Abstract: Numerous investigations suggest that Mesenchymal
Stem Cells (MSCs) in general represent a valuable tool for therapy of
symptoms related to chronic inflammatory diseases. Blue Horizon
Stem Cell Therapy Program is a leading provider of adult and
children’s stem cell therapies. Uniquely we have safely and
efficiently treated more than 600 patients with documenting each
procedure. The purpose of our study is primarily to monitor the
immune response in order to validate the safety of intravenous
infusion of human umbilical cord blood derived MSCs (UC-MSCs),
and secondly, to evaluate effects on biomarkers associated with
chronic inflammation. Nine patients were treated for conditions
associated with chronic inflammation and for the purpose of antiaging.
They have been given one intravenous infusion of UCMSCs.
Our study of blood test markers of 9 patients with chronic
inflammation before and within three months after MSCs treatment
demonstrates that there is no significant changes and MSCs treatment
was safe for the patients. Analysis of different indicators of chronic
inflammation and aging included in initial, 24-hours, two weeks and
three months protocols showed that stem cell treatment was safe for
the patients; there were no adverse reactions. Moreover data from
follow up protocols demonstrates significant improvement in energy
level, hair, nails growth and skin conditions. Intravenously
administered UC-MSCs were safe and effective in the improvement
of symptoms related to chronic inflammation. Further close
monitoring and inclusion of more patients are necessary to fully
characterize the advantages of UC-MSCs application in treatment of
symptoms related to chronic inflammation.
Abstract: Background: Diabetic sensorimotor polyneuropathy
(DSP) is one of the most common microvascular complications of
type 2 diabetes. Loss of sensation is thought to contribute to a lack of
static and dynamic stability and increased risk of falling. Purpose:
The purpose of this study was to compare the effects of low-level
laser (LLL) and monochromatic near-infrared photo energy (MIRE)
on pain, cutaneous sensation, static stability, and index of lower limb
blood flow in diabetic patients with peripheral neuropathy. Methods:
Forty diabetic patients with peripheral neuropathy were recruited for
participation in this study. They were divided into two groups: The
MIRE group, which contained 20 patients, and the LLL group, which
contained 20 patients. All patients who participated in the study had
been subjected to various physical assessment procedures, including
pain, cutaneous sensation, Doppler flow meter, and static stability
assessments. The baseline measurements were followed by treatment
sessions that were conducted twice a week for six successive weeks.
Results: The statistical analysis of the data revealed significant
improvement of pain in both groups, with significant improvement in
cutaneous sensation and static balance in the MIRE group compared
to the LLL group; on the other hand, the results showed no
significant differences in lower limb blood flow between the groups.
Conclusion: LLL and MIRE can improve painful symptoms in
patients with diabetic neuropathy. On the other hand, MIRE is also
useful in improving cutaneous sensation and static stability in
patients with diabetic neuropathy.
Abstract: Graphene was dispersed using a tip sonicator and the
effect of surfactants were analysed. Sodium Dodecyl Sulphate (SDS)
and Polyvinyl Alcohol (PVA) were compared to observe whether or
not they had any effect on any de-wrinkling, and secondly whether
they aided to achieve better dispersions. There is a huge demand for
wrinkle free graphene as this will greatly increase its usefulness in
various engineering applications. A comprehensive literature on dewrinkling
graphene has been discussed. Low magnification Scanning
Electronic Microscopy (SEM) was conducted to assess the quality of
graphene de-wrinkling. The utilization of the PVA has significant
effect on de-wrinkling whereas SDS had minimal effect on the dewrinkling
of graphene.
Abstract: In this paper, relationship between different properties
of IC concrete and water cement ratio, obtained from a
comprehensive experiment conducted on IC using local materials
(Burnt clay chips- BC) is presented. In addition, saturated SAP was
used as an IC material in some cases. Relationships have been
developed through regression analysis. The focus of this analysis is
on developing relationship between a dependent variable and an
independent variable. Different percent replacements of BC and
water cement ratios were used. Compressive strength, modulus of
elasticity, water permeability and chloride permeability were tested
and variations of these parameters were analyzed with respect to
water cement ratio.
