Development of an Immunoassay Platform for Diagnosis of Acute Kidney Injury

Acute kidney injury (AKI) is a new worldwide public health problem. A diagnosis of this disease using creatinine is still a problem in clinical practice. Therefore, a measurement of biomarkers responsible for AKI has received much attention in the past couple years. Cytokine interleukin-18 (IL-18) was reported as one of the early biomarkers for AKI. The most commonly used method to detect this biomarker is an immunoassay. This study used a planar platform to perform an immunoassay using fluorescence for detection. In this study, anti-IL-18 antibody was immobilized onto a microscope slide using a covalent binding method. Make-up samples were diluted at the concentration between 10 to 1000 pg/ml to create a calibration curve. The precision of the system was determined using a coefficient of variability (CV), which was found to be less than 10%. The performance of this immunoassay system was compared with the measurement from ELISA.

Fast Depth Estimation with Filters

Fast depth estimation from binocular vision is often desired for autonomous vehicles, but, most algorithms could not easily be put into practice because of the much time cost. We present an image-processing technique that can fast estimate depth image from binocular vision images. By finding out the lines which present the best matched area in the disparity space image, the depth can be estimated. When detecting these lines, an edge-emphasizing filter is used. The final depth estimation will be presented after the smooth filter. Our method is a compromise between local methods and global optimization.

Complementary Energy Path Adiabatic Logic based Full Adder Circuit

In this paper, we present the design and experimental evaluation of complementary energy path adiabatic logic (CEPAL) based 1 bit full adder circuit. A simulative investigation on the proposed full adder has been done using VIRTUOSO SPECTRE simulator of cadence in 0.18μm UMC technology and its performance has been compared with the conventional CMOS full adder circuit. The CEPAL based full adder circuit exhibits the energy saving of 70% to the conventional CMOS full adder circuit, at 100 MHz frequency and 1.8V operating voltage.

The Effect of Electrical Stimulation Intensity on VEGF Expression and Biomechanical Properties during Wound

We evaluated the effect of sensory (direct current (DC), 600μA) and motor (monophasic current, pulse duration 300μs, 100 Hz, 2.5-3mA) intensities of cathodal electrical stimulation (ES) current to release VEGF and biomechanical properties of wound. 54 male Sprague-dawley rats were randomly assigned into one control and two experimental groups. A full thickness skin incision was made on animals- dorsal region. The experimental groups received ES for 1h/day and every other day. VEGF expression was measured in skin on the 7th day after surgical incision and tensile strength was measured on 21st day. On the 7th day, the values of skin VEGF in the sensory group were significantly greater than those of the other groups (p < 0.05). Sensory and Motor intensity stimulation, can not improve the biomechanical properties of the repaired wounds. It seems the mechanical environment induced by sensory and motor intensity of electrical stimulation, could not simulate the role of normal daily stress and strain to maturation of collagen fibers and their cross links. Further work is needed to determine the relationship between VEGF expression after ES and its effect on tensile strength of healed wound.

Experiment Study on the Plasma Parameters Measurement in Backflow Region of Ion Thruster

The charge-exchange xenon (CEX) ion generated by ion thruster can backflow to the surface of spacecraft and threaten to the safety of spacecraft operation. In order to evaluate the effects of the induced plasma environment in backflow regions on the spacecraft, we designed a spherical single Langmuir probe of 5.8cm in diameter for measuring low-density plasma parameters in backflow region of ion thruster. In practice, the tests are performed in a two-dimensional array (40cm×60cm) composed of 20 sites. The experiment results illustrate that the electron temperature ranges from 3.71eV to 3.96eV, with the mean value of 3.82eV and the standard deviation of 0.064eV. The electron density ranges from 8.30×1012/m3 to 1.66×1013/m3, with the mean value of 1.30×1013/m3 and the standard deviation of 2.15×1012/m3. All data is analyzed according to the “ideal" plasma conditions of Maxwellian distributions.

