Abstract: Bone growth factors, such as Bone Morphogenic
Protein-2 (BMP-2) have been approved by the FDA to replace grafting for some surgical interventions, but the high dose requirement limits its use in patients. Noggin, an extracellular protein, blocks the effect of BMP-2 by binding to BMP. Preventing
the BMP-2/noggin interaction will help increase the free
concentration of BMP-2 and therefore should enhance its efficacy to
induce bone formation. The work presented here involves
computational design of novel small molecule inhibitory agents of BMP-2/noggin interaction, based on our current understanding of
BMP-2, and its known putative ligands (receptors and antagonists). A
successful acquisition of such an inhibitory agent of BMP-2/noggin interaction would allow clinicians to reduce the dose required of
BMP-2 protein in clinical applications to promote osteogenesis. The
available crystal structures of the BMPs, its receptors, and the binding partner noggin were analyzed to identify the critical residues
involved in their interaction. In presenting this study, LUDI de novo design method was utilized to perform virtual screening of a large
number of compounds from a commercially available library against the binding sites of noggin to identify the lead chemical compounds
that could potentially block BMP-noggin interaction with a high specificity.
Abstract: An attempt has been made several times to identify
and discuss the U.S. experience on the formation of political nation in
political science. The purpose of this research paper is to identify the
main aspects of the formation of civic identity in the United States
and Kazakhstan, through the identification of similarities and
differences that can get practical application in making decisions of
national policy issues in the context of globalization, as well as to
answer the questions “What should unite the citizens of Kazakhstan
to the nation?" and “What should be the dominant identity: civil or
ethnic (national) one?"
Can Kazakhstan being multiethnic country like America, adopt its
experience in the formation of a civic nation? Since it is believed that
the “multi-ethnic state of the population is a characteristic feature of
most modern countries in the world," it states that “inter-ethnic
integration is one of the most important aspects of the problem of
forming a new social community (metaetnic - Kazakh people,
Kazakh nation" [1].
Abstract: The paper provides the basic overview of simulation optimization. The procedure of its practical using is demonstrated on the real example in simulator Witness. The simulation optimization is presented as a good tool for solving many problems in real praxis especially in production systems. The authors also characterize their own experiences and they mention the strengths and weakness of simulation optimization.
Abstract: A generalized Digital Modulation Identification algorithm for adaptive demodulator has been developed and presented in this paper. The algorithm developed is verified using wavelet Transform and histogram computation to identify QPSK and QAM with GMSK and M–ary FSK modulations. It has been found that the histogram peaks simplifies the procedure for identification. The simulated results show that the correct modulation identification is possible to a lower bound of 5 dB and 12 dB for GMSK and QPSK respectively. When SNR is above 5 dB the throughput of the proposed algorithm is more than 97.8%. The receiver operating characteristics (ROC) has been computed to measure the performance of the proposed algorithm and the analysis shows that the probability of detection (Pd) drops rapidly when SNR is 5 dB and probability of false alarm (Pf) is smaller than 0.3. The performance of the proposed algorithm has been compared with existing methods and found it will identify all digital modulation schemes with low SNR.
Abstract: Video Mosaicing is the stitching of selected frames of
a video by estimating the camera motion between the frames and
thereby registering successive frames of the video to arrive at the
mosaic. Different techniques have been proposed in the literature for
video mosaicing. Despite of the large number of papers dealing with
techniques to generate mosaic, only a few authors have investigated
conditions under which these techniques generate good estimate of
motion parameters. In this paper, these techniques are studied under
different videos, and the reasons for failures are found. We propose
algorithms with incorporation of outlier removal algorithms for better
estimation of motion parameters.
Abstract: Automatic detection of bleeding is of practical
importance since capsule endoscopy produces an extremely large
number of images. Algorithm development of bleeding detection in
the digestive tract is difficult due to different contrasts among the
images, food dregs, secretion and others. In this study, were assigned
weighting factors derived from the independent features of the
contrast and brightness between bleeding and normality. Spectral
analysis based on weighting factors was fast and accurate. Results
were a sensitivity of 87% and a specificity of 90% when the accuracy
was determined for each pixel out of 42 endoscope images.
