Abstract: Lateral Geniculate Nucleus (LGN) is the relay center
in the visual pathway as it receives most of the input information
from retinal ganglion cells (RGC) and sends to visual cortex. Low
threshold calcium currents (IT) at the membrane are the unique
indicator to characterize this firing functionality of the LGN neurons
gained by the RGC input. According to the LGN functional
requirements such as functional mapping of RGC to LGN, the
morphologies of the LGN neurons were developed. During the
neurological disorders like glaucoma, the mapping between RGC and
LGN is disconnected and hence stimulating LGN electrically using
deep brain electrodes can restore the functionalities of LGN. A
computational model was developed for simulating the LGN neurons
with three predominant morphologies each representing different
functional mapping of RGC to LGN. The firings of action potentials
at LGN neuron due to IT were characterized by varying the
stimulation parameters, morphological parameters and orientation. A
wide range of stimulation parameters (stimulus amplitude, duration
and frequency) represents the various strengths of the electrical
stimulation with different morphological parameters (soma size,
dendrites size and structure). The orientation (0-1800) of LGN
neuron with respect to the stimulating electrode represents the angle
at which the extracellular deep brain stimulation towards LGN
neuron is performed. A reduced dendrite structure was used in the
model using Bush–Sejnowski algorithm to decrease the
computational time while conserving its input resistance and total
surface area. The major finding is that an input potential of 0.4 V is
required to produce the action potential in the LGN neuron which is
placed at 100 μm distance from the electrode. From this study, it can
be concluded that the neuroprostheses under design would need to
consider the capability of inducing at least 0.4V to produce action
potentials in LGN.
Abstract: Concurrent planning of project scheduling and
material ordering can provide more flexibility to the project
scheduling problem, as the project execution costs can be enhanced.
Hence, the issue has been taken into account in this paper. To do so, a
mixed-integer mathematical model is developed which considers the
aforementioned flexibility, in addition to the materials quantity
discount and space availability restrictions. Moreover, the activities
duration has been treated as decision variables. Finally, the efficiency
of the proposed model is tested by different instances. Additionally,
the influence of the aforementioned parameters is investigated on the
model performance.
Abstract: This paper concentrates on the sustainable traditional
architecture and urban planning in hot-humid regions of Iran. In a
vast country such as Iran with different climatic zones traditional
builders have presented series of logical solutions for human comfort.
The aim of this paper is to demonstrate traditional architecture in hothumid
climate of Iran as a sample of sustainable architecture. Iranian
traditional architecture has been able to response to environmental
problems for a long period of time. Its features are based on climatic
factors, local construction materials of hot-humid regions and culture.
This paper concludes that Iranian traditional architecture can be
addressed as a sustainable architecture.
Abstract: The objective of this work is to carryout critical
comparison of different actuation mechanisms like electrostatic,
thermal, piezoelectric, and magnetic with reference to a micro
cantilever. The relevant parameters like force generated,
displacement are compared in actuation methods. With these results,
helps in choosing the best actuation method for a particular
application. In this study, Comsol/Multiphysics software is used.
Modeling and simulation is done by considering the micro cantilever
of same dimensions as an actuator using all the above mentioned
actuation techniques. In addition to their small size, micro actuators
consume very little power and are capable of accurate results. In this
work, a comparison of actuation mechanisms is done to decide the
efficient system in micro domain.
Abstract: Within Rapid Prototyping technologies are used many
types of materials. Many of them are recyclable but there are still as
plastic like, so practically they do not degrade in the landfill.
Polylactic acid (PLA) is one of the special plastic materials, which
are biodegradable and available for 3D printing within Fused
Deposition Modeling (FDM) technology. The question is, if the
mechanical properties of produced models are comparable to similar
technical plastic materials which are usual for prototype production.
Presented paper shows the experiments results for tensile strength
measurements for specimens prepared with different 3D printer
settings and model orientation. Paper contains also the comparison of
tensile strength values with values measured on specimens produced
by conventional technologies as injection moulding.
