Abstract: Several embryonic cellular mechanism including cell
cycle, growth and apoptosis are regulated by phosphatidylinositol-3-
kinase (PI3K)/Akt signaling pathway. The goal of present study is to
determine the effects of annatto (Bixa orellana)-derived δ-tocotrienol
(δ-TCT) on the regulations of PI3K/Akt genes in murine morula.
Twenty four 6-8 week old (23-25g) female balb/c mice were
randomly divided into four groups (G1-G4; n=6). Those groups were
subjected to the following treatments for 7 consecutive days: G1
(control) received tocopherol stripped corn oil, G2 was given 60
mg/kg/day of δ-TCT mixture (contains 90% delta & 10% gamma
isomers), G3 was given 60 mg/kg/day of pure δ-TCT (>98% purity)
and G4 received 60 mg/kg/day α-TOC. On Day 8, females were
superovulated with 5 IU Pregnant Mare’s Serum Gonadotropin
(PMSG) for 48 hours followed with 5 IU human Chorionic
Gonadotropin (hCG) before mated with males at the ratio of 1:1.
Females were sacrificed by cervical dislocation for embryo collection
48 hours post-coitum. About fifty morulas from each group were
used in the gene expression analyses using Affymetrix QuantiGene
Plex 2.0 Assay. Present data showed a significant increase (p
Abstract: The goal of this paper is to present the diagnostic
contribution that the screening instrument, Mini-Mental State
Examination-2: Expanded Version (MMSE-2:EV), brings in
detecting the cognitive impairment or in monitoring the progress of
degenerative disorders. The diagnostic signification is underlined by
the interpretation of the MMSE-2:EV scores, resulted from the test
application to patients with mild and major neurocognitive disorders.
The cases were selected from current practice, in order to cover vast
and significant neurocognitive pathology: mild cognitive impairment,
Alzheimer’s disease, vascular dementia, mixed dementia, Parkinson’s
disease, conversion of the mild cognitive impairment into
Alzheimer’s disease. The MMSE-2:EV version was used: it was
applied one month after the initial assessment, three months after the
first reevaluation and then every six months, alternating the blue and
red forms. Correlated with age and educational level, the raw scores
were converted in T scores and then, with the mean and the standard
deviation, the z scores were calculated. The differences of raw scores
between the evaluations were analyzed from the point of view of
statistic signification, in order to establish the progression in time of
the disease. The results indicated that the psycho-diagnostic approach
for the evaluation of the cognitive impairment with MMSE-2:EV is
safe and the application interval is optimal. In clinical settings with a
large flux of patients, the application of the MMSE-2:EV is a safe
and fast psychodiagnostic solution. The clinicians can draw objective
decisions and for the patients: it does not take too much time and
energy, it does not bother them and it doesn’t force them to travel
frequently.
Abstract: The output error of the globoidal cam mechanism can
be considered as a relevant indicator of mechanism performance,
because it determines kinematic and dynamical behavior of
mechanical transmission. Based on the differential geometry and the
rigid body transformations, the mathematical model of surface
geometry of the globoidal cam is established. Then we present the
analytical expression of the output error (including the transmission
error and the displacement error along the output axis) by considering
different manufacture and assembly errors. The effects of the center
distance error, the perpendicular error between input and output axes
and the rotational angle error of the globoidal cam on the output error
are systematically analyzed. A globoidal cam mechanism which is
widely used in automatic tool changer of CNC machines is applied for
illustration. Our results show that the perpendicular error and the
rotational angle error have little effects on the transmission error but
have great effects on the displacement error along the output axis. This
study plays an important role in the design, manufacture and assembly
of the globoidal cam mechanism.
Abstract: Typical load-bearing biological materials like bone,
mineralized tendon and shell, are biocomposites made from both
organic (collagen) and inorganic (biomineral) materials. This
amazing class of materials with intrinsic internally designed
hierarchical structures show superior mechanical properties with
regard to their weak components from which they are formed.
Extensive investigations concentrating on static loading conditions
have been done to study the biological materials failure. However,
most of the damage and failure mechanisms in load-bearing
biological materials will occur whenever their structures are exposed
to dynamic loading conditions. The main question needed to be
answered here is: What is the relation between the layout and
architecture of the load-bearing biological materials and their
dynamic behavior? In this work, a staggered model has been
developed based on the structure of natural materials at nanoscale and
Finite Element Analysis (FEA) has been used to study the dynamic
behavior of the structure of load-bearing biological materials to
answer why the staggered arrangement has been selected by nature to
make the nanocomposite structure of most of the biological materials.
The results showed that the staggered structures will efficiently
attenuate the stress wave rather than the layered structure.