Abstract: Adequate analgesia following caesarean section
decreases morbidity, hastens ambulation, improves patient outcome
and facilitates care of the newborn. Intrathecal magnesium, an
NMDA antagonist, has been shown to prolong analgesia without
significant side effects in healthy parturients. The aim of this study
was to evaluate the onset and duration of sensory and motor block,
hemodynamic effect, postoperative analgesia, and adverse effects of
magnesium or fentanyl given intrathecally with hyperbaric 0.5%
bupivacaine in patients with mild preeclampsia undergoing caesarean
section. Sixty women with mild preeclampsia undergoing elective
caesarean section were included in a prospective, double blind,
controlled trial. Patients were randomly assigned to receive spinal
anesthesia with 2 mL 0.5% hyperbaric bupivacaine with 12.5 μg
fentanyl (group F) or 0.1 ml of 50% magnesium sulphate (50 mg)
(group M) with 0.15ml preservative free distilled water. Onset,
duration and recovery of sensory and motor block, time to maximum
sensory block, duration of spinal anaesthesia and postoperative
analgesic requirements were studied. Statistical comparison was
carried out using the Chi-square or Fisher’s exact tests and
Independent Student’s t-test where appropriate. The onset of both
sensory and motor block was slower in the magnesium group. The
duration of spinal anaesthesia (246 vs. 284) and motor block (186.3
vs. 210) were significantly longer in the magnesium group. Total
analgesic top up requirement was less in group M. Hemodynamic
parameters were similar in both the groups. Intrathecal magnesium
caused minimal side effects. Since Fentanyl and other opioid
congeners are not available throughout the country easily,
magnesium with its easy availability and less side effect profile can
be a cost effective alternative to fentanyl in managing pregnancy
induced hypertension (PIH) patients given along with Bupivacaine
intrathecally in caesarean section.
Abstract: The primary objective of this work was to study the
effect of resin chemistry, pH and molarity of binding and elution
buffer on aggregate removal using Cation Exchange Chromatography
and find the optimum conditions which can give efficient aggregate
removal with minimum loss of yield. Four different resins were used
for carrying out the experiments: Fractogel EMD SO3
-(S), Fractogel EMD COO-(M), Capto SP ImpRes and S Ceramic HyperD. Runs
were carried out on the AKTA Avant system. Design of Experiments
(DOE) was used for analysis using the JMP software. The
dependence of the yield obtained using different resins on the
operating conditions was studied. Success has been achieved in
obtaining yield greater than 90% using Capto SP ImpRes and
Fractogel EMD COO-(M) resins. It has also been found that a change
in the operating conditions generally has different effects on the
yields obtained using different resins.
Abstract: Mobile Ad Hoc Networks (MANETs) is a collection
of mobile devices forming a communication network without
infrastructure. MANET is vulnerable to security threats due to
network’s limited security, dynamic topology, scalability and the lack
of central management. The Quality of Service (QoS) routing in such
networks is limited by network breakage caused by node mobility or
nodes energy depletions. The impact of node mobility on trust
establishment is considered and its use to propagate trust through a
network is investigated in this paper. This work proposes an
enhanced Associativity Based Routing (ABR) with Fuzzy based
Trust (Fuzzy- ABR) routing protocol for MANET to improve QoS
and to mitigate network attacks.
Abstract: In this paper numerical studies have been carried out
to examine the pre-ignition flow features of high-performance solid
propellant rocket motors with two different port geometries but with
same propellant loading density. Numerical computations have been
carried out using a validated 3D, unsteady, 2nd-order implicit, SST k-
ω turbulence model. In the numerical study, a fully implicit finite
volume scheme of the compressible, Reynolds-Averaged, Navier-
Stokes equations is employed. We have observed from the numerical
results that in solid rocket motors with highly loaded propellants
having divergent port geometry the hot igniter gases can create preignition
pressure oscillations leading to thrust oscillations due to the
flow unsteadiness and recirculation. We have also observed that the
igniter temperature fluctuations are diminished rapidly thereby
reaching the steady state value faster in the case of solid propellant
rocket motors with convergent port than the divergent port
irrespective of the igniter total pressure. We have concluded that the
prudent selection of the port geometry, without altering the propellant
loading density, for damping the total temperature fluctuations within
the motor is a meaningful objective for the suppression and control of
instability and/or thrust oscillations often observed in solid propellant
rocket motors with non-uniform port geometry.