Abstract: Numerical study of the static response of
homogeneous clay stratum considering a wide range of cohesion and
subject to foundation loads is presented. The linear elastic–perfectly
plastic constitutive relation with the von Mises yield criterion were
utilised to develop a numerically cost effective finite element model
for the soil while imposing a rigid body constrain to the foundation
footing. From the analyses carried out, estimate of the bearing
capacity factor, Nc as well as the ultimate load-carrying capacities of
these soils, effect of cohesion on foundation settlements, stress fields
and failure propagation were obtained. These are consistent with
other findings in the literature and hence can be a useful guide in
design of safe foundations in clay soils for buildings and other
structure.
Abstract: The purpose of this research is to investigate the
marketing mix that is perceived to be important for the small sized
hotels in Pattaya. This research provides insights through a review of
the marketing activities performed by the small sized hotels. Nine
owners & marketing manager of small sized hotels and resorts, all
local Chonburi people, were selected for an in-depth interview. The
research suggests that seven marketing mixes (e.g. Product, Price,
Place, Promotion, People, Physical Evidence and Process) were
commonly used by these hotels, however, three types – People, Price
and Physical Evidence were considered most important by the
owners.
Abstract: The main cause of Alzheimer disease (AD) was
believed to be mainly due to the accumulation of free radicals owing
to oxidative stress (OS) in brain tissue. The mechanism of the
neurotoxicity of Aluminum chloride (AlCl3) induced AD in
hippocampus Albino wister rat brain tissue, the curative & the
protective effects of Lipidium sativum group (LS) water extract were
assessed after 8 weeks by attenuated total reflection spectroscopy
ATR-IR and histologically by light microscope. ATR-IR results
revealed that the membrane phospholipid undergo free radical
attacks, mediated by AlCl3, primary affects the polyunsaturated fatty
acids indicated by the increased of the olefinic -C=CH sub-band area
around 3012 cm-1 from the curve fitting analysis. The narrowing in
the half band width (HBW) of the sνCH2 sub-band around 2852 cm-1
due to Al intoxication indicates the presence of trans form fatty acids
rather than gauch rotomer. The degradation of hydrocarbon chain to
shorter chain length, increasing in membrane fluidity, disorder, and
decreasing in lipid polarity in AlCl3 group indicated by the detected
changes in certain calculated area ratios compared to the control.
Administration of LS was greatly improved these parameters
compared to the AlCl3 group. Al influences the Aβ aggregation and
plaque formation, which in turn interferes to and disrupts the
membrane structure. The results also showed a marked increase in
the β-parallel and antiparallel structure, that characterize the Aβ
formation in Al-induced AD hippocampal brain tissue, indicated by
the detected increase in both amide I sub-bands around 1674, 1692
cm-1. This drastic increase in Aβ formation was greatly reduced in the
curative and protective groups compared to the AlCl3 group and
approached nearly the control values. These results supported too by
the light microscope. AlCl3 group showed significant marked
degenerative changes in hippocampal neurons. Most cells appeared
small, shrieked and deformed. Interestingly, the administration of LS
in curative and protective groups markedly decreases the amount of
degenerated cells compared to the non-treated group. In addition, the
intensity of congo red stained cells was decreased. Hippocampal
neurons looked more/or less similar to those of control. This study showed a promising therapeutic effect of Lipidium
sativum group (LS) on AD rat model that seriously overcome the
signs of oxidative stress on membrane lipid and restore the protein
misfolding.