Furthermore, such staggered architecture is effectively in charge of
utilizing the capacity of the biostructure to resist both normal and
shear loads. In this work, the geometrical parameters of the model
like the thickness and aspect ratio of the mineral inclusions selected
from the typical range of the experimentally observed feature sizes
and layout dimensions of the biological materials such as bone and
mineralized tendon. Furthermore, the numerical results validated with
existing theoretical solutions. Findings of the present work emphasize
on the significant effects of dynamic behavior on the natural
evolution of load-bearing biological materials and can help scientists
to design bioinspired materials in the laboratories.
Abstract: Ceramic Waste Aggregates (CWAs) were made from
electric porcelain insulator wastes supplied from an electric power
company, which were crushed and ground to fine aggregate sizes. In
this study, to develop the CWA mortar as an eco–efficient, ground
granulated blast–furnace slag (GGBS) as a Supplementary
Cementitious Material (SCM) was incorporated. The water–to–binder
ratio (W/B) of the CWA mortars was varied at 0.4, 0.5, and 0.6. The
cement of the CWA mortar was replaced by GGBS at 20 and 40% by
volume (at about 18 and 37% by weight). Mechanical properties of
compressive and splitting tensile strengths, and elastic modulus were
evaluated at the age of 7, 28, and 91 days. Moreover, the chloride
ingress test was carried out on the CWA mortars in a 5.0% NaCl
solution for 48 weeks. The chloride diffusion was assessed by using an
electron probe microanalysis (EPMA). To consider the relation of the
apparent chloride diffusion coefficient and the pore size, the pore size
distribution test was also performed using a mercury intrusion
porosimetry at the same time with the EPMA. The compressive
strength of the CWA mortars with the GGBS was higher than that
without the GGBS at the age of 28 and 91 days. The resistance to the
chloride ingress of the CWA mortar was effective in proportion to the
GGBS replacement level.
Abstract: Live video streaming is one of the most widely used
service among end users, yet it is a big challenge for the network
operators in terms of quality. The only way to provide excellent
Quality of Experience (QoE) to the end users is continuous
monitoring of live video streaming. For this purpose, there are several
objective algorithms available that monitor the quality of the video in
a live stream. Subjective tests play a very important role in fine
tuning the results of objective algorithms. As human perception is
considered to be the most reliable source for assessing the quality of a
video stream subjective tests are conducted in order to develop more
reliable objective algorithms. Temporal impairments in a live video
stream can have a negative impact on the end users. In this paper we
have conducted subjective evaluation tests on a set of video
sequences containing temporal impairment known as frame freezing.
Frame Freezing is considered as a transmission error as well as a
hardware error which can result in loss of video frames on the
reception side of a transmission system. In our subjective tests, we
have performed tests on videos that contain a single freezing event
and also for videos that contain multiple freezing events. We have
recorded our subjective test results for all the videos in order to give a
comparison on the available No Reference (NR) objective
algorithms. Finally, we have shown the performance of no reference
algorithms used for objective evaluation of videos and suggested the
algorithm that works better. The outcome of this study shows the
importance of QoE and its effect on human perception. The results
for the subjective evaluation can serve the purpose for validating
objective algorithms.
Abstract: This paper shows the general perceptions of Spanish
university stakeholders in relation to the university’s annual reports
and the adequacy and potential of intellectual capital reporting. To
this end, a questionnaire was designed and sent to every member of
the Social Councils of Spanish public universities. It was thought that
these participants would provide a good example of the attitude of
university stakeholders since they represent the different social
groups connected with universities. From the results of this study we
are in the position of confirming the need for universities to offer
information on intellectual capital in their accounting information
model.
Abstract: Multiple User Interference (MUI) considers the
primary problem in Optical Code-Division Multiple Access
(OCDMA), which resulting from the overlapping among the users. In
this article we aim to mitigate this problem by studying an
interference cancellation scheme called successive interference
cancellation (SIC) scheme. This scheme will be tested on two
different detection schemes, spectral amplitude coding (SAC) and
direct detection systems (DS), using partial modified prime (PMP) as
the signature codes. It was found that SIC scheme based on both SAC
and DS methods had a potential to suppress the intensity noise, that is
to say it can mitigate MUI noise. Furthermore, SIC/DS scheme
showed much lower bit error rate (BER) performance relative to
SIC/SAC scheme for different magnitude of effective power. Hence,
many more users can be supported by SIC/DS receiver system.
Abstract: In recent years, fire accidents have been steadily
increased and the amount of property damage caused by the accidents
has gradually raised. Damaging building structure, fire incidents bring
about not only such property damage but also strength degradation and
member deformation. As a result, the building structure undermines its
structural ability. Examining the degradation and the deformation is
very important because reusing the building is more economical than
reconstruction. Therefore, engineers need to investigate the strength
degradation and member deformation well, and make sure that they
apply right rehabilitation methods. This study aims at evaluating
deformation characteristics of fire damaged and rehabilitated normal
strength concrete beams through both experiments and finite element
analyses. For the experiments, control beams, fire damaged beams and
rehabilitated beams are tested to examine deformation characteristics.
