Abstract: Batch production plants provide a wide range of
scheduling problems. In pharmaceutical industries a batch process
is usually described by a recipe, consisting of an ordering of tasks
to produce the desired product. In this research work we focused
on pharmaceutical production processes requiring the culture of
a microorganism population (i.e. bacteria, yeasts or antibiotics).
Several sources of uncertainty may influence the yield of the culture
processes, including (i) low performance and quality of the cultured
microorganism population or (ii) microbial contamination. For
these reasons, robustness is a valuable property for the considered
application context. In particular, a robust schedule will not collapse
immediately when a cell of microorganisms has to be thrown away
due to a microbial contamination. Indeed, a robust schedule should
change locally in small proportions and the overall performance
measure (i.e. makespan, lateness) should change a little if at all.
In this research work we formulated a constraint programming
optimization (COP) model for the robust planning of antibiotics
production. We developed a discrete-time model with a multi-criteria
objective, ordering the different criteria and performing a
lexicographic optimization. A feasible solution of the proposed
COP model is a schedule of a given set of tasks onto available
resources. The schedule has to satisfy tasks precedence constraints,
resource capacity constraints and time constraints. In particular
time constraints model tasks duedates and resource availability
time windows constraints. To improve the schedule robustness, we
modeled the concept of (a, b) super-solutions, where (a, b) are input
parameters of the COP model. An (a, b) super-solution is one in
which if a variables (i.e. the completion times of a culture tasks)
lose their values (i.e. cultures are contaminated), the solution can be
repaired by assigning these variables values with a new values (i.e.
the completion times of a backup culture tasks) and at most b other
variables (i.e. delaying the completion of at most b other tasks).
The efficiency and applicability of the proposed model is
demonstrated by solving instances taken from a real-life
pharmaceutical company. Computational results showed that
the determined super-solutions are near-optimal.
Abstract: The global demand for long-tailed macaques for
medical experimentation has continued to increase. Fulfillment of
Indonesian export demands has been mostly from natural habitats,
based on a harvesting quota. This quota has been determined
according to the total catch for a given year, and not based on
consideration of any demographic parameters or physical
environmental factors with regard to the animal; hence threatening
the sustainability of the various populations. It is therefore necessary
to formulate a method for calculating a sustainable harvesting quota,
based on population parameters in natural habitats. Considering the
possibility of variations in habitat characteristics and population
parameters, a time series observation of demographic and
physical/biotic parameters, in various habitats, was performed on 13
groups of long-tailed macaques, distributed throughout the West
Java, Lampung and Yogyakarta areas of Indonesia. These provinces
were selected for comparison of the influence of human/tourism
activities. Data on population parameters that was collected included
data on life expectancy according to age class, numbers of
individuals by sex and age class, and ‘ratio of infants to reproductive
females’. The estimation of population growth was based on a
population dynamic growth model: the Leslie matrix. The harvesting
quota was calculated as being the difference between the actual
population size and the MVP (minimum viable population) for each
sex and age class. Observation indicated that there were variations within group size
(24–106 individuals), gender (sex) ratio (1:1 to 1:1.3), life expectancy
value (0.30 to 0.93), and ‘ratio of infants to reproductive females’
(0.23 to 1.56). Results of subsequent calculations showed that
sustainable harvesting quotas for each studied group of long-tailed
macaques, ranged from 29 to 110 individuals. An estimation model
of the MVP for each age class was formulated as Log Y = 0.315 +
0.884 Log Ni (number of individual on ith age class). This study also
found that life expectancy for the juvenile age class was affected by
the humidity under tree stands, and dietary plants’ density at sapling,
pole and tree stages (equation: Y=2.296 – 1.535 RH + 0.002 Kpcg –
0.002 Ktg – 0.001 Kphn, R2 = 89.6% with a significance value of
0.001). By contrast, for the sub-adult-adult age class, life expectancy
was significantly affected by slope (equation: Y=0.377 = 0.012 Kml,
R2 = 50.4%, with significance level of 0.007). The infant-toreproductive-
female ratio was affected by humidity under tree stands,
and dietary plant density at sapling and pole stages (equation: Y = -
1.432 + 2.172 RH – 0.004 Kpcg + 0.003 Ktg, R2 = 82.0% with
significance level of 0.001). This research confirmed the importance
of population parameters in determining the minimum viable
population, and that MVP varied according to habitat characteristics
(especially food availability). It would be difficult therefore, to
formulate a general mathematical equation model for determining a
harvesting quota for the species as a whole.