Mathematical Modeling of SISO based Timoshenko Structures – A Case Study

This paper features the mathematical modeling of a single input single output based Timoshenko smart beam. Further, this mathematical model is used to design a multirate output feedback based discrete sliding mode controller using Bartoszewicz law to suppress the flexural vibrations. The first 2 dominant vibratory modes is retained. Here, an application of the discrete sliding mode control in smart systems is presented. The algorithm uses a fast output sampling based sliding mode control strategy that would avoid the use of switching in the control input and hence avoids chattering. This method does not need the measurement of the system states for feedback as it makes use of only the output samples for designing the controller. Thus, this methodology is more practical and easy to implement.

A CFD Study of Heat Transfer Enhancement in Pipe Flow with Al2O3 Nanofluid

Fluids are used for heat transfer in many engineering equipments. Water, ethylene glycol and propylene glycol are some of the common heat transfer fluids. Over the years, in an attempt to reduce the size of the equipment and/or efficiency of the process, various techniques have been employed to improve the heat transfer rate of these fluids. Surface modification, use of inserts and increased fluid velocity are some examples of heat transfer enhancement techniques. Addition of milli or micro sized particles to the heat transfer fluid is another way of improving heat transfer rate. Though this looks simple, this method has practical problems such as high pressure loss, clogging and erosion of the material of construction. These problems can be overcome by using nanofluids, which is a dispersion of nanosized particles in a base fluid. Nanoparticles increase the thermal conductivity of the base fluid manifold which in turn increases the heat transfer rate. In this work, the heat transfer enhancement using aluminium oxide nanofluid has been studied by computational fluid dynamic modeling of the nanofluid flow adopting the single phase approach.

Counterpropagation Neural Network for Solving Power Flow Problem

Power flow (PF) study, which is performed to determine the power system static states (voltage magnitudes and voltage angles) at each bus to find the steady state operating condition of a system, is very important and is the most frequently carried out study by power utilities for power system planning, operation and control. In this paper, a counterpropagation neural network (CPNN) is proposed to solve power flow problem under different loading/contingency conditions for computing bus voltage magnitudes and angles of the power system. The counterpropagation network uses a different mapping strategy namely counterpropagation and provides a practical approach for implementing a pattern mapping task, since learning is fast in this network. The composition of the input variables for the proposed neural network has been selected to emulate the solution process of a conventional power flow program. The effectiveness of the proposed CPNN based approach for solving power flow is demonstrated by computation of bus voltage magnitudes and voltage angles for different loading conditions and single line-outage contingencies in IEEE 14-bus system.

Analysis of Relation between Unlabeled and Labeled Data to Self-Taught Learning Performance

Obtaining labeled data in supervised learning is often difficult and expensive, and thus the trained learning algorithm tends to be overfitting due to small number of training data. As a result, some researchers have focused on using unlabeled data which may not necessary to follow the same generative distribution as the labeled data to construct a high-level feature for improving performance on supervised learning tasks. In this paper, we investigate the impact of the relationship between unlabeled and labeled data for classification performance. Specifically, we will apply difference unlabeled data which have different degrees of relation to the labeled data for handwritten digit classification task based on MNIST dataset. Our experimental results show that the higher the degree of relation between unlabeled and labeled data, the better the classification performance. Although the unlabeled data that is completely from different generative distribution to the labeled data provides the lowest classification performance, we still achieve high classification performance. This leads to expanding the applicability of the supervised learning algorithms using unsupervised learning.

Sound Teaching Practices in Conducting a Physical Education Program for Persons with an Intellectual Disability

This paper presents key challenges reported by a group of Australian undergraduate Physical Education students in conducting a program for persons with an intellectual disability. Strategies adopted to address these challenges are presented together with representative feedback given by the Physical Education students at the completion of the program. The significance of the program’s findings is summarized.

