Abstract: Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV.
Abstract: Lately management strategy that put Industrial Design (ID) in its core is recognized more important, as technology and price alone cannot differentiate a product. The needs to shorten the time to develop a product also shorten the development period of ID, and it necessitates the ID process management. This research analyzes the status of integration process of ID and Engineering Design (ED) of office equipment that requires the collaboration of ID and ED to clarify the issues for the efficiency of the development and to propose solutions.
Abstract: Data warehouse is a dedicated database used for querying and reporting. Queries in this environment show special characteristics such as multidimensionality and aggregation. Exploiting the nature of queries, in this paper we propose a query driven design framework. The proposed framework is general and allows a designer to generate a schema based on a set of queries.
Abstract: In this paper, we demonstrate the adaptive
least-mean-square (LMS) filter modeling using SystemC. SystemC is
a modeling language that allows designer to model both hardware and
software component and makes it possible to design from high level
system of abstraction to low level system of abstraction. We produced
five adaptive least-mean-square filter models that are classed as five
abstraction levels using SystemC proceeding from the abstract model
to the more concrete model.
Abstract: So much energy is used in high rise buildings to fulfill
the basic needs of users such as lighting and thermal comfort.
Malaysia has hot and humid climate, buildings especially high rise
buildings receive unnecessary solar radiation that cause more solar
heat gain. Energy use specially electricity consumption in high rise
buildings has increased. There have been growing concerns about
energy consumption and its effect on environment. Building, energy
and the environment are important issues that the designers should
consider to them. Self protected form is one of possible ways against
the impact of solar radiation in high rise buildings. The Energy
performance of building envelopes was investigated in term of the
Overall Thermal Transfer Value (OTTV ).In this paper, the amount
of OTTV reduction was calculated through OTTV Equations to
clear the effectiveness of self shading strategy on minimizing energy
consumption for cooling interior spaces in high rise buildings which
has considerable envelope areas against solar radiation. Also increasing
the optimum window area was investigated using self-shading
strategy in designing high rise buildings. As result, the significant
reduction in OTTV was shown based on WWR.In addition slight
increase was demonstrated in WWR that can influence on visible
comfort interior spaces.
Abstract: Electro-hydraulic power steering (EHPS) system for
the fuel rate reduction and steering feel improvement is comprised of
ECU including the logic which controls the steering system and BL
DC motor and produces the best suited cornering force, BLDC motor,
high pressure pump integrated module and basic oil-hydraulic circuit
of the commercial HPS system.
Electro-hydraulic system can be studied in two ways such as
experimental and computer simulation. To get accurate results in
experimental study of EHPS system, the real boundary management is
necessary which is difficult task. And the accuracy of the experimental
results depends on the preparation of the experimental setup and
accuracy of the data collection. The computer simulation gives
accurate and reliable results if the simulation is carried out considering
proper boundary conditions. So, in this paper, each component of
EHPS was modeled, and the model-based analysis and control logic
was designed by using AMESim
Abstract: Optimum communication and performance in
Wireless Sensor Networks, constitute multi-facet challenges due to
the specific networking characteristics as well as the scarce resource
availability. Furthermore, it is becoming increasingly apparent that
isolated layer based approaches often do not meet the demands posed
by WSNs applications due to omission of critical inter-layer
interactions and dependencies. As a counterpart, cross-layer is
receiving high interest aiming to exploit these interactions and
increase network performance. However, in order to clearly identify
existing dependencies, comprehensive performance studies are
required evaluating the effect of different critical network parameters
on system level performance and behavior.This paper-s main
objective is to address the need for multi-parametric performance
evaluations considering critical network parameters using a well
known network simulator, offering useful and practical conclusions
and guidelines. The results reveal strong dependencies among
considered parameters which can be utilized by and drive future
research efforts, towards designing and implementing highly efficient
protocols and architectures.
Abstract: In this paper a new method is suggested for risk
management by the numerical patterns in data-mining. These patterns
are designed using probability rules in decision trees and are cared to
be valid, novel, useful and understandable. Considering a set of
functions, the system reaches to a good pattern or better objectives.
The patterns are analyzed through the produced matrices and some
results are pointed out. By using the suggested method the direction
of the functionality route in the systems can be controlled and best
planning for special objectives be done.
