Abstract: The main aim is to perform mutational analysis of CTLA4 gene Exon 1 in SLE patients. A total of 61 SLE patients fulfilling “American College of Rheumatology (ACR) criteria" and 61 controls were enrolled in this study. The region of CTLA4 gene exon 1 was amplified by using Step-down PCR technique. Extracted DNA of band 354 bp was sequenced to analyze mutations in the exon-1 of CTLA-4 gene. Further, protein sequences were identified from nucleotide sequences of CTLA4 Exon 1 by using Expasy software and through Blast P software it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. No variations were found after patients sequences were compared with that of the control sequence. Furthermore it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. Thus CTLA4 gene may not be responsible for an autoimmune disease SLE.
Abstract: A techno-economic evaluation for efficient use of
energy in a large scale industrial plant of methanol is carried out.
This assessment is based on integration of a gas turbine with an
existing plant of methanol in which the outlet gas products of
exothermic reactor is expanded to power generation. Also, it is
decided that methanol production rate is constant through addition of
power generation system to the existing methanol plant. Having
incorporated a gas turbine with the existing plant, the economic
results showed total investment of MUSD 16.9, energy saving of 3.6
MUSD/yr with payback period of approximately 4.7 years.
Abstract: As a tool for human spatial cognition and thinking, the map has been playing an important role. Maps are perhaps as fundamental to society as language and the written word. Economic and social development requires extensive and in-depth understanding of their own living environment, from the scope of the overall global to urban housing. This has brought unprecedented opportunities and challenges for traditional cartography . This paper first proposed the concept of scaleless-map and its basic characteristics, through the analysis of the existing multi-scale representation techniques. Then some strategies are presented for automated mapping compilation. Taking into account the demand of automated map compilation, detailed proposed the software - WJ workstation must have four technical features, which are generalization operators, symbol primitives, dynamically annotation and mapping process template. This paper provides a more systematic new idea and solution to improve the intelligence and automation of the scaleless cartography.
Abstract: Rambutan is a tropical fruit which peel possesses antioxidant properties. This work was conducted to optimize extraction conditions of phenolic compounds from rambutan peel. Response surface methodology (RSM) was adopted to optimize subcritical water extraction (SWE) on temperature, extraction time and percent solvent mixture. The results demonstrated that the optimum conditions for SWE were as follows: temperature 160°C, extraction time 20min. and concentration of 50% ethanol. Comparison of the phenolic compounds from the rambutan peels in maceration 6h, soxhlet 4h, and SWE 20min., it indicated that total phenolic content (using Folin-Ciocalteu-s phenol reagent) was 26.42, 70.29, and 172.47mg of tannic acid equivalent (TAE) per g dry rambutan peel, respectively. The comparative study concluded that SWE was a promising technique for phenolic compounds extraction from rambutan peel, due to much more two times of conventional techniques and shorter extraction times.
Abstract: Project managers are the ultimate responsible for the
overall characteristics of a project, i.e. they should deliver the project
on time with minimum cost and with maximum quality. It is vital for
any manager to decide a trade-off between these conflicting
objectives and they will be benefited of any scientific decision
support tool. Our work will try to determine optimal solutions (rather
than a single optimal solution) from which the project manager will
select his desirable choice to run the project. In this paper, the
problem in project scheduling notated as
(1,T|cpm,disc,mu|curve:quality,time,cost) will be studied. The
problem is multi-objective and the purpose is finding the Pareto
optimal front of time, cost and quality of a project
(curve:quality,time,cost), whose activities belong to a start to finish
activity relationship network (cpm) and they can be done in different
possible modes (mu) which are non-continuous or discrete (disc), and
each mode has a different cost, time and quality . The project is
constrained to a non-renewable resource i.e. money (1,T). Because
the problem is NP-Hard, to solve the problem, a meta-heuristic is
developed based on a version of genetic algorithm specially adapted
to solve multi-objective problems namely FastPGA. A sample project
with 30 activities is generated and then solved by the proposed
method.
Abstract: The paper presents the study of synthetic transmit
aperture method applying the Golay coded transmission for medical
ultrasound imaging. Longer coded excitation allows to increase the
total energy of the transmitted signal without increasing the peak
pressure. Signal-to-noise ratio and penetration depth are improved
maintaining high ultrasound image resolution.