Abstract: Concrete is strong in compression however weak in
tension. The tensile strength as well as ductile property of concrete
could be improved by addition of short dispersed fibers. Polyethylene
terephthalate (PET) fiber obtained from hand cutting or mechanical
slitting of plastic sheets generally used as discrete reinforcement in
substitution of steel fiber. PET fiber obtained from the former process
is in the form of straight slit sheet pattern that impart weaker
mechanical bonding behavior in the concrete matrix. To improve the
limitation of straight slit sheet fiber the present study considered two
additional geometry of fiber namely (a) flattened end slit sheet and
(b) deformed slit sheet. The mix for plain concrete was design for a
compressive strength of 25 MPa at 28 days curing time with a watercement
ratio of 0.5. Cylindrical and beam specimens with 0.5% fibers
volume fraction and without fibers were cast to investigate the
influence of geometry on the mechanical properties of concrete. The
performance parameters mainly studied include flexural strength,
splitting tensile strength, compressive strength and ultrasonic pulse
velocity (UPV). Test results show that geometry of fiber has a
marginal effect on the workability of concrete. However, it plays a
significant role in achieving a good compressive and tensile strength
of concrete. Further, significant improvement in term of flexural and
energy dissipation capacity were observed from other fibers as
compared to the straight slit sheet pattern. Also, the inclusion of PET
fiber improved the ability in absorbing energy in the post-cracking
state of the specimen as well as no significant porous structures.
Abstract: Electrohydraulic servo system have been used in
industry in a wide number of applications. Its dynamics are highly
nonlinear and also have large extent of model uncertainties and
external disturbances. In this paper, a robust back-stepping control
(RBSC) scheme is proposed to overcome the problem of disturbances
and system uncertainties effectively and to improve the tracking
performance of EHS systems. In order to implement the proposed
control scheme, the system uncertainties in EHS systems are
considered as total leakage coefficient and effective oil volume. In
addition, in order to obtain the virtual controls for stabilizing system,
the update rule for the system uncertainty term is induced by
the Lyapunov control function (LCF). To verify the performance and
robustness of the proposed control system, computer simulation of
the proposed control system using Matlab/Simulink Software
is executed. From the computer simulation, it was found that the
RBSC system produces the desired tracking performance and has
robustness to the disturbances and system uncertainties of EHS
systems.
Abstract: Information technology plays an irreplaceable role in
introducing and improving business process orientation in a
company. It enables implementation of the theoretical concept,
measurement of results achieved and undertaking corrective
measures aimed at improvements. Information technology is a key
concept in the development and implementation of the business
process management systems as it establishes a connection to
business operations. Both in the literature and practice, insurance
companies are often seen as highly process oriented due to the nature
of their business and focus on customers. They are also considered
leaders in using information technology for business process
management. The research conducted aimed to investigate whether
the perceived leadership status of insurance companies is well
deserved, i.e. to establish the level of process orientation and explore
the practice of information technology use in insurance companies in
the region. The main instrument for primary data collection within
this research was an electronic survey questionnaire sent to the
management of insurance companies in the Republic of Croatia,
Bosnia and Herzegovina, Slovenia, Serbia and Macedonia. The
conducted research has shown that insurance companies have a
satisfactory level of process orientation, but that there is also a huge
potential for improvement, especially in the segment of information
technology and its connection to business processes.
Abstract: Financial innovations can be regarded as the cause
and the effect of the evolution of the financial system. Most of
financial innovations are created by various financial institutions for
their own purposes and needs. However, due to their diversity,
financial innovations can be also applied by various business entities
(other than financial institutions).
This paper focuses on the potential application of financial
innovations by non-financial companies. It is assumed that financial
innovations may be effectively applied in all fields of corporate
financial decisions integrating financial management with the risk
management process. Appropriate application of financial
innovations may enhance the development of the company and
increase its value by improving its financial situation and reducing
the level of risk. On the other hand, misused financial innovations
may become the source of extra risk for the company threatening its
further operation.
The main objective of the paper is to identify the major types of
financial innovations offered to non-financial companies by the
banking system in Poland. It also aims at identifying the main factors
determining the creation of financial innovations in the banking
system in Poland and indicating future directions of their
development.
This paper consists of conceptual and empirical part. Conceptual
part based on theoretical study is focused on the determinants of the
process of financial innovations and their application by the nonfinancial
companies. Theoretical study is followed by the empirical
research based on the analysis of the actual offer of the 20 biggest
banks operating in Poland with regard to financial innovations
offered to SMEs and large corporations. These innovations are
classified according to the main functions of the integrated financial
management, such as financing, investment, working capital
management and risk management.