Abstract: This paper develops and investigates a framework for
the assessment of customer involvement in the service design process
of result oriented product-service systems in order to improve the
service offering in a business-to-business (B2B) context. The
framework comprises five main criteria and fifteen sub-criteria that
contribute to customer involvement in a hierarchy using a maturity
grid to highlight the strengths and weaknesses for each criterion. To
develop the customer involvement framework, an extensive literature
review related to service design, result oriented product-service
system (PSS) and customer involvement in service design was
carried out. Key factors that significantly influence customer
involvement from industry and literature were identified to develop
the framework. A major contribution of the developed framework
includes a hierarchy of appropriate criteria for assessing customer
involvement in the service design process within results oriented
PSS; the definition of four maturity levels which are suitable to
describe the whole spectrum of customer involvement in the service
design process; and finally, The paper concludes by enabling service
providers to: take proactive decisions; screen and evaluate new
services; improve perceived service quality; and provide barriers
against imitation.
Abstract: In this paper, we present a new segmentation approach
for focal liver lesions in contrast enhanced ultrasound imaging. This
approach, based on a two-cluster Fuzzy C-Means methodology,
considers type-II fuzzy sets to handle uncertainty due to the image
modality (presence of speckle noise, low contrast, etc.), and to
calculate the optimum inter-cluster threshold. Fine boundaries are
detected by a local recursive merging of ambiguous pixels. The
method has been tested on a representative database. Compared to
both Otsu and type-I Fuzzy C-Means techniques, the proposed
method significantly reduces the segmentation errors.
Abstract: Sewer deposits have been identified as a major cause
of dysfunctions in combined sewer systems regarding sewer
management, which induces different negative consequents resulting
in poor hydraulic conveyance, environmental damages as well as
worker’s health. In order to overcome the problematics of
sedimentation, flushing has been considered as the most operative
and cost-effective way to minimize the sediments impacts and
prevent such challenges. Flushing, by prompting turbulent wave
effects, can modify the bed form depending on the hydraulic
properties and geometrical characteristics of the conduit. So far, the
dynamics of the bed-load during high-flow events in combined sewer
systems as a complex environment is not well understood, mostly due
to lack of measuring devices capable to work in the “hostile” in
combined sewer system correctly. In this regards, a one-episode
flushing issue from an opening gate valve with weir function was
carried out in a trunk sewer in Paris to understand its cleansing
efficiency on the sediments (thickness: 0-30 cm). During more than
1h of flushing within 5 m distance in downstream of this flushing
device, a maximum flowrate and a maximum level of water have
been recorded at 5 m in downstream of the gate as 4.1 m3/s and 2.1
m respectively. This paper is aimed to evaluate the efficiency of this
type of gate for around 1.1 km (from the point -50 m to +1050 m in
downstream from the gate) by (i) determining bed grain-size
distribution and sediments evolution through the sewer channel, as
well as their organic matter content, and (ii) identifying sections that
exhibit more changes in their texture after the flush. For the first one,
two series of sampling were taken from the sewer length and then
analyzed in laboratory, one before flushing and second after, at same
points among the sewer channel. Hence, a non-intrusive sampling
instrument has undertaken to extract the sediments smaller than the
fine gravels. The comparison between sediments texture after the
flush operation and the initial state, revealed the most modified zones
by the flush effect, regarding the sewer invert slope and hydraulic
parameters in the zone up to 400 m from the gate. At this distance,
despite the increase of sediment grain-size rages, D50 (median grainsize)
varies between 0.6 mm and 1.1 mm compared to 0.8 mm and 10
mm before and after flushing, respectively. Overall, regarding the
sewer channel invert slope, results indicate that grains smaller than
sands (< 2 mm) are more transported to downstream along about 400
m from the gate: in average 69% before against 38% after the flush
with more dispersion of grain-sizes distributions. Furthermore, high
effect of the channel bed irregularities on the bed material evolution
has been observed after the flush.
