accessible learning
process via the social media. In order to increase the capability and
freedom of the learner, the system can show the current and history
of the learning document, video conference and also has the chat
room for the learner and lecturer to interact to each other.
So the objectives of the “The Design and Applied of Learning
Management System via Social Media on Internet: Case Study of
Operating System for Business Subject” are to expand the
opportunity of learning and to increase the efficiency of learning as
well as increase the communication channel between lecturer and
student. The data of this research was collect from 30 users of the
system which are students who enroll in the subject. And the result of
the research is in the “Very Good” which is conformed to the
hypothesis.
Abstract: Cultures play a role in business communication and in
research. At the example of language in international business, this
paper addresses the issue of how the research cultures of management
research and linguistics as well as cultures as such can be linked.
After looking at existing research on language in international
business, this paper approaches communication in international
business from a linguistic angle and attempts to explain
communication issues in businesses based on linguistic research.
Thus the paper makes a step into cross-disciplinary research
combining management research with linguistics.
Abstract: The aim of this study is to analyze the role and
effectiveness of internal mechanism (audit committee) of corporate
governance on credit institutions performance in Croatia. Based on
research objective, sample of 78 credit institutions listed on Zagreb
Stock Exchange, from 2007 to 2012, has been collected and
efficiency index of audit committee (EIAC) has been created. Based
on the sample and created EIAC, conclusions are as follows: audit
committees of credit institutions have medium efficiency, based on
EIAC measurement; there is a significant difference in audit
committee effectiveness, in observed period; there is no positive
relationship between audit committee effectiveness and credit
institution performance; there is a significant difference between
level of audit committee effectiveness and audit firm type. Future
research should contain increased number of elements in EIAC
creation and increased sample, for all obligators who need to
establish audit committee.
Abstract: This study investigated some results of the use of
digital art tools by junior school children in order to discover if these
tools could promote artistic ability and creativity. The study considers
the ease of use and usefulness of the tools as well as how to assess
artwork produced by digital means. As the use of these tools is a
relatively new development in Art education, this study may help
educators in their choice of which tools to use and when to use them.
The study also aims to present a model for the assessment of
students’ artistic development and creativity by studying their artistic
activity. This model can help in determining differences in students’
creative ability and could be useful both for teachers, as a means of
assessing digital artwork, and for students, by providing the
motivation to use the tools to their fullest extent. Sixteen students
aged nine to ten years old were observed and recorded while they
used the digital drawing tools. The study found that, according to the
students’ own statements, it was not the ease of use but the successful
effects the tools provided which motivated the children to use them.
Abstract: The influences of cell-free solutions (CFSs) of lactic
acid bacteria (LAB) on cadaverine and other biogenic amines
production by Listeria monocytogenes and Staphylococcus aureus
were investigated in lysine decarboxylase broth (LDB) using HPLC.
Cell free solutions were prepared from Lactococcus lactis subsp.
lactis, Leuconostoc mesenteroides subsp. cremoris, Pediococcus
acidilactici and Streptococcus thermophiles. Two different
concentrations that were 50% and 25% CFS and the control without
CFSs were prepared. Significant variations on biogenic amine
production were observed in the presence of L. monocytogenes and S.
aureus (P < 0.05). The function of CFS on biogenic amine production
by foodborne pathogens varied depending on strains and specific
amine. Cadaverine formation by L. monocytogenes and S. aureus in
control were 500.9 and 948.1 mg/L, respectively while the CFSs of
LAB induced 4-fold lower cadaverine production by L.
monocytogenes and 7-fold lower cadaverine production by S. aureus.
The CFSs resulted in strong decreases in cadaverine and putrescine
production by L. monocytogenes and S. aureus, although remarkable
increases were observed for histamine, spermidine, spermine,
serotonin, dopamine, tyramine and agmatine in the presence of LAB
in lysine decarboxylase broth.
