Abstract: Targeted drug delivery is a method of delivering
medication to a patient in a manner that increases the concentration
of the medication in some parts of the body relative to others.
Targeted drug delivery seeks to concentrate the medication in the
tissues of interest while reducing the relative concentration of the
medication in the remaining tissues. This improves efficacy of the
while reducing side effects. In the present work, we investigate the
effect of magnetic field, flow rate and particle concentration on the
capturing of magnetic particles transported in a stent implanted
fluidic channel. Iron oxide magnetic nanoparticles (Fe3O4)
nanoparticles were synthesized via co-precipitation method. The
synthesized Fe3O4 nanoparticles were added in the de-ionized (DI)
water to prepare the Fe3O4 magnetic particle suspended fluid. This
fluid is transported in a cylindrical tube of diameter 8 mm with help
of a peristaltic pump at different flow rate (25-40 ml/min). A
ferromagnetic coil of SS 430 has been implanted inside the
cylindrical tube to enhance the capturing of magnetic nanoparticles
under magnetic field. The capturing of magnetic nanoparticles was
observed at different magnetic magnetic field, flow rate and particle
concentration. It is observed that capture efficiency increases from
47-67% at magnetic field 2-5kG, respectively at particle
concentration 0.6mg/ml and at flow rate 30 ml/min. However, the
capture efficiency decreases from 65 to 44% by increasing the flow
rate from 25 to 40 ml/min, respectively. Furthermore, it is observed
that capture efficiency increases from 51 to 67% by increasing the
particle concentration from 0.3 to 0.6 mg/ml, respectively.
Abstract: Introduction: The process to build a better safety
culture, methods of error analysis, and preventive measures, starts
with an understanding of the effects when human factors engineering
refer to remote microscopic diagnosis in surgery and specially in
organ transplantation for the remote evaluation of the grafts. It has
been estimated that even in well-organized transplant systems an
average of 8% to 14% of the grafts (G) that arrive at the recipient
hospitals may be considered as diseased, injured, damaged or
improper for transplantation. Digital microscopy adds information on
a microscopic level about the grafts in Organ Transplant (OT), and
may lead to a change in their management. Such a method will
reduce the possibility that a diseased G, will arrive at the recipient
hospital for implantation. Aim: Ergonomics of Digital Microscopy
(DM) based on virtual slides, on Telemedicine Systems (TS) for
Tele-Pathological (TPE) evaluation of the grafts (G) in organ
transplantation (OT). Material and Methods: By experimental
simulation, the ergonomics of DM for microscopic TPE of Renal
Graft (RG), Liver Graft (LG) and Pancreatic Graft (PG) tissues is
analyzed. In fact, this corresponded to the ergonomics of digital
microscopy for TPE in OT by applying Virtual Slide (VS) system for
graft tissue image capture, for remote diagnoses of possible
microscopic inflammatory and/or neoplastic lesions. Experimentation
included: a. Development of an OTE-TS similar Experimental
Telemedicine System (Exp.-TS), b. Simulation of the integration of
TS with the VS based microscopic TPE of RG, LG and PG applying
DM. Simulation of the DM based TPE was performed by 2
specialists on a total of 238 human Renal Graft (RG), 172 Liver Graft
(LG) and 108 Pancreatic Graft (PG) tissues digital microscopic
images for inflammatory and neoplastic lesions on four electronic
spaces of the four used TS. Results: Statistical analysis of specialist‘s
answers about the ability to diagnose accurately the diseased RG, LG
and PG tissues on the electronic space among four TS (A,B,C,D)
showed that DM on TS for TPE in OT is elaborated perfectly on the
ES of a Desktop, followed by the ES of the applied Exp.-TS. Tablet
and Mobile-Phone ES seem significantly risky for the application of
DM in OT (p
Abstract: Background: To improve the delivery of paediatric
healthcare in low resource settings, Community Health Workers
(CHW) have been provided with a paper-based set of protocols
known as Community Case Management (CCM). Yet research has
shown that CHW adherence to CCM guidelines is poor, ultimately
impacting health service delivery. Digitising the CCM guidelines via
mobile technology is argued in extant literature to improve CHW
adherence. However, little research exist which outlines how (a) this
process can be digitised and (b) adherence could be improved as a
result. Aim: To explore how an electronic mobile version of CCM
(eCCM) can overcome issues associated with the paper-based CCM
protocol (inadequate adherence to guidelines) vis-à-vis service
blueprinting. This service blueprint will outline how (a) the CCM
process can be digitised using mobile Clinical Decision Support
Systems software to support clinical decision-making and (b)
adherence can be improved as a result. Method: Development of a
single service blueprint for a standalone application which visually
depicts the service processes (eCCM) when supporting the CHWs,
using an application known as Supporting LIFE (SL eCCM app) as
an exemplar. Results: A service blueprint is developed which
illustrates how the SL eCCM app can be utilised by CHWs to assist
with the delivery of healthcare services to children. Leveraging
smartphone technologies can (a) provide CHWs with just-in-time
data to assist with their decision making at the point-of-care and (b)
improve CHW adherence to CCM guidelines. Conclusions: The
development of the eCCM opens up opportunities for the CHWs to
leverage the inherent benefit of mobile devices to assist them with
health service delivery in rural settings. To ensure that benefits are
achieved, it is imperative to comprehend the functionality and form
of the eCCM service process. By creating such a service blueprint for
an eCCM approach, CHWs are provided with a clear picture
regarding the role of the eCCM solution, often resulting in buy-in
from the end-users.