In the work the 128-element linear transducer array with 0.3 mm
inter-element spacing excited by one cycle and the 8 and 16-bit
Golay coded sequences at nominal frequencies 4 MHz was used.
Single element transmission aperture was used to generate a spherical
wave covering the full image region and all the elements received the
echo signals. The comparison of 2D ultrasound images of the wire
phantom as well as of the tissue mimicking phantom is presented to
demonstrate the benefits of the coded transmission. The results were
obtained using the synthetic aperture algorithm with transmit and
receive signals correction based on a single element directivity
function.
Abstract: The article deals with the classification of alternative water resources in terms of potential risks which is the prerequisite for incorporating these water resources to the emergency plans. The classification is based on the quantification of risks resulting from possible damage, disruption or total destruction of water resource caused by natural and anthropogenic hazards, assessment of water quality and availability, traffic accessibility of the assessed resource and finally its water yield. The aim is to achieve the development of an integrated rescue system, which will be capable of supplying the population with drinking water on the whole stricken territory during the states of emergency.
Abstract: Reliability assessment and risk analysis of rotating
machine rotors in various overload and malfunction situations
present challenge to engineers and operators. In this paper a new
analytical method for evaluation of rotor under large deformation is
addressed. Model is presented in general form to include also
composite rotors. Presented simulation procedure is based on
variational work method and has capability to account for geometric
nonlinearity, large displacement, nonlinear support effect and rotor
contacting other machine components. New shape functions are
presented which capable to predict accurate nonlinear profile of
rotor. The closed form solutions for various operating and
malfunction situations are expressed. Analytical simulation results
are discussed
Abstract: This work involved the use of phytoremediation to
remediate an aged soil contaminated with polychlorinated biphenyls
(PCBs). At microcosm scale, tests were prepared using soil samples
that have been collected in an industrial area with a total PCBs
concentration of about 250 μg kg-1. Medicago sativa and Lolium
italicum were the species selected in this study that is used as
“feasibility test" for full scale remediation. The experiment was
carried out with the addition of a mixture of randomly methylatedbeta-
cyclodextrins (RAMEB). At the end of the experiment analysis
of soil samples showed that in general the presence of plants has led
to a higher degradation of most congeners with respect to not
vegetated soil. The two plant species efficiencies were comparable
and improved by RAMEB addition with a final reduction of total
PCBs near to 50%. With increasing the chlorination of the congeners
the removal percentage of PCBs progressively decreased.
Abstract: By the application of an improved back-propagation
neural network (BPNN), a model of current densities for a solid oxide
fuel cell (SOFC) with 10 layers is established in this study. To build
the learning data of BPNN, Taguchi orthogonal array is applied to
arrange the conditions of operating parameters, which totally 7 factors
act as the inputs of BPNN. Also, the average current densities
achieved by numerical method acts as the outputs of BPNN.
Comparing with the direct solution, the learning errors for all learning
data are smaller than 0.117%, and the predicting errors for 27
forecasting cases are less than 0.231%. The results show that the
presented model effectively builds a mathematical algorithm to predict
performance of a SOFC stack immediately in real time.
Also, the calculating algorithms are applied to proceed with the
optimization of the average current density for a SOFC stack. The
operating performance window of a SOFC stack is found to be
between 41137.11 and 53907.89. Furthermore, an inverse predicting
model of operating parameters of a SOFC stack is developed here by
the calculating algorithms of the improved BPNN, which is proved to
effectively predict operating parameters to achieve a desired
performance output of a SOFC stack.
Abstract: The effects of coatings based on sodium alginate (S.A) and carboxyl methyl cellulose (CMC) on the color and moisture characteristics of potato round slices were investigated. It is the first time that this combination of polysaccharides is used as edible coating which alone had the best performance as inhibitor of potato color discoloration during the storage of 15 days at 4oC. When ascorbic acid (AA) and green tea (GT) were added in the above edible coating its effects on potato round slices changed. The mixtures of sodium alginate and carboxyl methyl cellulose with ascorbic acid or with green tea behave as a potential moisture barrier, resulting to the extent of potato samples self–life. These data suggests that both GT and AA are potential inhibitors of dehydration in potatoes and not only natural antioxidants.