Abstract: The production of activated carbon from low or zero cost of agricultural by-products or wastes has received great attention from academics and practitioners due to its economic and environmental benefits. In the production of bamboo furniture, a significant amount of bamboo waste is inevitably generated. Therefore, this research aimed to prepare activated carbons from bamboo furniture waste by chemical (KOH) activation and determine their properties and adsorption capacities for water treatment. The influence of carbonization time on the properties and adsorption capacities of activated carbons was also investigated. The finding showed that the bamboo-derived activated carbons had microporous characteristics. They exhibited high tendency for the reduction of impurities present in effluent water. Their adsorption capacities were comparable to the adsorption capacity of a commercial activated carbon regarding to the reduction in COD, TDS and turbidity of the effluent water.
Abstract: Traffic density, an indicator of traffic
conditions, is one of the most critical characteristics to
Intelligent Transport Systems (ITS). This paper investigates
recursive traffic density estimation using the information
provided from inductive loop detectors. On the basis of the
phenomenological relationship between speed and density, the
existing studies incorporate a state space model and update the
density estimate using vehicular speed observations via the
extended Kalman filter, where an approximation is made
because of the linearization of the nonlinear observation
equation. In practice, this may lead to substantial estimation
errors. This paper incorporates a suitable transformation to
deal with the nonlinear observation equation so that the
approximation is avoided when using Kalman filter to
estimate the traffic density. A numerical study is conducted. It
is shown that the developed method outperforms the existing
methods for traffic density estimation.
Abstract: An electronic portal image device (EPID) has become
a method of patient-specific IMRT dose verification for radiotherapy.
Research studies have focused on pre and post-treatment verification,
however, there are currently no interventional procedures using EPID
dosimetry that measure the dose in real time as a mechanism to
ensure that overdoses do not occur and underdoses are detected as
soon as is practically possible. As a result, an EPID-based real time
dose verification system for dynamic IMRT was developed and was
implemented with MATLAB/Simulink. The EPID image acquisition
was set to continuous acquisition mode at 1.4 images per second. The
system defined the time constraint gap, or execution gap at the image
acquisition time, so that every calculation must be completed before
the next image capture is completed. In addition, the
Abstract: Mercury adsorption on soil was investigated at
different ionic strengths using Ca(NO3)2 as a background electrolyte.
Results fitted the Langmuir equation and the adsorption isotherms
reached a plateau at higher equilibrium concentrations. Increasing
ionic strength decreased the sorption of mercury, due to the
competition of Ca ions for the sorption sites in the soils. The
influence of ionic strength was related to the mechanisms of heavy
metal sorption by the soil. These results can be of practical
importance both in the agriculture and contaminated soils since the
solubility of mercury in soils are strictly dependent on the adsorption
and release process.
Abstract: In this paper, we propose a novel concept of relative
distance measurement using Stereo Vision Technology and discuss
its implementation on a FPGA based real-time image processor. We
capture two images using two CCD cameras and compare them.
Disparity is calculated for each pixel using a real time dense disparity
calculation algorithm. This algorithm is based on the concept of
indexed histogram for matching. Disparity being inversely
proportional to distance (Proved Later), we can thus get the relative
distances of objects in front of the camera. The output is displayed on
a TV screen in the form of a depth image (optionally using pseudo
colors). This system works in real time on a full PAL frame rate (720
x 576 active pixels @ 25 fps).
Abstract: Unlike this study focused extensively on trading
behavior of option market, those researches were just taken their
attention to model-driven option pricing. For example, Black-Scholes
(B-S) model is one of the most famous option pricing models.
However, the arguments of B-S model are previously mentioned by
some pricing models reviewing. This paper following suggests the
importance of the dynamic character for option pricing, which is also
the reason why using the genetic algorithm (GA). Because of its
natural selection and species evolution, this study proposed a hybrid
model, the Genetic-BS model which combining GA and B-S to
estimate the price more accurate. As for the final experiments, the
result shows that the output estimated price with lower MAE value
than the calculated price by either B-S model or its enhanced one,
Gram-Charlier garch (G-C garch) model. Finally, this work would
conclude that the Genetic-BS pricing model is exactly practical.