Abstract: The current study focuses on the seismic design of
offshore pipelines against active faults. After an extensive literature
review of the provisions of the seismic norms worldwide and of the
available analytical methods, the study simulates numerically
(through finite-element modeling and strain-based criteria) the
distress of offshore pipelines subjected to PGDs induced by active
normal and reverse seismic faults at the seabed. Factors, such as the
geometrical properties of the fault, the mechanical properties of the
ruptured soil formations, and the pipeline characteristics, are
examined. After some interesting conclusions regarding the seismic
vulnerability of offshore pipelines, potential cost-effective mitigation
measures are proposed taking into account constructability issues.
Abstract: An unrecorded experiment of use of the smartphone
as a tool for practical classes of histology is presented in this paper.
Behavior and learning of students of science courses at the University
were analyzed and compared as well as the mode of teaching of this
discipline and the appreciation of the students, using either digital
photographs taken by phone or drawings for record microscopic
observations, analyze and interpret histological sections of human or
animal tissues.
Abstract: Abstract—[Tris (1,10-phenanthroline) lanthanum(III)]
trithiocyanate is a new compound that has shown high ability for
stopping the synthesis of DNA and also acting as a photosensitizer.
Nowadays, the radiation dose assessment resource (RADAR) method
is known as the most common method for absorbed dose calculation.
177Lu was produced by (n, gamma) reaction in a research reactor.
177Lu-PL3 was prepared in the optimized condition. The
radiochemical yield was checked by ITLC method. The
biodistribution of the complex was investigated by intravenously
injection to wild-type rats via their tail veins. In this study, the
absorbed dose of 177Lu-PL3 to human organs was estimated by
RADAR method. 177Lu was prepared with a specific activity of 2.6-3
GBq.mg-1 and radionuclide purity of 99.98 %. Final preparation of
the radiolabelled complex showed high radiochemical purity of >
99%. The results show that liver and spleen have received the highest
absorbed dose of 1.051 and 0.441 mSv/MBq, respectively. The
absorbed dose values for these two dose-limiting tissues suggest
more biological studies special in tumor-bearing animals.
Abstract: The energy need is growing rapidly due to the
population growth and the large new usage of power. Several works
put considerable efforts to make the electricity grid more intelligent
to reduce essentially energy consumption and provide efficiency and
reliability of power systems. The Smart Grid is a complex
architecture that covers critical devices and systems vulnerable to
significant attacks. Hence, security is a crucial factor for the success
and the wide deployment of Smart Grids. In this paper, we present
security issues of the Smart Grid architecture and we highlight open
issues that will make the Smart Grid security a challenging research
area in the future.
Abstract: The UK is leading in online retail and mobile
adoption. However, there is a dearth of information relating to mobile
apparel retail, and developing an understanding about consumer
browsing and purchase behaviour in m-retail channel would provide
apparel marketers, mobile website and app developers with the
necessary understanding of consumers’ needs. Despite the rapid
growth of mobile retail businesses, no published study has examined
shopping behaviour on fashion mobile apps and websites. A mixed method approach helped to understand why fashion
consumers prefer websites on smartphones, when diverse mobile
apps are also available. The following research methods were
employed: survey, eye-tracking experiments, observation, and
interview with retrospective think aloud. The mobile gaze tracking
device by SensoMotoric Instruments was used to understand
frustrations in navigation and other issues facing consumers in
mobile channel. This method helped to validate and compliment
other traditional user-testing approaches in order to optimize user
experience and enhance the development of mobile retail channel.