Abstract: A nanocrystalline thin film of ZnSe was successfully
electrodeposited on copper substrate using a non-aqueous solution
and subsequently annealed in air at 400°C. XRD analysis indicates
the polycrystalline deposit of (111) plane in both the cases. The
sharpness of the peak increases due to annealing of the film and
average grain size increases to 20 nm to 27nm. SEM photograph
indicate that grains are uniform and densely distributed over the
surface. Annealing increases the average grain size by 20%. The EDS
spectroscopy shows the ratio of Zn & Se is 1.1 in case of annealed
film. AFM analysis indicates the average roughness of the film
reduces from 181nm to 165nm due to annealing of the film. The
bandgap also decreases from 2.71eV to 2.62eV.
Abstract: This paper develops and extended eclectic paradigm
to fit the firm internationalization process with the real international
business world. The approach is based on Dunning´s, introducing
new concepts like mode of entry, international joint venture o
international mergers and acquisitions. At the same time is presented
a model to describe the Spanish international mergers and
acquisitions in order to determinate the most important factor that
influence in this type of foreign direct investment.
Abstract: The main objective of aircraft aerodynamics is to
enhance the aerodynamic characteristics and maneuverability of the
aircraft. This enhancement includes the reduction in drag and stall
phenomenon. The airfoil which contains dimples will have
comparatively less drag than the plain airfoil. Introducing dimples on
the aircraft wing will create turbulence by creating vortices which
delays the boundary layer separation resulting in decrease of pressure
drag and also increase in the angle of stall. In addition, wake
reduction leads to reduction in acoustic emission. The overall
objective of this paper is to improve the aircraft maneuverability by
delaying the flow separation point at stall and thereby reducing the
drag by applying the dimple effect over the aircraft wing. This project
includes both computational and experimental analysis of dimple
effect on aircraft wing, using NACA 0018 airfoil. Dimple shapes of
Semi-sphere, hexagon, cylinder, square are selected for the analysis;
airfoil is tested under the inlet velocity of 30m/s and 60m/s at
different angle of attack (5˚, 10˚, 15˚, 20˚, and 25˚). This analysis
favors the dimple effect by increasing L/D ratio and thereby
providing the maximum aerodynamic efficiency, which provides the
enhanced performance for the aircraft.
Abstract: There has been a significant decline in active travel
and a massive increase in the use of car dependent travel in many
countries during the past two decades. Evidential risks for people’s
physical and mental health problems are correlated with this
increased use of motorized travel. These health related problems
range from overweight and obesity to increased air pollution. In
response to these rising concerns health professionals, traffic planers,
local authorities and others have introduced a variety of initiatives to
counterbalance the dominance of cars for daily journeys.
However, the nature of travel behavior change interventions,
which aim to reduce car use, are very complex and challenging
regarding their interactions with human behavior. To change travel
behavior at least two aspects have to be taken into consideration.
First, how to alter attitudes and perceptions toward the sustainable
and healthy modes of travel, in competition with experiences of
private car use. And second, how to make these behavior change
processes irreversible and sustainable. There are no comprehensive
models available to guide policy interventions to increase the level of
success of travel behavior change interventions across both these
dimensions.
A comprehensive theoretical framework is required in the effort to
optimize how to facilitate and guide the processes of data collection
and analysis to achieve the best possible guidelines for policy
makers. Regarding the gaps in the travel behavior change research
literature, this paper attempted to identify and suggest a
multidimensional framework in order to facilitate planning the
implemented travel behavior change interventions. A structured
mixed-method model is suggested to improve the analytic power of
the results according to the complexity of human behavior.
In order to recognize people’s attitudes towards a specific travel
mode, the Theory of Planned Behavior (TPB) was operationalized.
But in order to capture decision making processes the Transtheoretical
model of Behavior Change (TTM) was also used.
Consequently, the combination of these two theories (TTM and TPB)
has resulted in a synthesis with appropriate concepts to identify and
design an implemented travel behavior change interventions.