Abstract: One of object oriented software developing problem
is the difficulty of searching the appropriate and suitable objects for
starting the system. In this work, ontologies appear in the part of
supporting the object discovering in the initial of object oriented
software developing. There are many researches try to demonstrate
that there is a great potential between object model and ontologies.
Constructing ontology from object model is called ontology
engineering can be done; On the other hand, this research is aiming to
support the idea of building object model from ontology is also
promising and practical. Ontology classes are available online in any
specific areas, which can be searched by semantic search engine.
There are also many helping tools to do so; one of them which are
used in this research is Protégé ontology editor and Visual Paradigm.
To put them together give a great outcome. This research will be
shown how it works efficiently with the real case study by using
ontology classes in travel/tourism domain area. It needs to combine
classes, properties, and relationships from more than two ontologies
in order to generate the object model. In this paper presents a simple
methodology framework which explains the process of discovering
objects. The results show that this framework has great value while
there is possible for expansion. Reusing of existing ontologies offers
a much cheaper alternative than building new ones from scratch.
More ontologies are becoming available on the web, and online
ontologies libraries for storing and indexing ontologies are increasing
in number and demand. Semantic and Ontologies search engines have
also started to appear, to facilitate search and retrieval of online
ontologies.
Abstract: Video sensor networks operate on stringent requirements
of latency. Packets have a deadline within which they have
to be delivered. Violation of the deadline causes a packet to be
treated as lost and the loss of packets ultimately affects the quality
of the application. Network latency is typically a function of many
interacting components. In this paper, we propose ways of reducing
the forwarding latency of a packet at intermediate nodes. The
forwarding latency is caused by a combination of processing delay
and queueing delay. The former is incurred in order to determine the
next hop in dynamic routing. We show that unless link failures in a
very specific and unlikely pattern, a vast majority of these lookups
are redundant. To counter this we propose source routing as the
routing strategy. However, source routing suffers from issues related
to scalability and being impervious to network dynamics. We propose
solutions to counter these and show that source routing is definitely
a viable option in practical sized video networks. We also propose a
fast and fair packet scheduling algorithm that reduces queueing delay
at the nodes. We support our claims through extensive simulation on
realistic topologies with practical traffic loads and failure patterns.
Abstract: Application of Geo-Informatic technology in land
tenure and land use on the economic crop area, to create sustainable
land, access to the area, and produce sustainable food for the demand
of its people in the community. The research objectives are to 1)
apply Geo-Informatic Technology on land ownership and agricultural
land use (cash crops) in the research area, 2) create GIS database on
land ownership and land use, 3) create database of an online Geoinformation
system on land tenure and land use. The results of this
study reveal that, first; the study area is on high slope, mountains and
valleys. The land is mainly in the forest zone which was included in
the Forest Act 1941 and National Conserved Forest 1964. Residents
gained the rights to exploit the land passed down from their
ancestors. The practice was recognized by communities. The land
was suitable for cultivating a wide variety of economic crops that was
the main income of the family. At present the local residents keep
expanding the land to grow cash crops. Second; creating a database
of the geographic information system consisted of the area range,
announcement from the Interior Ministry, interpretation of satellite
images, transportation routes, waterways, plots of land with a title
deed available at the provincial land office. Most pieces of land
without a title deed are located in the forest and national reserve
areas. Data were created from a field study and a land zone
determined by a GPS. Last; an online Geo-Informatic System can
show the information of land tenure and land use of each economic
crop. Satellite data with high resolution which could be updated and
checked on the online Geo-Informatic System simultaneously.
Abstract: Memristor is also known as the fourth fundamental
passive circuit element. When current flows in one direction through
the device, the electrical resistance increases and when current flows
in the opposite direction, the resistance decreases. When the current
is stopped, the component retains the last resistance that it had, and
when the flow of charge starts again, the resistance of the circuit will
be what it was when it was last active. It behaves as a nonlinear
resistor with memory. Recently memristors have generated wide
research interest and have found many applications. In this paper we
survey the various applications of memristors which include non
volatile memory, nanoelectronic memories, computer logic,
neuromorphic computer architectures low power remote sensing
applications, crossbar latches as transistor replacements, analog
computations and switches.