The study involved eight participants - females aged 18 to 35 years
old, who are existing mobile shoppers. The participants used the
Topshop mobile app and website on a smart phone to complete a task
according to a specified scenario leading to a purchase. The
comparative study was based on: duration and time spent at different
stages of the shopping journey, number of steps involved and product
pages visited, search approaches used, layout and visual clues, as
well as consumer perceptions and expectations. The results from the data analysis show significant differences in
consumer behaviour when using a mobile app or website on a smart
phone. Moreover, two types of problems were identified, namely
technical issues and human errors. Having a mobile app does not
guarantee success in satisfying mobile fashion consumers. The
differences in the layout and visual clues seem to influence the
overall shopping experience on a smart phone. The layout of search
results on the website was different from the mobile app. Therefore,
participants, in most cases, behaved differently on different
platforms. The number of product pages visited on the mobile app
was triple the number visited on the website due to a limited visibility
of products in the search results. Although, the data on traffic trends
held by retailers to date, including retail sector breakdowns for visits
and views, data on device splits and duration, might seem a valuable
source of information, it cannot explain why consumers visit many
product pages, stay longer on the website or mobile app, or abandon
the basket. A comprehensive list of pros and cons was developed by
highlighting issues for website and mobile app, and recommendations
provided. The findings suggest that fashion retailers need to be aware of
actual consumers’ behaviour on the mobile channel and their expectations in order to offer a seamless shopping experience. Added
to which is the challenge of retaining existing and acquiring new
customers. There seem to be differences in the way fashion
consumers search and shop on mobile, which need to be explored in
further studies.
Abstract: This paper presents an extensive review of literature
relevant to the modelling techniques adopted in sediment yield and
hydrological modelling. Several studies relating to sediment yield are
discussed. Many research areas of sedimentation in rivers, runoff and
reservoirs are presented. Different types of hydrological models,
different methods employed in selecting appropriate models for
different case studies are analysed. Applications of evolutionary
algorithms and artificial intelligence techniques are discussed and
compared especially in water resources management and modelling.
This review concentrates on Genetic Programming (GP) and fully
discusses its theories and applications. The successful applications of
GP as a soft computing technique were reviewed in sediment
modelling. Some fundamental issues such as benchmark,
generalization ability, bloat, over-fitting and other open issues
relating to the working principles of GP are highlighted. This paper
concludes with the identification of some research gaps in
hydrological modelling and sediment yield.
Abstract: The Green Urban Lab took the form of public
installations that were placed at various locations in four cities in
Cyprus. These installations - through which a series of events,
activities, workshops and research took place - were the main tools in
regenerating a series of urban public spaces in Cyprus. The purpose
of this project was to identify issues and opportunities related to
public space and to offer guidelines on how design and participatory
democracy improvements could strengthen civil society, while
raising the quality of the urban public scene. Giant inflatable
structures were injected in important urban fragments in order to
accommodate series of events. The design and playful installation
generated a wide community engagement. The fluid presence of the
installations acted as a catalyst for social interaction. They were
accessed and viewed effortlessly and surprisingly, creating
opportunities to rediscover public spaces.
Abstract: In this paper, various methods of providing restricted
earth fault protection are discussed. The proper operation of high and
low impedance Restricted Earth Fault (REF) protection for various
applications has been discussed. The maloperation of a relay due to
improper placement of CTs has been identified and a simple/unique
solution has been proposed in this work with a case study. Moreover,
it is found that the proper placement of CT in high impedance method
will provide the same result with reduced CT. This methodology has
been successfully implemented in Al Takreer refinery for a 2000
KVA transformer. The outcome of the paper may be included in
IEEEC37.91 standard to give the proper guidance for protection
engineers to sort out the issues related to mal functioning of REF
relays.
Abstract: Cortisol is essential to the regulation of the immune
system and pathological yawning is a symptom of multiple sclerosis
(MS). Electromyography activity (EMG) in the jaw muscles typically
rises when the muscles are moved – extended or flexed; and yawning
has been shown to be highly correlated with cortisol levels in healthy
people as shown in the Thompson Cortisol Hypothesis. It is likely
that these elevated cortisol levels are also seen in people with MS.
The possible link between EMG in the jaw muscles and rises in saliva
cortisol levels during yawning were investigated in a randomized
controlled trial of 60 volunteers aged 18-69 years who were exposed
to conditions that were designed to elicit the yawning response.