Abstract: Moodle is an open source learning management
system that enables creation of a powerful and flexible learning
environment. Many organizations, especially learning institutions
have customized Moodle open source LMS for their own use. In
general open source LMSs are of great interest due to many
advantages they offer in terms of cost, usage and freedom to
customize to fit a particular context. Tanzania Secondary School e-
Learning (TanSSe-L) system is the learning management system for
Tanzania secondary schools. TanSSe-L system was developed using
a number of methods, one of them being customization of Moodle
Open Source LMS. This paper presents few areas on the way Moodle
OS LMS was customized to produce a functional TanSSe-L system
fitted to the requirements and specifications of Tanzania secondary
schools’ context.
Abstract: Anxiety is a common psychological problem and also
implicated as a contributor to many chronic diseases which decreased
quality of life even with pharmacological treatment. At the present
time several yogic practices- meditation, pranayama, and mantra,
etcetera are playing important role in treating physiological and
psychological problems. Hence, the present investigation is aimed to
see the effect of Trataka on the level of anxiety among adolescents.
For the present study, a sample of 30 adolescents belonging to the
age range 20-30 years was selected from Devsanskriti Vishwa
Vidyalaya Haridwar through random sampling. In this investigation,
Sinha’s Comprehensive anxiety test has been used to measure the
level of anxiety. Statistical analysis has been done by using t-test.
Findings of this study reveal that Trataka significantly decreases the
level of anxiety among adolescents.
Abstract: The purpose of this paper is to describe the
perceptions of knowledge and information sharing by the Polish
academic community. An electronic questionnaire was used to gather
opinions of respondents. The presented results are a part of the
findings of empirical studies carried out amongst academics from
various types of universities and academia located throughout
Poland.
Abstract: The goal of this study is to identify success factors
that could influence the ISMS self-implementation in government
sector from qualitative perspective. This study is based on a case
study in one of the Malaysian government agency. Semi-structured
interviews involving five key informants were conducted to examine
factors addressed in the conceptual framework. Subsequently,
thematic analysis was executed to describe the influence of each
factor on the success implementation of ISMS. The result of this
study indicates that management commitment, implementer
commitment and implementer competency are part of the success
factors for ISMS self-implementation in Malaysian Government
Sector.
Abstract: Potato (Solanum tuberosum L.) is one of the major
vegetable crops that are grown world –wide because of its economic
importance. This experiment investigated the effect of local sands
(River Base, Al-Ekader and Karbala) on number and total weight of
minitubers. Statistical analysis revealed that there were no significant
differences among sand cultures in number of stem/plant, chlorophyll
index and tubers dry weight. River Base sand had the highest plant
height (74.9 cm), leaf number/plant number (39.3), leaf area (84.4
dcm2⁄plant), dry weight/plant (26.31), tubers number/plant (8.5),
tubers weight/plant (635.53 gm) and potato tuber yields/trove (28.60
kg), whereas the Karbala sand had lower performance. All the
characters had positive and significant correlation with yields except
the traits number of stem and tuber dry weight.
Abstract: The turbocharger and turbocharging have been the
inherent component of diesel engines, so that critical parameters of
such engines, as BSFC (Brake Specific Fuel Consumption) or
thermal efficiency, fuel consumption, BMEP (Brake Mean Effective
Pressure), the power density output and emission level have been
improved extensively. In general, the turbocharger can be considered
as the most complex component of diesel engines, because it has
closely interrelated turbomachinery concepts of the turbines and the
compressors to thermodynamic fundamentals of internal combustion
engines and stress analysis of all components.
In this paper, a waste gate for a conventional single stage radial
turbine is investigated by consideration of turbochargers operation
constrains and engine operation conditions, without any detail
designs in the turbine and the compressor. Amount of opening waste
gate which extended between the ranges of full opened and closed
valve, is demonstrated by limiting compressor boost pressure ratio.
Obtaining of an optimum point by regard above mentioned items is
surveyed by three linked meanline modeling programs together
which consist of Turbomatch®, Compal®, Rital® madules in concepts
NREC® respectively.