Abstract: The purposes of the study are to study and to
investigate the relationship among exposure, uses and gratifications
of television morning news among undergraduate students in
Bangkok. This study also compares differences in information
exposure, uses and gratifications of television morning news among
these students.
The research methodology employed a questionnaire as a
quantitative method. The respondents were undergraduate students at
public and private universities in Bangkok. Totally, 400 usable
questionnaires were received. Descriptive and inferential statistics
were used in data analysis.
The results indicated that information exposure of undergraduate
students in Bangkok was at a high level. Students’ uses and
gratifications were also at high level. Information exposure was
positively correlated with uses and gratifications. Uses of information
were positively correlated with satisfaction with information. The
results also showed that students with differences in sex and type of
university were not significantly different in information exposure,
and uses and gratifications.
Abstract: Structured phospholipids from commercial soybean
lecithin with oil enriched omega-3 fatty acid form by product of tuna
canning is alternative procedure to provides the stability of omega-3
fatty acid structure and increase these bioactive function in
metabolism. Best treatment condition was obtain in 18 hours
acidolysis reaction with 30% enzyme concentration, which EPADHA
incorporation level was 127,47 mg/g and incorporation
percentage of EPA-DHA was 51,04% at phospholipids structure.
This structured phospolipids could reduce atherosclerosis risk in
male Sprague dawley rat. Provision of structured phospholipids has
significant effect (α = 0.05) on changes in lipid profile, intima-media
thickness of aorta rats (male Sprague dawley) fed atherogenic diet.
Structured phospholipids intake can lower total cholesterol 78.36
mg/dL, total triglycerides 94,57 mg/dL, LDL levels 87.08 mg/dL and
increased HDL level as much as 12,64 mg/dL in 10 weeks cares.
Structured phospholipids intake also can prevent the thickening of
the intima-media layer of the aorta.
Abstract: Mixed model assembly lines (MMAL) are a type of
production line where a variety of product models similar in product
characteristics are assembled. The effective design of these lines
requires that schedule for assembling the different products is
determined. In this paper we tried to fit the sequencing problem with
the main characteristics of make to order (MTO) environment. The
problem solved in this paper is a multiple objective sequencing
problem in mixed model assembly lines sequencing using weighted
Sum Method (WSM) using GAMS software for small problem and
an effective GA for large scale problems because of the nature of
NP-hardness of our problem and vast time consume to find the
optimum solution in large problems. In this problem three practically
important objectives are minimizing: total utility work, keeping a
constant production rate variation, and minimizing earliness and
tardiness cost which consider the priority of each customer and
different due date which is a real situation in mixed model assembly
lines and it is the first time we consider different attribute to
prioritize the customers which help the company to reduce the cost of
earliness and tardiness. This mechanism is a way to apply an advance
available to promise (ATP) in mixed model assembly line sequencing
which is the main contribution of this paper.
Abstract: Background: Blunt aortic trauma (BAT) includes
various morphological changes that occur during deceleration,
acceleration and/or body compression in traffic accidents. The
various forms of BAT, from limited laceration of the intima to
complete transection of the aorta, depends on the force acting on the
vessel wall and the tolerance of the aorta to injury. The force depends
on the change in velocity, the dynamics of the accident and of the
seating position in the car. Tolerance to aortic injury depends on the
anatomy, histological structure and pathomorphological alterations
due to aging or disease of the aortic wall.
An overview of the literature and medical documentation reveals
that different terms are used to describe certain forms of BAT, which
can lead to misinterpretation of findings or diagnoses. We therefore,
propose a classification that would enable uniform systematic
screening of all forms of BAT. We have classified BAT into three
morphologycal types: TYPE I (intramural), TYPE II (transmural) and
TYPE III (multiple) aortic ruptures with appropriate subtypes.
Methods: All car accident casualties examined at the Institute of
Forensic Medicine from 2001 to 2009 were included in this
retrospective study. Autopsy reports were used to determine the
occurrence of each morphological type of BAT in deceased drivers,
front seat passengers and other passengers in cars and to define the
morphology of BAT in relation to the accident dynamics and the age
of the fatalities.
