Abstract: The p53 tumor suppressor gene plays two important
roles in genomic stability: blocking cell proliferation after DNA
damage until it has been repaired, and starting apoptosis if the
damage is too critical. Codon 72 exon4 polymorphism (Arg72Pro) of
the P53 gene has been implicated in cancer risk. Various studies have
been done to investigate the status of p53 at codon 72 for arginine
(Arg) and proline (Pro) alleles in different populations and also the
association of this codon 72 polymorphism with various tumors. Our
objective was to investigate the possible association between P53
Arg72Pro polymorphism and susceptibility to colorectal cancer
among Isfahan and Chaharmahal Va Bakhtiari (a part of south west
of Iran) population. We investigated the status of p53 at codon 72 for
Arg/Arg, Arg/Pro and Pro/Pro allele polymorphisms in blood
samples from 145 colorectal cancer patients and 140 controls by
Nested-PCR of p53 exon 4 and digestion with BstUI restriction
enzyme and the DNA fragments were then resolved by
electrophoresis in 2% agarose gel. The Pro allele was 279 bp, while
the Arg allele was restricted into two fragments of 160 and 119 bp.
Among the 145 colorectal cancer cases 49 cases (33.79%) were
homozygous for the Arg72 allele (Arg/Arg), 18 cases (12.41%) were
homozygous for the Pro72 allele (Pro/Pro) and 78 cases (53.8%)
found in heterozygous (Arg/Pro).
In conclusion, it can be said that p53Arg/Arg genotype may be
correlated with possible increased risk of this kind of cancers in south
west of Iran.
Abstract: In the recent past Learning Classifier Systems have
been successfully used for data mining. Learning Classifier System
(LCS) is basically a machine learning technique which combines
evolutionary computing, reinforcement learning, supervised or
unsupervised learning and heuristics to produce adaptive systems. A
LCS learns by interacting with an environment from which it
receives feedback in the form of numerical reward. Learning is
achieved by trying to maximize the amount of reward received. All
LCSs models more or less, comprise four main components; a finite
population of condition–action rules, called classifiers; the
performance component, which governs the interaction with the
environment; the credit assignment component, which distributes the
reward received from the environment to the classifiers accountable
for the rewards obtained; the discovery component, which is
responsible for discovering better rules and improving existing ones
through a genetic algorithm. The concatenate of the production rules
in the LCS form the genotype, and therefore the GA should operate
on a population of classifier systems. This approach is known as the
'Pittsburgh' Classifier Systems. Other LCS that perform their GA at
the rule level within a population are known as 'Mitchigan' Classifier
Systems. The most predominant representation of the discovered
knowledge is the standard production rules (PRs) in the form of IF P
THEN D. The PRs, however, are unable to handle exceptions and do
not exhibit variable precision. The Censored Production Rules
(CPRs), an extension of PRs, were proposed by Michalski and
Winston that exhibit variable precision and supports an efficient
mechanism for handling exceptions. A CPR is an augmented
production rule of the form: IF P THEN D UNLESS C, where
Censor C is an exception to the rule. Such rules are employed in
situations, in which conditional statement IF P THEN D holds
frequently and the assertion C holds rarely. By using a rule of this
type we are free to ignore the exception conditions, when the
resources needed to establish its presence are tight or there is simply
no information available as to whether it holds or not. Thus, the IF P
THEN D part of CPR expresses important information, while the
UNLESS C part acts only as a switch and changes the polarity of D
to ~D. In this paper Pittsburgh style LCSs approach is used for
automated discovery of CPRs. An appropriate encoding scheme is
suggested to represent a chromosome consisting of fixed size set of
CPRs. Suitable genetic operators are designed for the set of CPRs
and individual CPRs and also appropriate fitness function is proposed
that incorporates basic constraints on CPR. Experimental results are
presented to demonstrate the performance of the proposed learning
classifier system.
Abstract: A Comparison and evaluation of the different
condition monitoring (CM) techniques was applied experimentally
on RC e.g. Dynamic cylinder pressure and crankshaft Instantaneous
Angular Speed (IAS), for the detection and diagnosis of valve faults
in a two - stage reciprocating compressor for a programme of
condition monitoring which can successfully detect and diagnose a
fault in machine. Leakage in the valve plate was introduced
experimentally into a two-stage reciprocating compressor. The effect
of the faults on compressor performance was monitored and the
differences with the normal, healthy performance noted as a fault
signature been used for the detection and diagnosis of faults.