Saliva samples were collected at the start and after yawning, or at the
end of the presentation of yawning-provoking stimuli, in the absence
of a yawn, and EMG data was additionally collected during rest and
yawning phases. Hospital Anxiety and Depression Scale, Yawning
Susceptibility Scale, General Health Questionnaire, demographic,
and health details were collected and the following exclusion criteria
were adopted: chronic fatigue, diabetes, fibromyalgia, heart
condition, high blood pressure, hormone replacement therapy,
multiple sclerosis, and stroke. Significant differences were found
between the saliva cortisol samples for the yawners, t (23) = -4.263, p
= 0.000, as compared with the non-yawners between rest and poststimuli,
which was non-significant. There were also significant
differences between yawners and non-yawners for the EMG
potentials with the yawners having higher rest and post-yawning
potentials. Significant evidence was found to support the Thompson
Cortisol Hypothesis suggesting that rises in cortisol levels are
associated with the yawning response. Further research is underway
to explore the use of cortisol as a potential diagnostic tool as an assist
to the early diagnosis of symptoms related to neurological disorders.
Bournemouth University Research & Ethics approval granted:
JC28/1/13-KA6/9/13. Professional code of conduct, confidentiality,
and safety issues have been addressed and approved in the Ethics
submission. Trials identification number: ISRCTN61942768.
http://www.controlled-trials.com/isrctn/
Abstract: Heart is the most important part in the body of living
organisms. It affects and is affected by any factor in the body.
Therefore, it is a good detector for all conditions in the body. Heart
signal is a non-stationary signal; thus, it is utmost important to study
the variability of heart signal. The Heart Rate Variability (HRV) has
attracted considerable attention in psychology, medicine and has
become important dependent measure in psychophysiology and
behavioral medicine. The standards of measurements, physiological
interpretation and clinical use for HRV that are most often used were
described in many researcher papers, however, remain complex
issues are fraught with pitfalls. This paper presents one of the nonlinear
techniques to analyze HRV. It discusses many points like, what
Poincaré plot is and how Poincaré plot works; also, Poincaré plot's
merits especially in HRV. Besides, it discusses the limitation of
Poincaré cause of standard deviation SD1, SD2 and how to overcome
this limitation by using complex correlation measure (CCM). The
CCM is most sensitive to changes in temporal structure of the
Poincaré plot as compared toSD1 and SD2.
Abstract: Health of a person plays a vital role in the collective
health of his community and hence the well-being of the society as a
whole. But, in today’s fast paced technology driven world, health
issues are increasingly being associated with human behaviors – their
lifestyle. Social networks have tremendous impact on the health
behavior of individuals. Many researchers have used social network
analysis to understand human behavior that implicates their social
and economic environments. It would be interesting to use a similar
analysis to understand human behaviors that have health
implications. This paper focuses on concepts of those behavioural
analyses that have health implications using social networks analysis
and provides possible algorithmic approaches. The results of these
approaches can be used by the governing authorities for rolling out
health plans, benefits and take preventive measures, while the
pharmaceutical companies can target specific markets, helping health
insurance companies to better model their insurance plans.
Abstract: Food supply chain is one of the most complex supply
chain networks due to its perishable nature and customer oriented
products, and food safety is the major concern for this industry. IT
system could help to minimize the production and consumption of
unsafe food by controlling and monitoring the entire system.
However, there have been many issues in adoption of IT system in
this industry specifically within SMEs sector. With this regard, this
study presents a novel approach to use IT and tractability systems in
the food supply chain, using application of RFID and central
database.
Abstract: Health workforce is a fundamental component of
health system and plays a significant role in delivering effective
health care services. However, there is a crucial shortage of skilled
personnel which make them prone to work in stressful conditions. In
spite of excessively high workload and burnout among the staff, little
attention is given to their job satisfaction level which has serious
implications on the productivity and effective performance of staff to
achieve organizational goals. Therefore, this study aims to explore
the job satisfaction of midwives working in the labor ward of the
Lady Dufferin Hospital, Karachi. A cross-sectional survey was
conducted. The short version of Minnesota Job Satisfaction
Questionnaire was administered on a convenient sample group of 22
midwives to gather information on their job satisfaction. The results
demonstrated that midwives were overall satisfied with their job. The
level of job satisfaction was however found different in various
positions within midwifery cadre. The head of midwives was highly
satisfied as compared to midwifery staff who works under the
supervision of head. The level of satisfaction of team leaders fall
between the head and staff of midwifery. Similar trends were
observed for both intrinsic and extrinsic job satisfaction. Such
evidences on these issues are essential and useful as it helps explore
the attitudes of individuals towards work which has direct
implications on access to quality care services. Strategic interventions
are required at organizational level to provide motivators and
satisfiers to health workers for their work related satisfaction and
enhanced motivation.