Assessing the Function of Light and Colorin Architectural View

Light is one of the most important qualitative and symbolic factors and has a special position in architecture and urban development in regard to practical function. The main function of light, either natural or artificial, is lighting up the environment and the constructional forms which is called lighting. However, light is used to redefine the urban spaces by architectural genius with regard to three aesthetic, conceptual and symbolic factors. In architecture and urban development, light has a function beyond lighting up the environment, and the designers consider it as one of the basic components. The present research aims at studying the function of light and color in architectural view and their effects in buildings.

Assessing the Effects of Explosion Waves on Office and Residential Buildings

Explosions may cause intensive damage to buildings and sometimes lead to total and progressive destruction. Pressures induced by explosions are one of the most destructive loads a structure may experience. While designing structures for great explosions may be expensive and impractical, engineers are looking for methods for preventing destructions resulted from explosions. A favorable structural system is a system which does not disrupt totally due to local explosion, since such structures sustain less loss in comparison with structural ones which really bear the load and suddenly disrupt. Designing and establishing vital and necessary installations in a way that it is resistant against direct hit of bomb and rocket is not practical, economical, or expedient in many cases, because the cost of construction and installation with such specifications is several times more than the total cost of the related equipment.

A Practical Approach for Testing the Process Quality

Process capability index Cpk is the most widely used index in making managerial decisions since it provides bounds on the process yield for normally distributed processes. However, existent methods for assessing process performance which constructed by statistical inference may unfortunately lead to fine results, because uncertainties exist in most real-world applications. Thus, this study adopts fuzzy inference to deal with testing of Cpk . A brief score is obtained for assessing a supplier’s process instead of a severe evaluation.

Boundary Segmentation of Microcalcification using Parametric Active Contours

A mammography image is composed of low contrast area where the breast tissues and the breast abnormalities such as microcalcification can hardly be differentiated by the medical practitioner. This paper presents the application of active contour models (Snakes) for the segmentation of microcalcification in mammography images. Comparison on the microcalcifiation areas segmented by the Balloon Snake, Gradient Vector Flow (GVF) Snake, and Distance Snake is done against the true value of the microcalcification area. The true area value is the average microcalcification area in the original mammography image traced by the expert radiologists. From fifty images tested, the result obtained shows that the accuracy of the Balloon Snake, GVF Snake, and Distance Snake in segmenting boundaries of microcalcification are 96.01%, 95.74%, and 95.70% accuracy respectively. This implies that the Balloon Snake is a better segmentation method to locate the exact boundary of a microcalcification region.

A CFD Study of Turbulent Convective Heat Transfer Enhancement in Circular Pipeflow

Addition of milli or micro sized particles to the heat transfer fluid is one of the many techniques employed for improving heat transfer rate. Though this looks simple, this method has practical problems such as high pressure loss, clogging and erosion of the material of construction. These problems can be overcome by using nanofluids, which is a dispersion of nanosized particles in a base fluid. Nanoparticles increase the thermal conductivity of the base fluid manifold which in turn increases the heat transfer rate. Nanoparticles also increase the viscosity of the basefluid resulting in higher pressure drop for the nanofluid compared to the base fluid. So it is imperative that the Reynolds number (Re) and the volume fraction have to be optimum for better thermal hydraulic effectiveness. In this work, the heat transfer enhancement using aluminium oxide nanofluid using low and high volume fraction nanofluids in turbulent pipe flow with constant wall temperature has been studied by computational fluid dynamic modeling of the nanofluid flow adopting the single phase approach. Nanofluid, up till a volume fraction of 1% is found to be an effective heat transfer enhancement technique. The Nusselt number (Nu) and friction factor predictions for the low volume fractions (i.e. 0.02%, 0.1 and 0.5%) agree very well with the experimental values of Sundar and Sharma (2010). While, predictions for the high volume fraction nanofluids (i.e. 1%, 4% and 6%) are found to have reasonable agreement with both experimental and numerical results available in the literature. So the computationally inexpensive single phase approach can be used for heat transfer and pressure drop prediction of new nanofluids.