Abstract: This study aims to investigate the mixing behaviors of
deionized (DI) water and carboxymethyl cellulose (CMC) solutions in
C-shaped serpentine micromixers over a wide range of flow
conditions. The flow of CMC solutions exhibits shear-thinning
behaviors. Numerical simulations are performed to investigate the
effects of the mean flow speed, fluid properties and geometry
parameters on flow and mixing in the micromixers with the serpentine
channel of the same overall channel length. From the results, we can
find the following trends. When convection dominates fluid mixing,
the curvature-induced vortices enhance fluid mixing effectively. The
mixing efficiency of a micromixer consisting of semicircular C-shaped
repeating units with a smaller centerline radius is better than that of a
micromixer consisting of major segment repeating units with a larger
centerline radius. The viscosity of DI water is less than the overall
average apparent viscosity of CMC solutions, and so the effect of
curvature-induced vortices on fluid mixing in DI water is larger than
that in CMC solutions for the cases with the same mean flow speed.
Abstract: Commercial banks in Nigeria adopted many strategies
to attract fresh deposits including the use of high deposit rate.
However, pricing of banking services moved in favor of the banks at
the expense of customers, resulting in their seeking other investment
alternatives rather than saving their money in the bank. Both deposit
and lending rates were greatly influenced by the Central Bank of
Nigeria (CBN) decision on interest rate. Therefore, commercial bank
effort to attract deposits via manipulation of her rates was greatly
limited, otherwise the banks will be giving out more than it earned.
The study aimed at examining the relationship between interest rate
and fixed fund deposit of commercial banks, how policy-controlled
interest rate affected commercial bank’s fixed fund deposit The
researcher employed ordinary least square technique, using, multiple
linear regression, unrestricted vector auto-regression, correlation
matrix test, granger causality and impulse response graph in the
analysis. Commercial bank’s interest rates affected commercial
bank’s fixed fund deposit significantly while policy-controlled
interest rate did not significantly transmit through the commercial
bank’s interest rates to affect fixed fund deposit. While commercial
banks seek creative ways to expand their fixed fund deposit, policy
authorities in Nigeria should better coordinate interest rate fluctuation
and induce competition in the entire financial sector.
Abstract: A large amount of software products offer a wide
range and number of features. This is called featuritis or creeping
featurism and tends to rise with each release of the product. Feautiris
often adds unnecessary complexity to software, leading to longer
learning curves and overall confusing the users and degrading their
experience. We take a look to a new design approach tendency that
has been coming up, the so-called “What You Get is What You
Need” concept that argues that products should be very focused,
simple and with minimalistic interfaces in order to help users conduct
their tasks in distraction-free ambiences. This isn’t as simple to
implement as it might sound and the developers need to cut down
features. Our contribution illustrates and evaluates this design method
through a novel distraction-free diagramming tool named Delineato
Pro for Mac OS X in which the user is confronted with an empty
canvas when launching the software and where tools only show up
when really needed.
Abstract: Steel slag is a by-product of the steel industry and can
be used potentially as aggregate in the asphalt mixture. This study
evaluates the use of Steel Slag Aggregates (SSA) as a substitute for
natural aggregates in the production of hot mix asphalt (HMA) for
road construction. Based on intensive laboratory testing program, the
characteristic properties of SSA were assessed to determine its
suitability to be used in HMA. Four different percentages (0, 50, 75,
and 100%) of SSA were used, and the proposed mix designs for
HMA were conducted in accordance with Marshall mix design. The
experiment results revealed that the addition of SSA has a significant
improvement on the properties of HMA. An increase in density and
stability and a reduction in flow and air voids values were clearly
observed in specimens prepared with 100% SSA. It is concluded that
the steel slag can be considered reasonable alternative source of
aggregate for concrete asphalt mixture production.