The paper concludes with what is considered to be a unique
approach to condition monitoring. First, each of the two most useful
techniques is used to produce a Truth Table which details the
circumstances in which each method can be used to detect and
diagnose a fault. The two Truth Tables are then combined into a
single Decision Table to provide a unique and reliable method of
detection and diagnosis of each of the individual faults introduced
into the compressor. This gives accurate diagnosis of compressor
faults.
Abstract: Data objects are usually organized hierarchically, and
the relations between them are analyzed based on a corresponding
concept hierarchy. The relation between data objects, for example how
similar they are, are usually analyzed based on the conceptual distance
in the hierarchy. If a node is an ancestor of another node, it is enough
to analyze how close they are by calculating the distance vertically.
However, if there is not such relation between two nodes, the vertical
distance cannot express their relation explicitly. This paper tries to fill
this gap by improving the analysis method for data objects based on
hierarchy. The contributions of this paper include: (1) proposing an
improved method to evaluate the vertical distance between concepts;
(2) defining the concept horizontal distance and a method to calculate
the horizontal distance; and (3) discussing the methods to confine a
range by the horizontal distance and the vertical distance, and
evaluating the relation between concepts.
Abstract: The paper deals with the estimation of amplitude and phase of an analogue multi-harmonic band-limited signal from irregularly spaced sampling values. To this end, assuming the signal fundamental frequency is known in advance (i.e., estimated at an independent stage), a complexity-reduced algorithm for signal reconstruction in time domain is proposed. The reduction in complexity is achieved owing to completely new analytical and summarized expressions that enable a quick estimation at a low numerical error. The proposed algorithm for the calculation of the unknown parameters requires O((2M+1)2) flops, while the straightforward solution of the obtained equations takes O((2M+1)3) flops (M is the number of the harmonic components). It is applied in signal reconstruction, spectral estimation, system identification, as well as in other important signal processing problems. The proposed method of processing can be used for precise RMS measurements (for power and energy) of a periodic signal based on the presented signal reconstruction. The paper investigates the errors related to the signal parameter estimation, and there is a computer simulation that demonstrates the accuracy of these algorithms.
Abstract: Three alumina-supported Pt-Sn catalysts have been
prepared by means of co-impregnation and characterized by XRD and
N2 adsorption. The influence of catalyst composition and reaction
conditions on the conversion and selectivity were investigated in the
hydrogenation of acetic acid in an isothermal integral fixed bed
reactor. The experiments were performed on the temperature interval
468-548 K, liquid hourly space velocity (LHSV) of 0.3-0.7h-1,
pressures between 1.0 and 5.0Mpa. A good compromise of
0.75%Pt-1.5%Sn can act as an optimized acetic acid hydrogenation
catalyst, and the conversion and selectivity can be tuned through the
variation of reaction conditions.
Abstract: In this paper, two very different optimization
algorithms, Genetic and DIRECT algorithms, are used to history
match a bottomhole pressure response for a reservoir with wellbore
storage and skin with the best possible analytical model. No initial
guesses are available for reservoir parameters. The results show that
the matching process is much faster and more accurate for DIRECT
method in comparison with Genetic algorithm. It is furthermore
concluded that the DIRECT algorithm does not need any initial
guesses, whereas Genetic algorithm needs to be tuned according to
initial guesses.
Abstract: This study presents a new approach based on Tanaka's
fuzzy linear regression (FLP) algorithm to solve well-known power
system economic load dispatch problem (ELD). Tanaka's fuzzy linear
regression (FLP) formulation will be employed to compute the
optimal solution of optimization problem after linearization. The
unknowns are expressed as fuzzy numbers with a triangular
membership function that has middle and spread value reflected on
the unknowns. The proposed fuzzy model is formulated as a linear
optimization problem, where the objective is to minimize the sum of
the spread of the unknowns, subject to double inequality constraints.
Linear programming technique is employed to obtain the middle and
the symmetric spread for every unknown (power generation level).
Simulation results of the proposed approach will be compared with
those reported in literature.
Abstract: Heat-inducible gene expression vectors are useful for hyperthermia-induced cancer gene therapy, because the combination
of hyperthermia and gene therapy can considerably improve the therapeutic effects. In the present study, we developed an enhanced
heat-inducible transgene expression system in which a heat-shock
protein (HSP) promoter and tetracycline-responsive transactivator
were combined. When the transactivator plasmid containing the
tetracycline-responsive transactivator gene was co-transfected with
the reporter gene expression plasmid, a high level of heat-induced gene expression was observed compared with that using the HSP
promoter without the transactivator. In vitro evaluation of the
therapeutic effect using HeLa cells showed that heat-induced therapeutic gene expression caused cell death in a high percentage of
these cells, indicating that this strategy is promising for cancer gene therapy.