Ten test beam specimens with compressive strength of 21MPa are
fabricated and main test variables are selected as cover thickness of
40mm and 50mm and fire exposure time of 1 hour or 2 hours. After
heating, fire damaged beams are air-recurred for 2 months and
rehabilitated beams are repaired with polymeric cement mortar after
being removed the fire damaged concrete cover. All beam specimens
are tested under four points loading. FE analyses are executed to
investigate the effects of main parameters applied to experimental
study. Test results show that both maximum load and stiffness of the
rehabilitated beams are higher than those of the fire damaged beams.
In addition, predicted structural behaviors from the analyses also show
good rehabilitation effect and the predicted load-deflection curves are
similar to the experimental results. For the further, the proposed
analytical method can be used to predict deformation characteristics of
fire damaged and rehabilitated concrete beams without suffering from
time and cost consuming of experimental process.
Abstract: Sound processing is one the subjects that newly
attracts a lot of researchers. It is efficient and usually less expensive
than other methods. In this paper the flow generated sound is used to
estimate the flow speed of free flows. Many sound samples are
gathered. After analyzing the data, a parameter named wave power is
chosen. For all samples the wave power is calculated and averaged
for each flow speed. A curve is fitted to the averaged data and a
correlation between the wave power and flow speed is found. Test
data are used to validate the method and errors for all test data were
under 10 percent. The speed of the flow can be estimated by
calculating the wave power of the flow generated sound and using the
proposed correlation.
Abstract: Significant attention has recently been paid to the
cross-cultural negotiations due to the growth of international
businesses. Despite the substantial body of literature examining the
influence of National Culture (NC) dimensions on negotiations, there
is a lack of studies comparing the influence of NC in Latin America
with a Western European countries, In particular, an extensive review
of the literature revealed that a contribution to knowledge would be
derived from the comparison of the influence of NC dimensions on
negotiations in UK and Venezuela. The primary data was collected
through qualitative interviews, to obtain an insight about the
perceptions and beliefs of Venezuelan and British business managers
about their negotiating styles. The findings of this study indicated
that NC has a great influence on the negotiating styles. In particular,
Venezuelan and British managers demonstrated to have opposed
negotiating styles, affecting the way they communicate, approach
people and their willingness to take risks.
Abstract: This research aims to identify traditional Mon cuisines
as well as gather and classify traditional cuisines of Mon
communities in Bangkok. The studying of this research is used by
methodology of the quantitative research. Using the questionnaire as
the method in collecting information from sampling totally amount of
450 persons analyzed via frequency, percentage and mean value. The
results showed that a variety of traditional Mon cuisines of Bangkok
could split into 6 categories of meat diet with 54 items and 6
categories of desserts with 19 items.
Abstract: Transparent nickel doped cobalt sulfide was fabricated
on a SnO2:F electrode and tested as an efficient electrocatalyst and as
an alternative to the expensive platinum counter electrode. In order to
investigate how this electrode could affect the electrical
characteristics of a dye-sensitized solar cell, we manufactured cells
with the same TiO2 photoanode sensitized with dye (N719) and
employing the same quasi-solid electrolyte, altering only the counter
electrode used. The cells were electrically and electrochemically
characterized and it was observed that the ones with the Ni doped
CoS2 outperformed the efficiency of the cells with the Pt counter
electrode (3.76% and 3.44% respectively). Particularly, the higher
efficiency of the cells with the Ni doped CoS2 counter electrode (CE)
is mainly because of the enhanced photocurrent density which is
attributed to the enhanced electrocatalytic ability of the CE and the
low charge transfer resistance at the CE/electrolyte interface.
Abstract: This contribution presents a friction estimator for
industrial purposes which identifies Coulomb friction in a steering
system. The estimator only needs a few, usually known, steering
system parameters. Friction occurs on almost every mechanical
system and has a negative influence on high-precision position
control. This is demonstrated on a steering angle controller for highly
automated driving. In this steering system the friction induces limit
cycles which cause oscillating vehicle movement when the vehicle
follows a given reference trajectory. When compensating the friction
with the introduced estimator, limit cycles can be suppressed. This
is demonstrated by measurements in a series vehicle.
Abstract: Psychopathic disorders are taking an important part in
judge sentencing, especially in Canada. First, we will see how this
phenomenon can be illustrated by the high proportion of psychopath
offenders incarcerated in North American prisons. Many decisions in
Canadians courtrooms seem to point out that psychopathy is often
used as a strong argument by the judges to preserve public safety.