Abstract: The use of Flexible AC Transmission System
(FACTS) devices in a power system can potentially overcome
limitations of the present mechanically controlled transmission
system. Also, the advance of technology makes possible to include
new energy storage devices in the electrical power system. The
integration of Superconducting Magnetic Energy Storage (SMES)
into Static Synchronous Compensator (STATCOM) can lead to
increase their flexibility in improvement of power system dynamic
behaviour by exchanging both active and reactive powers with power
grids. This paper describes structure and behaviour of SMES,
specifications and performance principles of the STATCOM/SMES
compensator. Moreover, the benefits and effectiveness of integrated
SMES with STATCOM in power systems is presented. Also, the
performance of the STATCOM/SMES compensator is evaluated
using an IEEE 3-bus system through the dynamic simulation by
PSCAD/EMTDC software.
Abstract: High frequency automotive interior noise above 500
Hz considerably affects automotive passenger comfort. To reduce this
noise, sound insulation material is often laminated on body panels or
interior trim panels. For a more effective noise reduction, the sound
reduction properties of this laminated structure need to be estimated.
We have developed a new calculate tool that can roughly calculate the
sound absorption and insulation properties of laminate structure and
handy for designers. In this report, the outline of this tool and an
analysis example applied to floor mat are introduced.
Abstract: There is currently a gap in the technology covering the
rapid establishment of control after a reconfiguration in a
Reconfigurable Manufacturing System. This gap involves the
detection of the factory floor state and the communication link
between the factory floor and the high-level software. In this paper, a
thin, hardware-supported Middleware Management System (MMS) is
proposed and its design and implementation are discussed. The
research found that a cost-effective localization technique can be
combined with intelligent software to speed up the ramp-up of a
reconfigured system. The MMS makes the process more intelligent,
more efficient and less time-consuming, thus supporting the
industrial implementation of the RMS paradigm.
Abstract: Determination of genetic variation is useful for plant
breeding and hence production of more efficient plant species under
different conditions, like drought stress. In this study a sample of 28
recombinant inbred lines (RILs) of wheat developed from the cross of
Norstar and Zagross varieties, together with their parents, were
evaluated for two years (2010-2012) under normal and water stress
conditions using split plot design with three replications. Main plots
included two irrigation treatments of 70 and 140 mm evaporation
from Class A pan and sub-plots consisted of 30 genotypes. The effect
of genotypes and interaction of genotypes with years and water
regimes were significant for all characters. Significant genotypic
effect implies the existence of genetic variation among the lines
under study. Heritability estimates were high for 1000 grain weight
(0.87). Biomass and grain yield showed the lowest heritability values
(0.42 and 0.50, respectively). Highest genotypic and phenotypic
coefficients of variation (GCV and PCV) belonged to harvest index.
Moderate genetic advance for most of the traits suggested the
feasibility of selection among the RILs under investigation. Some
RILs were higher yielding than either parent at both environments.
Abstract: This paper presents a methodology for probabilistic
assessment of bearing capacity and prediction of failure mechanism
of masonry vaults at the ultimate state with consideration of the
natural variability of Young’s modulus of stones. First, the
computation model is explained. The failure mode corresponds to the
four-hinge mechanism. Based on this consideration, the study of a
vault composed of 16 segments is presented. The Young’s modulus of
the segments is considered as random variable defined by a mean
value and a coefficient of variation. A relationship linking the vault
bearing capacity to the voussoirs modulus variation is proposed. The
most probable failure mechanisms, in addition to that observed in the
deterministic case, are identified for each variability level as well as
their probability of occurrence. The results show that the mechanism
observed in the deterministic case has decreasing probability of
occurrence in terms of variability, while the number of other
mechanisms and their probability of occurrence increases with the
coefficient of variation of Young’s modulus. This means that if a
significant change in the Young’s modulus of the segments is proven,
taking it into account in computations becomes mandatory, both for
determining the vault bearing capacity and for predicting its failure
mechanism.