Abstract: DC-DC converters are widely used in regulated switched mode power supplies and in DC motor drive applications. There are several sources of unwanted nonlinearity in practical power converters. In addition, their operation is characterized by switching that gives birth to a variety of nonlinear dynamics. DC-DC buck and boost converters controlled by pulse-width modulation (PWM) have been simulated. The voltage waveforms and attractors obtained from the circuit simulation have been studied. With the onset of instability, the phenomenon of subharmonic oscillations, quasi-periodicity, bifurcations, and chaos have been observed. This paper is mainly motivated by potential contributions of chaos theory in the design, analysis and control of power converters, in particular and power electronics circuits, in general.
Abstract: An application framework provides a reusable design
and implementation for a family of software systems. Application
developers extend the framework to build their particular
applications using hooks. Hooks are the places identified to show
how to use and customize the framework. Hooks define Framework
Interface Classes (FICs) and their possible specifications, which
helps in building reusable test cases for the implementations of these
classes. In applications developed using gray-box frameworks, FICs
inherit framework classes or use them without inheritance. In this
paper, a test-case generation technique is extended to build test cases
for FICs built for gray-box frameworks. A tool is developed to
automate the introduced technique.
Abstract: In this paper, a new model order reduction
phenomenon is introduced at the design stage of linear phase digital
IIR filter. The complexity of a system can be reduced by adopting the
model order reduction method in their design. In this paper a mixed
method of model order reduction is proposed for linear IIR filter. The
proposed method employs the advantages of factor division technique
to derive the reduced order denominator polynomial and the reduced
order numerator is obtained based on the resultant denominator
polynomial. The order reduction technique is used to reduce the delay
units at the design stage of IIR filter. The validity of the proposed
method is illustrated with design example in frequency domain and
stability is also examined with help of nyquist plot.
Abstract: Crawling movement as a motive mode seen in nature
of some animals such as snakes possesses a specific syntactic and
dynamic analysis. Serpentine robot designed by inspiration from
nature and snake-s crawling motion, is regarded as a crawling robot.
In this paper, a serpentine robot with spiral motion model will be
analyzed. The purpose of this analysis is to calculate the vertical and
tangential forces along snake-s body and to determine the parameters
affecting on these forces. Two types of serpentine robots have been
designed in order to examine the achieved relations explained below.
Abstract: This paper addresses the problem of asymptotic tracking
control of a linear parabolic partial differential equation with indomain
point actuation. As the considered model is a non-standard
partial differential equation, we firstly developed a map that allows
transforming this problem into a standard boundary control problem
to which existing infinite-dimensional system control methods can
be applied. Then, a combination of energy multiplier and differential
flatness methods is used to design an asymptotic tracking controller.
This control scheme consists of stabilizing state-feedback derived
from the energy multiplier method and feed-forward control based
on the flatness property of the system. This approach represents
a systematic procedure to design tracking control laws for a class
of partial differential equations with in-domain point actuation. The
applicability and system performance are assessed by simulation
studies.
Abstract: In this research, Forming Limit Diagrams for supertension
sheet metals which are using in automobile industry have
been obtained. The exerted strains to sheet metals have been
measured with four different methods and the errors of each method
have also been represented. These methods have been compared with
together and the most efficient and economic way of extracting of the
exerted strains to sheet metals has been introduced. In this paper total
error and uncertainty of FLD extraction procedures have been
derived. Determination of the measurement uncertainty in extracting
of FLD has a great importance in design and analysis of the sheet
metal forming process.
Abstract: The effect of different combinations of response
feedback on the performance of active control system on nonlinear
frames has been studied in this paper. To this end different feedback
combinations including displacement, velocity, acceleration and full
response feedback have been utilized in controlling the response of
an eight story bilinear hysteretic frame which has been subjected to a
white noise excitation and controlled by eight actuators which could
fully control the frame. For active control of nonlinear frame
Newmark nonlinear instantaneous optimal control algorithm has been
used which a diagonal matrix has been selected for weighting
matrices in performance index. For optimal design of active control
system while the objective has been to reduce the maximum drift to
below the yielding level, Distributed Genetic Algorithm (DGA) has
been used to determine the proper set of weighting matrices. The
criteria to assess the effect of each combination of response feedback
have been the minimum required control force to reduce the
maximum drift to below the yielding drift. The results of numerical
simulation show that the performance of active control system is
dependent on the type of response feedback where the velocity
feedback is more effective in designing optimal control system in
comparison with displacement and acceleration feedback. Also using
full feedback of response in controller design leads to minimum
control force amongst other combinations. Also the distributed
genetic algorithm shows acceptable convergence speed in solving the
optimization problem of designing active control systems.