Abstract: The goal of this work is to describe a new algorithm for finding the optimal variable order, number of nodes for any order and other ROBDD parameters, based on a tabular method. The tabular method makes use of a pre-built backend database table that stores the ROBDD size for selected combinations of min-terms. The user uses the backend table and the proposed algorithm to find the necessary ROBDD parameters, such as best variable order, number of nodes etc. Experimental results on benchmarks are given for this technique.
Abstract: Morphological operators transform the original image
into another image through the interaction with the other image of
certain shape and size which is known as the structure element.
Mathematical morphology provides a systematic approach to analyze
the geometric characteristics of signals or images, and has been
applied widely too many applications such as edge detection,
objection segmentation, noise suppression and so on. Fuzzy
Mathematical Morphology aims to extend the binary morphological
operators to grey-level images. In order to define the basic
morphological operations such as fuzzy erosion, dilation, opening
and closing, a general method based upon fuzzy implication and
inclusion grade operators is introduced. The fuzzy morphological
operations extend the ordinary morphological operations by using
fuzzy sets where for fuzzy sets, the union operation is replaced by a
maximum operation, and the intersection operation is replaced by a
minimum operation.
In this work, it consists of two articles. In the first one, fuzzy set
theory, fuzzy Mathematical morphology which is based on fuzzy
logic and fuzzy set theory; fuzzy Mathematical operations and their
properties will be studied in details. As a second part, the application
of fuzziness in Mathematical morphology in practical work such as
image processing will be discussed with the illustration problems.
Abstract: This paper presented the technique of robot control by event-related potentials (ERPs) of brain waves. Based on the proposed technique, severe physical disabilities can free browse outside world. A specific component of ERPs, N2P3, was found and used to control the movement of robot and the view of camera on the designed brain-computer interface (BCI). Users only required watching the stimuli of attended button on the BCI, the evoked potentials of brain waves of the target button, N2P3, had the greatest amplitude among all control buttons. An experimental scene had been constructed that the robot required walking to a specific position and move the view of camera to see the instruction of the mission, and then completed the task. Twelve volunteers participated in this experiment, and experimental results showed that the correct rate of BCI control achieved 80% and the average of execution time was 353 seconds for completing the mission. Four main contributions included in this research: (1) find an efficient component of ERPs, N2P3, for BCI control, (2) embed robot's viewpoint image into user interface for robot control, (3) design an experimental scene and conduct the experiment, and (4) evaluate the performance of the proposed system for assessing the practicability.
Abstract: We propose a novel prioritized limited
processor-sharing (PS) rule and a simulation algorithm for the performance evaluation of this rule. The performance measures of practical interest are evaluated using this algorithm. Suppose that there
are two classes and that an arriving (class-1 or class-2) request encounters n1 class-1 and n2 class-2 requests (including the arriving
one) in a single-server system. According to the proposed rule, class-1
requests individually and simultaneously receive m / (m * n1+ n2) of the service-facility capacity, whereas class-2 requests receive 1 / (m *n1 + n2) of it, if m * n1 + n2 ≤ C. Otherwise (m * n1 + n2 > C), the arriving request will be queued in the corresponding class waiting
room or rejected. Here, m (1) denotes the priority ratio, and C ( ∞), the service-facility capacity. In this rule, when a request arrives at [or
departs from] the system, the extension [shortening] of the remaining
sojourn time of each request receiving service can be calculated using
the number of requests of each class and the priority ratio. Employing
a simulation program to execute these events and calculations enables
us to analyze the performance of the proposed prioritized limited PS
rule, which is realistic in a time-sharing system (TSS) with a
sufficiently small time slot. Moreover, this simulation algorithm is
expanded for the evaluation of the prioritized limited PS system with
N 3 priority classes.