Intellectual Capital and Competitive Advantage: An Analysis of the Biotechnology Industry

Intellectual capital measurement is a central aspect of knowledge management. The measurement and the evaluation of intangible assets play a key role in allowing an effective management of these assets as sources of competitiveness. For these reasons, managers and practitioners need conceptual and analytical tools taking into account the unique characteristics and economic significance of Intellectual Capital. Following this lead, we propose an efficiency and productivity analysis of Intellectual Capital, as a determinant factor of the company competitive advantage. The analysis is carried out by means of Data Envelopment Analysis (DEA) and Malmquist Productivity Index (MPI). These techniques identify Bests Practice companies that have accomplished competitive advantage implementing successful strategies of Intellectual Capital management, and offer to inefficient companies development paths by means of benchmarking. The proposed methodology is employed on the Biotechnology industry in the period 2007-2010.

Investigating the Determinants of Purchase Intention in C2C E-Commerce

This study aims to examine the determinants of purchase intention in C2C e-commerce. Specifically the role of instant messaging in the C2C e-commerce contextis investigated. In addition to instant messaging, we brought in two antecedents of purchase intention - trust and customer satisfaction - to establish a theoretical research model. Structural equation modeling using LISREL was used to analyze the data.We discussed the research findings and suggested some implications for researchers and practitioners.

Mechanical Evaluation of Stainless Steel and Titanium Dynamic Hip Screws for Trochanteric Fracture

This study aimed to present the mechanical performance evaluation of the dynamic hip screw (DHS) for trochanteric fracture by means of finite element method. The analyses were performed based on stainless steel and titanium implant material definitions at various stages of bone healing and including implant removal. The assessment of the mechanical performance used two parameters, von Mises stress to evaluate the strength of bone and implant and elastic strain to evaluate fracture stability. The results show several critical aspects of dynamic hip screw for trochanteric fracture stabilization. In the initial stage of bone healing process, partial weight bearing should be applied to avoid the implant failure. In the late stage of bone healing, stainless steel implant should be removed.

Analysis of FWM Penalties in DWDM Systems Based on G.652, G.653, and G.655 Optical Fibers

This paper presents an investigation of the power penalties imposed by four-wave mixing (FWM) on G.652 (Single- Mode Fiber - SMF), G.653 (Dispersion-Shifted Fiber - DSF), and G.655 (Non-Zero Dispersion-Shifted Fiber - NZDSF) compliant fibers, considering the DWDM grids suggested by the ITU-T Recommendations G.692, and G.694.1, with uniform channel spacing of 100, 50, 25, and 12.5 GHz. The mathematical/numerical model assumes undepleted pumping, and shows very clearly the deleterious effect of FWM on the performance of DWDM systems, measured by the signal-to-noise ratio (SNR). The results make it evident that non-uniform channel spacing is practically mandatory for WDM systems based on DSF fibers.

A Model for Estimation of Efforts in Development of Software Systems

Software effort estimation is the process of predicting the most realistic use of effort required to develop or maintain software based on incomplete, uncertain and/or noisy input. Effort estimates may be used as input to project plans, iteration plans, budgets. There are various models like Halstead, Walston-Felix, Bailey-Basili, Doty and GA Based models which have already used to estimate the software effort for projects. In this study Statistical Models, Fuzzy-GA and Neuro-Fuzzy (NF) Inference Systems are experimented to estimate the software effort for projects. The performances of the developed models were tested on NASA software project datasets and results are compared with the Halstead, Walston-Felix, Bailey-Basili, Doty and Genetic Algorithm Based models mentioned in the literature. The result shows that the NF Model has the lowest MMRE and RMSE values. The NF Model shows the best results as compared with the Fuzzy-GA based hybrid Inference System and other existing Models that are being used for the Effort Prediction with lowest MMRE and RMSE values.