Abstract: Lagos urban mini bus drivers play a critical role in the
transportation sector. The current major mode of transportation
within Lagos metropolis remains road transportation and this
confirms the relevance of urban mini-bus drivers in transporting the
populace to their various destinations. Other modes of transportation
such as the train and waterways are currently inadequate. Various
threats to the well-being of urban bus drivers include congested
traffic typical of modern day lifestyles, dwindling financial returns
due to long hours in traffic, fewer hours of sleep, inadequate diet,
time pressure, and assaults related to fare disputes. Several healthrelated
problems have been documented to be associated with urban
bus driving. For instance, greater rates of hypertension, obesity and
cholesterol level have been reported. Research studies are yet to
identify the influence of age and marital status on the well-being of
urban mini-bus drivers in Lagos metropolis. A study of this nature is
necessary as it is culturally perceived in Nigeria that older and
married people are especially influenced by family affiliation and
would behave in ways that would project positive outcomes. The
study sample consisted of 150 urban mini-bus drivers who were
conveniently sampled from six (6) different terminuses where their
journey begins and terminates. The well-being questionnaire was
administered to participants. The criteria for inclusion in the study
included the ability to read in English language and the confirmation
that interested participants were on duty and suited to be driving
mini-buses. Due to the nature of the job of bus driving, the researcher
administered the questionnaires on participants who were free and
willing to respond to the survey. All participants were males of
various age groups and of different marital statuses. Results of
analyses conducted revealed no significant influence of age and
marital status on the well-being of urban mini-bus drivers. This
indicates that the well-being of urban mini bus drivers is not
influenced by age or marital status. The findings of this study have
cultural implications. It negates the popularly held belief that older
and married people care more about their well-being than younger
and single people. It brings to fore the need to also identify and
consider other factors when certifying people for the job of urban bus
driving.
Abstract: Highly developed technology and highly competitive
global market highlight the important role of competitive advantages
and operation performances in sustainable company operation.
Activity-Based Costing (ABC) provides accurate operation cost and
operation performance information. Rich literatures provide relevant
research with cases study on Activity-Based Costing application, but
the research on cause relationship between key success factors and its
specific outcome, such as profitability or share market are few. These
relationships provide the ways to handle the key success factors to
achieve the specific outcomes for ensuring to promote the competitive
advantages and operation performances. The main purposes of this
research are exploring the key success paths by Key Success Paths
approach which will lead the ways to apply Activity-Base Costing.
The Key Success Paths is the innovative method which is exploring
the cause relationships and explaining what are the effects of key
success factors to specific outcomes of Activity-Based Costing
implementation. The cause relationships between key success factors
and successful specific outcomes are Key Success Paths (KSPs). KSPs
are the guidelines to lead the cost management strategies to achieve the
goals of competitive advantages and operation performances. The
research findings indicate that good management system design may
affect the well outcomes of Activity-Based Costing application and
achieve to outstanding competitive advantage, operating performance
and profitability as well by KSPs exploration.
Abstract: This study was aimed to measure effective transverse
relaxation rates (R2*) in the liver and muscle of normal New Zealand
White (NZW) rabbits. R2* relaxation rate has been widely used in
various hepatic diseases for iron overload by quantifying iron contents
in liver. R2* relaxation rate is defined as the reciprocal of T2*
relaxation time and mainly depends on the constituents of tissue.
Different tissues would have different R2* relaxation rates. The signal
intensity decay in Magnetic resonance imaging (MRI) may be
characterized by R2* relaxation rates. In this study, a 1.5T GE Signa
HDxt whole body MR scanner equipped with an 8-channel high
resolution knee coil was used to observe R2* values in NZW rabbit’s
liver and muscle. Eight healthy NZW rabbits weighted 2 ~ 2.5 kg were
recruited. After anesthesia using Zoletil 50 and Rompun 2% mixture,
the abdomen of rabbit was landmarked at the center of knee coil to
perform 3-plane localizer scan using fast spoiled gradient echo
(FSPGR) pulse sequence. Afterwards, multi-planar fast gradient echo
(MFGR) scans were performed with 8 various echo times (TEs) to
acquire images for R2* measurements. Regions of interest (ROIs) at
liver and muscle were measured using Advantage workstation.
Finally, the R2* was obtained by a linear regression of ln(sı) on TE.
The results showed that the longer the echo time, the smaller the signal
intensity. The R2* values of liver and muscle were 44.8 ± 10.9 s-1 and
37.4 ± 9.5 s-1, respectively. It implies that the iron concentration of
liver is higher than that of muscle. In conclusion, the more the iron
contents in tissue, the higher the R2*. The correlations between R2*
and iron content in NZW rabbits might be valuable for further
exploration.