Results: A total of 391 fatalities in car accidents were included in
the study. TYPE I, TYPE II and TYPE III BAT were observed in
10,9%, 55,6% and 33,5%, respectively. The incidence of BAT in
drivers, front seat and other passengers was 36,7%, 43,1% and
28,6%, respectively. In frontal collisions, the incidence of BAT was
32,7%, in lateral collisions 54,2%, and in other traffic accidents
29,3%. The average age of fatalities with BAT was 42,8 years and of
those without BAT 39,1 years.
Conclusion: Identification and early recognition of the risk factors
of BAT following a traffic accident is crucial for successful treatment
of patients with BAT. Front seat passengers over 50 years of age who
have been injured in a lateral collision are the most at risk of BAT.
Abstract: A brushless DC motor with integrated drive circuit for air management system is presented. Using magnetic equivalent circuit model a basic design of the motor is determined, and specific configurations are inspected thanks to finite element analysis. In order to reduce an unbalanced magnetic force in an axial direction, induced forces between a stator core and a permanent magnet are calculated with respect to the relative positions of them. For the high efficiency, and high power density, BLDC motor and drive are developed. Also vibration mode and eccentricity of a rotor are considered at the rated and maximum rotational speed Through the experimental results, a validity of the simulated one is confirmed.
Abstract: This paper proposes a new methodology for the
optimal allocation and sizing of Embedded Generation (EG)
employing Real Coded Genetic Algorithm (RCGA) to minimize the
total power losses and to improve voltage profiles in the radial
distribution networks. RCGA is a method that uses continuous
floating numbers as representation which is different from
conventional binary numbers. The RCGA is used as solution tool,
which can determine the optimal location and size of EG in radial
system simultaneously. This method is developed in MATLAB. The
effect of EG units- installation and their sizing to the distribution
networks are demonstrated using 24 bus system.
Abstract: In diversity rich environments, such as in Ultra-
Wideband (UWB) applications, the a priori determination of the
number of strong diversity branches is difficult, because of the considerably large number of diversity paths, which are characterized
by a variety of power delay profiles (PDPs). Several
Rake implementations have been proposed in the past, in order to reduce the number of the estimated and combined paths. To this
aim, we introduce two adaptive Rake receivers, which combine
a subset of the resolvable paths considering simultaneously the
quality of both the total combining output signal-to-noise ratio (SNR) and the individual SNR of each path. These schemes achieve
better adaptation to channel conditions compared to other known receivers, without further increasing the complexity. Their performance
is evaluated in different practical UWB channels, whose models are based on extensive propagation measurements. The
proposed receivers compromise between the power consumption,
complexity and performance gain for the additional paths, resulting in important savings in power and computational resources.
Abstract: Traffic congestion has become a major problem in
many countries. One of the main causes of traffic congestion is due
to road merges. Vehicles tend to move slower when they reach the
merging point. In this paper, an enhanced algorithm for traffic
simulation based on the fluid-dynamic algorithm and kinematic wave
theory is proposed. The enhanced algorithm is used to study traffic
congestion at a road merge. This paper also describes the
development of a dynamic traffic simulation tool which is used as a
scenario planning and to forecast traffic congestion level in a certain
time based on defined parameter values. The tool incorporates the
enhanced algorithm as well as the two original algorithms. Output
from the three above mentioned algorithms are measured in terms of
traffic queue length, travel time and the total number of vehicles
passing through the merging point. This paper also suggests an
efficient way of reducing traffic congestion at a road merge by
analyzing the traffic queue length and travel time.
Abstract: In this work, we propose a hybrid heuristic in order to
solve the Team Orienteering Problem (TOP). Given a set of points (or
customers), each with associated score (profit or benefit), and a team
that has a fixed number of members, the problem to solve is to visit a
subset of points in order to maximize the total collected score. Each
member performs a tour starting at the start point, visiting distinct
customers and the tour terminates at the arrival point. In addition,
each point is visited at most once, and the total time in each tour
cannot be greater than a given value. The proposed heuristic combines
beam search and a local optimization strategy. The algorithm was
tested on several sets of instances and encouraging results were
obtained.