Empirical study has proved that the biggest banks operating in the
Polish market offer to their business customers many types and
classes of financial innovations. This offer appears vast and adequate
to the needs and purposes of the Polish non-financial companies. It
was observed that financial innovations pertained to financing
decisions dominate in the banks’ offer. However, due to high
diversification of the offered financial innovations, business
customers may effectively apply them in all fields and areas of
integrated financial management. It should be underlined, that the
banks’ offer is highly dispersed, which may limit the implementation
of financial innovations in the corporate finance. It would be also
recommended for the banks operating in the Polish market to
intensify the education campaign aiming at increasing knowledge
about financial innovations among business customers.
Abstract: Land reallocation is one of the most important steps in
land consolidation projects. Many different models were proposed for
land reallocation in the literature such as Fuzzy Logic, block priority
based land reallocation and Spatial Decision Support Systems. A
model including four parts is considered for automatic block
reallocation with genetic algorithm method in land consolidation
projects. These stages are preparing data tables for a project land,
determining conditions and constraints of land reallocation, designing
command steps and logical flow chart of reallocation algorithm and
finally writing program codes of Genetic Algorithm respectively. In
this study, we designed the first three steps of the considered model
comprising four steps.
Abstract: In recent years, the use of the aluminum based alloys
in the industry and technology are increasing. Alloying elements in
aluminum have further been improving the strength and stiffness
properties that provide superior compared to other metals. In this
study, investigation of physical properties (microstructure,
microhardness, tensile strength, electrical conductivity and thermal
properties) in the Al-12.6wt.%Si-%2wt.Ni ternary alloy were
investigated. Al-Si-Ni alloy was prepared in vacuum atmosphere. The
samples were directionally solidified upwards with different growth
rate V (8.3−165.45 μm/s) at constant temperature gradient G (7.73
K/mm). The flake spacings (λ), microhardness (HV), ultimate tensile
strength (σ), electrical resistivity (ρ) and thermal properties (H, Cp,
Tm) of the samples were measured. Influence of the growth rate and
spacings on microhardness, ultimate tensile strength and electrical
resistivity were investigated and relationships between them were
obtained. According to results, λ values decrease with increasing V,
but HV, σ and ρ values increase with increasing V. Variations of
electrical resistivity (ρ) of solidified samples were also measured.
The enthalpy of fusion (H) and specific heat (Cp) for the alloy was
also determined by differential scanning calorimeter (DSC) from
heating trace during the transformation from liquid to solid. The
results in this work were compared with the previous similar
experimental results.
Abstract: The paper presents an advanced control system for
tennis ball throwing machines to improve their accuracy according to
the ball impact points. A further advantage of the system is the much
easier calibration process involving the intelligent solution of the
automatic adjustment of the stroking parameters according to the ball
elasticity, the self-calibration, the use of the safety margin at very flat
strokes and the possibility to placing the machine to any position of
the half court. The system applies mathematical methods to
determine the exact ball trajectories and special approximating
processes to access all points on the aimed half court.
Abstract: The localization information is crucial for the
operation of WSN. There are principally two types of localization
algorithms. The Range-based localization algorithm has strict
requirements on hardware, thus is expensive to be implemented in
practice. The Range-free localization algorithm reduces the hardware
cost. However, it can only achieve high accuracy in ideal scenarios.
In this paper, we locate unknown nodes by incorporating the
advantages of these two types of methods. The proposed algorithm
makes the unknown nodes select the nearest anchor using the
Received Signal Strength Indicator (RSSI) and choose two other
anchors which are the most accurate to achieve the estimated
location. Our algorithm improves the localization accuracy compared
with previous algorithms, which has been demonstrated by the
simulating results.