Abstract: Main objective of this paper is to establish a link
between inertial forces of the bearings used in construction of wind
power plant and its behavior. Using bearings with lower inertial
forces has the immediate effect of decreasing inertia rotor system,
with significant results in increased energy efficiency, due to
decreased friction forces between rollers and raceways. The F.E.M.
analysis shows the appearance of uniform contact stress at the ends of
the rollers, demonstrated the necessity of production of low mass
bearings. Favorable results are expected in the economic field, by
reducing material consumption and by increasing the durability of
bearings. Using low mass bearings with hollow rollers instead of
solid rollers has an impact on working temperature, on vibrations and
noise which decrease. Implementation of types of hollow rollers of
cylindrical tubular type, instead of expensive rollers with logarithmic
profile, will bring significant inertial forces decrease with large
benefits in behavior of wind power plant.
Abstract: Localization of nodes is one of the key issues of
Wireless Sensor Network (WSN) that gained a wide attention in
recent years. The existing localization techniques can be generally
categorized into two types: range-based and range-free. Compared
with rang-based schemes, the range-free schemes are more costeffective,
because no additional ranging devices are needed. As a
result, we focus our research on the range-free schemes. In this paper
we study three types of range-free location algorithms to compare the
localization error and energy consumption of each one. Centroid
algorithm requires a normal node has at least three neighbor anchors,
while DV-hop algorithm doesn’t have this requirement. The third
studied algorithm is the amorphous algorithm similar to DV-Hop
algorithm, and the idea is to calculate the hop distance between two
nodes instead of the linear distance between them. The simulation
results show that the localization accuracy of the amorphous
algorithm is higher than that of other algorithms and the energy
consumption does not increase too much.
Abstract: Effects of nicotine on pre-partum body weight and
preimplantation embryonic development has been reported
previously. Present study was conducted to determine the effects of
annatto (Bixa orellana)-derived delta-tocotrienol (TCT) (with
presence of 10% gamma-TCT isomer) on the nicotine-induced
reduction in body weight and 8-cell embryonic growth in mice.
Twenty-four 6-8 weeks old (23-25g) female balb/c mice were
randomly divided into four groups (G1-G4; n=6). Those groups were
subjected to the following treatments for 7 consecutive days: G1
(control) were gavaged with 0.1 ml tocopherol stripped corn oil. G2
was subcutaneously (s.c.) injected with 3 mg/kg/day of nicotine. G3
received concurrent treatment of nicotine (3 mg/kg/day) and 60
mg/kg/day of δ-TCT mixture (contains 90% delta & 10% gamma
isomers) and G4 was given 60 mg/kg/day of δ-TCT mixture alone.