Abstract: In this study, the effect of nanofluids on the pool film
boiling was experimentally investigated at saturated condition under
atmospheric pressure. For this purpose, four different water-based
nanofluids (Al2O3, SiO2, TiO2 and CuO) with 0.1% particle volume
fraction were prepared. To investigate the boiling heat transfer, a
cylindrical rod with high temperature was used. The rod heated up to
high temperatures was immersed into nanofluids. The center
temperature of rod during the cooling process was recorded by using
a K-type thermocouple. The quenching curves showed that the pool
boiling heat transfer was strongly dependent on the nanoparticle
materials. During the repetitive quenching tests, the cooling time
decreased and thus, the film boiling vanished. Consequently, the
primary reason of this was the change of the surface characteristics
due to the nanoparticles deposition on the rod-s surface.
Abstract: In this study we investigate silica nanoparticle (SiO2- NP) effects on the structure and phase properties of supported lipid monolayers and bilayers, coupling surface pressure measurements, fluorescence microscopy and atomic force microscopy. SiO2-NPs typically in size range of 10nm to 100 nm in diameter are tested. Our results suggest first that lipid molecules organization depends to their nature. Secondly, lipid molecules in the vinicity of big aggregates nanoparticles organize in liquid condensed phase whereas small aggregates are localized in both fluid liquid-expanded (LE) and liquid-condenced (LC). We demonstrated also by atomic force microscopy that by measuring friction forces it is possible to get information as if nanoparticle aggregates are recovered or not by lipid monolayers and bilayers.
Abstract: Chronic diseases prevailed along with economic
growth as well as life style changed in recent years in Taiwan.
According to the governmental statistics, hypertension related disease
is the tenth of death causes with 1,816 died directly from hypertension
in 2010. There were more death causes amongst the top ten had been
proofed that having strong association with the hypertension, such as
heart diseases, cardiovascular diseases, and diabetes. Hypertension or
High blood pressure is one of the major indicators for chronic diseases,
and was generally perceived as the major causes of mortality. The
literature generally suggested that regular physical exercise was
helpful to prevent the occurrence or to ease the progress of a
hypertension. This paper reported the process and outcomes in
detailed of an improvement project of physical exercise intervention
specific for hypertension patients. Physical information were
measured before and after the project to obtain information such as
weight, waistline, cholesterol (HD & LD), blood examination, as well
as self-perceived health status. The intervention project involved a
six-week exercise program, of which contained three times a week, 30
minutes of tutored physical exercise intervention. The project had
achieved several gains in changing the subjects- behavior in terms of
many important biophysical indexes. Around 20% of the participants
had significantly improved their cholesterols, BMI, and changed
unhealthy behaviors. Results from the project were encouraging, and
would be good reference for other samples.
Abstract: Buildings and associated construction methods have a significant impact on the environment. As construction activity increases in Kuwait, there is a need to create design and construction strategies which will minimize the environmental impact of new buildings. Green construction is a design philosophy intended to improve the sustainability of construction by the minimization of resource depletion and CO2 emissions throughout the life cycle of buildings. This paper presents and discusses the results of a survey that was conducted in Kuwait, with the objective of investigating the awareness of developers and other stakeholders regarding their understanding and use of green construction strategies. The results of the survey demonstrate that whilst there seems to be a reasonable level of awareness amongst the stakeholders, this awareness is not currently well reflected in the design and construction practices actually being applied. It is therefore concluded is there is a pressing need for intervention from Government in order that the use of sustainable green design and construction strategies becomes the norm in Kuwait.
Abstract: In this paper, we proposed an efficient data
compression strategy exploiting the multi-resolution characteristic of
the wavelet transform. We have developed a sensor node called
“Smart Sensor Node; SSN". The main goals of the SSN design are
lightweight, minimal power consumption, modular design and robust
circuitry. The SSN is made up of four basic components which are a
sensing unit, a processing unit, a transceiver unit and a power unit.
FiOStd evaluation board is chosen as the main controller of the SSN
for its low costs and high performance. The software coding of the
implementation was done using Simulink model and MATLAB
programming language. The experimental results show that the
proposed data compression technique yields recover signal with good
quality. This technique can be applied to compress the collected data
to reduce the data communication as well as the energy consumption
of the sensor and so the lifetime of sensor node can be extended.