Abstract: Various nanomaterials can be used as a drug delivery
vehicles in nanomedicine, called nanocarriers. They can either be
organic or inorganic, synthetic or natural-based. Although synthetic
nanocarriers are easier to produce, they can often be toxic for the
organism and thus not suitable for use in treatment. From naturalbased
nanocarriers, the most commonly used are protein cages or
viral capsids. In this work, virus bacteriophage λ was used for
delivery of different cytotoxic drugs (cisplatin, carboplatin,
oxaliplatin and doxorubicin). Large quantities of phage λ were
obtained from phage λ-producing strain of E. coli cultivated in
medium with 0.2% maltose. After killing of E. coli with chloroform
and its removal by centrifugation, the phage was concentrated by
ultracentrifugation at 130 000×g and 4°C for 3 h. The encapsulation
of the drugs was performed by infusion method and four different
concentrations of the drugs were encapsulated (200; 100; 50; 25
μg·mL-1). Free drug molecules were removed by filtration. The
encapsulation was verified using the absorbance for doxorubicin and
atomic absorption spectrometry for platinum cytostatics. The amount
of encapsulated drug linearly increased with the increasing
concentration of applied drug with the determination coefficient
R2=0.989 for doxorubicin; R2=0.967 for cisplatin; R2=0.989 for
carboplatin and R2=0.996 for oxaliplatin. The overall encapsulation
efficiency was calculated as 50% for doxorubicin; 8% for cisplatin;
6% for carboplatin and 10% for oxaliplatin.
Abstract: Millions of girls are forcibly married during the
transitional period between puberty and adulthood. At a stage of
vulnerability cultural practices, religious rights and social standards
place her in a position where she is catapult into womanhood. An
advocate against forced child marriage could argue that child rights,
cultural rights, religious rights, right to marry, right to life, right to
health, right to education, right to be free from slavery, right to be
free from torture, right to consent to marriage are all violated by the
practice of child marriage. The author is this advocate and this paper
will present how some of these rights are violated and establish the
need for change.
Abstract: The practical efficient approach is suggested for
estimation of the seismoacoustic sources energy in C-OTDR
monitoring systems. This approach is represents the sequential plan
for confidence estimation both the seismoacoustic sources energy, as
well the absorption coefficient of the soil. The sequential plan
delivers the non-asymptotic guaranteed accuracy of obtained
estimates in the form of non-asymptotic confidence regions with
prescribed sizes. These confidence regions are valid for a finite
sample size when the distributions of the observations are unknown.
Thus, suggested estimates are non-asymptotic and nonparametric,
and also these estimates guarantee the prescribed estimation accuracy
in form of prior prescribed size of confidence regions, and prescribed
confidence coefficient value.
Abstract: This paper discusses the thematic structure of Yoruba
popular music of Southwest Nigeria. It examines the use of themes
and variations in early and contemporary Juju music. The work is an
outcome of a research developed by the author in his doctoral studies
at the University of Lagos, Nigeria, with the aim of analyzing the
thematic and motivic developments in Yoruba popular genres.
Observations, interviews, live recordings and CDs were used as
methods for eliciting information. Field recordings and CDs of
selected musical samples were also transcribed and notated. The
research established the prevalent use of string of themes by Juju
musicians as a compositional technique in moving from one musical
section to another, as they communicate the verbal messages in their
song. These themes consist of the popular ‘call and response’ form
found in most African music, analogous to the western ‘subject and
answer’ style of the fugue or sonata form, although without the tonic–
dominant relations. Due to the short and repetitive form of African
melodies and rhythms, a theme is restated as a variation, where its
rhythmic and melodic motifs are stylistically developed and repeated,
but still retaining its recognizable core musical structure. The
findings of this study showed that Juju musicians generally often
employ a thematic plan where new themes are used to arrange the
songs into sections, and each theme is developed into variations in
order to further expand the music, eliminate monotony, and create
musical aesthetics, serving as hallmark of its musical identity. The
study established the musical and extra-musical attributes of the
genre, while recommending further research towards analyzing the
various compositional techniques employed in African popular
genres.