Abstract: Academic libraries in Malaysia are still not prepared
for disaster even though several occasions have been reported. The
study sets out to assess the current status of preparedness in disaster
management among Malaysian academic libraries in the State of
Selangor and the Federal Territory of Kuala Lumpur. To obtain a
base level of knowledge on disaster preparedness of current practices,
a questionnaire was distributed to chief librarians or their assignees in
charge of disaster or emergency preparedness at 40 academic
libraries and 34 responses were received. The study revolved around
the current status of preparedness, on various issues including
existence of disaster preparedness plan among academic libraries in
Malaysia, disaster experiences by the academic libraries, funding,
risk assessment activities and involvement of library staff in disaster
management. Frequency and percentage tables were used in the
analysis of the data collected. Some of the academic libraries under
study have experienced one form of disaster or the other. Most of the
academic libraries do not have a written disaster preparedness plan.
The risk assessments and staff involvement in disaster preparedness
by these libraries were generally adequate.
Abstract: This paper focuses on how judiciaries in post-conflict societies can gain legitimacy through reformation. Legitimacy plays a pivotal role in shaping people’s behavior to submit to the law and verifies the rightfulness of an organ for taking binding decisions. Among various dynamics, judicial independence, access to justice and behavioral changes of the judicial officials broadly contribute to legitimation of judiciary in general, and the courts in particular. Increasing independence of judiciary through reform limits, inter alia, government interference in judicial issues and protects basic rights of the citizens. Judicial independence does not only matter in institutional terms, individual independence also influences the impartiality and integrity of judges, which can be increased through education and better administration of justice. Finally, access to justice as an intertwined concept both at the legal and moral spectrum of judicial reform avails justice to the citizens and increases the level of public trust and confidence. Efficient legal decisions on fostering such elements through holistic reform create a rule of law atmosphere. Citizens neither accept an illegitimate judiciary nor do they trust its decisions. Lack of such tolerance and confidence deters the rule of law and thus, undermines the democratic development of a society.
Abstract: The objective of this paper is to analyze the role played by the institute of the public hearings in the Brazilian Supreme Court. The public hearings are regulated since 1999 by the Brazilian Laws nº 9.868, nº 9.882 and by the Intern Regiment of the Brazilian Supreme Court. According to this legislation, the public hearings are supposed to be called when a matter of circumstance of fact must be clarified, what can be done through the hearing of the testimonies of persons with expertise and authority in the theme related to the cause. This work aims to investigate what is the role played by the public hearings and by the experts in the Brazilian Supreme Court. The hypothesis of this research is that: (I) The public hearings in the Brazilian Supreme Court are used to uphold a rhetoric of a democratic legitimacy of the Court`s decisions; (II) The Legislative intentions have been distorted. To test this hypothesis, the adopted methodology involves an empirical study of the Brazilian jurisprudence. As a conclusion, it follows that the public hearings convened by the Brazilian Supreme Court do not correspond, in practice, to the role assigned to them by the Congress since they do not serve properly to epistemic interests. The public hearings not only do not legitimate democratically the decisions, but also, do not properly clarify technical issues.
Abstract: A teeming set of doctors that graduated from various
universities within and outside Nigeria with the hope of practicing in
the country, has their hope shattered because of poor financing, lack
of medical equipments and a very weak healthcare systems. Such
hydra headed challenges, allows room for quackery which
increasingly contributes to the cause of mortality in Nigeria. With a
view of reversing the challenges of healthcare delivery and financing
in Nigeria, African Health Market for Equity (AHME), a project
funded by the Bill and Melinda Gates foundation [With contribution
from Department For International Development (DFID)] and
currently implemented in three African Countries (Nigeria, Kenya
and Ghana) over a Five (5) year period supports the healthcare sector
via Medical credit fund (MCF). The study examines the impact of
credit policy and medical credit funding on Nigerian health market.
Ordinary least square analysis, correlation and granger causality tests
were employed to measure the extent to which the Nigerian
healthcare market has been influenced. Medical credit fund
significantly and positively influenced average monthly turnover of
private healthcare providers and Commercial bank’s lending rate had
a weak relationship with access to credit/approved loans (13.46%).
The programme has so far made 13.91% progress, which is very
poor, considering the minimum targeted private health care providers
(437.6) and expected number of loan approvals (180.4) for the two
years. Medical credit policy in Nigeria should be revised to include
private healthcare providers in rural area for more positive impact
and increased returns. Good brand advert and sensitization of the
programme to stakeholders and health pressure group, and an
extension of the programme beyond five years is necessary to better
address the issues raised in the study.