Abstract: The dynamics of a delayed mathematical model for
Hes1 oscillatory expression are investigated. The linear stability of
positive equilibrium and existence of local Hopf bifurcation are
studied. Moreover, the global existence of large periodic solutions
has been established due to the global bifurcation theorem.
Abstract: For any country the project management has been a
vital part for its development. The highly competitive business world
has created tremendous pressure on the project managers to achieve
success. The pressure is derived from survival and profit building in
business organizations which compels the project managers to pursue
unethical practices. As a result unethical activities in business
projects can be found easily where situations or issues arise due to
dubious business practice, high corruption, or absolute violation of
the law. The recent spur on Commonwealth games to be organized in
New Delhi indicates towards the same. It has been seen that the
project managers mainly focus on cost, time, and quality rather than
social impact and long term effects of the project. Surprisingly the
literature as well as the practitioner-s perspective also does not
identify the role of ethics in project success. This paper identifies
ethics as the fourth most important dimension in the project based
organizations. The paper predicts that the approach of considering
ethics will result in sustainability of the project. It will increase
satisfaction and loyalty of the customers as well as create harmony,
trust, brotherhood, values and morality among the team members.
This paper is conceptual in nature as inadequate literature exists
linking the project success with an ethical approach.
Abstract: This Paper proposes a new facial feature extraction approach, Wash-Hadamard Transform (WHT). This approach is based on correlation between local pixels of the face image. Its primary advantage is the simplicity of its computation. The paper compares the proposed approach, WHT, which was traditionally used in data compression with two other known approaches: the Principal Component Analysis (PCA) and the Discrete Cosine Transform (DCT) using the face database of Olivetti Research Laboratory (ORL). In spite of its simple computation, the proposed algorithm (WHT) gave very close results to those obtained by the PCA and DCT. This paper initiates the research into WHT and the family of frequency transforms and examines their suitability for feature extraction in face recognition applications.
Abstract: The purpose of this paper is to elucidate the flow unsteady behavior for moving plug in convergent-divergent variable thrust nozzle. Compressible axisymmetric Navier-Stokes equations are used to study this physical phenomenon. Different velocities are set for plug to investigate the effect of plug movement on flow unsteadiness. Variation of mass flow rate and thrust are compared under two conditions: First, the plug is placed at different positions and flow is simulated to reach the steady state (quasi steady simulation) and second, the plug is moved with assigned velocity and flow simulation is coupled with plug movement (unsteady simulation). If plug speed is high enough and its movement time scale is at the same order of the flow time scale, variation of the mass flow rate and thrust level versus plug position demonstrate a vital discrepancy under the quasi steady and unsteady conditions. This phenomenon should be considered especially from response time viewpoints in thrusters design.
Abstract: This research details a Computational Fluid Dynamics (CFD) approach to model fluid flow in a journal bearing with 8 equispaced semi-circular axial grooves. Water is used as the lubricant and is fed from one end of the bearing to the other, under pressure. The geometry of the bearing is modeled using a commercially available modeling software GAMBIT and the flow analysis is performed using a dedicated CFD analysis software FLUENT. The pressure distribution in the bearing clearance is obtained from FLUENT for various whirl ratios and is used to calculate the hydrodynamic force components in the radial and tangential direction of the bearing. These values along with the various whirl speeds can be used to do a regression analysis to determine the stiffness and damping coefficients. The values obtained are then compared with the stiffness and damping coefficients of a 3 Axial groove water lubricated journal bearing and those obtained from a FORTRAN code for a similar bearing.
Abstract: Heat source addition to the axisymmetric supersonic
inlet may improve the performance parameters, which will increase
the inlet efficiency. In this investigation the heat has been added to
the flow field at some distance ahead of an axisymmetric inlet by
adding an imaginary thermal source upstream of cowl lip. The effect
of heat addition on the drag coefficient, mass flow rate and the
overall efficiency of the inlet have been investigated. The results
show that heat addition causes flow separation, hence to prevent this
phenomena, roughness has been added on the spike surface.
However, heat addition reduces the drag coefficient and the inlet
mass flow rate considerably. Furthermore, the effects of position,
size, and shape on the inlet performance were studied. It is found that
the thermal source deflects the flow streamlines. By improper
location of the thermal source, the optimum condition has been
obtained. For the optimum condition, the drag coefficient is
considerably reduced and the inlet mass flow rate and its efficiency
have been increased slightly. The optimum shape of the heat source
is obtained too.