Abstract: The plastic industry plays very important role in the
economy of any country. It is generally among the leading share of
the economy of the country. Since metals and their alloys are very
rarely available on the earth. Therefore, to produce plastic products
and components, which finds application in many industrial as well
as household consumer products is beneficial. Since 50% plastic
products are manufactured by injection moulding process. For
production of better quality product, we have to control quality
characteristics and performance of the product. The process
parameters plays a significant role in production of plastic, hence the
control of process parameter is essential. In this paper the effect of
the parameters selection on injection moulding process has been
described. It is to define suitable parameters in producing plastic
product. Selecting the process parameter by trial and error is neither
desirable nor acceptable, as it is often tends to increase the cost and
time. Hence, optimization of processing parameter of injection
moulding process is essential. The experiments were designed with
Taguchi’s orthogonal array to achieve the result with least number of
experiments. Plastic material polypropylene is studied. Tensile
strength test of material is done on universal testing machine, which
is produced by injection moulding machine. By using Taguchi
technique with the help of MiniTab-14 software the best value of
injection pressure, melt temperature, packing pressure and packing
time is obtained. We found that process parameter packing pressure
contribute more in production of good tensile plastic product.
Abstract: The customers use the best compromise criterion
between price and quality of service (QoS) to select or change
their Service Provider (SP). The SPs share the same market and
are competing to attract more customers to gain more profit. Due
to the divergence of SPs interests, we believe that this situation is a
non-cooperative game of price and QoS. The game converges to an
equilibrium position known Nash Equilibrium (NE). In this work, we
formulate a game theoretic framework for the dynamical behaviors
of SPs. We use Genetic Algorithms (GAs) to find the price and
QoS strategies that maximize the profit for each SP and illustrate
the corresponding strategy in NE. In order to quantify how this NE
point is performant, we perform a detailed analysis of the price of
anarchy induced by the NE solution. Finally, we provide an extensive
numerical study to point out the importance of considering price and
QoS as a joint decision parameter.
Abstract: We consider fast and accurate solutions of scattering
problems by large perfectly conducting objects (PEC) formulated
by an optimization of the Method of Auxiliary Sources (MAS). We
present various techniques used to reduce the total computational cost
of the scattering problem. The first technique is based on replacing
the object by an array of finite number of small (PEC) object with the
same shape. The second solution reduces the problem on considering
only the half of the object.These t
Abstract: Sub-Saharan Africa is described as the second fastest
growing in mobile phone penetration in the world more than in the
United States or the European Union. Mobile phones have been used
to provide a lot of opportunities to improve people’s lives in the
region such as in banking, marketing, entertainment, and paying for
various bills such as water, TV, and electricity. However, the
potential of mobile phones to enhance teaching and learning has not
been explored. This study presents an experience of developing and
delivering SMS based quiz questions used to assess mastery of
subject content knowledge of science and mathematics secondary
school teachers in Tanzania. The SMS quizzes were used as a follow
up support mechanism to 500 teachers who participated in a project
to upgrade subject content knowledge of teachers in science and
mathematics subjects in Tanzania. Quizzes of 10-15 questions were
sent to teachers each week for 8 weeks and the results were analyzed
using SPSS. Results show that teachers who participated in chemistry
and biology subjects have better performance compared to those who
participated in mathematics and physics subjects. Teachers reported
some challenges that led to poor performance, This research has
several practical implications for those who are implementing or
planning to use mobile phones in teaching and learning especially in
rural secondary schools in sub-Saharan Africa.
Abstract: The aim of sustainable architecture is to design
buildings with the least adverse effects on the environment and
provide better conditions for people. What building forms make the
best use of land? This question was addressed in the late 1960s at the
center of Land Use and Built Form Studies in Cambridge. This led to
a number of influential papers which had a great influence on the
practice of urban design. This paper concentrates on the results of
sustainability caused by climatic conditions in Iranian traditional
architecture in hot-arid regions. As people spent a significant amount
of their time in houses, it was very important to have such houses to
fulfill their needs physically and spiritually as well as satisfying their
cultural and religious aspects of their lifestyles. In a vast country such
as Iran with different climatic zones, traditional builders have
presented series of logical solutions for human comfort. These
solutions have been able to response to the environmental problems
for a long period of time. As a result, by considering the experience
in traditional architecture of hot–arid climate in Iran, it is possible to
attain sustainable architecture.