Body weights were recorded daily during the treatment. On Day 8,
females were superovulated with 5 IU Pregnant Mare’s Serum
Gonadotropin (PMSG) for 48 hours followed with 5 IU human
Chorionic Gonadotropin (hCG) before mated with males at the ratio
of 1:1. Females were sacrificed by cervical dislocation for embryo
collection 48 hours post-coitum. Collected embryos were cultured in
vitro. Results showed that throughout Day 1 to Day 7, the body
weight of nicotine treated group (G2) was significantly lower
(p
Abstract: The Northeast China (NEC) was the most important
agriculture areas and known as the Golden-Maize-Belt. Based on
observed crop data and crop model, we design four simulating
experiments and separate relative impacts and contribution under
climate change, planting date shift, and varieties change as well
change of varieties and planting date. Without planting date and
varieties change, maize yields had no significant change trend at
Hailun station located in the north of NEC, and presented significant
decrease by 0.2 - 0.4 t/10a at two stations, which located in the middle
and the south of NEC. With planting date change, yields showed a
significant increase by 0.09 - 0.47 t/10a. With varieties change, maize
yields had significant increase by 1.8~ 1.9 t/10a at Hailun and Huadian
stations, but a non-significant and low increase by 0.2t /10a at Benxi
located in the south of NEC. With change of varieties and planting
date, yields presented a significant increasing by 0.53- 2.0 t/10a. Their
contribution to yields was -25% ~ -55% for climate change, 15% ~
35% for planting date change, and 20% ~110% for varieties change as
well 30% ~135% for varieties with planting date shift. It found that
change in varieties and planting date were highest yields and were
responsible for significant increases in maize yields, varieties was
secondly, and planting date was thirdly. It found that adaptation in
varieties and planting date greatly improved maize yields, and
increased yields annual variability. The increase of contribution with
planting date and varieties change in 2000s was lower than in 1990s.
Yields with the varieties change and yields with planting date and
varieties change all showed a decreasing trend at Huadian and Benxi
since 2002 or so. It indicated that maize yields increasing trend
stagnated in the middle and south of NEC, and continued in the north
of NEC.
Abstract: Studying on the response of vegetation phenology to
climate change at different temporal and spatial scales is important for
understanding and predicting future terrestrial ecosystem dynamics
and the adaptation of ecosystems to global change. In this study, the
Moderate Resolution Imaging Spectroradiometer (MODIS)
Normalized Difference Vegetation Index (NDVI) dataset and climate
data were used to analyze the dynamics of grassland phenology as well
as their correlation with climatic factors in different eco-geographic
regions and elevation units across the Tibetan Plateau. The results
showed that during 2003–2012, the start of the grassland greening
season (SOS) appeared later while the end of the growing season
(EOS) appeared earlier following the plateau’s precipitation and heat
gradients from southeast to northwest. The multi-year mean value of
SOS showed differences between various eco-geographic regions and
was significantly impacted by average elevation and regional average
precipitation during spring. Regional mean differences for EOS were
mainly regulated by mean temperature during autumn. Changes in
trends of SOS in the central and eastern eco-geographic regions were
coupled to the mean temperature during spring, advancing by about
7d/°C. However, in the two southwestern eco-geographic regions,
SOS was delayed significantly due to the impact of spring
precipitation. The results also showed that the SOS occurred later with
increasing elevation, as expected, with a delay rate of 0.66 d/100m.
For 2003–2012, SOS showed an advancing trend in low-elevation
areas, but a delayed trend in high-elevation areas, while EOS was
delayed in low-elevation areas, but advanced in high-elevation areas.
Grassland SOS and EOS changes may be influenced by a variety of
other environmental factors in each eco-geographic region.
Abstract: The influence of physicochemical water quality
parameters on the abundance and diversity of caddisfly larvae was
studied in seven sampling stations in Mae Tao and Mae Ku
watersheds, Mae Sot District, Tak Province, northern Thailand. The
streams: MK2 and MK8 as reference site, and impacted streams
(MT1-MT5) were sampled bi-monthly during July 2011 to May
2012. A total of 4,584 individual of caddisfly larvae belonging to 10
family and 17 genera were found. The larvae of family
Hydropsychidae were the most abundance, followed by
Philopotamidae, Odontoceridae, and Leptoceridae, respectively. The
genus Cheumatopsyche, Hydropsyche, and Chimarra were the most
abundance genera in this study. Results of CCA ordination showed
the total dissolved solids, sulfate, water temperature, dissolved
oxygen and pH were the most important physicochemical factors to
affect distribution of caddisflies communities. Changes in the
caddisfly fauna may indicate changes in physicochemical factors
owing to agricultural pollution, urbanization, or other human
activities. Results revealed that the order Trichoptera, identified to
species or genus, can be potentially used to assess environmental
water quality status in freshwater ecosystems.