Abstract: Expansive soils are often encountered in many parts
of the world, especially in arid and semi-arid fields. Such kind of
soils, generally including active clay minerals in low water content,
enlarge in volume by absorbing the water through the surface and
cause a great harm to the light structures such as channel coating,
roads and airports. The expansive soils were encountered on the path
of Apa-Hotamış conveyance channel belonging to the State
Hydraulic Works in the region of Konya. In the research done in this
area, it is predicted that the soil has a swollen nature and the soil
should be filled with proper granular equipments by digging the
ground to 50-60 cm. In this study, for purpose of helping the other
research to be done in the same area, it is thought that instead of
replacing swollen soil with the granular soil, by stabilizing it with
polypropylene fiber and using it its original place decreases effect of
swelling percent, in this way the cost will be decreased. Therefore,
laboratory tests were conducted to study the effects of polypropylene
fiber on swelling characteristics of expansive soil. Test results
indicated that inclusion of fiber reduced swell percent of expansive
soil. As the fiber content increased, the unconfined compressive
strength was increased. Finally, it can be said that stabilization of
expansive soils with polypropylene fiber is an effective method.
Abstract: The right to basic sanitation, was elevated to the
category of fundamental right by the Constitution of 1988 to protect
the ecologically balanced environment, ensuring social rights to
health and adequate housing and put the dignity of the human person
as the foundation of the Brazilian Democratic State. Before their
essentiality to humans, this article seeks to understand why universal
access to basic sanitation is a goal so difficult to achieve in Brazil.
Therefore, this research uses the deductive and analytical method.
Given the nature of the research literature, research techniques were
centered in specialized books on the subject, journals, theses and
dissertations, laws, relevant law case and raising social indicators
relating to the theme. The relevance of the topic stems, among other
things, the fact that sanitation services are essential for a dignified
life, i.e., everyone is entitled to the maintenance of the necessary
existence conditions are satisfied. However, the effectiveness of this
right is undermined in society, since Brazil has huge deficit in
sanitation services, denying thus a worthy life to most of the
population. Thus, it can be seen that the provision of water and
sewage services in Brazil is still characterized by a large imbalance,
since the municipalities with lower population index have greater
disability in the sanitation service. The truth is that the precariousness
of water and sewage services in Brazil is still very concentrated in the
North and Northeast regions, limiting the effective implementation of
the Law 11.445/2007 in the country. Therefore, there is urgent need
for a positive service by the State in the provision of sanitation
services in order to prevent and control disease, improve quality of
life and productivity of individuals, besides preventing contamination
of water resources. More than just social and economic necessity,
there is a government duty to implement such services. In this sense,
given the current scenario, to achieve universal access to basic
sanitation imposes many hurdles. These are mainly in the field of
properly formulated and implemented public policies, i.e., it requires
an excellent institutional organization, management services,
strategic planning, social control, in order to provide answers to
complex challenges.
Abstract: Below-knee amputees commonly experience
asymmetrical gait patterns. It is generally believed that ischemia is
related to the formation of pressure sores due to uneven distribution
of forces. Micro-vascular responses can reveal local malnutrition.
Changes in local skin blood supply under various external loading
conditions have been studied for a number of years. Radionuclide
clearance, photo-plethysmography, trans-cutaneous oxygen tension
along with other studies showed that the blood supply would be
influenced by the epidermal forces, and the rate and the amount of
blood supply would decrease with increased epidermal loads being
shear forces or normal forces. Several cases of socket designs were
investigated using Finite Element Model (FEM) and Design of
Experiment (DOE) to increase flexibility and minimize the pressure
at the limb/socket interface using ultra high molecular weight
polyethylene (UHMWPE) and polyamide 6 (PA6) or Duraform. The
pressure reliefs at designated areas where reducing thickness is
involved are seen to be critical in determination of amputees’ comfort
and are very important to clinical applications. Implementing a hole
between the Patellar Tendon (PT) and Distal Tibia (DT) would
decrease stiffness and increase prosthesis range of motion where
flexibility is needed. In addition, displacement and prosthetic energy
storage increased without compromising mechanical efficiency and
prosthetic design integrity.
Abstract: Useful lifetime evaluation of chevron rubber spring
was very important in design procedure to assure the safety and
reliability. It is, therefore, necessary to establish a suitable criterion
for the replacement period of chevron rubber spring. In this study, we
performed characteristic analysis and useful lifetime prediction of
chevron rubber spring. Rubber material coefficient was obtained by
curve fittings of uniaxial tension equibiaxial tension and pure shear
test. Computer simulation was executed to predict and evaluate the
load capacity and stiffness for chevron rubber spring. In order to
useful lifetime prediction of rubber material, we carried out the
compression set with heat aging test in an oven at the temperature
ranging from 50°C to 100°C during a period 180 days. By using the
Arrhenius plot, several useful lifetime prediction equations for rubber
material was proposed.