The fact that psychopathy is often associated with violence,
recklessness and recidivism, could explain why many judges consider
psychopathic disorders as an aggravating factor. Generally, the judge
reasoning is based on Article 753 of Canadian Criminal Code related
to dangerous offenders, which is used for individuals who show a
pattern of repetitive and persistent aggressive behaviour. Then we
will show how, with cognitive neurosciences, the psychopath’s
situation in courtrooms would probably change. Cerebral imaging
and news data provided by the neurosciences show that emotional
and volitional functions in psychopath’s brains are impaired.
Understanding these new issues could enable some judges to
recognize psychopathic disorders as a mitigating factor. Finally, two
important questions ought to be raised in this article: can exploring
psychopaths ‘brains really change the judge sentencing in Canadian
courtrooms? If yes, can judges consider psychopathy more as a
mitigating factor than an aggravating factor?
Abstract: Human beings have the ability to make logical
decisions. Although human decision - making is often optimal, it is
insufficient when huge amount of data is to be classified. Medical
dataset is a vital ingredient used in predicting patient’s health
condition. In other to have the best prediction, there calls for most
suitable machine learning algorithms. This work compared the
performance of Artificial Neural Network (ANN) and Decision Tree
Algorithms (DTA) as regards to some performance metrics using
diabetes data. WEKA software was used for the implementation of
the algorithms. Multilayer Perceptron (MLP) and Radial Basis
Function (RBF) were the two algorithms used for ANN, while
RegTree and LADTree algorithms were the DTA models used. From
the results obtained, DTA performed better than ANN. The Root
Mean Squared Error (RMSE) of MLP is 0.3913 that of RBF is
0.3625, that of RepTree is 0.3174 and that of LADTree is 0.3206
respectively.
Abstract: The quantitative study of cell mechanics is of
paramount interest, since it regulates the behaviour of the living cells
in response to the myriad of extracellular and intracellular
mechanical stimuli. The novel experimental techniques together with
robust computational approaches have given rise to new theories and
models, which describe cell mechanics as combination of
biomechanical and biochemical processes. This review paper
encapsulates the existing continuum-based computational approaches
that have been developed for interpreting the mechanical responses of
living cells under different loading and boundary conditions. The
salient features and drawbacks of each model are discussed from both
structural and biological points of view. This discussion can
contribute to the development of even more precise and realistic
computational models of cell mechanics based on continuum
approaches or on their combination with microstructural approaches,
which in turn may provide a better understanding of
mechanotransduction in living cells.
Abstract: A bauxite ore can be utilized in Bayer Process, if the
mass ratio of Al2O3 to SiO2 is greater than 10. Otherwise, its FexOy
and SiO2 content should be removed. On the other hand, removal of
TiO2 from the bauxite ore would be beneficial because of both
lowering the red mud residue and obtaining a valuable raw material
containing TiO2 mineral. In this study, the low grade diasporic
bauxite ore of Yalvaç, Isparta, Turkey was roasted under reducing
atmosphere and subjected to magnetic separation. According to the
experimental results, 800°C for reduction temperature and 20000
Gauss of magnetic intensity were found to be the optimum
parameters for removal of iron oxide and rutile from the nonmagnetic
ore. On the other hand, 600°C and 5000 Gauss were
determined to be the optimum parameters for removal of silica from
the non-magnetic ore.
Abstract: The lifetime of a wireless sensor network can be
effectively increased by using scheduling operations. Once the
sensors are randomly deployed, the task at hand is to find the largest
number of disjoint sets of sensors such that every sensor set provides
complete coverage of the target area. At any instant, only one of these
disjoint sets is switched on, while all other are switched off. This
paper proposes a heuristic search method to find the maximum
number of disjoint sets that completely cover the region. A
population of randomly initialized members is made to explore the
solution space. A set of heuristics has been applied to guide the
members to a possible solution in their neighborhood. The heuristics
escalate the convergence of the algorithm. The best solution explored
by the population is recorded and is continuously updated. The
proposed algorithm has been tested for applications which require
sensing of multiple target points, referred to as point coverage
applications. Results show that the proposed algorithm outclasses the
existing algorithms. It always finds the optimum solution, and that
too by making fewer number of fitness function evaluations than the
existing approaches.
Abstract: Nanotechnology has become the world attention in
various applications including the solar cells devices due to the
uniqueness and benefits of achieving low cost and better
performances of devices. Recently, thin film solar cells such as
Cadmium Telluride (CdTe), Copper-Indium-Gallium-diSelenide
(CIGS), Copper-Zinc-Tin-Sulphide (CZTS), and Dye-Sensitized
Solar Cells (DSSC) enhanced by nanotechnology have attracted
much attention. Thus, a compilation of nanotechnology devices
giving the progress in the solar cells has been presented. It is much
related to nanoparticles or nanocrystallines, carbon nanotubes, and
nanowires or nanorods structures.