Abstract: Within the last years, several technologies have been developed to help building e-learning portals. Most of them follow approaches that deliver a vast amount of functionalities, suitable for class-like learning. The SuGI project, as part of the D-Grid (funded by the BMBF), targets on delivering a highly scalable and sustainable learning solution to provide materials (e.g. learning modules, training systems, webcasts, tutorials, etc.) containing knowledge about Grid computing to the D-Grid community. In this article, the process of the development of an e-learning portal focused on the requirements of this special user group is described. Furthermore, it deals with the conceptual and technical design of an e-learning portal, addressing the special needs of heterogeneous target groups. The main focus lies on the quality management of the software development process, Web templates for uploading new contents, the rich search and filter functionalities which will be described from a conceptual as well as a technical point of view. Specifically, it points out best practices as well as concepts to provide a sustainable solution to a relatively unknown and highly heterogeneous community.
Abstract: The birdhouses and dovecotes, which are the indicator
of naturalness and human-animal relationship, are one of the
traditional cultural values of Turkey. With their structures compatible
with nature and respectful to humans the bird houses and dovecotes,
which have an important position in local urbanization models as a
representative of the civil architecture with their unique form and
function are important subjects that should be evaluated in a wide
frame comprising from architecture to urbanism, from ecologic
agriculture to globalization. The traditional bird houses and
dovecotes are disregarded due to the insensitivity affecting the city
life and the change in the public sense of art. In this study, the
characteristic properties of traditional dovecotes and birdhouses,
started in 13th century and ended in 19th century in Anatolia, are
tried to be defined for the sustainability of the tradition and for giving
a new direction to the designers.
Abstract: Frequently a group of people jointly decide and authorize
a specific person as a representative in some business/poitical
occasions, e.g., the board of a company authorizes the chief executive
officer to close a multi-billion acquisition deal. In this paper, an
integrated proxy multi-signature scheme that allows anonymously
vetoable delegation is proposed. This protocol integrates mechanisms
of private veto, distributed proxy key generation, secure transmission
of proxy key, and existentially unforgeable proxy multi-signature
scheme. First, a provably secure Guillou-Quisquater proxy signature
scheme is presented, then the “zero-sharing" protocol is extended
over a composite modulus multiplicative group, and finally the above
two are combined to realize the GQ proxy multi-signature with
anonymously vetoable delegation. As a proxy signature scheme, this
protocol protects both the original signers and the proxy signer.
The modular design allows simplified implementation with less
communication overheads and better computation performance than
a general secure multi-party protocol.
Abstract: Ratio and regression type estimators have been used by previous authors to estimate a population mean for the principal variable from samples in which both auxiliary x and principal y variable data are available. However, missing data are a common problem in statistical analyses with real data. Ratio and regression type estimators have also been used for imputing values of missing y data. In this paper, six new ratio and regression type estimators are proposed for imputing values for any missing y data and estimating a population mean for y from samples with missing x and/or y data. A simulation study has been conducted to compare the six ratio and regression type estimators with a previous estimator of Rueda. Two population sizes N = 1,000 and 5,000 have been considered with sample sizes of 10% and 30% and with correlation coefficients between population variables X and Y of 0.5 and 0.8. In the simulations, 10 and 40 percent of sample y values and 10 and 40 percent of sample x values were randomly designated as missing. The new ratio and regression type estimators give similar mean absolute percentage errors that are smaller than the Rueda estimator for all cases. The new estimators give a large reduction in errors for the case of 40% missing y values and sampling fraction of 30%.
Abstract: In the globalized e-learning environment, students coming from different cultures and countries have different characteristics and require different support designed for their approaches to study and learning styles. This paper explores the ways in which cultural background influences students- approaches to study and learning styles. Participants in the study consisted of 131 eastern students and 54 western students from an Australian university. The students were tested using the Study Process Questionnaire (SPQ) for assessing their approaches to study and the Index of Learning Styles Questionnaire (ILS) for assessing their learning styles. The results of the study led to a set of principles being proposed to guide personalization of e-learning system design on the basis of cultural differences.